JP2007520489A5 - - Google Patents
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- Publication number
- JP2007520489A5 JP2007520489A5 JP2006551189A JP2006551189A JP2007520489A5 JP 2007520489 A5 JP2007520489 A5 JP 2007520489A5 JP 2006551189 A JP2006551189 A JP 2006551189A JP 2006551189 A JP2006551189 A JP 2006551189A JP 2007520489 A5 JP2007520489 A5 JP 2007520489A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- piperidin
- acetic acid
- phenyl
- enyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- -1 n- propyl Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- XJBDYSZZGSHJBC-SJIDKOTRSA-N (6r)-6-[(e)-4-(3-chlorophenyl)-3-hydroxybut-1-enyl]-1-[4-(2-hydroxyethoxy)but-2-ynyl]piperidin-2-one Chemical compound C1CCC(=O)N(CC#CCOCCO)[C@H]1\C=C\C(O)CC1=CC=CC(Cl)=C1 XJBDYSZZGSHJBC-SJIDKOTRSA-N 0.000 claims 2
- OHTBRSPZGKGPNX-WBVIWABJSA-N 2-[(z)-4-[(2r)-2-(3-hydroxy-4-phenylbutyl)-6-oxopiperidin-1-yl]but-2-enoxy]acetic acid Chemical compound C=1C=CC=CC=1CC(O)CC[C@H]1CCCC(=O)N1C\C=C/COCC(O)=O OHTBRSPZGKGPNX-WBVIWABJSA-N 0.000 claims 2
- LPEUSZSVDXCEMU-WNWYLPOESA-N 2-[4-[(2r)-2-[(e)-4-(3-chlorophenyl)-3-hydroxybut-1-enyl]-6-oxopiperidin-1-yl]but-2-ynoxy]acetic acid Chemical compound C(\[C@@H]1N(C(=O)CCC1)CC#CCOCC(O)=O)=C/C(O)CC1=CC=CC(Cl)=C1 LPEUSZSVDXCEMU-WNWYLPOESA-N 0.000 claims 2
- UEQLULDETPANRS-WNWYLPOESA-N 2-[4-[(2r)-2-[(e)-4-(3-chlorophenyl)-3-hydroxybut-1-enyl]-6-oxopiperidin-1-yl]butoxy]acetamide Chemical compound C1CCC(=O)N(CCCCOCC(=O)N)[C@H]1\C=C\C(O)CC1=CC=CC(Cl)=C1 UEQLULDETPANRS-WNWYLPOESA-N 0.000 claims 2
- PDOUDCKFVFFXHP-WNWYLPOESA-N 2-[4-[(2r)-2-[(e)-4-(3-chlorophenyl)-3-hydroxybut-1-enyl]-6-oxopiperidin-1-yl]butoxy]acetic acid Chemical compound C(\[C@@H]1N(C(=O)CCC1)CCCCOCC(O)=O)=C/C(O)CC1=CC=CC(Cl)=C1 PDOUDCKFVFFXHP-WNWYLPOESA-N 0.000 claims 2
- JBGTUEDUAGTTJQ-QZEKMECESA-N 2-[4-[(2r)-2-[(e)-4-(3-chlorophenyl)-3-oxobut-1-enyl]-6-oxopiperidin-1-yl]but-2-ynoxy]acetic acid Chemical compound C1CCC(=O)N(CC#CCOCC(=O)O)[C@H]1\C=C\C(=O)CC1=CC=CC(Cl)=C1 JBGTUEDUAGTTJQ-QZEKMECESA-N 0.000 claims 2
- WYWYULSOYCDXOI-QBFDXINUSA-N COC(COCCCCN1C(CCC[C@@H]1CCC(CC1=CC=CC=C1)=O)=O)=O.O=C1N([C@H](CCC1)C=CC(CC1=CC=CC=C1)=O)CC=C/COCC(=O)O Chemical compound COC(COCCCCN1C(CCC[C@@H]1CCC(CC1=CC=CC=C1)=O)=O)=O.O=C1N([C@H](CCC1)C=CC(CC1=CC=CC=C1)=O)CC=C/COCC(=O)O WYWYULSOYCDXOI-QBFDXINUSA-N 0.000 claims 2
- DPNFQFGJOKLUQJ-FLXLDNCDSA-N COC(COC\C=C/CN1[C@H](CCCC1=O)\C=C\C(CC1=CC=CC=C1)O)=O.O=C1N([C@H](CCC1)CCC(CC1=CC=CC=C1)=O)CCCCOCC(=O)O Chemical compound COC(COC\C=C/CN1[C@H](CCCC1=O)\C=C\C(CC1=CC=CC=C1)O)=O.O=C1N([C@H](CCC1)CCC(CC1=CC=CC=C1)=O)CCCCOCC(=O)O DPNFQFGJOKLUQJ-FLXLDNCDSA-N 0.000 claims 2
- RTJCONSQUNWOGC-ZZNOMVLQSA-N OC(/C=C/[C@@H]1N(C(CCC1)=O)CCCCOCC(=O)O)CC1=CC=CC=C1.COC(COCCCCN1[C@H](CCCC1=O)\C=C\C(CC1=CC=CC=C1)O)=O Chemical compound OC(/C=C/[C@@H]1N(C(CCC1)=O)CCCCOCC(=O)O)CC1=CC=CC=C1.COC(COCCCCN1[C@H](CCCC1=O)\C=C\C(CC1=CC=CC=C1)O)=O RTJCONSQUNWOGC-ZZNOMVLQSA-N 0.000 claims 2
- RTZZGUGPNIHURJ-UAXUGEBOSA-N OC(CC[C@@H]1N(C(CCC1)=O)CCCCOCC(=O)O)CC1=CC=CC=C1.COC(COCCCCN1[C@H](CCCC1=O)CCC(CC1=CC=CC=C1)O)=O Chemical compound OC(CC[C@@H]1N(C(CCC1)=O)CCCCOCC(=O)O)CC1=CC=CC=C1.COC(COCCCCN1[C@H](CCCC1=O)CCC(CC1=CC=CC=C1)O)=O RTZZGUGPNIHURJ-UAXUGEBOSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- XEMXOPBICSGFHY-VVAUDMOXSA-N methyl 2-[(z)-4-[(6r)-2-oxo-6-[(e)-3-oxo-4-phenylbut-1-enyl]piperidin-1-yl]but-2-enoxy]acetate Chemical compound C1CCC(=O)N(C\C=C/COCC(=O)OC)[C@H]1\C=C\C(=O)CC1=CC=CC=C1 XEMXOPBICSGFHY-VVAUDMOXSA-N 0.000 claims 2
- UNLLTRAXOAFIER-AFZDNSHWSA-N methyl 2-[4-[(2r)-2-[(e)-4-(3-chlorophenyl)-3-hydroxybut-1-enyl]-6-oxopiperidin-1-yl]but-2-ynoxy]acetate Chemical compound C1CCC(=O)N(CC#CCOCC(=O)OC)[C@H]1\C=C\C(O)CC1=CC=CC(Cl)=C1 UNLLTRAXOAFIER-AFZDNSHWSA-N 0.000 claims 2
- WGVLUPHVOIIKAU-GNISGLHKSA-N methyl 2-[4-[(2r)-2-[(e)-4-(3-chlorophenyl)-3-oxobut-1-enyl]-6-oxopiperidin-1-yl]but-2-ynoxy]acetate Chemical compound C1CCC(=O)N(CC#CCOCC(=O)OC)[C@H]1\C=C\C(=O)CC1=CC=CC(Cl)=C1 WGVLUPHVOIIKAU-GNISGLHKSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229940054534 ophthalmic solution Drugs 0.000 claims 2
- 239000002997 ophthalmic solution Substances 0.000 claims 2
- BQWMDNYVFXHHHA-YJWAVEFUSA-N propan-2-yl 2-[4-[(2r)-2-[(e)-4-(3-chlorophenyl)-3-hydroxybut-1-enyl]-6-oxopiperidin-1-yl]but-2-ynoxy]acetate Chemical compound C1CCC(=O)N(CC#CCOCC(=O)OC(C)C)[C@H]1\C=C\C(O)CC1=CC=CC(Cl)=C1 BQWMDNYVFXHHHA-YJWAVEFUSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 0 *C*CC=CCN1OCCCC1CCS*C** Chemical compound *C*CC=CCN1OCCCC1CCS*C** 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/763,702 | 2004-01-22 | ||
| US10/763,702 US6977260B2 (en) | 2004-01-22 | 2004-01-22 | Piperidinyl prostaglandin E analogs |
| PCT/US2005/001461 WO2005072735A1 (en) | 2004-01-22 | 2005-01-14 | Piperidinyl prostaglandin e analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007520489A JP2007520489A (ja) | 2007-07-26 |
| JP2007520489A5 true JP2007520489A5 (https=) | 2008-02-28 |
| JP4740883B2 JP4740883B2 (ja) | 2011-08-03 |
Family
ID=34795110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551189A Expired - Fee Related JP4740883B2 (ja) | 2004-01-22 | 2005-01-14 | ピペリジニルプロスタグランジンｅ類似体 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6977260B2 (https=) |
| EP (1) | EP1722795B1 (https=) |
| JP (1) | JP4740883B2 (https=) |
| AR (1) | AR047436A1 (https=) |
| AT (1) | ATE394101T1 (https=) |
| AU (1) | AU2005209209B2 (https=) |
| CA (1) | CA2553387C (https=) |
| DE (1) | DE602005006534D1 (https=) |
| ES (1) | ES2303672T3 (https=) |
| TW (1) | TWI348370B (https=) |
| WO (1) | WO2005072735A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326716B2 (en) * | 2003-06-06 | 2008-02-05 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| WO2006047466A2 (en) * | 2004-10-21 | 2006-05-04 | Duke University | Ophthamological drugs |
| US20070254920A1 (en) * | 2006-04-26 | 2007-11-01 | Aerie Pharmaceuticals, Inc. | Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3220156C2 (de) * | 1982-05-28 | 1990-01-25 | Heida Houston Tex. Thurlow | Mit Metallgriffen, insbesondere Edelstahlgriffen, versehenes Koch- und Bratgeschirr mit Deckel |
| IT1225716B (it) * | 1988-10-26 | 1990-11-22 | Esacontrol Spa | Dispositivo per la protezione dei rele' di binario dai disturbi elettrici |
| US5028624A (en) * | 1989-07-27 | 1991-07-02 | Allergan, Inc. | Intraocular pressure reducing 9,15-diacyl prostaglandins |
| US5034413A (en) | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| CA2021316C (en) | 1989-07-27 | 2000-10-24 | Ming Fai Chan | Intraocular pressure reducing 11-acyl prostaglandins |
| US4994274A (en) * | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| DE4318713C1 (de) * | 1993-06-07 | 1994-09-15 | Daimler Benz Ag | Zahnräderwechselgetriebe der Vorgelegebauart |
| AU2003233729B2 (en) * | 2002-06-06 | 2007-10-04 | Merck Frosst Canada Ltd | 1,5-distributed pyrrolid-2-one derivatives for use as EP4 receptor agonists in the treatment of eye diseases such as glaucoma |
| US7053085B2 (en) | 2003-03-26 | 2006-05-30 | Merck & Co. Inc. | EP4 receptor agonist, compositions and methods thereof |
| CA2511255C (en) | 2003-01-10 | 2009-04-07 | F. Hoffmann-La Roche Ag | 2-piperidone derivatives as prostaglandin agonists |
| US6747037B1 (en) * | 2003-06-06 | 2004-06-08 | Allergan, Inc. | Piperidinyl prostaglandin E analogs |
| BRPI0411057A (pt) * | 2003-06-06 | 2006-07-25 | Allergan Inc | análogos de prostaglandina e de piperidinila |
-
2004
- 2004-01-22 US US10/763,702 patent/US6977260B2/en not_active Expired - Lifetime
-
2005
- 2005-01-07 TW TW094100542A patent/TWI348370B/zh not_active IP Right Cessation
- 2005-01-14 EP EP05705822A patent/EP1722795B1/en not_active Expired - Lifetime
- 2005-01-14 ES ES05705822T patent/ES2303672T3/es not_active Expired - Lifetime
- 2005-01-14 AU AU2005209209A patent/AU2005209209B2/en not_active Ceased
- 2005-01-14 DE DE602005006534T patent/DE602005006534D1/de not_active Expired - Lifetime
- 2005-01-14 AT AT05705822T patent/ATE394101T1/de not_active IP Right Cessation
- 2005-01-14 CA CA2553387A patent/CA2553387C/en not_active Expired - Fee Related
- 2005-01-14 JP JP2006551189A patent/JP4740883B2/ja not_active Expired - Fee Related
- 2005-01-14 WO PCT/US2005/001461 patent/WO2005072735A1/en not_active Ceased
- 2005-01-20 AR ARP050100195A patent/AR047436A1/es not_active Application Discontinuation
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