ZA200506204B - 2-propylidene-19-nor-vitamin D compounds - Google Patents
2-propylidene-19-nor-vitamin D compounds Download PDFInfo
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- ZA200506204B ZA200506204B ZA200506204A ZA200506204A ZA200506204B ZA 200506204 B ZA200506204 B ZA 200506204B ZA 200506204 A ZA200506204 A ZA 200506204A ZA 200506204 A ZA200506204 A ZA 200506204A ZA 200506204 B ZA200506204 B ZA 200506204B
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- ZA
- South Africa
- Prior art keywords
- compound
- hydroxy
- group
- hydrogen
- isomer
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 251
- 229910052739 hydrogen Inorganic materials 0.000 claims description 103
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 103
- 239000001257 hydrogen Substances 0.000 claims description 99
- 150000002431 hydrogen Chemical class 0.000 claims description 77
- 239000000203 mixture Substances 0.000 claims description 67
- 125000000217 alkyl group Chemical group 0.000 claims description 54
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- 201000010099 disease Diseases 0.000 claims description 32
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- 238000000034 method Methods 0.000 claims description 29
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 28
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- 229910052799 carbon Inorganic materials 0.000 claims description 27
- 125000004043 oxo group Chemical group O=* 0.000 claims description 26
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 24
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
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- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
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- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
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| US46195803P | 2003-04-10 | 2003-04-10 |
Publications (1)
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| ZA200506204B true ZA200506204B (en) | 2006-10-25 |
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| CN (2) | CN100534981C (es) |
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| MXPA05009336A (es) * | 2003-04-10 | 2005-11-04 | Wisconsin Alumni Res Found | Compuestos de 2-propiliden-19-nor-vitamina d. |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| AU2006213722B2 (en) * | 2005-02-11 | 2011-09-22 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20S-24epi)-1alpha,25-dihydroxyvitamin-D2 |
| EP1853274B1 (en) * | 2005-02-11 | 2013-01-23 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor- (20s-24s) - 1alpha, 25-dihydroxyvitamine-d2 |
| US8114393B2 (en) | 2005-09-14 | 2012-02-14 | Wisconsin Alumni Research Foundation | Methods and compositions for phosphate binding |
| US20090281340A1 (en) * | 2006-04-05 | 2009-11-12 | Deluca Hector F | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof |
| US8058265B2 (en) * | 2006-04-05 | 2011-11-15 | Wisconsin Alumni Research Foundation | 1a-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and treatment thereof |
| US7538098B2 (en) * | 2006-04-06 | 2009-05-26 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2 or 3,2 heterocyclic ring |
| WO2008125901A2 (en) * | 2006-04-06 | 2008-10-23 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof |
| MX2008012672A (es) * | 2006-04-06 | 2008-10-15 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a-hidroxi-18,19,21-trinor vitamina d3 y sus usos. |
| US8404666B2 (en) | 2006-04-06 | 2013-03-26 | Wisconsin Alumni Research Foundation | 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof |
| US7648973B2 (en) * | 2006-04-06 | 2010-01-19 | Wisconsin Alumni Research Foundation | 2-methylene-1α,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
| CA2646909A1 (en) * | 2006-04-06 | 2008-03-27 | Hector F. Deluca | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
| ATE496885T1 (de) * | 2006-04-10 | 2011-02-15 | Wisconsin Alumni Res Found | 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette |
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| EP0078704B1 (en) | 1981-11-02 | 1987-04-29 | Research Institute For Medicine And Chemistry Inc. | Intermediates in the synthesis of vitamin d derivatives |
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
| ES2123505T3 (es) | 1990-09-07 | 1999-01-16 | Wisconsin Alumni Res Found | Nuevo uso de compuestos de 19-nor-vitamina d 1alfa-hidroxilada para tratar la psoriasis. |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP3213092B2 (ja) * | 1991-11-01 | 2001-09-25 | 中外製薬株式会社 | ２β位に置換基を有するビタミンＤ誘導体 |
| DE69400495T2 (de) * | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| WO1996001811A1 (en) * | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| AU4235696A (en) | 1994-11-21 | 1996-06-17 | Wisconsin Alumni Research Foundation | 18,19-dinor-vitamin d compounds |
| US5877168A (en) * | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| IL118156A (en) * | 1995-05-09 | 2001-08-26 | Duphar Int Res | Vitamin d compounds, their preparation and pharmaceutical compositions containing them |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| GB9915839D0 (en) * | 1999-07-06 | 1999-09-08 | Textron Automotive U K | Valve assembly for vehicle washing system |
| DK1286962T3 (da) | 2000-05-31 | 2008-10-06 | Wisconsin Alumni Res Found | 2-Ethyl og 2-ethyliden-19-nor-vitamin D-forbindelser |
| EP1524264A3 (en) * | 2000-05-31 | 2010-01-20 | Wisconsin Alumni Research Foundation | 2-ethylidene-19-nor-vitamin D compounds |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| MXPA05009336A (es) * | 2003-04-10 | 2005-11-04 | Wisconsin Alumni Res Found | Compuestos de 2-propiliden-19-nor-vitamina d. |
| EP1694333A2 (en) * | 2003-11-25 | 2006-08-30 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
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Also Published As
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| US7241747B2 (en) | 2007-07-10 |
| JP2006523239A (ja) | 2006-10-12 |
| US20060293291A1 (en) | 2006-12-28 |
| CN101293894A (zh) | 2008-10-29 |
| CN100534981C (zh) | 2009-09-02 |
| JP5005340B2 (ja) | 2012-08-22 |
| EP1613588B1 (en) | 2012-05-09 |
| MXPA05009336A (es) | 2005-11-04 |
| CA2516233A1 (en) | 2004-10-28 |
| ATE556999T1 (de) | 2012-05-15 |
| BRPI0409194A (pt) | 2006-04-11 |
| CN101293894B (zh) | 2011-04-06 |
| WO2004092118A3 (en) | 2005-01-27 |
| US20040229851A1 (en) | 2004-11-18 |
| AU2004230948A1 (en) | 2004-10-28 |
| NZ542674A (en) | 2009-03-31 |
| KR20050120787A (ko) | 2005-12-23 |
| CN1771226A (zh) | 2006-05-10 |
| US7531527B2 (en) | 2009-05-12 |
| WO2004092118A2 (en) | 2004-10-28 |
| MY146504A (en) | 2012-08-15 |
| CA2516233C (en) | 2011-09-20 |
| EP1613588A2 (en) | 2006-01-11 |
| US20070213546A1 (en) | 2007-09-13 |
| HK1086817A1 (en) | 2006-09-29 |
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