JP2007522229A5 - - Google Patents
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- JP2007522229A5 JP2007522229A5 JP2006553251A JP2006553251A JP2007522229A5 JP 2007522229 A5 JP2007522229 A5 JP 2007522229A5 JP 2006553251 A JP2006553251 A JP 2006553251A JP 2006553251 A JP2006553251 A JP 2006553251A JP 2007522229 A5 JP2007522229 A5 JP 2007522229A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- factor
- binding fragment
- human factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000003712 Complement factor B Human genes 0.000 claims 35
- 108090000056 Complement factor B Proteins 0.000 claims 35
- 230000027455 binding Effects 0.000 claims 30
- 239000000427 antigen Substances 0.000 claims 27
- 102000036639 antigens Human genes 0.000 claims 27
- 108091007433 antigens Proteins 0.000 claims 27
- 239000012634 fragment Substances 0.000 claims 25
- 241001465754 Metazoa Species 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 206010020751 Hypersensitivity Diseases 0.000 claims 4
- 208000026935 allergic disease Diseases 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 230000009610 hypersensitivity Effects 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 208000037883 airway inflammation Diseases 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 241000709661 Enterovirus Species 0.000 claims 2
- 241000283086 Equidae Species 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- 241000282887 Suidae Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000010370 Adenoviridae Infections Diseases 0.000 claims 1
- 206010060931 Adenovirus infection Diseases 0.000 claims 1
- 206010052613 Allergic bronchitis Diseases 0.000 claims 1
- 206010003557 Asthma exercise induced Diseases 0.000 claims 1
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 208000004657 Exercise-Induced Asthma Diseases 0.000 claims 1
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 208000016999 Parasitic Lung disease Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 208000011589 adenoviridae infectious disease Diseases 0.000 claims 1
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000009137 competitive binding Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000009580 eosinophilic pneumonia Diseases 0.000 claims 1
- 208000024695 exercise-induced bronchoconstriction Diseases 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 229940071648 metered dose inhaler Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000007892 occupational asthma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000036273 reactive airway disease Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54359404P | 2004-02-10 | 2004-02-10 | |
| US60/543,594 | 2004-02-10 | ||
| USPCT/US2004/015040 | 2004-05-13 | ||
| PCT/US2004/015040 WO2004103288A2 (en) | 2003-05-13 | 2004-05-13 | Method of preventing recurrent miscarriages |
| US63623904P | 2004-12-14 | 2004-12-14 | |
| US60/636,239 | 2004-12-14 | ||
| PCT/US2005/004346 WO2005077417A1 (en) | 2004-02-10 | 2005-02-10 | Inhibition of factor b, the alternative complement pathway and methods related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007522229A JP2007522229A (ja) | 2007-08-09 |
| JP2007522229A5 true JP2007522229A5 (https=) | 2008-04-03 |
| JP5137053B2 JP5137053B2 (ja) | 2013-02-06 |
Family
ID=38007673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553251A Expired - Fee Related JP5137053B2 (ja) | 2004-02-10 | 2005-02-10 | 抗ｂ因子抗体もしくはその抗原結合性フラグメント、それを含む組成物、抗原結合性ポリペプチド、および治療薬 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7999082B2 (https=) |
| JP (1) | JP5137053B2 (https=) |
| BR (1) | BRPI0506629A (https=) |
| CY (1) | CY1114558T1 (https=) |
| DK (1) | DK1713503T3 (https=) |
| ES (1) | ES2432112T3 (https=) |
| PT (1) | PT1713503E (https=) |
Families Citing this family (69)
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| ES2432112T3 (es) * | 2004-02-10 | 2013-11-29 | The Regents Of The University Of Colorado, A Body Corporate | Inhibición del factor B, de la vía alternativa del complemento y métodos relacionados |
| CA2610340C (en) * | 2005-05-26 | 2016-02-16 | Vernon Michael Holers | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
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| WO2006083533A2 (en) | 2005-01-14 | 2006-08-10 | The Regents Of The University Of California | Compositions and methods for inhibiting drusen formation and for diagnosing or treating drusen-related disorders |
| EP2357254A1 (en) | 2005-02-14 | 2011-08-17 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
| CA2610340C (en) | 2005-05-26 | 2016-02-16 | Vernon Michael Holers | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
| CN101262855A (zh) | 2005-09-08 | 2008-09-10 | 帝斯曼知识产权资产管理有限公司 | 治疗或预防年龄相关性黄斑变性的方法 |
| US20080318264A1 (en) | 2005-09-09 | 2008-12-25 | University Of Iowa Research Foundation | Biomarkers Associated With Age-Related Macular Degeneration |
| EP3299027A1 (en) | 2005-11-04 | 2018-03-28 | Genentech, Inc. | Use of complement pathway inhibitors to treat ocular diseases |
| WO2007149567A2 (en) | 2006-06-21 | 2007-12-27 | Musc Foundation For Research Development | Targeting complement factor h for treatment of diseases |
| CA2680344A1 (en) | 2007-03-14 | 2008-11-20 | Woodruff Emlen | Humaneered anti-factor b antibody |
| PE20090329A1 (es) | 2007-05-30 | 2009-03-27 | Abbott Lab | Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos |
| JP5871798B2 (ja) | 2009-07-02 | 2016-03-01 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | 肝再生を刺激する方法 |
| MX2012005151A (es) | 2009-11-05 | 2012-08-23 | Federico Ii University Of Naples | Tratamiento de hemoglobinuria nocturna paroxismica, anemias hemoliticas y estados de enfermedad que involucran hemolisis intravascular y extravascular. |
| WO2011143637A1 (en) | 2010-05-14 | 2011-11-17 | The Regents Of The University Of Colorado, A Body Corporate | Improved complement receptor 2 (cr2) targeting groups |
| US9815890B2 (en) | 2010-06-22 | 2017-11-14 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the C3d fragment of complement component 3 |
-
2005
- 2005-02-10 ES ES05722948T patent/ES2432112T3/es not_active Expired - Lifetime
- 2005-02-10 JP JP2006553251A patent/JP5137053B2/ja not_active Expired - Fee Related
- 2005-02-10 DK DK05722948.6T patent/DK1713503T3/da active
- 2005-02-10 US US11/057,047 patent/US7999082B2/en not_active Expired - Fee Related
- 2005-02-10 PT PT57229486T patent/PT1713503E/pt unknown
- 2005-02-10 BR BRPI0506629-8A patent/BRPI0506629A/pt not_active IP Right Cessation
-
2007
- 2007-08-03 US US11/888,997 patent/US8652475B2/en not_active Expired - Fee Related
- 2007-08-22 US US11/843,617 patent/US8703140B2/en not_active Expired - Fee Related
-
2013
- 2013-10-30 CY CY20131100959T patent/CY1114558T1/el unknown
-
2014
- 2014-02-18 US US14/183,213 patent/US20140154307A1/en not_active Abandoned
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