JP2007522502A5 - - Google Patents
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- JP2007522502A5 JP2007522502A5 JP2006551974A JP2006551974A JP2007522502A5 JP 2007522502 A5 JP2007522502 A5 JP 2007522502A5 JP 2006551974 A JP2006551974 A JP 2006551974A JP 2006551974 A JP2006551974 A JP 2006551974A JP 2007522502 A5 JP2007522502 A5 JP 2007522502A5
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- JP
- Japan
- Prior art keywords
- field
- sample
- fluorescent
- microscope
- uniform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003550 marker Substances 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 26
- 238000009826 distribution Methods 0.000 claims description 24
- 230000005684 electric field Effects 0.000 claims description 20
- 230000005855 radiation Effects 0.000 claims description 17
- 210000004508 polar body Anatomy 0.000 claims description 10
- 230000003287 optical effect Effects 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 7
- 238000003384 imaging method Methods 0.000 claims description 5
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 description 40
- 230000005426 magnetic field effect Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 238000000799 fluorescence microscopy Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 230000003047 cage effect Effects 0.000 description 1
- 238000010888 cage effect Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000001744 histochemical effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04100462 | 2004-02-09 | ||
| EP04100462.3 | 2004-02-09 | ||
| PCT/IB2005/050354 WO2005076050A1 (en) | 2004-02-09 | 2005-01-27 | Fluorescence microscope arrangement |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007522502A JP2007522502A (ja) | 2007-08-09 |
| JP2007522502A5 true JP2007522502A5 (enExample) | 2011-04-21 |
| JP4804363B2 JP4804363B2 (ja) | 2011-11-02 |
Family
ID=34833743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551974A Expired - Fee Related JP4804363B2 (ja) | 2004-02-09 | 2005-01-27 | 蛍光顕微鏡装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070161075A1 (enExample) |
| EP (1) | EP1716444B1 (enExample) |
| JP (1) | JP4804363B2 (enExample) |
| CN (1) | CN100526932C (enExample) |
| AT (1) | ATE418084T1 (enExample) |
| DE (1) | DE602005011763D1 (enExample) |
| WO (1) | WO2005076050A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060248944A1 (en) * | 2003-04-15 | 2006-11-09 | Koninklijke Philips Electronics N.V. | Method to determine the spatial distribution of magnetic particles and magnetic particle administering compositions |
| DE102005017817A1 (de) * | 2005-04-18 | 2006-10-26 | Siemens Ag | Verfahren und Vorrichtung zur Untersuchung eines biologischen Gewebes |
| WO2007015190A2 (en) * | 2005-08-01 | 2007-02-08 | Philips Intellectual Property & Standards Gmbh | Optical imaging |
| JP2011022201A (ja) * | 2009-07-13 | 2011-02-03 | Jikei Univ | 顕微鏡装置用の光源装置、及び光源装置付き観察試料載置具、並びに顕微鏡装置 |
| EP3955042B1 (en) | 2013-08-26 | 2024-08-21 | S.D. Sight Diagnostics Ltd. | Digital microscopy systems, methods and computer program products |
| CN103575716A (zh) * | 2013-11-15 | 2014-02-12 | 中国科学院长春应用化学研究所 | 磁场调控的超分辨荧光成像方法 |
| CA2998829A1 (en) | 2015-09-17 | 2017-03-23 | S.D. Sight Diagnostics Ltd | Methods and apparatus for detecting an entity in a bodily sample |
| EP3436864B1 (en) | 2016-03-30 | 2021-04-28 | S.D. Sight Diagnostics Ltd. | Image processing device for identifying blood parasites |
| WO2017195205A1 (en) | 2016-05-11 | 2017-11-16 | S.D. Sight Diagnostics Ltd | Sample carrier for optical measurements |
| AU2017263807B2 (en) | 2016-05-11 | 2023-02-02 | S.D. Sight Diagnostics Ltd | Performing optical measurements on a sample |
| JP7214729B2 (ja) | 2017-11-14 | 2023-01-30 | エス．ディー．サイト ダイアグノスティクス リミテッド | 光学測定用試料収容器 |
| DE102018206406C5 (de) | 2018-04-25 | 2025-05-15 | Carl Zeiss Meditec Ag | Mikroskopiesystem |
| CA3155820A1 (en) | 2019-10-22 | 2021-04-29 | S.D. Sight Diagnostics Ltd | Accounting for errors in optical measurements |
| WO2021116962A1 (en) | 2019-12-12 | 2021-06-17 | S.D. Sight Diagnostics Ltd | Artificial generation of color blood smear image |
| CA3160695A1 (en) | 2019-12-12 | 2021-06-17 | S.D. Sight Diagnostics Ltd | Analyzing an analyte disposed within a medium |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4578167A (en) * | 1982-09-28 | 1986-03-25 | Biofusion, Inc. | Cell fusion |
| US4676640A (en) * | 1984-09-12 | 1987-06-30 | Syntex (U.S.A.) Inc. | Fluctuation analysis for enhanced particle detection |
| DE19508366C2 (de) * | 1995-03-10 | 1998-01-29 | Evotec Biosystems Gmbh | Verfahren zum direkten Nachweisen weniger Nucleinsäurestränge |
| MY139225A (en) * | 1998-02-26 | 2009-08-28 | Anglo Operations Ltd | Method and apparatus for separating particles |
| DE19903001A1 (de) * | 1999-01-26 | 2000-08-24 | Evotec Biosystems Ag | Verfahren und Vorrichtung zur Detektion mikroskopisch kleiner Objekte |
| US6271660B1 (en) * | 1999-06-11 | 2001-08-07 | Mts Sytems Corporation | Permanent multi-pole position magnet |
| US6437551B1 (en) * | 1999-11-02 | 2002-08-20 | The Regents Of The University Of California | Microfabricated AC impedance sensor |
| JP4994560B2 (ja) * | 2000-08-25 | 2012-08-08 | アムニス コーポレイション | 細胞などの小さな移動物体の速度測定 |
| DE10103304A1 (de) * | 2001-01-25 | 2002-08-01 | Gnothis Holding Sa Ecublens | Verfahren zur fluoreszenzspektroskopischen, insbesondere fluoreszenzkorrelationsspektroskopischen Untersuchung einer Messprobe sowie Einrichtung zur Durchführung desselben |
| US20020127144A1 (en) * | 2001-03-08 | 2002-09-12 | Mehta Shailesh P. | Device for analyzing particles and method of use |
| US7968305B2 (en) * | 2001-03-24 | 2011-06-28 | Aviva Biosciences Corporation | Biochips including ion transport detecting structures and methods of use |
| DE10151778A1 (de) * | 2001-10-19 | 2003-05-08 | Philips Corp Intellectual Pty | Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel |
| JP4890242B2 (ja) * | 2003-04-15 | 2012-03-07 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 検査エリアにおける状態変数の空間分解を決定する装置及び方法 |
-
2005
- 2005-01-27 CN CNB2005800043133A patent/CN100526932C/zh not_active Expired - Fee Related
- 2005-01-27 US US10/597,667 patent/US20070161075A1/en not_active Abandoned
- 2005-01-27 JP JP2006551974A patent/JP4804363B2/ja not_active Expired - Fee Related
- 2005-01-27 DE DE602005011763T patent/DE602005011763D1/de not_active Expired - Lifetime
- 2005-01-27 EP EP05702809A patent/EP1716444B1/en not_active Expired - Lifetime
- 2005-01-27 WO PCT/IB2005/050354 patent/WO2005076050A1/en not_active Ceased
- 2005-01-27 AT AT05702809T patent/ATE418084T1/de not_active IP Right Cessation
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