JP2007514663A5 - - Google Patents
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- Publication number
- JP2007514663A5 JP2007514663A5 JP2006542113A JP2006542113A JP2007514663A5 JP 2007514663 A5 JP2007514663 A5 JP 2007514663A5 JP 2006542113 A JP2006542113 A JP 2006542113A JP 2006542113 A JP2006542113 A JP 2006542113A JP 2007514663 A5 JP2007514663 A5 JP 2007514663A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- compound
- pharmaceutical composition
- leukemia
- bromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 11
- 208000032839 leukemia Diseases 0.000 claims 8
- 201000009030 Carcinoma Diseases 0.000 claims 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 6
- 206010025323 Lymphomas Diseases 0.000 claims 6
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 6
- 201000005202 lung cancer Diseases 0.000 claims 6
- 208000020816 lung neoplasm Diseases 0.000 claims 6
- 201000002510 thyroid cancer Diseases 0.000 claims 6
- -1 O-glucosyl Chemical group 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 5
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 206010039491 Sarcoma Diseases 0.000 claims 4
- 125000001246 bromo group Chemical group Br* 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 201000010536 head and neck cancer Diseases 0.000 claims 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims 4
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 4
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 201000002528 pancreatic cancer Diseases 0.000 claims 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 4
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 3
- 230000005907 cancer growth Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000003200 Adenoma Diseases 0.000 claims 2
- 206010001233 Adenoma benign Diseases 0.000 claims 2
- 201000003076 Angiosarcoma Diseases 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010005949 Bone cancer Diseases 0.000 claims 2
- 208000018084 Bone neoplasm Diseases 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000005243 Chondrosarcoma Diseases 0.000 claims 2
- 201000009047 Chordoma Diseases 0.000 claims 2
- 208000006332 Choriocarcinoma Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 208000009798 Craniopharyngioma Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 2
- 201000008808 Fibrosarcoma Diseases 0.000 claims 2
- 208000021309 Germ cell tumor Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 2
- 208000000172 Medulloblastoma Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 208000006735 Periostitis Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 201000000582 Retinoblastoma Diseases 0.000 claims 2
- 201000010208 Seminoma Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000008383 Wilms tumor Diseases 0.000 claims 2
- 208000009956 adenocarcinoma Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 201000007455 central nervous system cancer Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 201000002660 colon sarcoma Diseases 0.000 claims 2
- 230000003511 endothelial effect Effects 0.000 claims 2
- 208000010932 epithelial neoplasm Diseases 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 230000009033 hematopoietic malignancy Effects 0.000 claims 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 206010024627 liposarcoma Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 208000012804 lymphangiosarcoma Diseases 0.000 claims 2
- 210000004698 lymphocyte Anatomy 0.000 claims 2
- 230000001589 lymphoproliferative effect Effects 0.000 claims 2
- 208000000516 mast-cell leukemia Diseases 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 208000001611 myxosarcoma Diseases 0.000 claims 2
- 208000025189 neoplasm of testis Diseases 0.000 claims 2
- 201000008026 nephroblastoma Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 210000003460 periosteum Anatomy 0.000 claims 2
- 208000029255 peripheral nervous system cancer Diseases 0.000 claims 2
- 210000004560 pineal gland Anatomy 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 201000003120 testicular cancer Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 230000002861 ventricular Effects 0.000 claims 2
- 229930194542 Keto Natural products 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000000468 ketone group Chemical group 0.000 claims 1
- 150000002596 lactones Chemical class 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52608103P | 2003-12-02 | 2003-12-02 | |
| PCT/IL2004/001098 WO2005054172A2 (en) | 2003-12-02 | 2004-12-01 | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007514663A JP2007514663A (ja) | 2007-06-07 |
| JP2007514663A5 true JP2007514663A5 (https=) | 2007-11-08 |
Family
ID=34652413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006542113A Pending JP2007514663A (ja) | 2003-12-02 | 2004-12-01 | ジャスモネート誘導体化合物、製薬組成物及びその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7425651B2 (https=) |
| EP (1) | EP1689696A2 (https=) |
| JP (1) | JP2007514663A (https=) |
| CN (1) | CN1902156A (https=) |
| AU (1) | AU2004295206A1 (https=) |
| CA (1) | CA2548173A1 (https=) |
| WO (1) | WO2005054172A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005054172A2 (en) * | 2003-12-02 | 2005-06-16 | Ramot At Tel-Aviv University Ltd. | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
| CA2630666A1 (en) | 2005-12-07 | 2007-06-14 | Sepal Pharma Ltd. | Jasmonate derivatives, pharmaceutical compositions and methods of use thereof |
| US20090291904A1 (en) * | 2005-12-07 | 2009-11-26 | Yoel Kashman | Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof |
| US9284274B2 (en) | 2005-12-07 | 2016-03-15 | Ramot At Tel-Aviv University Ltd. | Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof |
| CA2657375A1 (en) * | 2006-07-10 | 2008-01-17 | Ramot At Tel-Aviv University Ltd. | Combination methods of treating cancer |
| WO2008111088A2 (en) | 2007-03-15 | 2008-09-18 | Ramot At Tel-Aviv University Ltd. | Jasmonate based assays for identifying compounds that selectively inhibit mitochondrial bound hexokinases |
| US9284252B2 (en) | 2009-06-09 | 2016-03-15 | Sepal Pharma Ltd. | Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders |
| CN103140223A (zh) * | 2010-05-19 | 2013-06-05 | 布罗迪健康科学有限公司 | 茉莉酮酸酯用于治疗心力衰竭及相关心脏病症的用途 |
| RU2623878C2 (ru) | 2010-12-10 | 2017-06-29 | Броади Хэлс Сайенсис, Эл Эл Си | Применение жасмоната для лечения нарушения функции мочевого пузыря |
| WO2013040556A1 (en) | 2011-09-16 | 2013-03-21 | Nanocare Technologies, Inc. | Compositions of jasmonate compounds and methods of use |
| CA2971870A1 (en) | 2014-12-31 | 2016-07-07 | Nanocare Technologies, Inc. | Jasmonate derivatives and compositions thereof |
| WO2017168416A1 (en) | 2016-03-28 | 2017-10-05 | Vidac Pharma Ltd. | Stable pharmaceutical compositions for topical administration and uses thereof |
| US11266639B2 (en) | 2016-11-07 | 2022-03-08 | Vidac Pharma Ltd. | Use of hexokinase 2/mitochondria-detaching compounds for treating hexokinase-2 (HK2)-expressing cancers |
| WO2018083704A1 (en) | 2016-11-07 | 2018-05-11 | Vidac Pharma Ltd. | Use of hexokinase 2/mitochondria-detaching compounds for activating immune responses |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0441414A (ja) * | 1990-06-04 | 1992-02-12 | Fujisawa Pharmaceut Co Ltd | 育毛料 |
| US5118711A (en) * | 1990-09-27 | 1992-06-02 | International Flavors & Fragrances Inc. | Ketone, ketoesters and alcohol in repelling insects; use of aliphatic ester in attracting insects and process and apparatus for determination of insect repellency and attractancy |
| US5436226A (en) * | 1993-11-03 | 1995-07-25 | The United States Of America, As Represented By The Secretary Of Agriculture | Natural suppression of sprouting in stored potatoes using jasmonates |
| ES2176686T3 (es) * | 1996-02-28 | 2002-12-01 | Nippon Zeon Co | Regulador del crecimiento para plantas de cultivo y procedimiento para la regulacion del crecimiento de plantas de cultivo. |
| JP3568325B2 (ja) | 1996-07-12 | 2004-09-22 | 株式会社ノエビア | 抗アンドロゲン剤及び養毛剤並びに毛髪用化粧料 |
| US6469061B1 (en) * | 2001-04-04 | 2002-10-22 | Ramot University Authority For Applied Research And Industrial Development Limited | Jasmonate pharmaceutical composition for treatment of cancer |
| WO2005054172A2 (en) * | 2003-12-02 | 2005-06-16 | Ramot At Tel-Aviv University Ltd. | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
-
2004
- 2004-12-01 WO PCT/IL2004/001098 patent/WO2005054172A2/en not_active Ceased
- 2004-12-01 US US10/581,546 patent/US7425651B2/en not_active Expired - Lifetime
- 2004-12-01 JP JP2006542113A patent/JP2007514663A/ja active Pending
- 2004-12-01 EP EP04801585A patent/EP1689696A2/en not_active Withdrawn
- 2004-12-01 CN CNA2004800358482A patent/CN1902156A/zh active Pending
- 2004-12-01 CA CA002548173A patent/CA2548173A1/en not_active Abandoned
- 2004-12-01 AU AU2004295206A patent/AU2004295206A1/en not_active Abandoned
-
2008
- 2008-08-26 US US12/198,559 patent/US7683211B2/en not_active Expired - Lifetime
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