AU2004308757B2 - Assembly of gas-filled microvesicle with active component for contrast imaging - Google Patents

Assembly of gas-filled microvesicle with active component for contrast imaging

Info

Publication number
AU2004308757B2
AU2004308757B2 AU2004308757A AU2004308757A AU2004308757B2 AU 2004308757 B2 AU2004308757 B2 AU 2004308757B2 AU 2004308757 A AU2004308757 A AU 2004308757A AU 2004308757 A AU2004308757 A AU 2004308757A AU 2004308757 B2 AU2004308757 B2 AU 2004308757B2
Authority
AU
Australia
Prior art keywords
assembly
gas
active component
contrast imaging
filled microvesicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004308757A
Other languages
English (en)
Other versions
AU2004308757A1 (en
Inventor
Philippe Bussat
Michel Schneider
Anne Senente
Feng Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Publication of AU2004308757A1 publication Critical patent/AU2004308757A1/en
Application granted granted Critical
Publication of AU2004308757B2 publication Critical patent/AU2004308757B2/en
Assigned to BRACCO SUISSE S.A. reassignment BRACCO SUISSE S.A. Request to Amend Deed and Register Assignors: BRACCO RESEARCH SA
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2004308757A 2003-12-22 2004-12-21 Assembly of gas-filled microvesicle with active component for contrast imaging Ceased AU2004308757B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03079014.1 2003-12-22
EP03079014 2003-12-22
PCT/IB2004/004233 WO2005063306A1 (en) 2003-12-22 2004-12-21 Assembly of gas-filled microvesicle with active component for contrast imaging

Publications (2)

Publication Number Publication Date
AU2004308757A1 AU2004308757A1 (en) 2005-07-14
AU2004308757B2 true AU2004308757B2 (en) 2010-06-17

Family

ID=34717205

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004308757A Ceased AU2004308757B2 (en) 2003-12-22 2004-12-21 Assembly of gas-filled microvesicle with active component for contrast imaging

Country Status (9)

Country Link
US (2) US20070081946A1 (enExample)
EP (1) EP1696965B1 (enExample)
JP (1) JP2007515471A (enExample)
CN (1) CN1897978B (enExample)
AU (1) AU2004308757B2 (enExample)
CA (1) CA2545362C (enExample)
ES (1) ES2531751T3 (enExample)
NO (1) NO338317B1 (enExample)
WO (1) WO2005063306A1 (enExample)

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AU2004210221B2 (en) 2003-02-04 2008-11-20 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
JP5513708B2 (ja) * 2003-12-22 2014-06-04 ブラッコ・シュイス・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
WO2005070473A1 (en) * 2004-01-15 2005-08-04 Koninklijke Philips Electronics N.V. Ultrasound contrast agents for molecular imaging
CN103120799A (zh) 2004-08-18 2013-05-29 博莱科瑞士股份有限公司 用于反差成像的充气微泡组合物
JP2009519975A (ja) * 2005-12-16 2009-05-21 ユニバーシティ・オブ・カンザス 治療薬を送達するナノクラスター
CA2662087C (en) 2006-09-05 2015-01-06 Bracco Research Sa Gas-filled microvesicles with polymer-modified lipids
WO2008042855A2 (en) * 2006-09-29 2008-04-10 The Trustees Of The University Of Pennsylvania Use of ultrasound as an antivascular agent
US20090234231A1 (en) * 2008-03-13 2009-09-17 Knight Jon M Imaging Catheter With Integrated Contrast Agent Injector
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
JP5491511B2 (ja) * 2008-10-07 2014-05-14 ブラッコ・シュイス・ソシエテ・アノニム 抗ポリマー抗体およびそれと結合するリポソームまたは微小胞を含むターゲッティング構築物
EA037404B1 (ru) 2008-11-10 2021-03-24 Арбутус Биофарма Корпорэйшн Липиды и композиции для доставки лекарственных средств
CN106362171A (zh) 2009-02-13 2017-02-01 华盛顿大学 用于磁共振成像的钆表现脂质纳米颗粒
EP2253308A1 (en) 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US20120328529A1 (en) * 2009-08-05 2012-12-27 The Trustees Of The University Of Pennsylvania Microfluidic-based generation of functionalized microbubbles for ultrasound imaging and therapy
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS AND DEVICES FOR PRODUCING GAS-FILLED MICROBUBBLES
US9700640B2 (en) 2009-09-21 2017-07-11 Drexel University Stabilized ultrasound contrast agent
US8974818B2 (en) * 2010-01-20 2015-03-10 Henry Wu Custom-formulated phospholipid microbubbles and methods and uses thereof
EP2600771A1 (en) * 2010-08-06 2013-06-12 The Trustees of Columbia University in the City of New York Medical imaging contrast devices, methods, and systems
TW201208706A (en) 2010-08-17 2012-03-01 Univ Nat Yang Ming Ultrasonically-triggered drug vehicle with magnetic resonance imaging function
KR101292939B1 (ko) 2010-12-31 2013-08-02 삼성전자주식회사 엠알유도 고강도집속초음파 치료 및 진단용 인지질 나노입자 및 이의 제조방법
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
HRP20221118T1 (hr) 2013-09-27 2022-12-23 Exact Therapeutics As Dostava lijekova posredovana ultrazvukom
JP6202563B2 (ja) * 2013-10-21 2017-09-27 ネッパジーン株式会社 負電荷バブルリポソーム及びカチオン性ペプチドからなる薬物送達キャリア
KR101595795B1 (ko) * 2014-03-19 2016-02-22 (주)아이엠지티 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법
IL277165B2 (en) * 2018-03-07 2024-07-01 Bracco Suisse Sa Preparation of size-controlled microvesicles
CA3120179A1 (en) 2018-12-21 2020-06-25 Bracco Suisse Sa Gas-filled microvesicles with ligand
GB2595513B (en) * 2020-05-29 2023-03-29 Act Therapeutics Ltd Treatment of infections
KR20240035750A (ko) * 2021-07-14 2024-03-18 브라코 스위스 에스.에이. 양이온성 보정된 크기의 기체 충전된 미세소포
WO2024059715A2 (en) * 2022-09-14 2024-03-21 Drexel University Microbubbles and methods of making same

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO1995023615A1 (en) * 1994-03-01 1995-09-08 Holmes, Michael, John Gas-containing microcapsules useful as contrast agents for diagnostic imaging
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors

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US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
DE3581471D1 (de) * 1984-10-19 1991-02-28 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (enExample) * 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
ATE281183T1 (de) * 1993-07-30 2004-11-15 Alliance Pharma Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
IL116328A (en) * 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
PT881915E (pt) * 1996-02-19 2003-09-30 Amersham Health As Melhorias em ou relativas a agentes de contraste
NZ335596A (en) * 1996-10-28 2000-10-27 Nycomed Imaging As Diagnostic and therapeutic agents comprising microbubbles of a reporter, a surfactant and a vector
NZ335799A (en) * 1996-10-28 2000-11-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
CA2319433C (en) * 1998-02-09 2008-04-22 Bracco Research S.A. Targeted delivery of biologically active media
GB9808599D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
JP2002212108A (ja) * 2001-01-17 2002-07-31 Fuji Photo Film Co Ltd 超音波散乱体
MXPA04001468A (es) * 2001-08-16 2004-05-20 Bristol Myers Squibb Pharma Co Compuestos de liposomas y microesfera de gas.
JP5513708B2 (ja) * 2003-12-22 2014-06-04 ブラッコ・シュイス・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
WO1995023615A1 (en) * 1994-03-01 1995-09-08 Holmes, Michael, John Gas-containing microcapsules useful as contrast agents for diagnostic imaging
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors

Also Published As

Publication number Publication date
EP1696965A1 (en) 2006-09-06
US20110150778A1 (en) 2011-06-23
CA2545362A1 (en) 2005-07-14
NO338317B1 (no) 2016-08-08
CN1897978A (zh) 2007-01-17
ES2531751T3 (es) 2015-03-18
CA2545362C (en) 2013-02-12
AU2004308757A1 (en) 2005-07-14
EP1696965B1 (en) 2014-12-10
JP2007515471A (ja) 2007-06-14
US20070081946A1 (en) 2007-04-12
WO2005063306A1 (en) 2005-07-14
CN1897978B (zh) 2011-11-23
NO20063420L (no) 2006-09-22

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired