JP2007523872A5 - - Google Patents
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- Publication number
- JP2007523872A5 JP2007523872A5 JP2006520275A JP2006520275A JP2007523872A5 JP 2007523872 A5 JP2007523872 A5 JP 2007523872A5 JP 2006520275 A JP2006520275 A JP 2006520275A JP 2006520275 A JP2006520275 A JP 2006520275A JP 2007523872 A5 JP2007523872 A5 JP 2007523872A5
- Authority
- JP
- Japan
- Prior art keywords
- controlled release
- drug
- matrix
- soft capsule
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000013270 controlled release Methods 0.000 claims 34
- 239000007901 soft capsule Substances 0.000 claims 22
- 239000011159 matrix material Substances 0.000 claims 21
- 229940079593 drug Drugs 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 18
- 239000004480 active ingredient Substances 0.000 claims 14
- 239000007887 hard shell capsule Substances 0.000 claims 11
- 239000000839 emulsion Substances 0.000 claims 10
- 239000012071 phase Substances 0.000 claims 10
- 235000014113 dietary fatty acids Nutrition 0.000 claims 7
- 239000000194 fatty acid Substances 0.000 claims 7
- 229930195729 fatty acid Natural products 0.000 claims 7
- 239000002775 capsule Substances 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- -1 fatty acid ester Chemical class 0.000 claims 5
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 5
- 239000004615 ingredient Substances 0.000 claims 4
- 239000008384 inner phase Substances 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000008385 outer phase Substances 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 230000001088 anti-asthma Effects 0.000 claims 2
- 239000000924 antiasthmatic agent Substances 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 2
- 239000008206 lipophilic material Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000003607 modifier Substances 0.000 claims 2
- 229960005181 morphine Drugs 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
- 239000008158 vegetable oil Substances 0.000 claims 2
- 239000001993 wax Substances 0.000 claims 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 239000002327 cardiovascular agent Substances 0.000 claims 1
- 229940125692 cardiovascular agent Drugs 0.000 claims 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 1
- 229960000590 celecoxib Drugs 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 1
- 229960001259 diclofenac Drugs 0.000 claims 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims 1
- 229960004166 diltiazem Drugs 0.000 claims 1
- 230000009969 flowable effect Effects 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 1
- 229960000991 ketoprofen Drugs 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 229960002009 naproxen Drugs 0.000 claims 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 1
- 239000003887 narcotic antagonist Substances 0.000 claims 1
- 230000003533 narcotic effect Effects 0.000 claims 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims 1
- 229960001597 nifedipine Drugs 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 235000019198 oils Nutrition 0.000 claims 1
- 229960002085 oxycodone Drugs 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- 229960000278 theophylline Drugs 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48796803P | 2003-07-17 | 2003-07-17 | |
| US60/487,968 | 2003-07-17 | ||
| PCT/US2004/022456 WO2005009409A2 (en) | 2003-07-17 | 2004-07-14 | Controlled release preparations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007523872A JP2007523872A (ja) | 2007-08-23 |
| JP2007523872A5 true JP2007523872A5 (https=) | 2007-10-04 |
| JP5296314B2 JP5296314B2 (ja) | 2013-09-25 |
Family
ID=34102731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520275A Expired - Fee Related JP5296314B2 (ja) | 2003-07-17 | 2004-07-14 | 制御放出製剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20060115527A1 (https=) |
| EP (2) | EP1653931A2 (https=) |
| JP (1) | JP5296314B2 (https=) |
| CN (2) | CN1826100B (https=) |
| AU (2) | AU2004258894B2 (https=) |
| CA (1) | CA2533013C (https=) |
| CY (1) | CY1118182T1 (https=) |
| DK (1) | DK2279729T3 (https=) |
| ES (1) | ES2592504T3 (https=) |
| HR (1) | HRP20161374T1 (https=) |
| HU (1) | HUE031092T2 (https=) |
| LT (1) | LT2279729T (https=) |
| PL (1) | PL2279729T3 (https=) |
| PT (1) | PT2279729T (https=) |
| SI (1) | SI2279729T1 (https=) |
| WO (1) | WO2005009409A2 (https=) |
Families Citing this family (42)
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| ATE482695T1 (de) | 2002-12-13 | 2010-10-15 | Durect Corp | Orale darreichungsform mit flüssigen hochviskosen trägersystemen |
| CN101351196B (zh) * | 2005-10-26 | 2013-07-03 | 班纳制药公司 | 作为胶囊填充物的基于亲脂性载体的双重控释基质系统 |
| CA2627292C (en) * | 2005-10-26 | 2012-04-17 | Banner Pharmacaps, Inc. | Hydrophilic vehicle-based dual controlled release matrix system |
| US10960077B2 (en) * | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| FR2901478B1 (fr) * | 2006-05-24 | 2015-06-05 | Flamel Tech Sa | Forme pharmaceutique orale multimicroparticulaire a liberation prolongee |
| US9023400B2 (en) | 2006-05-24 | 2015-05-05 | Flamel Technologies | Prolonged-release multimicroparticulate oral pharmaceutical form |
| EP2042165A1 (de) * | 2007-09-28 | 2009-04-01 | Swiss Caps Rechte und Lizenzen AG | Hot-Melt-Befüllte Weichkapseln |
| EP2219622A1 (en) * | 2007-12-06 | 2010-08-25 | Durect Corporation | Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition |
| US20090155355A1 (en) * | 2007-12-12 | 2009-06-18 | Multi Formulations Ltd. | Particles in a capsule |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| CN102307576A (zh) * | 2008-12-15 | 2012-01-04 | 班纳制药公司 | 用于增强水不溶性活性剂的释放和吸收的方法 |
| CN102133406B (zh) * | 2011-03-17 | 2013-06-19 | 泰州市康特生物工程有限公司 | 阿片类药物油相制剂及其制备方法 |
| TW201521769A (zh) | 2013-03-15 | 2015-06-16 | Durect Corp | 具有流變改質劑以減少溶解變異性之組成物 |
| EP2968081A4 (en) | 2013-03-15 | 2016-08-10 | Banner Life Sciences Llc | MOLLE ENTERIC CAPSULES NOT CONTAINING GELATIN |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US9504656B2 (en) * | 2013-10-21 | 2016-11-29 | Banner Life Sciences, LLC | Pharmaceutical compositions for poorly soluble active ingredients |
| WO2015074898A1 (en) * | 2013-11-19 | 2015-05-28 | Qiagen Gmbh | Method for generating emulsions |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10744131B2 (en) | 2013-12-31 | 2020-08-18 | Kashiv Biosciences, Llc | Abuse-resistant drug formulations |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| ES2713157T3 (es) | 2014-02-28 | 2019-05-20 | Banner Life Sciences Llc | Cápsulas blandas entéricas de liberación controlada de ésteres de fumarato |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US10772842B2 (en) | 2015-01-09 | 2020-09-15 | Patheon Softgels Inc. | Abuse-deterrent opioids |
| US10182992B2 (en) | 2014-04-07 | 2019-01-22 | Patheon Softgels Inc. | Abuse-deterrent controlled release formulations |
| WO2015195989A1 (en) | 2014-06-20 | 2015-12-23 | Banner Life Sciences Llc | Enteric soft capsule compositions |
| US20150366814A1 (en) | 2014-06-23 | 2015-12-24 | Banner Life Sciences Llc | All-natural enteric soft capsules comprising active ingredients |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| AU2015328676B2 (en) * | 2014-10-08 | 2017-07-20 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
| AU2015336065A1 (en) * | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
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| US20070010498A1 (en) * | 2005-07-07 | 2007-01-11 | Klaus Theobald | Method for reducing blood loss associated with cardio-pulmonary bypass surgery |
-
2004
- 2004-07-14 SI SI200432345A patent/SI2279729T1/sl unknown
- 2004-07-14 JP JP2006520275A patent/JP5296314B2/ja not_active Expired - Fee Related
- 2004-07-14 PL PL10075739T patent/PL2279729T3/pl unknown
- 2004-07-14 CN CN2004800206901A patent/CN1826100B/zh not_active Expired - Fee Related
- 2004-07-14 EP EP04778128A patent/EP1653931A2/en not_active Withdrawn
- 2004-07-14 AU AU2004258894A patent/AU2004258894B2/en not_active Ceased
- 2004-07-14 DK DK10075739.2T patent/DK2279729T3/da active
- 2004-07-14 WO PCT/US2004/022456 patent/WO2005009409A2/en not_active Ceased
- 2004-07-14 CN CN201010559247.9A patent/CN102000042B/zh not_active Expired - Fee Related
- 2004-07-14 HU HUE10075739A patent/HUE031092T2/en unknown
- 2004-07-14 CA CA2533013A patent/CA2533013C/en not_active Expired - Fee Related
- 2004-07-14 ES ES10075739.2T patent/ES2592504T3/es not_active Expired - Lifetime
- 2004-07-14 PT PT100757392T patent/PT2279729T/pt unknown
- 2004-07-14 LT LTEP10075739.2T patent/LT2279729T/lt unknown
- 2004-07-14 EP EP10075739.2A patent/EP2279729B1/en not_active Expired - Lifetime
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2006
- 2006-01-17 US US11/275,563 patent/US20060115527A1/en not_active Abandoned
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2010
- 2010-08-20 AU AU2010212463A patent/AU2010212463A1/en not_active Ceased
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2014
- 2014-08-15 US US14/460,747 patent/US20150010623A1/en not_active Abandoned
-
2016
- 2016-10-20 HR HRP20161374TT patent/HRP20161374T1/hr unknown
- 2016-11-03 CY CY20161101121T patent/CY1118182T1/el unknown
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2017
- 2017-09-22 US US15/712,258 patent/US20180008548A1/en not_active Abandoned
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