JP2007516302A5 - - Google Patents

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JP2007516302A5
JP2007516302A5 JP2006516436A JP2006516436A JP2007516302A5 JP 2007516302 A5 JP2007516302 A5 JP 2007516302A5 JP 2006516436 A JP2006516436 A JP 2006516436A JP 2006516436 A JP2006516436 A JP 2006516436A JP 2007516302 A5 JP2007516302 A5 JP 2007516302A5
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initiator
following formula
polypeptide
protein
compound
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JP2006516436A
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JP5264073B2 (ja
JP2007516302A (ja
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Priority claimed from GBGB0314472.2A external-priority patent/GB0314472D0/en
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Claims (7)

  1. 前記触媒が
    Mが一形式酸化状態により酸化され得る遷移金属、特にCu+、Cu2+、Fe2+、Fe3+、Ru2+、Ru3+、Cr2+、Cr3+、Mo2+、Mo3+、W2+、W3+、Mn3+、Mn4+、Rh3+、Rh4+、Re2+、Re3+Co + 、Co2+、V2+、V3+、Zn+、Zn2+、Au+、Au2+、Ag+及びAg2+であり、Yは一価又は二価の対イオンである、第一化合物MYと、
    窒素のうちの少なくとも1つが芳香族環の一部にないオルガノジイミンとを含むことを特徴とする、請求項1〜6のいずれか一項に記載の方法。
  2. 前記開始剤が、次式を有することを特徴とする、請求項1〜18のいずれか一項に記載の方法。
    Figure 2007516302
  3. ポリマーに結合したとき、タンパク質又はポリペプチドと結合し得る部分を含む、リビングラジカル重合反応に用いられ得る開始剤。
  4. 前記開始剤が、次式を有することを特徴とする、請求項35〜39のいずれか一項に記載の開始剤。
    Figure 2007516302
  5. 前記開始剤が、次式を有することを特徴とする、請求項35〜40のいずれか一項に記載の開始剤。
    Figure 2007516302
  6. タンパク質又はポリペプチド、チオール及び/又はベンジルアミン含有化合物であることを特徴とする、請求項49に記載の化合物。
  7. 生物学的に活性であることを特徴とする請求項49または50に記載の化合物。
JP2006516436A 2003-06-20 2004-06-18 ポリペプチド等と反応し得る官能基を含むリビングラジカル重合開始剤、それを用いて得られる櫛形ポリマー、それから得られるポリペプチド複合体及び薬剤 Expired - Fee Related JP5264073B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0314472.2 2003-06-20
GBGB0314472.2A GB0314472D0 (en) 2003-06-20 2003-06-20 Polymer
PCT/GB2004/002608 WO2004113394A2 (en) 2003-06-20 2004-06-18 Living radical polymerization initiator comprising a functional group capable of reacting with polypeptides or the like, comb polymer obtained therewith, polypeptide conjugates and drugs obtained therefrom

Publications (3)

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JP2007516302A JP2007516302A (ja) 2007-06-21
JP2007516302A5 true JP2007516302A5 (ja) 2007-08-02
JP5264073B2 JP5264073B2 (ja) 2013-08-14

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JP2006516436A Expired - Fee Related JP5264073B2 (ja) 2003-06-20 2004-06-18 ポリペプチド等と反応し得る官能基を含むリビングラジカル重合開始剤、それを用いて得られる櫛形ポリマー、それから得られるポリペプチド複合体及び薬剤

Country Status (12)

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US (2) US8436104B2 (ja)
EP (2) EP2161291A2 (ja)
JP (1) JP5264073B2 (ja)
AT (1) ATE427322T1 (ja)
AU (1) AU2004249489A1 (ja)
CA (1) CA2530001C (ja)
DE (1) DE602004020347D1 (ja)
DK (1) DK1646661T3 (ja)
ES (1) ES2324994T3 (ja)
GB (1) GB0314472D0 (ja)
WO (1) WO2004113394A2 (ja)
ZA (1) ZA200600590B (ja)

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