JP2008520704A5 - - Google Patents
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- Publication number
- JP2008520704A5 JP2008520704A5 JP2007543268A JP2007543268A JP2008520704A5 JP 2008520704 A5 JP2008520704 A5 JP 2008520704A5 JP 2007543268 A JP2007543268 A JP 2007543268A JP 2007543268 A JP2007543268 A JP 2007543268A JP 2008520704 A5 JP2008520704 A5 JP 2008520704A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- alkyl
- hydroxy
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 70
- 239000001257 hydrogen Substances 0.000 claims 70
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 65
- 125000000217 alkyl group Chemical group 0.000 claims 64
- 150000002431 hydrogen Chemical class 0.000 claims 57
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 229910052805 deuterium Inorganic materials 0.000 claims 16
- 125000001153 fluoro group Chemical group F* 0.000 claims 16
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 16
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 16
- 125000004043 oxo group Chemical group O=* 0.000 claims 16
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 16
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 125000006239 protecting group Chemical group 0.000 claims 9
- 125000001118 alkylidene group Chemical group 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 8
- 125000004430 oxygen atom Chemical group O* 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000004434 sulfur atom Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 229930003316 Vitamin D Natural products 0.000 claims 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 4
- 235000019166 vitamin D Nutrition 0.000 claims 4
- 239000011710 vitamin D Substances 0.000 claims 4
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 4
- 229940046008 vitamin d Drugs 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- AEDMQUAPBVOJNN-UHFFFAOYSA-N [3-[2-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3-thiazol-5-yl]-1,2,4-oxadiazol-5-yl]methanol Chemical compound O1C(CO)=NC(C=2SC(=NC=2)N2CCC(CC2)OC=2C(=CC=CC=2)C(F)(F)F)=N1 AEDMQUAPBVOJNN-UHFFFAOYSA-N 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000006409 renal osteodystrophy Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000002374 sebum Anatomy 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 230000037393 skin firmness Effects 0.000 claims 1
- 230000037067 skin hydration Effects 0.000 claims 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63000704P | 2004-11-22 | 2004-11-22 | |
| US60/630,007 | 2004-11-22 | ||
| PCT/US2005/041819 WO2006057900A2 (en) | 2004-11-22 | 2005-11-18 | 17,20(z)-dehydro vitamin d analogs and their uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008520704A JP2008520704A (ja) | 2008-06-19 |
| JP2008520704A5 true JP2008520704A5 (https=) | 2009-01-15 |
| JP5161582B2 JP5161582B2 (ja) | 2013-03-13 |
Family
ID=36216285
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007543269A Pending JP2008520705A (ja) | 2004-11-22 | 2005-11-18 | ２−メチレン−１９−ノル−１α−ヒドロキシ−１７−エン−ホモプレグナカルシフェロールおよびその使用 |
| JP2007543268A Expired - Fee Related JP5161582B2 (ja) | 2004-11-22 | 2005-11-18 | １７，２０（ｚ）−デヒドロビタミンｄ類似体およびそれらの使用 |
| JP2007543228A Expired - Fee Related JP5043673B2 (ja) | 2004-11-22 | 2005-11-18 | １７，２０（ｅ）−デヒドロビタミンｄ類似体およびそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007543269A Pending JP2008520705A (ja) | 2004-11-22 | 2005-11-18 | ２−メチレン−１９−ノル−１α−ヒドロキシ−１７−エン−ホモプレグナカルシフェロールおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007543228A Expired - Fee Related JP5043673B2 (ja) | 2004-11-22 | 2005-11-18 | １７，２０（ｅ）−デヒドロビタミンｄ類似体およびそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US7241750B2 (https=) |
| EP (3) | EP1828114B1 (https=) |
| JP (3) | JP2008520705A (https=) |
| AT (3) | ATE465144T1 (https=) |
| AU (3) | AU2005309790B2 (https=) |
| CA (3) | CA2588401C (https=) |
| DE (3) | DE602005021702D1 (https=) |
| ES (3) | ES2346774T3 (https=) |
| MX (3) | MX2007006261A (https=) |
| NZ (3) | NZ555278A (https=) |
| WO (3) | WO2006057885A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030188756A1 (en) * | 2002-08-19 | 2003-10-09 | Cantorna Margherita T | Treatment of inflammatory bowel disease with vitamin d compounds |
| US8404667B2 (en) | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
| MX2007006261A (es) | 2004-11-22 | 2007-07-10 | Wisconsin Alumni Res Found | Analogos de 17,20(z)-deshidro vitamina d y sus usos. |
| DE602005021245D1 (de) * | 2004-11-22 | 2010-06-24 | Wisconsin Alumni Res Found | 2-methylen-19,26,27-trinor-(20s)-1-alpha-hydroxyvitamin d3 and dessen verwendungen |
| WO2008091686A2 (en) * | 2007-01-25 | 2008-07-31 | Bioxell S.P.A. | SYNTHESIS OF 1α-FLUORO-25-HYDROXY-16-23E-DIENE-26,27-BISHOMO-20-EPI-CHOLECALCIFEROL |
| US7893043B2 (en) * | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
| US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| AU2009337184A1 (en) * | 2009-01-16 | 2011-07-28 | Anzamed International Limited | Medicament for the treatment of pain and inflammation |
| US20120237472A1 (en) * | 2009-07-24 | 2012-09-20 | The Johns Hopkins University | Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents |
| EP2525799B1 (en) * | 2009-10-02 | 2014-09-03 | Wisconsin Alumni Research Foundation | (20s,22e)-2-methylene-19-nor-22-ene-1alpha,25-dihydroxyvitamin d3 analogs |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| CA2793727C (en) * | 2010-03-23 | 2017-01-03 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1.alpha.,25-dihydroxyvitamin d3 |
| US8604009B2 (en) * | 2010-03-23 | 2013-12-10 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3 |
| CA2851283C (en) * | 2011-10-21 | 2020-07-14 | Wisconsin Alumni Research Foundation | 2-methylene-vitamin d analogs and their uses |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US5145846A (en) | 1988-01-20 | 1992-09-08 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| GB9004544D0 (en) | 1990-03-01 | 1990-04-25 | Leo Pharm Prod Ltd | Novel treatment ii |
| US5362719A (en) | 1990-03-01 | 1994-11-08 | Leo Pharmaceutical Products, Ltd. A/S Lovens Kemiske Fabrik Produktionsaktieselskab) | Use of vitamin-D analogues in the treatment of acne |
| ES2070307T3 (es) | 1990-07-04 | 1995-06-01 | Marcin Krotkiewski | Una preparacion para el tratamiento de la hipertension. |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| GB9214202D0 (en) * | 1992-07-03 | 1992-08-12 | Leo Pharm Prod Ltd | Chemical compounds |
| EP0619306B1 (en) * | 1993-04-05 | 1996-09-11 | Wisconsin Alumni Research Foundation | 19-Nor-vitamin D3 compounds with substituent at 2-position |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| EP0717034B1 (en) | 1994-12-14 | 1999-04-07 | Duphar International Research B.V | Vitamin D compounds and method of preparing these compounds |
| GB9625271D0 (en) * | 1996-12-04 | 1997-01-22 | Leo Pharm Prod Ltd | Chemical compounds |
| JP2001511811A (ja) * | 1997-02-13 | 2001-08-14 | ボーン ケア インターナショナル インコーポレイテッド | ビタミンｄ化合物の標的治療放出 |
| US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6306844B1 (en) * | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US5936105A (en) * | 1997-06-13 | 1999-08-10 | Tetrionics, Inc. | 14-EPI-19-nor-vitamin D compounds and methods |
| KR100593238B1 (ko) | 1997-06-25 | 2006-06-26 | 데이진 가부시키가이샤 | 비타민 ｄ3 유도체 및 이로부터 제조된 염증성 호흡기 질환 치료제 |
| GB9721156D0 (en) * | 1997-10-06 | 1997-12-03 | Leo Pharm Prod Ltd | Novel vitamin d analogues |
| WO1999049870A1 (en) * | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
| NZ522909A (en) * | 2000-05-31 | 2004-09-24 | Wisconsin Alumni Res Found | 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds |
| EP1301479A2 (en) * | 2000-07-18 | 2003-04-16 | Bone Care International, Inc. | STABILIZED 1$g(a)-HYDROXY VITAMIN D |
| NZ524657A (en) * | 2000-09-08 | 2004-12-24 | Wisconsin Alumni Res Found | 1 alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| ATE410172T1 (de) | 2001-05-22 | 2008-10-15 | Bioxell Spa | Verwendung eines analoges des vitamins d3 zur behandlung des autoimmunen diabetes |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| HK1079766B (zh) * | 2002-03-29 | 2007-05-25 | 威斯康星校友研究基金会 | 合成1α-羟基-2-亚甲基-19-去甲-高孕钙化醇的方法 |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| GB0305332D0 (en) | 2003-03-10 | 2003-04-09 | Leuven K U Res & Dev | Biological evaluation of novel vitamin D analogues |
| US20050009792A1 (en) | 2003-07-08 | 2005-01-13 | Deluca Hector F. | (20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3 and its uses |
| MXPA06005887A (es) | 2003-11-25 | 2006-06-27 | Wisconsin Alumni Res Found | Analogos de vitamina d para la prevencion y el tratamiento de la obesidad. |
| EP1694333A2 (en) | 2003-11-25 | 2006-08-30 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
| MX2007006261A (es) * | 2004-11-22 | 2007-07-10 | Wisconsin Alumni Res Found | Analogos de 17,20(z)-deshidro vitamina d y sus usos. |
| AU2005309789A1 (en) | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2alpha-methyl and 2beta-methyl analogs of 19,26,27-trinor-(20S)-1alpha-hydroxyvitamin D3 and their uses |
| WO2008035207A2 (en) | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
| DK2148684T3 (da) * | 2007-04-25 | 2013-04-22 | Cytochroma Inc | Fremgangsmåde til behandling af vitamin D-insufficiens og -deficiens |
-
2005
- 2005-11-18 MX MX2007006261A patent/MX2007006261A/es active IP Right Grant
- 2005-11-18 ES ES05849730T patent/ES2346774T3/es not_active Expired - Lifetime
- 2005-11-18 ES ES05851805T patent/ES2347058T3/es not_active Expired - Lifetime
- 2005-11-18 CA CA2588401A patent/CA2588401C/en not_active Expired - Fee Related
- 2005-11-18 EP EP05851757A patent/EP1828114B1/en not_active Expired - Lifetime
- 2005-11-18 DE DE602005021702T patent/DE602005021702D1/de not_active Expired - Lifetime
- 2005-11-18 NZ NZ555278A patent/NZ555278A/en not_active IP Right Cessation
- 2005-11-18 DE DE602005021538T patent/DE602005021538D1/de not_active Expired - Lifetime
- 2005-11-18 AT AT05851757T patent/ATE465144T1/de not_active IP Right Cessation
- 2005-11-18 CA CA2588410A patent/CA2588410C/en not_active Expired - Fee Related
- 2005-11-18 WO PCT/US2005/041670 patent/WO2006057885A2/en not_active Ceased
- 2005-11-18 NZ NZ555277A patent/NZ555277A/en not_active IP Right Cessation
- 2005-11-18 US US11/283,125 patent/US7241750B2/en not_active Expired - Lifetime
- 2005-11-18 AU AU2005309790A patent/AU2005309790B2/en not_active Ceased
- 2005-11-18 DE DE602005020842T patent/DE602005020842D1/de not_active Expired - Lifetime
- 2005-11-18 JP JP2007543269A patent/JP2008520705A/ja active Pending
- 2005-11-18 MX MX2007006546A patent/MX2007006546A/es active IP Right Grant
- 2005-11-18 AU AU2005309806A patent/AU2005309806B2/en not_active Expired - Fee Related
- 2005-11-18 ES ES05851757T patent/ES2344989T3/es not_active Expired - Lifetime
- 2005-11-18 WO PCT/US2005/041820 patent/WO2006057901A2/en not_active Ceased
- 2005-11-18 AT AT05851805T patent/ATE469883T1/de not_active IP Right Cessation
- 2005-11-18 AU AU2005309805A patent/AU2005309805B2/en not_active Ceased
- 2005-11-18 US US11/283,291 patent/US7241752B2/en not_active Expired - Lifetime
- 2005-11-18 US US11/283,090 patent/US7241748B2/en not_active Expired - Lifetime
- 2005-11-18 WO PCT/US2005/041819 patent/WO2006057900A2/en not_active Ceased
- 2005-11-18 CA CA2588396A patent/CA2588396C/en not_active Expired - Fee Related
- 2005-11-18 EP EP05851805A patent/EP1846370B1/en not_active Expired - Lifetime
- 2005-11-18 JP JP2007543268A patent/JP5161582B2/ja not_active Expired - Fee Related
- 2005-11-18 EP EP05849730A patent/EP1817279B1/en not_active Expired - Lifetime
- 2005-11-18 MX MX2007006262A patent/MX2007006262A/es active IP Right Grant
- 2005-11-18 NZ NZ555282A patent/NZ555282A/en not_active IP Right Cessation
- 2005-11-18 AT AT05849730T patent/ATE469127T1/de not_active IP Right Cessation
- 2005-11-18 JP JP2007543228A patent/JP5043673B2/ja not_active Expired - Fee Related
-
2007
- 2007-07-09 US US11/775,108 patent/US7741313B2/en not_active Expired - Fee Related
- 2007-07-09 US US11/775,117 patent/US7704982B2/en not_active Expired - Fee Related
- 2007-07-09 US US11/775,061 patent/US8232263B2/en not_active Expired - Fee Related
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