JP2007517857A5 - - Google Patents
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- Publication number
- JP2007517857A5 JP2007517857A5 JP2006548476A JP2006548476A JP2007517857A5 JP 2007517857 A5 JP2007517857 A5 JP 2007517857A5 JP 2006548476 A JP2006548476 A JP 2006548476A JP 2006548476 A JP2006548476 A JP 2006548476A JP 2007517857 A5 JP2007517857 A5 JP 2007517857A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- azulen
- tetraaza
- piperidin
- benzo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- 208000005171 Dysmenorrhea Diseases 0.000 claims 4
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- DAZVNXGSTMSXNP-UHFFFAOYSA-N 1-[4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-2-(2-methylphenyl)ethanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C(CC1)CCN1C(=O)CC1=CC=CC=C1C DAZVNXGSTMSXNP-UHFFFAOYSA-N 0.000 claims 1
- GWELJOVUHDEZOG-UHFFFAOYSA-N 1-[4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-2-cyclopropylethanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C(CC1)CCN1C(=O)CC1CC1 GWELJOVUHDEZOG-UHFFFAOYSA-N 0.000 claims 1
- OCIOIOFHZYPZMC-UHFFFAOYSA-N 1-[4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]butan-1-one Chemical compound C1CN(C(=O)CCC)CCC1C1=NN=C2N1C1=CC=C(Cl)C=C1CN(C)C2 OCIOIOFHZYPZMC-UHFFFAOYSA-N 0.000 claims 1
- 206010002383 Angina Pectoris Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 229940124638 COX inhibitor Drugs 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 208000001362 Fetal Growth Retardation Diseases 0.000 claims 1
- 206010070531 Foetal growth restriction Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000029422 Hypernatremia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 claims 1
- 208000005107 Premature Birth Diseases 0.000 claims 1
- 206010036590 Premature baby Diseases 0.000 claims 1
- 208000003782 Raynaud disease Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- DMEKQAADBPOJEO-UHFFFAOYSA-N [4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-(1-methylcyclohexyl)methanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C(CC1)CCN1C(=O)C1(C)CCCCC1 DMEKQAADBPOJEO-UHFFFAOYSA-N 0.000 claims 1
- LUNAHEGNSDARJA-UHFFFAOYSA-N [4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-(1h-indol-2-yl)methanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C1CCN(C(=O)C=2NC3=CC=CC=C3C=2)CC1 LUNAHEGNSDARJA-UHFFFAOYSA-N 0.000 claims 1
- HMOVLAJSVILELK-UHFFFAOYSA-N [4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-(1h-indol-3-yl)methanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C1CCN(C(=O)C=2C3=CC=CC=C3NC=2)CC1 HMOVLAJSVILELK-UHFFFAOYSA-N 0.000 claims 1
- QZGGATRCENWZPA-UHFFFAOYSA-N [4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-(1h-indol-6-yl)methanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C1CCN(C(=O)C=2C=C3NC=CC3=CC=2)CC1 QZGGATRCENWZPA-UHFFFAOYSA-N 0.000 claims 1
- LEGRMMSSDMQWQP-UHFFFAOYSA-N [4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-(2-hydroxy-5-methylphenyl)methanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C(CC1)CCN1C(=O)C1=CC(C)=CC=C1O LEGRMMSSDMQWQP-UHFFFAOYSA-N 0.000 claims 1
- NBNGJKUNWJBONP-UHFFFAOYSA-N [4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-(3-fluorophenyl)methanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C(CC1)CCN1C(=O)C1=CC=CC(F)=C1 NBNGJKUNWJBONP-UHFFFAOYSA-N 0.000 claims 1
- KGIPOTCNKIWDSY-UHFFFAOYSA-N [4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-(3-methoxyphenyl)methanone Chemical compound COC1=CC=CC(C(=O)N2CCC(CC2)C=2N3C4=CC=C(Cl)C=C4CN(C)CC3=NN=2)=C1 KGIPOTCNKIWDSY-UHFFFAOYSA-N 0.000 claims 1
- IQCZYHLCFHWYEP-UHFFFAOYSA-N [4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-(4-fluorophenyl)methanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C(CC1)CCN1C(=O)C1=CC=C(F)C=C1 IQCZYHLCFHWYEP-UHFFFAOYSA-N 0.000 claims 1
- KGKBDXALAUYHBL-UHFFFAOYSA-N [4-(8-chloro-5-methyl-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)piperidin-1-yl]-cyclopropylmethanone Chemical compound N12C3=CC=C(Cl)C=C3CN(C)CC2=NN=C1C(CC1)CCN1C(=O)C1CC1 KGKBDXALAUYHBL-UHFFFAOYSA-N 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000030941 fetal growth restriction Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 201000003152 motion sickness Diseases 0.000 claims 1
- 239000002840 nitric oxide donor Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229940127234 oral contraceptive Drugs 0.000 claims 1
- 239000003539 oral contraceptive agent Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0400700.1A GB0400700D0 (en) | 2004-01-13 | 2004-01-13 | Compounds useful in therapy |
| US54486604P | 2004-02-13 | 2004-02-13 | |
| PCT/IB2005/000263 WO2005068466A1 (en) | 2004-01-13 | 2005-01-05 | Compounds useful in therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007517857A JP2007517857A (ja) | 2007-07-05 |
| JP2007517857A5 true JP2007517857A5 (enExample) | 2008-02-14 |
Family
ID=31726109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006548476A Withdrawn JP2007517857A (ja) | 2004-01-13 | 2005-01-05 | 治療に有用な化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070167430A1 (enExample) |
| EP (1) | EP1706409A1 (enExample) |
| JP (1) | JP2007517857A (enExample) |
| BR (1) | BRPI0506848A (enExample) |
| CA (1) | CA2554382A1 (enExample) |
| GB (1) | GB0400700D0 (enExample) |
| WO (1) | WO2005068466A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2616937A1 (en) | 2005-07-29 | 2007-02-08 | F. Hoffman-La Roche Ag | Indol-3-yl-carbonyl-piperidin and piperazin derivatives |
| JP5313875B2 (ja) | 2006-04-12 | 2013-10-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | 増殖性疾患の処置のためのタンパク質キナーゼｐｌｋ１の阻害剤として有用な４，５−ジヒドロ−［１，２，４］トリアゾロ［４，３−ｆ］プテリジン |
| EP2102207B1 (en) * | 2006-12-07 | 2010-06-02 | F.Hoffmann-La Roche Ag | Spiro-piperidine derivatives as via receptor antagonists |
| ES2351949T3 (es) * | 2006-12-29 | 2011-02-14 | F. Hoffmann-La Roche Ag | Derivados de azaspiro. |
| EP2356123B1 (en) | 2008-11-13 | 2012-10-03 | F.Hoffmann-La Roche Ag | Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulenes |
| JP5384659B2 (ja) | 2008-11-18 | 2014-01-08 | エフ．ホフマン−ラ ロシュ アーゲー | ジヒドロテトラアザベンゾアズレンのアルキルシクロヘキシルエーテル |
| AU2013202813B2 (en) * | 2008-11-28 | 2014-10-23 | F. Hoffmann-La Roche Ag | Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists |
| RU2507205C2 (ru) * | 2008-11-28 | 2014-02-20 | Ф. Хоффманн-Ля Рош Аг | Арилциклогексилэфиры дигидротетраазабензоазуленов для применения в качестве антагонистов рецептора вазопрессина v1a |
| NZ599356A (en) | 2009-09-25 | 2013-08-30 | Vertex Pharma | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| KR20120096474A (ko) | 2009-09-25 | 2012-08-30 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제로서 유용한 피리미딘 유도체의 제조 방법 |
| US8420633B2 (en) * | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
| US8492376B2 (en) * | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8481528B2 (en) * | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8513238B2 (en) * | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
| US8828989B2 (en) * | 2011-09-26 | 2014-09-09 | Hoffmann-La Roche Inc. | Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists |
| KR20140082765A (ko) * | 2011-10-05 | 2014-07-02 | 에프. 호프만-라 로슈 아게 | V1a 길항제로서의 사이클로헥실-4H,6H-5-옥사-2,3,10b-트라이아자-벤조[e]아줄렌 |
| WO2015082370A1 (en) | 2013-12-05 | 2015-06-11 | F. Hoffmann-La Roche Ag | Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| HU231206B1 (hu) * | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
| TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物 |
| CN114644635B (zh) * | 2020-12-21 | 2023-02-03 | 上海济煜医药科技有限公司 | 三氮唑类三并环衍生物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4481360A (en) * | 1983-08-26 | 1984-11-06 | The Upjohn Company | 4H-1,2,4-Triazol-3-yl compounds |
| WO2001058880A1 (en) * | 2000-02-08 | 2001-08-16 | Yamanouchi Pharmaceutical Co., Ltd. | Novel triazole derivatives |
| PL359340A1 (en) * | 2000-05-19 | 2004-08-23 | Triazole derivatives |
-
2004
- 2004-01-13 GB GBGB0400700.1A patent/GB0400700D0/en not_active Ceased
-
2005
- 2005-01-05 WO PCT/IB2005/000263 patent/WO2005068466A1/en not_active Ceased
- 2005-01-05 BR BRPI0506848-7A patent/BRPI0506848A/pt not_active IP Right Cessation
- 2005-01-05 JP JP2006548476A patent/JP2007517857A/ja not_active Withdrawn
- 2005-01-05 CA CA002554382A patent/CA2554382A1/en not_active Abandoned
- 2005-01-05 US US10/588,878 patent/US20070167430A1/en not_active Abandoned
- 2005-01-05 EP EP05702410A patent/EP1706409A1/en not_active Withdrawn
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