JP2007515471A - 造影イメージング用の活性成分を有する気体封入マイクロベシクルのアセンブリー - Google Patents

造影イメージング用の活性成分を有する気体封入マイクロベシクルのアセンブリー Download PDF

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Publication number
JP2007515471A
JP2007515471A JP2006546390A JP2006546390A JP2007515471A JP 2007515471 A JP2007515471 A JP 2007515471A JP 2006546390 A JP2006546390 A JP 2006546390A JP 2006546390 A JP2006546390 A JP 2006546390A JP 2007515471 A JP2007515471 A JP 2007515471A
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assembly
microvesicle
gas
microvesicles
component
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JP2006546390A
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Japanese (ja)
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JP2007515471A5 (enExample
Inventor
ミシェル・シュナイダー
フィリップ・ビュサ
フェン・ヤン
アンヌ・セナント
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Bracco Research SA
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Bracco Research SA
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Publication of JP2007515471A5 publication Critical patent/JP2007515471A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2006546390A 2003-12-22 2004-12-21 造影イメージング用の活性成分を有する気体封入マイクロベシクルのアセンブリー Pending JP2007515471A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03079014 2003-12-22
PCT/IB2004/004233 WO2005063306A1 (en) 2003-12-22 2004-12-21 Assembly of gas-filled microvesicle with active component for contrast imaging

Publications (2)

Publication Number Publication Date
JP2007515471A true JP2007515471A (ja) 2007-06-14
JP2007515471A5 JP2007515471A5 (enExample) 2008-02-14

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JP2006546390A Pending JP2007515471A (ja) 2003-12-22 2004-12-21 造影イメージング用の活性成分を有する気体封入マイクロベシクルのアセンブリー

Country Status (9)

Country Link
US (2) US20070081946A1 (enExample)
EP (1) EP1696965B1 (enExample)
JP (1) JP2007515471A (enExample)
CN (1) CN1897978B (enExample)
AU (1) AU2004308757B2 (enExample)
CA (1) CA2545362C (enExample)
ES (1) ES2531751T3 (enExample)
NO (1) NO338317B1 (enExample)
WO (1) WO2005063306A1 (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007515470A (ja) * 2003-12-22 2007-06-14 ブラッコ・リサーチ・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
JP2007517858A (ja) * 2004-01-15 2007-07-05 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ モレキュラーイメージング用の超音波造影剤
JP2012518012A (ja) * 2009-02-13 2012-08-09 ユニヴァーシティ オブ ワシントン 磁気共鳴イメージングのためのガドリニウム発現脂質ナノ粒子
JP2015081228A (ja) * 2013-10-21 2015-04-27 学校法人東京薬科大学 負電荷バブルリポソーム及びカチオン性ペプチドからなる薬物送達キャリア
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
US9364569B2 (en) 2003-02-04 2016-06-14 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
JP2016532718A (ja) * 2013-09-27 2016-10-20 フェニックス・ソリューションズ・アーエス 超音波により媒介される薬物送達
JP2023529237A (ja) * 2020-05-29 2023-07-07 アクト セラピューティクス リミテッド 感染の治療

Families Citing this family (21)

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JP2009519975A (ja) * 2005-12-16 2009-05-21 ユニバーシティ・オブ・カンザス 治療薬を送達するナノクラスター
CA2662087C (en) 2006-09-05 2015-01-06 Bracco Research Sa Gas-filled microvesicles with polymer-modified lipids
WO2008042855A2 (en) * 2006-09-29 2008-04-10 The Trustees Of The University Of Pennsylvania Use of ultrasound as an antivascular agent
US20090234231A1 (en) * 2008-03-13 2009-09-17 Knight Jon M Imaging Catheter With Integrated Contrast Agent Injector
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
JP5491511B2 (ja) * 2008-10-07 2014-05-14 ブラッコ・シュイス・ソシエテ・アノニム 抗ポリマー抗体およびそれと結合するリポソームまたは微小胞を含むターゲッティング構築物
EA037404B1 (ru) 2008-11-10 2021-03-24 Арбутус Биофарма Корпорэйшн Липиды и композиции для доставки лекарственных средств
EP2253308A1 (en) 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US20120328529A1 (en) * 2009-08-05 2012-12-27 The Trustees Of The University Of Pennsylvania Microfluidic-based generation of functionalized microbubbles for ultrasound imaging and therapy
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES
US9700640B2 (en) 2009-09-21 2017-07-11 Drexel University Stabilized ultrasound contrast agent
US8974818B2 (en) * 2010-01-20 2015-03-10 Henry Wu Custom-formulated phospholipid microbubbles and methods and uses thereof
EP2600771A1 (en) * 2010-08-06 2013-06-12 The Trustees of Columbia University in the City of New York Medical imaging contrast devices, methods, and systems
TW201208706A (en) 2010-08-17 2012-03-01 Univ Nat Yang Ming Ultrasonically-triggered drug vehicle with magnetic resonance imaging function
KR101292939B1 (ko) 2010-12-31 2013-08-02 삼성전자주식회사 엠알유도 고강도집속초음파 치료 및 진단용 인지질 나노입자 및 이의 제조방법
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
KR101595795B1 (ko) * 2014-03-19 2016-02-22 (주)아이엠지티 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법
IL277165B2 (en) * 2018-03-07 2024-07-01 Bracco Suisse Sa Preparation of size-controlled microvesicles
CA3120179A1 (en) 2018-12-21 2020-06-25 Bracco Suisse Sa Gas-filled microvesicles with ligand
KR20240035750A (ko) * 2021-07-14 2024-03-18 브라코 스위스 에스.에이. 양이온성 보정된 크기의 기체 충전된 미세소포
WO2024059715A2 (en) * 2022-09-14 2024-03-21 Drexel University Microbubbles and methods of making same

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JP2002512206A (ja) * 1998-04-22 2002-04-23 ニユコメド・イメージング・アクシエセルカペト 改良された造影剤
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JP2007515470A (ja) * 2003-12-22 2007-06-14 ブラッコ・リサーチ・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー

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JP2001511765A (ja) * 1996-10-28 2001-08-14 ニユコメド・イメージング・アクシエセルカペト 改良された診断／治療用薬剤
JP2001524983A (ja) * 1997-05-13 2001-12-04 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 新規の音響活性薬剤輸送系
JP2002502829A (ja) * 1998-02-09 2002-01-29 ブラッコ・リサーチ・ソシエテ・アノニム 生物学的に活性な媒質の標的に向けた送達
JP2002512206A (ja) * 1998-04-22 2002-04-23 ニユコメド・イメージング・アクシエセルカペト 改良された造影剤
JP2002212108A (ja) * 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9364569B2 (en) 2003-02-04 2016-06-14 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
JP2007515470A (ja) * 2003-12-22 2007-06-14 ブラッコ・リサーチ・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
US9750821B2 (en) 2003-12-22 2017-09-05 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
JP2007517858A (ja) * 2004-01-15 2007-07-05 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ モレキュラーイメージング用の超音波造影剤
US10076580B2 (en) 2004-08-18 2018-09-18 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
JP2016094425A (ja) * 2009-02-13 2016-05-26 ユニヴァーシティ オブ ワシントン 磁気共鳴イメージングのためのガドリニウム発現脂質ナノ粒子
JP2012518012A (ja) * 2009-02-13 2012-08-09 ユニヴァーシティ オブ ワシントン 磁気共鳴イメージングのためのガドリニウム発現脂質ナノ粒子
US11207430B2 (en) 2009-02-13 2021-12-28 University Of Washington Gadolinium expressed lipid nanoparticles for magnetic resonance imaging
JP2016532718A (ja) * 2013-09-27 2016-10-20 フェニックス・ソリューションズ・アーエス 超音波により媒介される薬物送達
JP2020114846A (ja) * 2013-09-27 2020-07-30 フェニックス・ソリューションズ・アーエス 超音波により媒介される薬物送達
JP7042862B2 (ja) 2013-09-27 2022-03-28 イグザクト・セラピューティクス・アーエス 超音波により媒介される薬物送達
JP2015081228A (ja) * 2013-10-21 2015-04-27 学校法人東京薬科大学 負電荷バブルリポソーム及びカチオン性ペプチドからなる薬物送達キャリア
JP2023529237A (ja) * 2020-05-29 2023-07-07 アクト セラピューティクス リミテッド 感染の治療

Also Published As

Publication number Publication date
EP1696965A1 (en) 2006-09-06
AU2004308757B2 (en) 2010-06-17
US20110150778A1 (en) 2011-06-23
CA2545362A1 (en) 2005-07-14
NO338317B1 (no) 2016-08-08
CN1897978A (zh) 2007-01-17
ES2531751T3 (es) 2015-03-18
CA2545362C (en) 2013-02-12
AU2004308757A1 (en) 2005-07-14
EP1696965B1 (en) 2014-12-10
US20070081946A1 (en) 2007-04-12
WO2005063306A1 (en) 2005-07-14
CN1897978B (zh) 2011-11-23
NO20063420L (no) 2006-09-22

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