JP2007529714A - 遺伝子分析のための方法 - Google Patents

遺伝子分析のための方法 Download PDF

Info

Publication number
JP2007529714A
JP2007529714A JP2007502088A JP2007502088A JP2007529714A JP 2007529714 A JP2007529714 A JP 2007529714A JP 2007502088 A JP2007502088 A JP 2007502088A JP 2007502088 A JP2007502088 A JP 2007502088A JP 2007529714 A JP2007529714 A JP 2007529714A
Authority
JP
Japan
Prior art keywords
individual
risk
score
group
allele
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007502088A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007529714A5 (https=
Inventor
デビッド アール. コックス
マーク マクカミッシュ
Original Assignee
パーレジェン サイエンス インク.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by パーレジェン サイエンス インク. filed Critical パーレジェン サイエンス インク.
Publication of JP2007529714A publication Critical patent/JP2007529714A/ja
Publication of JP2007529714A5 publication Critical patent/JP2007529714A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40Population genetics; Linkage disequilibrium
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Primary Health Care (AREA)
  • Evolutionary Computation (AREA)
  • Signal Processing (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Software Systems (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2007502088A 2004-03-05 2005-03-03 遺伝子分析のための方法 Withdrawn JP2007529714A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55066204P 2004-03-05 2004-03-05
US56630204P 2004-04-28 2004-04-28
US59053404P 2004-07-22 2004-07-22
US10/956,224 US7127355B2 (en) 2004-03-05 2004-09-30 Methods for genetic analysis
PCT/US2005/007375 WO2005086770A2 (en) 2004-03-05 2005-03-03 Methods for genetic analysis

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013151528A Division JP2013240344A (ja) 2004-03-05 2013-07-22 遺伝子分析のための方法

Publications (2)

Publication Number Publication Date
JP2007529714A true JP2007529714A (ja) 2007-10-25
JP2007529714A5 JP2007529714A5 (https=) 2008-04-17

Family

ID=34916521

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007502088A Withdrawn JP2007529714A (ja) 2004-03-05 2005-03-03 遺伝子分析のための方法
JP2013151528A Pending JP2013240344A (ja) 2004-03-05 2013-07-22 遺伝子分析のための方法
JP2016016966A Pending JP2016082984A (ja) 2004-03-05 2016-02-01 遺伝子分析のための方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013151528A Pending JP2013240344A (ja) 2004-03-05 2013-07-22 遺伝子分析のための方法
JP2016016966A Pending JP2016082984A (ja) 2004-03-05 2016-02-01 遺伝子分析のための方法

Country Status (4)

Country Link
US (2) US7127355B2 (https=)
EP (1) EP1725967A4 (https=)
JP (3) JP2007529714A (https=)
WO (1) WO2005086770A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016155840A (ja) * 2009-09-29 2016-09-01 ノバルティス アーゲー S1p受容体モジュレーターの投与計画
JP2019216732A (ja) * 2010-11-01 2019-12-26 ジェネンテック, インコーポレイテッド 多遺伝子スコアを用いた後期加齢性黄斑変性症への進行の予測
WO2022080389A1 (ja) * 2020-10-14 2022-04-21 Craif株式会社 観測値の確からしさを評価する方法、及びプログラム

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7127355B2 (en) * 2004-03-05 2006-10-24 Perlegen Sciences, Inc. Methods for genetic analysis
US20090087854A1 (en) * 2007-09-27 2009-04-02 Perlegen Sciences, Inc. Methods for genetic analysis
US20060166224A1 (en) * 2005-01-24 2006-07-27 Norviel Vernon A Associations using genotypes and phenotypes
WO2006110853A2 (en) * 2005-04-12 2006-10-19 Maren Alianna J System and method for evidence accumulation and hypothesis generation
EP2468901B1 (en) 2005-11-29 2017-04-05 Cambridge Enterprise Limited Markers for breast cancer
US20110143344A1 (en) * 2006-03-01 2011-06-16 The Washington University Genetic polymorphisms and substance dependence
KR20080114773A (ko) * 2006-03-01 2008-12-31 펄리건 사이언시스, 인코퍼레이티드 중독에 대한 마커
CA2672246A1 (en) 2006-06-30 2008-03-13 Rosetta Genomics Ltd Detecting nucleic acids
US8005627B2 (en) * 2006-09-08 2011-08-23 Richard Porwancher Bioinformatic approach to disease diagnosis
GB2444410B (en) * 2006-11-30 2011-08-24 Navigenics Inc Genetic analysis systems and methods
US20080131887A1 (en) * 2006-11-30 2008-06-05 Stephan Dietrich A Genetic Analysis Systems and Methods
US20080228700A1 (en) * 2007-03-16 2008-09-18 Expanse Networks, Inc. Attribute Combination Discovery
US20090012839A1 (en) * 2007-07-03 2009-01-08 American Express Travel Related Services Company, Inc. Determining Brand Affiliations
US20090043752A1 (en) * 2007-08-08 2009-02-12 Expanse Networks, Inc. Predicting Side Effect Attributes
CN101842496A (zh) * 2007-09-26 2010-09-22 纳维哲尼克斯公司 使用祖先数据进行基因组分析的方法和系统
WO2009085196A1 (en) * 2007-12-21 2009-07-09 Wake Forest University Health Sciences Methods and compositions for correlating genetic markers with prostate cancer risk
CR20170001A (es) 2008-04-28 2017-08-10 Genentech Inc Anticuerpos anti factor d humanizados
US20090326832A1 (en) * 2008-06-27 2009-12-31 Microsoft Corporation Graphical models for the analysis of genome-wide associations
KR20110053995A (ko) * 2008-08-08 2011-05-24 네이비제닉스 인크. 개인별 활동 계획을 위한 방법 및 체계
US8200509B2 (en) 2008-09-10 2012-06-12 Expanse Networks, Inc. Masked data record access
US7917438B2 (en) * 2008-09-10 2011-03-29 Expanse Networks, Inc. System for secure mobile healthcare selection
GB2477868A (en) * 2008-09-12 2011-08-17 Navigenics Inc Methods and systems for incorporating multiple environmental and genetic risk factors
US8386519B2 (en) 2008-12-30 2013-02-26 Expanse Networks, Inc. Pangenetic web item recommendation system
US20100169338A1 (en) * 2008-12-30 2010-07-01 Expanse Networks, Inc. Pangenetic Web Search System
US8255403B2 (en) 2008-12-30 2012-08-28 Expanse Networks, Inc. Pangenetic web satisfaction prediction system
US8108406B2 (en) * 2008-12-30 2012-01-31 Expanse Networks, Inc. Pangenetic web user behavior prediction system
WO2010077336A1 (en) 2008-12-31 2010-07-08 23Andme, Inc. Finding relatives in a database
US20120323600A1 (en) * 2009-05-07 2012-12-20 Pathway Genomics Genome-based drug management systems
DK2438193T3 (en) 2009-06-01 2015-10-19 Genetic Technologies Ltd Methods for assessing the risk of breast cancer
US9732389B2 (en) 2010-09-03 2017-08-15 Wake Forest University Health Sciences Methods and compositions for correlating genetic markers with prostate cancer risk
US9534256B2 (en) 2011-01-06 2017-01-03 Wake Forest University Health Sciences Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer
US20130218581A1 (en) * 2011-04-26 2013-08-22 Selventa, Inc. Stratifying patient populations through characterization of disease-driving signaling
US20140378351A1 (en) * 2013-06-22 2014-12-25 Brian Meshkin System and method for processing genotype information relating to treatment with pain medication
SG11201601044XA (en) 2013-08-12 2016-03-30 Genentech Inc Compositions and method for treating complement-associated conditions
AU2015253042A1 (en) 2014-05-01 2016-10-20 Genentech, Inc. Anti-factor D antibody variants and uses thereof
WO2016044233A1 (en) * 2014-09-18 2016-03-24 Illumina, Inc. Methods and systems for analyzing nucleic acid sequencing data
CA2962691C (en) 2014-09-30 2023-05-23 Genetic Technologies Limited Methods for assessing risk of developing breast cancer
EP3207161A4 (en) * 2014-10-14 2018-09-12 Wake Forest University Health Sciences Methods and compositions for correlating genetic markers with cancer risk
US10152298B1 (en) * 2015-06-29 2018-12-11 Amazon Technologies, Inc. Confidence estimation based on frequency
US10407510B2 (en) 2015-10-30 2019-09-10 Genentech, Inc. Anti-factor D antibodies and conjugates
EP3368090A1 (en) 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Anti-factor d antibody variant conjugates and uses thereof
JP7126704B2 (ja) 2016-01-28 2022-08-29 ザ ユニバーシティー オブ メルボルン 結腸直腸癌発症のリスクを評価するための方法
US20170240965A1 (en) * 2016-02-22 2017-08-24 Cedars-Sinai Medical Center Methods for prognosing heart transplant
US10783997B2 (en) 2016-08-26 2020-09-22 International Business Machines Corporation Personalized tolerance prediction of adverse drug events
RU2678441C1 (ru) * 2018-07-02 2019-01-29 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ прогнозирования риска развития гипертонической болезни с учетом генетических и средовых факторов
KR20230019872A (ko) 2020-05-27 2023-02-09 지네틱 테크놀로지스 리미티드 코로나바이러스 감염에 대한 중증 반응의 발생 위험을 평가하는 방법
EP4211150A4 (en) * 2020-09-10 2024-10-16 Microgenesis Corporation METHODS AND COMPOSITIONS FOR THE EVALUATION OF INFLAMMATORY DISEASES RELATED TO FERTILITY
US20250149176A1 (en) * 2023-11-08 2025-05-08 Optum Services (Ireland) Limited Model-based risk prediction and treatment pathway prioritization

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030232398A1 (en) * 2002-03-28 2003-12-18 Macmurray James P. Use of ROC plots of genetic risk factor to predict risk of sporadic breast cancer

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3023A (en) * 1843-03-30 peters
US20020048749A1 (en) 1998-04-15 2002-04-25 Robert J. Lipshutz Methods for polymorphism identifcation and profiling
US5834248A (en) 1995-02-10 1998-11-10 Millennium Pharmaceuticals Inc. Compositions and methods using rchd534, a gene uregulated by shear stress
US6274332B1 (en) 1995-12-22 2001-08-14 Univ. Of Utah Research Foundation Mutations in the KCNE1 gene encoding human minK which cause arrhythmia susceptibility thereby establishing KCNE1 as an LQT gene
US5817461A (en) 1996-01-03 1998-10-06 Hamilton Civic Hospitals Research Development Inc. Methods and compositions for diagnosis of hyperhomocysteinemia
WO2000028080A2 (en) 1998-11-10 2000-05-18 Genset Methods, software and apparati for identifying genomic regions harboring a gene associated with a detectable trait
US20040171056A1 (en) 1999-02-22 2004-09-02 Variagenics, Inc., A Delaware Corporation Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing
AU5638600A (en) 1999-06-25 2001-01-31 Genaissance Pharmaceuticals, Inc. Methods for obtaining and using haplotype data
US20020077756A1 (en) * 1999-11-29 2002-06-20 Scott Arouh Neural-network-based identification, and application, of genomic information practically relevant to diverse biological and sociological problems, including drug dosage estimation
EP1248832A4 (en) * 2000-01-21 2004-07-07 Variagenics Inc IDENTIFICATION OF THE GENETIC COMPONENTS OF A MEDICINE REACTION
US6931326B1 (en) * 2000-06-26 2005-08-16 Genaissance Pharmaceuticals, Inc. Methods for obtaining and using haplotype data
WO2002016643A2 (en) * 2000-08-18 2002-02-28 Curagen Corporation Dna pooling methods for quantitative traits using unrelated populations or sib pairs
US20020098498A1 (en) 2000-09-29 2002-07-25 Bader Joel S. Method of identifying genetic regions associated with disease and predicting responsiveness to therapeutic agents
US6828103B2 (en) 2001-02-22 2004-12-07 Wake Forest University Genetic polymorphisms of estrogen receptor alpha associated with favorable response to hormone replacement therapy
AU2002322775A1 (en) * 2001-07-27 2003-02-17 The Regents Of The University Of California Stk15 (stk6) gene polymorphism and methods of determining cancer risk
US20040086886A1 (en) 2001-09-11 2004-05-06 Goldstein Steven A.N. Polymorphisms associated with cardiac arrythmia
US20030162207A1 (en) * 2001-12-14 2003-08-28 Comings David E. Multi-gene tests with ROC plots for the assessment of risk for polygenic disorders
AU2003212806A1 (en) * 2002-01-15 2003-07-30 Vanderbilt University Method and apparatus for multifactor dimensionality reduction
US20040115701A1 (en) 2002-08-30 2004-06-17 Comings David E Method for risk assessment for polygenic disorders
WO2004044163A2 (en) * 2002-11-06 2004-05-27 Sequenom, Inc. Methods for identifying risk of melanoma and treatments thereof
US20050032066A1 (en) * 2003-08-04 2005-02-10 Heng Chew Kiat Method for assessing risk of diseases with multiple contributing factors
US20050037366A1 (en) * 2003-08-14 2005-02-17 Joseph Gut Individual drug safety
US7470513B2 (en) * 2003-11-10 2008-12-30 Academia Sinica Risk assessment for adverse drug reactions
US7127355B2 (en) * 2004-03-05 2006-10-24 Perlegen Sciences, Inc. Methods for genetic analysis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030232398A1 (en) * 2002-03-28 2003-12-18 Macmurray James P. Use of ROC plots of genetic risk factor to predict risk of sporadic breast cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6012003799; 分子心血管病, (2002), 3, [5], p.603-608 *
JPN6012003802; 臨床病理, (2002), 50, [12], p.1124-1129 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016155840A (ja) * 2009-09-29 2016-09-01 ノバルティス アーゲー S1p受容体モジュレーターの投与計画
JP2018172401A (ja) * 2009-09-29 2018-11-08 ノバルティス アーゲー S1p受容体モジュレーターの投与計画
JP2020203892A (ja) * 2009-09-29 2020-12-24 ノバルティス アーゲー S1p受容体モジュレーターの投与計画
JP7185426B2 (ja) 2009-09-29 2022-12-07 ノバルティス アーゲー S1p受容体モジュレーターの投与計画
JP2019216732A (ja) * 2010-11-01 2019-12-26 ジェネンテック, インコーポレイテッド 多遺伝子スコアを用いた後期加齢性黄斑変性症への進行の予測
WO2022080389A1 (ja) * 2020-10-14 2022-04-21 Craif株式会社 観測値の確からしさを評価する方法、及びプログラム
JPWO2022080389A1 (https=) * 2020-10-14 2022-04-21

Also Published As

Publication number Publication date
US7127355B2 (en) 2006-10-24
JP2013240344A (ja) 2013-12-05
EP1725967A4 (en) 2008-01-02
US20070037198A1 (en) 2007-02-15
WO2005086770A3 (en) 2006-08-10
EP1725967A2 (en) 2006-11-29
US20050196770A1 (en) 2005-09-08
JP2016082984A (ja) 2016-05-19
WO2005086770A2 (en) 2005-09-22
WO2005086770A9 (en) 2006-10-26

Similar Documents

Publication Publication Date Title
US7127355B2 (en) Methods for genetic analysis
EP2772553B1 (en) Methods for genetic analysis
Hoffmann et al. A large multiethnic genome-wide association study of adult body mass index identifies novel loci
Eggert et al. Genome-wide linkage and association analyses implicate FASN in predisposition to uterine leiomyomata
KR101459057B1 (ko) 임신성 당뇨병 이후 제2형 당뇨병 발병 예측 방법
US20130338012A1 (en) Genetic risk factors of sick sinus syndrome
JP2009541336A (ja) アルツハイマー病の進行に関するバイオマーカー
Mouton et al. MYBPH acts as modifier of cardiac hypertrophy in hypertrophic cardiomyopathy (HCM) patients
WO2018045240A1 (en) Methods and composition for the prediction of the activity of enzastaurin
Gusev Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies
Caskey Using genetic diagnosis to determine individual therapeutic utility
JP2018164451A (ja) シミになり易さを判定する方法
JP2018164452A (ja) ソバカスになり易さを判定する方法
CN1950826A (zh) 遗传分析的方法
Hong et al. Identification of pleiotropic genetic variants affecting osteoporosis risk in a Korean elderly cohort
CN108753959A (zh) 一种位于disc1fp1基因的与放疗引起的放射性脑损伤相关的snp标志物及其应用
WO2025014806A1 (en) Multiple-ancestry polygenic risk assessment for breast cancer
CN106929581B (zh) 单核苷酸多态性rs7576984和rs2066802在检测结核易感性中的应用
JP2026047651A (ja) 縄文祖先検査用バイオマーカー
JP2019033739A (ja) 二重まぶたである可能性の高さを判定する方法
JP2019030289A (ja) 毛深さを判定する方法
WO2019153241A1 (zh) 与主要不良心血管事件相关的单核苷酸多态性位点及其应用
CN108715895A (zh) 一种位于kctd1基因的与放疗引起的放射性脑损伤相关的snp标志物及其应用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080226

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080226

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110119

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110415

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120126

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120413

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120420

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130321

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130722

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20130723

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130912

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20130919

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20140226

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20140226

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150106

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20150413