JP2007530582A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007530582A5 JP2007530582A5 JP2007505199A JP2007505199A JP2007530582A5 JP 2007530582 A5 JP2007530582 A5 JP 2007530582A5 JP 2007505199 A JP2007505199 A JP 2007505199A JP 2007505199 A JP2007505199 A JP 2007505199A JP 2007530582 A5 JP2007530582 A5 JP 2007530582A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- compound
- group
- aryl
- cycloheteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 76
- -1 -C (O) H Chemical group 0.000 claims 41
- 125000000217 alkyl group Chemical group 0.000 claims 30
- 125000003710 aryl alkyl group Chemical group 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 125000003107 substituted aryl group Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000001309 chloro group Chemical group Cl* 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000001153 fluoro group Chemical group F* 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 125000002757 morpholinyl group Chemical group 0.000 claims 5
- 230000010076 replication Effects 0.000 claims 5
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical class NS(=O)(=O)* 0.000 claims 4
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 125000006371 dihalo methyl group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000004951 trihalomethoxy group Chemical group 0.000 claims 3
- 125000004953 trihalomethyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 claims 2
- 208000005176 Hepatitis C Diseases 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 2
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000004405 heteroalkoxy group Chemical group 0.000 claims 2
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 2
- 125000006372 monohalo methyl group Chemical group 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 125000005936 piperidyl group Chemical group 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 230000002194 synthesizing effect Effects 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- PUDFKSZFWZMYLT-UHFFFAOYSA-N 4,4a,5,6,7,8a-hexahydropyrano[2,3-d][1,3]dioxine-5,7-diol Chemical compound C1OCOC2OC(O)CC(O)C21 PUDFKSZFWZMYLT-UHFFFAOYSA-N 0.000 claims 1
- PXRCACAJKIBESG-UHFFFAOYSA-N 5,7-dihydroxy-4,4a,5,6,7,8a-hexahydropyrano[2,3-d][1,3]dioxin-2-one Chemical compound C1OC(=O)OC2OC(O)CC(O)C21 PXRCACAJKIBESG-UHFFFAOYSA-N 0.000 claims 1
- PMMURAAUARKVCB-UHFFFAOYSA-N 6-(hydroxymethyl)oxane-2,4,5-triol Chemical compound OCC1OC(O)CC(O)C1O PMMURAAUARKVCB-UHFFFAOYSA-N 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000004572 morpholin-3-yl group Chemical group N1C(COCC1)* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000005338 substituted cycloalkoxy group Chemical group 0.000 claims 1
- 150000001420 substituted heterocyclic compounds Chemical class 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 150000003527 tetrahydropyrans Chemical class 0.000 claims 1
- 150000003585 thioureas Chemical class 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 150000003672 ureas Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55662504P | 2004-03-26 | 2004-03-26 | |
| US58290304P | 2004-06-24 | 2004-06-24 | |
| PCT/US2005/009909 WO2005097760A1 (en) | 2004-03-26 | 2005-03-25 | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007530582A JP2007530582A (ja) | 2007-11-01 |
| JP2007530582A5 true JP2007530582A5 (https=) | 2008-05-01 |
Family
ID=34963905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007505199A Pending JP2007530582A (ja) | 2004-03-26 | 2005-03-25 | 代謝可能部分を含む複素環抗ウイルス化合物およびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20050239751A1 (https=) |
| EP (1) | EP1740556A1 (https=) |
| JP (1) | JP2007530582A (https=) |
| WO (1) | WO2005097760A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7410979B2 (en) | 2003-11-19 | 2008-08-12 | Rigel Pharmaceuticals, Inc. | Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections |
| CA2606106A1 (en) * | 2005-05-02 | 2007-03-08 | Rigel Pharmaceuticals, Inc. | Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses |
| PT2178858E (pt) | 2007-08-02 | 2012-02-24 | Recordati Ireland Ltd | Novos compostos heterocíclicos como antagonistas de mglu5 |
| WO2010091306A1 (en) * | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| WO2011009484A1 (en) * | 2009-07-22 | 2011-01-27 | Novartis Ag | Arylpyrazoles and arylisoxazoles and their use as pkd modulators |
| US20130210836A1 (en) | 2010-07-19 | 2013-08-15 | Syngenta Crop Protection Llc | Microbicides |
| EP2595985A1 (en) | 2010-07-19 | 2013-05-29 | Syngenta Participations AG | Isoxazole, isothiazole, furane and thiophene compounds as microbicides |
| WO2013007550A1 (en) | 2011-07-08 | 2013-01-17 | Syngenta Participations Ag | Fungicide mixtures |
| WO2013011010A1 (en) | 2011-07-19 | 2013-01-24 | Syngenta Participations Ag | Fungizide mixtures |
| WO2014027696A1 (ja) | 2012-08-17 | 2014-02-20 | 中外製薬株式会社 | 抗ｈｃｖ作用を有する経口投与可能なビリジオファンジン誘導体 |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| CN103145688A (zh) * | 2013-04-02 | 2013-06-12 | 黄冈鲁班药业有限公司 | 4，5-二氯甲基-1，3-二氧杂环戊烯-2-酮的制备方法 |
| CA2920317A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| US10703712B2 (en) | 2015-09-16 | 2020-07-07 | Metacrine, Inc. | Farnesoid X receptor agonists and uses thereof |
| JP7258763B2 (ja) | 2017-03-15 | 2023-04-17 | メタクリン，インク． | ファルネソイドｘ受容体アゴニストおよびその使用 |
| CA3055990A1 (en) | 2017-03-15 | 2018-09-20 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
| AU2019344903B2 (en) | 2018-09-18 | 2025-02-27 | Eli Lilly And Company | Farnesoid X receptor agonists and uses thereof |
| WO2021188695A1 (en) | 2020-03-18 | 2021-09-23 | Metacrine, Inc. | Formulations of a farnesoid x receptor agonist |
| KR20220155356A (ko) | 2020-03-18 | 2022-11-22 | 메타크린, 인크. | 파르네소이드 x 수용체 효능제의 결정형 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2852503A (en) * | 1953-12-31 | 1958-09-16 | American Cyanamid Co | 2, 5-bis (p-aminophenyl) furan azo derivatives |
| NL217825A (https=) * | 1956-06-04 | |||
| BE581861A (https=) * | 1958-08-20 | |||
| US3335149A (en) * | 1963-08-21 | 1967-08-08 | Monsanto Co | Thiazole diamines |
| US4087409A (en) * | 1966-11-07 | 1978-05-02 | Monsanto Company | Ordered heterocyclic copolymers |
| US3964896A (en) * | 1971-08-09 | 1976-06-22 | Uniroyal, Inc. | Oxadiazole benzoic acid derivatives as herbicides |
| US3853893A (en) * | 1973-04-02 | 1974-12-10 | Squibb & Sons Inc | Anthelmintic 5-(pyridyl)-3-(isothiocyanophenyl) oxadiazoles |
| DE2659709C3 (de) * | 1976-12-31 | 1982-05-06 | Hoechst Ag, 6000 Frankfurt | 2,5-Bis-(4-aminophenyl)-1,3,4-oxadiazole und ihre Verwendung |
| DE3514182A1 (de) * | 1985-04-19 | 1986-10-23 | Basf Ag, 6700 Ludwigshafen | Elektrophotographisches aufzeichnungsmaterial |
| DE3623302A1 (de) * | 1985-11-09 | 1987-05-14 | Bayer Ag | Nicotinsaeurederivate |
| US4777258A (en) * | 1987-04-23 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Method for preparing 2,5-dipcryl-1,3,4-oxadiazole |
| DE4016049A1 (de) * | 1990-05-18 | 1991-11-21 | Basf Ag | 3-isoxazolylbenzylester, ihre herstellung und ihre verwendung |
| DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4137940A1 (de) * | 1991-11-18 | 1993-05-19 | Basf Ag | 3-isoxazolylphenylverbindungen, ihre herstellung und ihre verwendung |
| DE4408084A1 (de) * | 1994-03-10 | 1995-09-14 | Hoechst Ag | 3,5-Disubstituierte und 3,4,5-trisubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US20020035156A1 (en) * | 1997-04-18 | 2002-03-21 | Barbara Roniker | Combination therapy in the prevention of cardiovascular disorders |
| CA2307613A1 (en) * | 1997-10-22 | 1999-04-29 | Eisai Co., Ltd. | Retinoic acid agonist as a prophylactic and therapeutic agent for nephritis |
| US6579880B2 (en) * | 2000-06-06 | 2003-06-17 | Ortho-Mcneil Pharmaceutical, Inc. | Isoxazoles and oxadiazoles as anti-inflammatory inhibitors of IL-8 |
| MY151199A (en) * | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| HRP20050168A2 (en) * | 2002-08-23 | 2005-10-31 | Rigel Pharmaceuticals | Pyridyl substituted heterocycles useful for treating or preventing hcv infection |
| US20050113423A1 (en) * | 2003-03-12 | 2005-05-26 | Vangoor Frederick F. | Modulators of ATP-binding cassette transporters |
| WO2004099164A1 (en) * | 2003-05-02 | 2004-11-18 | Rigel Pharmaceuticals, Inc. | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating hcv infection |
| US7220745B2 (en) * | 2003-05-15 | 2007-05-22 | Rigel Pharmaceuticals | Heterocyclic compounds useful to treat HCV |
-
2005
- 2005-03-25 WO PCT/US2005/009909 patent/WO2005097760A1/en not_active Ceased
- 2005-03-25 JP JP2007505199A patent/JP2007530582A/ja active Pending
- 2005-03-25 US US11/090,823 patent/US20050239751A1/en not_active Abandoned
- 2005-03-25 EP EP05726121A patent/EP1740556A1/en not_active Withdrawn