JP2007527424A - ＭＣＨ拮抗作用を有するβ−ケトアミド化合物及びこれを含む医薬 - Google Patents

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Publication number

JP2007527424A

JP2007527424A JP2007501195A JP2007501195A JP2007527424A JP 2007527424 A JP2007527424 A JP 2007527424A JP 2007501195 A JP2007501195 A JP 2007501195A JP 2007501195 A JP2007501195 A JP 2007501195A JP 2007527424 A JP2007527424 A JP 2007527424A

Authority

JP

Japan

Prior art keywords

alkyl

group

atoms

amino

cycloalkyl

Prior art date

2004-03-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 29
• 239000000126 substance Substances 0.000 claims abstract description 21
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• 108010047068 Melanin-concentrating hormone receptor Proteins 0.000 claims abstract description 16
• 206010006550 Bulimia nervosa Diseases 0.000 claims abstract description 8
• 235000005911 diet Nutrition 0.000 claims abstract description 8
• 230000000378 dietary effect Effects 0.000 claims abstract description 6
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• 102000006953 melanin-concentrating hormone receptor activity proteins Human genes 0.000 claims abstract 2
• 125000004432 carbon atom Chemical group C* 0.000 claims description 139
• 150000001875 compounds Chemical class 0.000 claims description 94
• 239000013543 active substance Substances 0.000 claims description 92
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 78
• 239000000203 mixture Substances 0.000 claims description 73
• 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 58
• 125000001424 substituent group Chemical group 0.000 claims description 58
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• 101800002739 Melanin-concentrating hormone Proteins 0.000 claims description 56
• 150000003839 salts Chemical class 0.000 claims description 54
• 229910052799 carbon Inorganic materials 0.000 claims description 53
• 229910052739 hydrogen Inorganic materials 0.000 claims description 49
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 49
• 125000000623 heterocyclic group Chemical group 0.000 claims description 46
• 239000002904 solvent Substances 0.000 claims description 46
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• 125000004122 cyclic group Chemical group 0.000 claims description 38
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 35
• PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims description 32
• KZOWNALBTMILAP-JBMRGDGGSA-N ancitabine hydrochloride Chemical compound Cl.N=C1C=CN2[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3OC2=N1 KZOWNALBTMILAP-JBMRGDGGSA-N 0.000 claims description 32
• 125000000217 alkyl group Chemical group 0.000 claims description 31
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• 239000002253 acid Substances 0.000 claims description 16
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• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 6
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• 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims description 4
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 4
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 3
• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 3
• JVQIKJMSUIMUDI-UHFFFAOYSA-N 3-pyrroline Chemical compound C1NCC=C1 JVQIKJMSUIMUDI-UHFFFAOYSA-N 0.000 claims description 3
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• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
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