WO2006071773A3 - Treatment of osteochondral diseases using postpartum-derived cells and products thereof - Google Patents
Treatment of osteochondral diseases using postpartum-derived cells and products thereof Download PDFInfo
- Publication number
- WO2006071773A3 WO2006071773A3 PCT/US2005/046782 US2005046782W WO2006071773A3 WO 2006071773 A3 WO2006071773 A3 WO 2006071773A3 US 2005046782 W US2005046782 W US 2005046782W WO 2006071773 A3 WO2006071773 A3 WO 2006071773A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- postpartum
- products
- treatment
- derived cells
- cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/42—Organic phosphate, e.g. beta glycerophosphate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/19—Growth and differentiation factors [GDF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Abstract
Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products such as lysates related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions such as osteoarthritis.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05855357A EP1838842A2 (en) | 2004-12-23 | 2005-12-22 | Treatment of osteochondral diseases using postpartum-derived cells and products thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63870304P | 2004-12-23 | 2004-12-23 | |
US60/638,703 | 2004-12-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006071773A2 WO2006071773A2 (en) | 2006-07-06 |
WO2006071773A3 true WO2006071773A3 (en) | 2006-12-21 |
Family
ID=36615443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/046782 WO2006071773A2 (en) | 2004-12-23 | 2005-12-22 | Treatment of osteochondral diseases using postpartum-derived cells and products thereof |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1838842A2 (en) |
WO (1) | WO2006071773A2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8916146B2 (en) | 2007-02-12 | 2014-12-23 | Anthrogenesis Corporation | Treatment of inflammatory diseases using placental stem cells |
US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
US9234172B2 (en) | 2003-06-27 | 2016-01-12 | DePuy Synthes Products, Inc. | Repair and regeneration of ocular tissue using postpartum-derived cells |
US9498501B2 (en) | 2003-06-27 | 2016-11-22 | DePuy Synthes Products, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
WO2006071802A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells |
WO2007070870A1 (en) | 2005-12-16 | 2007-06-21 | Ethicon, Inc. | Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
ZA200902233B (en) * | 2006-10-23 | 2010-07-28 | Anthrogenesis Corp | Methods and compositions for treatment of bone defects with placental cell populations |
CN101688177A (en) | 2007-02-12 | 2010-03-31 | 人类起源公司 | Liver cell and chondrocyte from adherent placental stem cells; And CD34 +, CD45 -The cell mass of placenta stem-cell enrichment |
EP2164953A4 (en) | 2007-06-18 | 2010-06-30 | Childrens Hosp & Res Ct Oak | Method of isolating stem and progenitor cells from placenta |
EP2379088B1 (en) | 2008-12-19 | 2018-02-28 | DePuy Synthes Products, Inc. | Treatment of lung and pulmonary diseases and disorders |
US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
US8771677B2 (en) | 2008-12-29 | 2014-07-08 | Vladimir B Serikov | Colony-forming unit cell of human chorion and method to obtain and use thereof |
JP5908394B2 (en) | 2009-03-26 | 2016-04-26 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | Human umbilical cord tissue cells as a therapy for Alzheimer's disease |
WO2011153512A2 (en) | 2010-06-03 | 2011-12-08 | Indiana University Research And Technology Corporation | Use of compounds with thrombopoietic activity to promote bone growth and healing |
US20140147419A1 (en) * | 2010-10-29 | 2014-05-29 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for formation of bone tissue |
US8574899B2 (en) | 2010-12-22 | 2013-11-05 | Vladimir B Serikov | Methods for augmentation collection of placental hematopoietic stem cells and uses thereof |
WO2013010045A1 (en) * | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
JP6301263B2 (en) | 2011-12-23 | 2018-03-28 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | Detection of human umbilical cord tissue-derived cells |
EP3327439A1 (en) * | 2016-11-24 | 2018-05-30 | Vito NV | Flatbed exposure module for testing toxicity of nanoparticles on cells grown at air-liquid interface |
CA3151890A1 (en) * | 2019-09-03 | 2021-03-11 | Enlivex Therapeutics Ltd | Therapeutic apoptotic cells for treatment of osteoarthritis |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5919702A (en) * | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
US20030032179A1 (en) * | 2000-12-06 | 2003-02-13 | Hariri Robert J. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
WO2003068937A2 (en) * | 2002-02-13 | 2003-08-21 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells |
US20030161818A1 (en) * | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
WO2003087392A2 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
WO2004072273A1 (en) * | 2003-02-11 | 2004-08-26 | Davies John E | Progenitor cells from wharton's jelly of human umbilical cord |
WO2005001076A2 (en) * | 2003-06-27 | 2005-01-06 | Ethicon, Incorporated | Postpartum cells derived from placental tissue, and methods of making and using the same |
-
2005
- 2005-12-22 WO PCT/US2005/046782 patent/WO2006071773A2/en active Application Filing
- 2005-12-22 EP EP05855357A patent/EP1838842A2/en not_active Withdrawn
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5919702A (en) * | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
US20030032179A1 (en) * | 2000-12-06 | 2003-02-13 | Hariri Robert J. | Post-partum mammalian placenta, its use and placental stem cells therefrom |
WO2003068937A2 (en) * | 2002-02-13 | 2003-08-21 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells |
US20030161818A1 (en) * | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
WO2003087392A2 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
WO2004072273A1 (en) * | 2003-02-11 | 2004-08-26 | Davies John E | Progenitor cells from wharton's jelly of human umbilical cord |
WO2005001076A2 (en) * | 2003-06-27 | 2005-01-06 | Ethicon, Incorporated | Postpartum cells derived from placental tissue, and methods of making and using the same |
WO2005003334A2 (en) * | 2003-06-27 | 2005-01-13 | Ethicon, Incorporated | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
WO2005038012A2 (en) * | 2003-06-27 | 2005-04-28 | Ethicon Incorporated | Cartilage and bone repair and regeneration using postpartum-derived cells |
Non-Patent Citations (9)
Title |
---|
EBLENKAMP M ET AL: "[Umbilical cord stromal cells (UCSC). Cells featuring osteogenic differentiation potential]", DER ORTHOPADE. DEC 2004, vol. 33, no. 12, December 2004 (2004-12-01), pages 1338 - 1345, XP002331941, ISSN: 0085-4530 * |
FUKUCHI Y ET AL: "HUMAN PLACENTA-DERIVED CELLS HAVE MESENCHYMAL STEM/PROGENITOR CELL POTENTIAL", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 22, no. 5, 2004, pages 649 - 658, XP009046573, ISSN: 1066-5099 * |
ISHII M ET AL: "Molecular markers distinguish bone marrow mesenchymal stem cells from fibroblasts", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 332, no. 1, 24 June 2005 (2005-06-24), pages 297 - 303, XP004892979, ISSN: 0006-291X * |
JOHNSTONE B ET AL: "IN VITRO CHONDROGENESIS OF BONE MARROW-DERIVED MESENCHYMAL PROGENITOR CELLS", EXPERIMENTAL CELL RESEARCH, SAN DIEGO, CA, US, vol. 238, no. 1, 1998, pages 265 - 272, XP000881888, ISSN: 0014-4827 * |
LODIE T A ET AL: "Systematic analysis of reportedly distinct populations of multipotent bone marrow-derived stem cells reveals a lack of distinction", TISSUE ENGINEERING, LARCHMONT, NY, US, vol. 8, no. 5, October 2002 (2002-10-01), pages 739 - 751, XP002306489, ISSN: 1076-3279 * |
MITCHELL K E ET AL: "Matrix cells from Wharton's jelly form neurons and glia", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 21, no. 1, January 2003 (2003-01-01), pages 50 - 60, XP002281007, ISSN: 1066-5099 * |
ROMANOV YURI A ET AL: "Searching for alternative sources of postnatal human mesenchymal stem cells: Candidate MSC-like cells from umbilical cord.", STEM CELLS (MIAMISBURG), vol. 21, no. 1, January 2003 (2003-01-01), pages 105 - 110, XP002331940, ISSN: 1066-5099 * |
TREMAIN N ET AL: "MICROSAGE ANALYSIS OF 2,353 EXPRESSED GENES IN A SINGLE CELL-DERIVED COLONY OF UNDIFFERENTIATED HUMAN MESENCHYMAL STEM CELLS REVEALS MRNAS OF MULTIPLE CELL LINEAGES", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 19, 2001, pages 408 - 418, XP002907879, ISSN: 1066-5099 * |
WULF G G ET AL: "MESENGENIC PROGENITOR CELLS DERIVED FROM HUMAN PLACENTA", TISSUE ENGINEERING, LARCHMONT, NY, US, vol. 10, no. 7/8, July 2004 (2004-07-01), pages 1136 - 1147, XP001206075, ISSN: 1076-3279 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9234172B2 (en) | 2003-06-27 | 2016-01-12 | DePuy Synthes Products, Inc. | Repair and regeneration of ocular tissue using postpartum-derived cells |
US9498501B2 (en) | 2003-06-27 | 2016-11-22 | DePuy Synthes Products, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making and using the same |
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
US9585918B2 (en) | 2005-12-28 | 2017-03-07 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
US8916146B2 (en) | 2007-02-12 | 2014-12-23 | Anthrogenesis Corporation | Treatment of inflammatory diseases using placental stem cells |
Also Published As
Publication number | Publication date |
---|---|
EP1838842A2 (en) | 2007-10-03 |
WO2006071773A2 (en) | 2006-07-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2006071773A3 (en) | Treatment of osteochondral diseases using postpartum-derived cells and products thereof | |
WO2005038012A3 (en) | Cartilage and bone repair and regeneration using postpartum-derived cells | |
WO2007016112A3 (en) | Use of adipose tissue-derived stromal cells in spinal fusion | |
WO2006083394A3 (en) | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same | |
IL147271A0 (en) | Compounds that bind her2 | |
ATE365045T1 (en) | PRODUCTION OF SOFT AND BONE TISSUE USING PRECURSOR CELLS FROM MUSCLE, AS WELL AS ASSOCIATED COMPOSITIONS AND FORMS OF TREATMENT | |
EP2182006A3 (en) | Compositions and methods for the treatment of immune related diseases | |
EP1077254A3 (en) | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof | |
WO2002036751A3 (en) | Human cord blood derived unrestricted somatic stem cells (ussc) | |
MY161991A (en) | Proteasome inhibitors | |
WO2010057112A3 (en) | Genetic variants underlying human cognition and methods of use thereof as diagnostic and therapeutic targets | |
WO2004047728A3 (en) | Compositions and methods for the treatment of immune related diseases | |
WO2004039956A3 (en) | Compositions and methods for the treatment of immune related diseases | |
WO2005032471A3 (en) | Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease | |
WO2005062881A3 (en) | Gene therapy using transposon-based vectors | |
WO2004024097A8 (en) | Compositions and methods for the treatment of immune related diseases | |
AU2003221745A1 (en) | rAAV VECTOR-BASED COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MAMMALIAN DISEASES | |
WO2005079195A3 (en) | Pyrazolopyridines and analogs thereof | |
TW200606162A (en) | Pyrazolopyridine derivatives | |
UA95715C2 (en) | Phosphadiazine derivatives, pharmaceutical composition and use thereof | |
DE602007010764D1 (en) | Benzamidglucokinaseaktivatoren | |
WO2001094541A3 (en) | Human mesenchymal progenitor cell | |
MX2007001876A (en) | Vla-4 antagonists. | |
WO2004024072A3 (en) | Novel compositions and methods for the treatment of immune related diseases | |
MY134738A (en) | New product |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005855357 Country of ref document: EP |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |