JP2007530595A5 - - Google Patents

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Publication number
JP2007530595A5
JP2007530595A5 JP2007505245A JP2007505245A JP2007530595A5 JP 2007530595 A5 JP2007530595 A5 JP 2007530595A5 JP 2007505245 A JP2007505245 A JP 2007505245A JP 2007505245 A JP2007505245 A JP 2007505245A JP 2007530595 A5 JP2007530595 A5 JP 2007530595A5
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JP
Japan
Prior art keywords
compound
agent
heteroatoms
independently
optionally substituted
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007505245A
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English (en)
Japanese (ja)
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JP2007530595A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/010204 external-priority patent/WO2005100342A1/en
Publication of JP2007530595A publication Critical patent/JP2007530595A/ja
Publication of JP2007530595A5 publication Critical patent/JP2007530595A5/ja
Pending legal-status Critical Current

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JP2007505245A 2004-03-26 2005-03-25 Ｅｒｋ２のピリジンインヒビターおよびそれらの使用 Pending JP2007530595A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55676604P 2004-03-26 2004-03-26
PCT/US2005/010204 WO2005100342A1 (en) 2004-03-26 2005-03-25 Pyridine inhibitors of erk2 and uses thereof
US11/089,701 US7462612B2 (en) 2004-03-26 2005-03-25 Pyridine inhibitors of ERK2 and uses thereof

Publications (2)

Publication Number Publication Date
JP2007530595A JP2007530595A (ja) 2007-11-01
JP2007530595A5 true JP2007530595A5 (https=) 2008-05-08

Family

ID=34964893

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007505245A Pending JP2007530595A (ja) 2004-03-26 2005-03-25 Ｅｒｋ２のピリジンインヒビターおよびそれらの使用

Country Status (4)

Country Link
US (1) US7462612B2 (https=)
EP (1) EP1730134A1 (https=)
JP (1) JP2007530595A (https=)
WO (1) WO2005100342A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101163674A (zh) * 2005-02-18 2008-04-16 阿斯利康(瑞典)有限公司 作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物
EP2527337A1 (en) * 2005-04-14 2012-11-28 Bristol-Myers Squibb Company Inhibitors of 11-beta hydroxysteroid dehydrogenase type I
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8211919B2 (en) 2005-09-02 2012-07-03 Astellas Pharma Inc. Amide derivatives as rock inhibitors
US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
MX2008010635A (es) 2006-02-16 2008-10-28 Schering Corp Derivados de pirrolidina como inhibidores de cinasa regulada por señales extracelulares.
ATE478865T1 (de) 2006-05-12 2010-09-15 Vertex Pharma Selektive rock-proteinkinasehemmer und ihre verwendung
EP2044061A2 (en) * 2006-07-20 2009-04-08 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
WO2008041118A2 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
CN101611007A (zh) * 2006-12-20 2009-12-23 先灵公司 新颖的jnk抑制剂
TW200916472A (en) 2007-06-20 2009-04-16 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
US20090099242A1 (en) * 2007-08-15 2009-04-16 Cuny Gregory D Heterocyclic inhibitors of necroptosis
WO2009105500A1 (en) 2008-02-21 2009-08-27 Schering Corporation Compounds that are erk inhibitors
EP2376502B1 (en) 2008-12-19 2015-06-17 GlaxoSmithKline LLC Thiazolopyridine sirtuin modulating compounds
JP5502397B2 (ja) * 2009-08-25 2014-05-28 公益財団法人微生物化学研究会 新規化合物アミコロース誘導体、並びにその製造方法及びその用途
CN103420902A (zh) * 2012-05-18 2013-12-04 苏州爱斯鹏药物研发有限责任公司 一种2-氯-4-碘-5-甲基吡啶的制备方法
US9725452B2 (en) 2013-03-15 2017-08-08 Presidents And Fellows Of Harvard College Substituted indoles and pyrroles as RIP kinase inhibitors
CN103193704B (zh) * 2013-04-12 2016-03-09 四川铂瑞生物医药有限公司 2-羟基-4-氨基-5-甲基吡啶杂环化合物
US20160264536A1 (en) * 2013-10-23 2016-09-15 Takeda Pharmaceutical Company Limited Heterocyclic compound
EP4088719A1 (en) 2015-10-13 2022-11-16 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
WO2017064119A1 (en) 2015-10-13 2017-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion
US20190073895A1 (en) * 2017-09-07 2019-03-07 Timetec Holding Sdn Bhd Alarm system
JOP20210242A1 (ar) 2019-03-05 2023-01-30 Bayer Ag تصنيع 4-أمينو-5-مثيل-1h- بيريدين-2(1h)-ون (مركب وسيط لتصنيع فينيرينون مضاد لـ mr) من أكسيد-2-كلورو-5-مثيل-4-نيترو-بيريدين-1 باستخدام المركب الوسيط 2-كلورو-5-مثيل-4-بيريدين أمين
CN113929591A (zh) * 2021-10-09 2022-01-14 中国科学技术大学 具有抗增殖活性的抑制剂
CN117024335A (zh) * 2023-07-10 2023-11-10 杭州小蓓医药科技有限公司 一种非奈利酮中间体4-氨基-5-甲基-1h-吡啶-2(i)-酮的合成工艺
WO2025224050A1 (en) 2024-04-22 2025-10-30 Institut National de la Santé et de la Recherche Médicale Methods of treatment of patients suffering from hypomelanosis of ito

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018122A2 (en) 1993-12-30 1995-07-06 Ciba-Geigy Ag Heteroarylpyrroles
US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
HUP0202332A2 (en) 2000-02-05 2002-10-28 Vertex Pharma Pyrazole compositions useful as inhibitors of erk
AU2003237121A1 (en) 2002-04-26 2003-11-10 Vertex Pharmaceuticals Incorporated Pyrrole derivatives as inhibitors of erk2 and uses thereof
CN1747949A (zh) 2002-12-20 2006-03-15 法马西亚公司 无环吡唑化合物
JP2006518381A (ja) * 2003-02-07 2006-08-10 バーテックス　ファーマシューティカルズ　インコーポレイテッド プロテインキナーゼのインヒビターとして有用なヘテロアリール置換ピロール
LT3305776T (lt) * 2004-05-14 2020-01-10 Vertex Pharmaceuticals Incorporated Pirolo junginiai kaip erk baltymo kinazės inhibitoriai, ir farmacinės kompozicijos su šiais junginiais

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