JP2007519742A5 - - Google Patents
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- JP2007519742A5 JP2007519742A5 JP2006551500A JP2006551500A JP2007519742A5 JP 2007519742 A5 JP2007519742 A5 JP 2007519742A5 JP 2006551500 A JP2006551500 A JP 2006551500A JP 2006551500 A JP2006551500 A JP 2006551500A JP 2007519742 A5 JP2007519742 A5 JP 2007519742A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ring
- compound
- optionally substituted
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 46
- 125000000217 alkyl group Chemical group 0.000 claims 36
- -1 phenyloxy, benzyl Chemical group 0.000 claims 24
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 16
- 201000010099 disease Diseases 0.000 claims 15
- 125000005842 heteroatom Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000002950 monocyclic group Chemical group 0.000 claims 8
- 239000001301 oxygen Substances 0.000 claims 8
- 239000011593 sulfur Substances 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 208000030507 AIDS Diseases 0.000 claims 6
- 125000004429 atom Chemical group 0.000 claims 6
- 229910052794 bromium Inorganic materials 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 229910052801 chlorine Inorganic materials 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 125000002541 furyl group Chemical group 0.000 claims 5
- 229910052740 iodine Inorganic materials 0.000 claims 5
- 230000001404 mediated effect Effects 0.000 claims 5
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 5
- 229930192474 thiophene Natural products 0.000 claims 5
- 125000006413 ring segment Chemical group 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 230000003463 hyperproliferative effect Effects 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 206010039083 rhinitis Diseases 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 241000721454 Pemphigus Species 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 2
- 206010042953 Systemic sclerosis Diseases 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000035939 Alveolitis allergic Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000036487 Arthropathies Diseases 0.000 claims 1
- 201000008283 Atrophic Rhinitis Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010011686 Cutaneous vasculitis Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 206010014954 Eosinophilic fasciitis Diseases 0.000 claims 1
- 206010014989 Epidermolysis bullosa Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- 208000027445 Farmer Lung Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 201000003838 Idiopathic interstitial pneumonia Diseases 0.000 claims 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- 206010024229 Leprosy Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029164 Nephrotic syndrome Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 206010036774 Proctitis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 206010039088 Rhinitis atrophic Diseases 0.000 claims 1
- 208000036284 Rhinitis seasonal Diseases 0.000 claims 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 1
- 208000009359 Sezary Syndrome Diseases 0.000 claims 1
- 208000021388 Sezary disease Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 1
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 1
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 235000014787 Vitis vinifera Nutrition 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000017760 chronic graft versus host disease Diseases 0.000 claims 1
- 201000009151 chronic rhinitis Diseases 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 1
- 231100000321 erythema Toxicity 0.000 claims 1
- 208000022195 farmer lung disease Diseases 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000011486 lichen planus Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000008585 mastocytosis Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 201000009240 nasopharyngitis Diseases 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 0 CC(N12)=C(*)C(**)=NC1=NC(*)=C(*)C2=O Chemical compound CC(N12)=C(*)C(**)=NC1=NC(*)=C(*)C2=O 0.000 description 1
- UCBZYLNJRPNAKV-UHFFFAOYSA-N CC(N12)=CC(Nc3cc(C4CC4)n[nH]3)=NC1=Nc1ccccc1C2=O Chemical compound CC(N12)=CC(Nc3cc(C4CC4)n[nH]3)=NC1=Nc1ccccc1C2=O UCBZYLNJRPNAKV-UHFFFAOYSA-N 0.000 description 1
- AEXWWGYBXSBBBX-UHFFFAOYSA-N Cc1n[nH]c(NC(c(cccc2)c2N23)=NC2=Nc2cc(N)ccc2C3=O)c1 Chemical compound Cc1n[nH]c(NC(c(cccc2)c2N23)=NC2=Nc2cc(N)ccc2C3=O)c1 AEXWWGYBXSBBBX-UHFFFAOYSA-N 0.000 description 1
- OODYCAJLBKRODK-JRUCOHCHSA-N N/C(/NC(c(cccc1)c1N12)=NC1=Nc1ccccc1C2=O)=C\C(c1ccccc1)=N Chemical compound N/C(/NC(c(cccc1)c1N12)=NC1=Nc1ccccc1C2=O)=C\C(c1ccccc1)=N OODYCAJLBKRODK-JRUCOHCHSA-N 0.000 description 1
- FPLXBPGPGOATHB-UHFFFAOYSA-N Nc(cc1N=C(N2C=C3)N=C3Nc3cc(C4CC4)n[nH]3)ccc1C2=O Chemical compound Nc(cc1N=C(N2C=C3)N=C3Nc3cc(C4CC4)n[nH]3)ccc1C2=O FPLXBPGPGOATHB-UHFFFAOYSA-N 0.000 description 1
- MDEGEGZLYAKXIQ-UHFFFAOYSA-N Nc(cc1N=C(N2c3c4cccc3)N=C4Nc3n[nH]c(C4CC4)c3)ccc1C2=O Chemical compound Nc(cc1N=C(N2c3c4cccc3)N=C4Nc3n[nH]c(C4CC4)c3)ccc1C2=O MDEGEGZLYAKXIQ-UHFFFAOYSA-N 0.000 description 1
- JHTFTJHZPGOBPS-UHFFFAOYSA-N O=C1N(c(cccc2)c2C(Nc2cc(C3CC3)n[nH]2)=N2)C2=Nc2ccccc12 Chemical compound O=C1N(c(cccc2)c2C(Nc2cc(C3CC3)n[nH]2)=N2)C2=Nc2ccccc12 JHTFTJHZPGOBPS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53917604P | 2004-01-26 | 2004-01-26 | |
| PCT/US2005/002725 WO2005095406A1 (en) | 2004-01-26 | 2005-01-26 | Compositions useful as inhibitors of protein kinases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011045758A Division JP2011105775A (ja) | 2004-01-26 | 2011-03-02 | プロテインキナーゼの阻害剤として有用な組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007519742A JP2007519742A (ja) | 2007-07-19 |
| JP2007519742A5 true JP2007519742A5 (https=) | 2008-02-28 |
Family
ID=34960536
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551500A Pending JP2007519742A (ja) | 2004-01-26 | 2005-01-26 | プロテインキナーゼの阻害剤として有用な組成物 |
| JP2011045758A Withdrawn JP2011105775A (ja) | 2004-01-26 | 2011-03-02 | プロテインキナーゼの阻害剤として有用な組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011045758A Withdrawn JP2011105775A (ja) | 2004-01-26 | 2011-03-02 | プロテインキナーゼの阻害剤として有用な組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7855214B2 (https=) |
| EP (1) | EP1716151A1 (https=) |
| JP (2) | JP2007519742A (https=) |
| CN (1) | CN1934113B (https=) |
| AU (1) | AU2005228845A1 (https=) |
| CA (1) | CA2554551A1 (https=) |
| WO (1) | WO2005095406A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080098490A (ko) * | 2006-01-13 | 2008-11-10 | 파마시클릭스, 인코포레이티드 | 티로신 키나제 억제제 및 이의 용도 |
| MX2008014450A (es) * | 2006-05-18 | 2009-03-09 | Mannkind Corp | Inhibidores de cinasa intracelular. |
| BRPI0622054B8 (pt) | 2006-09-22 | 2021-05-25 | Oxford Amherst Llc | composto e composição farmacêutica |
| US20120101114A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| US20090301928A1 (en) * | 2008-06-05 | 2009-12-10 | United Comb & Novelty Corporation | Packaging For Lipped Containers |
| ES2660418T3 (es) | 2008-07-16 | 2018-03-22 | Pharmacyclics Llc | Inhibidores de la tirosina quinasa de Bruton para el tratamiento de tumores sólidos |
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| WO2012158913A2 (en) * | 2011-05-17 | 2012-11-22 | Discoverybiomed Inc. | Treating protein folding disorders with small molecule cftr correctors |
| US9138436B2 (en) | 2011-07-13 | 2015-09-22 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| WO2013153539A1 (en) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Tricyclic compounds as tec kinase inhibitors |
| JO3754B1 (ar) | 2012-06-04 | 2021-01-31 | Pharmacyclics Llc | أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| EA201590855A1 (ru) | 2012-11-15 | 2015-11-30 | Фармасайкликс, Инк. | Соединения пирролопиримидина как ингибиторы киназ |
| US9546176B2 (en) | 2012-11-20 | 2017-01-17 | Discoverybiomed, Inc. | Small molecule bicyclic and tricyclic CFTR correctors |
| EP2922852A4 (en) | 2012-11-20 | 2016-05-25 | Discoverybiomed Inc | SMALL MOLECULAR CFTR CORRECTORS |
| CA2919996A1 (en) | 2013-08-02 | 2015-02-05 | Pharmacyclics Llc | Methods for the treatment of solid tumors |
| US9415050B2 (en) | 2013-08-12 | 2016-08-16 | Pharmacyclics Llc | Methods for the treatment of HER2 amplified cancer |
| CA2925124A1 (en) | 2013-09-30 | 2015-04-02 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| US9795604B2 (en) | 2013-10-25 | 2017-10-24 | Pharmacyclics Llc | Methods of treating and preventing graft versus host disease |
| WO2015143400A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics, Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| AU2015296215A1 (en) | 2014-08-01 | 2017-03-23 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| SG11201700849XA (en) | 2014-08-07 | 2017-03-30 | Pharmacyclics Llc | Novel formulations of a bruton's tyrosine kinase inhibitor |
| IL315294A (en) | 2015-03-03 | 2024-10-01 | Pharmacyclics Llc | Pharmaceutical formulations of bruton's tyrosine kinase inhibitor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1268170A1 (ru) * | 1974-01-04 | 1986-11-07 | Киевский научно-исследовательский институт фармакологии и токсикологии | Антиревматическое средство "пиримидант |
| SU1323560A1 (ru) * | 1981-08-14 | 1987-07-15 | Киевский научно-исследовательский институт фармакологии и токсикологии | Хлоргидраты эфиров 2- /О-карбоксифениламино/-6-пиримидо-[2,1-в]-хиназолона-6,про вл ющие противовоспалительную,анальгезирующую и жаропонижающую активность |
| SU1174433A1 (ru) * | 1981-10-19 | 1985-08-23 | Киевский научно-исследовательский институт фармакологии и токсикологии | Соли-2-( @ -карбоксифениламино)-6 @ -пиримидо @ 2,1- @ хиназолона-6,про вл ющие противовоспалительную активность |
| US4455312A (en) | 1982-08-19 | 1984-06-19 | Portnyagina Vera A | 2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof, and application as antiphlogistics |
| GB2125785B (en) * | 1982-08-20 | 1986-07-23 | Ki Nii Farmakologii Toksikolog | 2-(o-carboxyphenylamino)-6h-pyrimido (2 1-b)-quinazolone -6 and derivatives thereof |
| JPS5955884A (ja) * | 1982-09-14 | 1984-03-31 | キエフスキ−・ナウチノ−イスレドワ−チエルスキ−・インスチツ−ト・フアルマコロギイ・イ・トクシコロギイ | ２−（Ｏ−カルボキシフエニルアミノ）−６Ｈ−ピリミド（２，１−ｂ）−キナゾロン−６およびその誘導体、製法および使用 |
| EP1857443B1 (en) * | 2000-01-24 | 2012-03-28 | AstraZeneca AB | Therapeutic morpholino-substituted compounds |
| EP1485100B1 (en) * | 2002-03-15 | 2010-05-05 | Vertex Pharmaceuticals Incorporated | Azinylaminoazoles as inhibitors of protein kinases |
-
2005
- 2005-01-26 US US11/046,664 patent/US7855214B2/en not_active Expired - Fee Related
- 2005-01-26 WO PCT/US2005/002725 patent/WO2005095406A1/en not_active Ceased
- 2005-01-26 JP JP2006551500A patent/JP2007519742A/ja active Pending
- 2005-01-26 CN CN2005800089989A patent/CN1934113B/zh not_active Expired - Fee Related
- 2005-01-26 AU AU2005228845A patent/AU2005228845A1/en not_active Abandoned
- 2005-01-26 EP EP05712244A patent/EP1716151A1/en not_active Withdrawn
- 2005-01-26 CA CA002554551A patent/CA2554551A1/en not_active Abandoned
-
2011
- 2011-03-02 JP JP2011045758A patent/JP2011105775A/ja not_active Withdrawn
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