JP2007516302A5 - - Google Patents
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- Publication number
- JP2007516302A5 JP2007516302A5 JP2006516436A JP2006516436A JP2007516302A5 JP 2007516302 A5 JP2007516302 A5 JP 2007516302A5 JP 2006516436 A JP2006516436 A JP 2006516436A JP 2006516436 A JP2006516436 A JP 2006516436A JP 2007516302 A5 JP2007516302 A5 JP 2007516302A5
- Authority
- JP
- Japan
- Prior art keywords
- initiator
- following formula
- polypeptide
- protein
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003999 initiator Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N Benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000010526 radical polymerization reaction Methods 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical group 0.000 claims 1
Claims (7)
- 前記触媒が
Mが一形式酸化状態により酸化され得る遷移金属、特にCu+、Cu2+、Fe2+、Fe3+、Ru2+、Ru3+、Cr2+、Cr3+、Mo2+、Mo3+、W2+、W3+、Mn3+、Mn4+、Rh3+、Rh4+、Re2+、Re3+、Co + 、Co2+、V2+、V3+、Zn+、Zn2+、Au+、Au2+、Ag+及びAg2+であり、Yは一価又は二価の対イオンである、第一化合物MYと、
窒素のうちの少なくとも1つが芳香族環の一部にないオルガノジイミンとを含むことを特徴とする、請求項1〜6のいずれか一項に記載の方法。
- ポリマーに結合したとき、タンパク質又はポリペプチドと結合し得る部分を含む、リビングラジカル重合反応に用いられ得る開始剤。
- タンパク質又はポリペプチド、チオール及び/又はベンジルアミン含有化合物であることを特徴とする、請求項49に記載の化合物。
- 生物学的に活性であることを特徴とする請求項49または50に記載の化合物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0314472.2 | 2003-06-20 | ||
GBGB0314472.2A GB0314472D0 (en) | 2003-06-20 | 2003-06-20 | Polymer |
PCT/GB2004/002608 WO2004113394A2 (en) | 2003-06-20 | 2004-06-18 | Living radical polymerization initiator comprising a functional group capable of reacting with polypeptides or the like, comb polymer obtained therewith, polypeptide conjugates and drugs obtained therefrom |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007516302A JP2007516302A (ja) | 2007-06-21 |
JP2007516302A5 true JP2007516302A5 (ja) | 2007-08-02 |
JP5264073B2 JP5264073B2 (ja) | 2013-08-14 |
Family
ID=27637062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006516436A Expired - Fee Related JP5264073B2 (ja) | 2003-06-20 | 2004-06-18 | ポリペプチド等と反応し得る官能基を含むリビングラジカル重合開始剤、それを用いて得られる櫛形ポリマー、それから得られるポリペプチド複合体及び薬剤 |
Country Status (12)
Country | Link |
---|---|
US (2) | US8436104B2 (ja) |
EP (2) | EP2161291A2 (ja) |
JP (1) | JP5264073B2 (ja) |
AT (1) | ATE427322T1 (ja) |
AU (1) | AU2004249489A1 (ja) |
CA (1) | CA2530001C (ja) |
DE (1) | DE602004020347D1 (ja) |
DK (1) | DK1646661T3 (ja) |
ES (1) | ES2324994T3 (ja) |
GB (1) | GB0314472D0 (ja) |
WO (1) | WO2004113394A2 (ja) |
ZA (1) | ZA200600590B (ja) |
Families Citing this family (44)
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GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
WO2006003352A1 (en) * | 2004-07-06 | 2006-01-12 | Warwick Effect Polymers Limited | Living radical polymerization initiator comprising a functional group capable of reacting with polyeptides or the like, comb polymer obtained therewith, polypeptide conjugates and drugs obtained therefrom |
ES2382879T3 (es) * | 2005-09-14 | 2012-06-14 | Ucb Pharma, S.A. | Conjugado de anticuerpo - polímero de peine. |
EP3222142A1 (en) * | 2006-02-28 | 2017-09-27 | Kodiak Sciences Inc. | Acryloyloxyethylphosphorylcholine containing polymer conjugates and their preparation |
CN100406479C (zh) * | 2006-05-25 | 2008-07-30 | 中国科学院长春应用化学研究所 | 含有三氟甲基的β-二酮单亚胺钒烯烃聚合催化剂及制备方法和应用 |
EP3231442B1 (en) | 2006-06-23 | 2019-12-25 | ADC Therapeutics SA | Polynucleotides and polypeptide sequences involved in cancer |
ITRM20060682A1 (it) * | 2006-12-19 | 2008-06-20 | Sicit Chemitech S P A | Nuovi derivati polimerici biodegradabili |
US8685417B2 (en) * | 2006-12-20 | 2014-04-01 | Arkema, Inc. | Polymer encapsulation and/or binding |
US8575397B2 (en) | 2007-02-14 | 2013-11-05 | Biocompatibles Uk Limited | Derivatisation of biological molecules |
KR20100072185A (ko) | 2007-09-24 | 2010-06-30 | 녹손 파르마 아게 | 씨파이브에이 결합형 핵산 |
WO2009053700A1 (en) * | 2007-10-23 | 2009-04-30 | Cancer Research Technology Limited | Modification of nucleic acid-containing biological entities |
WO2009112301A2 (de) * | 2008-03-10 | 2009-09-17 | Basf Se | Polypeptidwirkstoffe in der form von konjugaten aus keratinbindenden polypeptiden, polymeren und effektormolekülen, verfahren zu ihrer herstellung und ihre verwendung |
BRPI0921805A2 (pt) | 2008-11-03 | 2016-11-01 | Alethia Biotherapeutics Inc | anticorpos que especificamente bloqueiam a atividade biológica de um antígeno de tumor |
WO2010108657A2 (en) | 2009-03-23 | 2010-09-30 | Noxxon Pharma Ag | C5a binding nucleic acids and the use thereof |
US8067201B2 (en) | 2009-04-17 | 2011-11-29 | Bristol-Myers Squibb Company | Methods for protein refolding |
GB0912160D0 (en) | 2009-07-13 | 2009-08-26 | Warwick Effect Polymers Ltd | Polymer modified macromolecules |
KR20120114234A (ko) * | 2009-11-27 | 2012-10-16 | 바스프 에스이 | 낮은 용해도의 활성 물질을 가용화시키기 위한 수지상 폴리우레아 |
US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
CN102906265B (zh) | 2010-04-21 | 2016-08-24 | 诺松制药股份公司 | 脂质结合核酸 |
WO2012025251A1 (en) | 2010-08-27 | 2012-03-01 | Noxxon Pharma Ag | Nucleic acids for treatment of chronic complications of diabetes |
US20130310442A1 (en) | 2010-09-09 | 2013-11-21 | Noxxon Pharma Ag | SDF-1 Binding Nucleic Acids and the use Thereof in Cancer Treatment |
WO2012055573A1 (en) | 2010-10-29 | 2012-05-03 | Noxxon Pharma Ag | Use of hepcidin binding nucleic acids for depletion of hepcidin from the body |
KR20140026357A (ko) | 2011-01-10 | 2014-03-05 | 녹손 파르마 아게 | 목표 분자에 결합력을 갖는 핵산 및 이를 제조하는 방법 |
DK2691421T3 (en) | 2011-03-31 | 2017-02-20 | Alethia Biotherapeutics Inc | ANTIBODIES AGAINST NON-REFERENCE ANTIGEN 1 AND ANTIGIN BINDING FRAGMENTS |
EP2768960A1 (en) | 2011-10-21 | 2014-08-27 | Noxxon Pharma AG | Glucagon binding nucleic acids |
DK2802351T3 (da) | 2012-01-09 | 2019-05-13 | Adc Therapeutics Sa | Midler til behandling af triple-negativ brystkræft |
JP6415327B2 (ja) | 2012-01-10 | 2018-10-31 | ノクソン・ファルマ・アクチエンゲゼルシャフト | 新規なc5a結合性核酸 |
MX2014008456A (es) | 2012-01-10 | 2014-11-25 | Noxxon Pharma Ag | Acidos nucleicos que enlazan especificamente a cgrp. |
ES2819217T3 (es) | 2013-09-08 | 2021-04-15 | Kodiak Sciences Inc | Conjugados de polímeros iónicos dipolares y factor VIII |
JP2017502075A (ja) | 2013-11-04 | 2017-01-19 | ノクソン ファーマ エージー | 腎障害治療の手段および方法 |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
EP3207128B1 (en) | 2014-10-17 | 2022-07-27 | Kodiak Sciences Inc. | Butyrylcholinesterase zwitterionic polymer conjugates |
US10098960B2 (en) | 2015-04-03 | 2018-10-16 | Ucl Business Plc | Polymer conjugate |
RU2744860C2 (ru) | 2015-12-30 | 2021-03-16 | Кодиак Сайенсиз Инк. | Антитела и их конъюгаты |
WO2017178119A1 (en) | 2016-04-15 | 2017-10-19 | Noxxon Pharma Ag | Method of modulating the number and the distribution of tumor-infiltrating leukocytes in tumors |
ES2965349T3 (es) | 2016-06-06 | 2024-04-12 | Abzena Uk Ltd | Anticuerpos, usos de los mismos y conjugados de los mismos |
GB201614162D0 (en) | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
CN114520325B (zh) * | 2022-01-07 | 2023-07-04 | 惠州锂威新能源科技有限公司 | 一种氮掺杂碳材料的制备方法及制品、负极片和二次电池 |
WO2023247651A1 (en) | 2022-06-21 | 2023-12-28 | TME Pharma AG | Methods for treating a tumor in a subject |
EP4306640A1 (en) | 2022-06-21 | 2024-01-17 | TME Pharma AG | Method for treating a tumor in a subject |
WO2024022313A1 (zh) * | 2022-07-25 | 2024-02-01 | 南京金斯瑞生物科技有限公司 | 一种定点合成蛋白-活性分子偶联物的方法 |
WO2024026148A1 (en) * | 2022-07-29 | 2024-02-01 | University Of Virginia Patent Foundation | Compositions comprising linear, star-shaped, and comb-like stapled p9-peg conjugates and methods of use thereof |
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KR20050093856A (ko) | 2002-09-09 | 2005-09-23 | 넥타르 테라퓨틱스 에이엘, 코포레이션 | 수용성 중합체 알카날 |
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EP1656410B1 (en) | 2003-07-22 | 2010-03-10 | Nektar Therapeutics | Method for preparing functionalized polymers from polymer alcohols |
-
2003
- 2003-06-20 GB GBGB0314472.2A patent/GB0314472D0/en not_active Ceased
-
2004
- 2004-06-18 JP JP2006516436A patent/JP5264073B2/ja not_active Expired - Fee Related
- 2004-06-18 WO PCT/GB2004/002608 patent/WO2004113394A2/en active Application Filing
- 2004-06-18 ES ES04742963T patent/ES2324994T3/es not_active Expired - Lifetime
- 2004-06-18 EP EP09002932A patent/EP2161291A2/en not_active Withdrawn
- 2004-06-18 AU AU2004249489A patent/AU2004249489A1/en not_active Abandoned
- 2004-06-18 EP EP04742963A patent/EP1646661B1/en not_active Expired - Lifetime
- 2004-06-18 DK DK04742963T patent/DK1646661T3/da active
- 2004-06-18 DE DE602004020347T patent/DE602004020347D1/de not_active Expired - Lifetime
- 2004-06-18 AT AT04742963T patent/ATE427322T1/de not_active IP Right Cessation
- 2004-06-18 CA CA2530001A patent/CA2530001C/en not_active Expired - Fee Related
- 2004-06-18 ZA ZA200600590A patent/ZA200600590B/xx unknown
-
2006
- 2006-08-03 US US11/498,525 patent/US8436104B2/en not_active Expired - Fee Related
-
2013
- 2013-04-05 US US13/857,513 patent/US9200104B2/en not_active Expired - Fee Related
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