JP2007518680A - ジ−アリール尿素化合物の製造方法 - Google Patents

ジ−アリール尿素化合物の製造方法 Download PDF

Info

Publication number
JP2007518680A
JP2007518680A JP2006518643A JP2006518643A JP2007518680A JP 2007518680 A JP2007518680 A JP 2007518680A JP 2006518643 A JP2006518643 A JP 2006518643A JP 2006518643 A JP2006518643 A JP 2006518643A JP 2007518680 A JP2007518680 A JP 2007518680A
Authority
JP
Japan
Prior art keywords
alkyl
compound
formula
alkoxy
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006518643A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007518680A5 (https=
Inventor
ニザー ハダッド
シュードン ウェイ
クリス ヒュー セナナヤケ
ジングア シュー
ネイサン イー
Original Assignee
ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド filed Critical ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド
Publication of JP2007518680A publication Critical patent/JP2007518680A/ja
Publication of JP2007518680A5 publication Critical patent/JP2007518680A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2006518643A 2003-06-30 2004-06-11 ジ−アリール尿素化合物の製造方法 Pending JP2007518680A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48372003P 2003-06-30 2003-06-30
PCT/US2004/018694 WO2005005396A1 (en) 2003-06-30 2004-06-11 Process of making di-aryl urea compounds

Publications (2)

Publication Number Publication Date
JP2007518680A true JP2007518680A (ja) 2007-07-12
JP2007518680A5 JP2007518680A5 (https=) 2007-08-23

Family

ID=34061980

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006518643A Pending JP2007518680A (ja) 2003-06-30 2004-06-11 ジ−アリール尿素化合物の製造方法

Country Status (6)

Country Link
US (1) US7265222B2 (https=)
EP (1) EP1644341A1 (https=)
JP (1) JP2007518680A (https=)
CN (1) CN1812975A (https=)
CA (1) CA2530776A1 (https=)
WO (1) WO2005005396A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563115B2 (en) 2008-08-12 2013-10-22 Xerox Corporation Protective coatings for solid inkjet applications
US8191992B2 (en) 2008-12-15 2012-06-05 Xerox Corporation Protective coatings for solid inkjet applications
KR102283876B1 (ko) 2013-04-02 2021-07-29 옥슬러 액퀴지션즈 리미티드 키나제 저해제로서 유용한 우레아 유도체
EP3083604A1 (en) 2013-12-20 2016-10-26 Respivert Limited Urea derivatives useful as kinase inhibitors
MA40774A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
CA3015978A1 (en) 2016-04-06 2017-10-12 Topivert Pharma Limited Kinase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03009000A (es) * 2001-04-13 2004-02-12 Boehringer Ingelheim Pharma Compuestos benzo-fusionados 1,4-disustituidos.
WO2002092576A1 (en) * 2001-05-16 2002-11-21 Boehringer Ingelheim Pharmaceuticals, Inc. Diarylurea derivatives useful as anti-inflammatory agents
CA2494824A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Fluorinated phenyl-naphthalenyl-urea compounds as inhibitors of cytokines involved in inflammatory processes

Also Published As

Publication number Publication date
CN1812975A (zh) 2006-08-02
EP1644341A1 (en) 2006-04-12
WO2005005396A1 (en) 2005-01-20
US20040266767A1 (en) 2004-12-30
CA2530776A1 (en) 2005-01-20
US7265222B2 (en) 2007-09-04

Similar Documents

Publication Publication Date Title
EP1232150B1 (en) Urea derivatives as anti-inflammatory agents
US6608052B2 (en) Compounds useful as anti-inflammatory agents
EP0502169B1 (en) Piperazine derivatives
US6603000B2 (en) Synthesis for heteroarylamine compounds
FI66865C (fi) Foerfarande foer framstaellning av pyrimido(6,1-a)isokinolin-2,4-dioner
US6172227B1 (en) 4,5-diaminopyrimidine derivatives and a method for the preparation thereof
JPH0524917B2 (https=)
KR20060130126A (ko) 1-피페라진- 및 1-호모피페라진-카르복실레이트의 유도체,이의 제법 및 치료 용도
Zanatta et al. Haloacetylated enol ethers. 9. Synthesis of 4‐trifluoromethyl‐2‐methyl [phenyl] pyrimidines and tetrahydro derivatives
KR20060009900A (ko) 피페리디닐- 및 피페라지닐-알킬 카르바메이트 유도체,그의 제조 방법 및 그의 치료 용도
US5210086A (en) 2-aminopyrimidine-4-carboxamide derivatives, their preparation and their use in therapy
JP2004339080A (ja) ピラゾ−ル誘導体を含有する高血圧治療剤
JP2018509407A (ja) ＭＥＫキナーゼ阻害剤のｐ−トルエンスルホン酸塩、およびその結晶形およびその製造法
Solovyev et al. A new synthesis of 4-or/and 6-CF3-containing hexahydro-and 1, 2, 3, 4-tetrahydropyrimidin-2-ones
EP0520883B1 (fr) Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique
CA2278988C (en) An efficient synthesis of furan sulfonamide compounds useful in the synthesis of new il-1 inhibitors
JP2007518680A (ja) ジ−アリール尿素化合物の製造方法
CN108473428B (zh) 一种吡啶衍生物类化合物的制备方法及其中间体和晶型
AU2005219689B2 (en) Novel cyclic compound having 4-pyridylalkylthio group having (un)substituted amino introduced therein
US5229392A (en) 2-aminopyrimidine-4-carboxamide derivatives, their preparaton and their application in therapy
US4940712A (en) Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors
US5051424A (en) Substituted aromatic compounds having an action on the central nervous system
CA1336516C (en) Acyl derivatives of 2-amino-4-substituted-5-hydroxy pyrimidines
JPH06100545A (ja) ２−アミノ−ｎ−［［［４−（アミノカルボニル）ピリミジン−２−イル］アミノ］アルキル］ピリミジン−４−カルボキシアミド誘導体、その製造および医薬への応用
JP2552905B2 (ja) Ｎ−［（２−オキソ−１−ピロリジニル）アセチル］ピペラジン誘導体、その製造方法および老人性痴呆症薬

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070611

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070611

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101025

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110404