JP2007514663A - ジャスモネート誘導体化合物、製薬組成物及びその使用方法 - Google Patents
ジャスモネート誘導体化合物、製薬組成物及びその使用方法 Download PDFInfo
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- 239000002562 thickening agent Substances 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- 125000000101 thioether group Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 229950002929 trinitrophenol Drugs 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 125000000297 undecanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 239000003981 vehicle Substances 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52608103P | 2003-12-02 | 2003-12-02 | |
| PCT/IL2004/001098 WO2005054172A2 (en) | 2003-12-02 | 2004-12-01 | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007514663A true JP2007514663A (ja) | 2007-06-07 |
| JP2007514663A5 JP2007514663A5 (https=) | 2007-11-08 |
Family
ID=34652413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006542113A Pending JP2007514663A (ja) | 2003-12-02 | 2004-12-01 | ジャスモネート誘導体化合物、製薬組成物及びその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7425651B2 (https=) |
| EP (1) | EP1689696A2 (https=) |
| JP (1) | JP2007514663A (https=) |
| CN (1) | CN1902156A (https=) |
| AU (1) | AU2004295206A1 (https=) |
| CA (1) | CA2548173A1 (https=) |
| WO (1) | WO2005054172A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005054172A2 (en) * | 2003-12-02 | 2005-06-16 | Ramot At Tel-Aviv University Ltd. | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
| CA2630666A1 (en) | 2005-12-07 | 2007-06-14 | Sepal Pharma Ltd. | Jasmonate derivatives, pharmaceutical compositions and methods of use thereof |
| US20090291904A1 (en) * | 2005-12-07 | 2009-11-26 | Yoel Kashman | Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof |
| US9284274B2 (en) | 2005-12-07 | 2016-03-15 | Ramot At Tel-Aviv University Ltd. | Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof |
| CA2657375A1 (en) * | 2006-07-10 | 2008-01-17 | Ramot At Tel-Aviv University Ltd. | Combination methods of treating cancer |
| WO2008111088A2 (en) | 2007-03-15 | 2008-09-18 | Ramot At Tel-Aviv University Ltd. | Jasmonate based assays for identifying compounds that selectively inhibit mitochondrial bound hexokinases |
| US9284252B2 (en) | 2009-06-09 | 2016-03-15 | Sepal Pharma Ltd. | Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders |
| CN103140223A (zh) * | 2010-05-19 | 2013-06-05 | 布罗迪健康科学有限公司 | 茉莉酮酸酯用于治疗心力衰竭及相关心脏病症的用途 |
| RU2623878C2 (ru) | 2010-12-10 | 2017-06-29 | Броади Хэлс Сайенсис, Эл Эл Си | Применение жасмоната для лечения нарушения функции мочевого пузыря |
| WO2013040556A1 (en) | 2011-09-16 | 2013-03-21 | Nanocare Technologies, Inc. | Compositions of jasmonate compounds and methods of use |
| CA2971870A1 (en) | 2014-12-31 | 2016-07-07 | Nanocare Technologies, Inc. | Jasmonate derivatives and compositions thereof |
| WO2017168416A1 (en) | 2016-03-28 | 2017-10-05 | Vidac Pharma Ltd. | Stable pharmaceutical compositions for topical administration and uses thereof |
| US11266639B2 (en) | 2016-11-07 | 2022-03-08 | Vidac Pharma Ltd. | Use of hexokinase 2/mitochondria-detaching compounds for treating hexokinase-2 (HK2)-expressing cancers |
| WO2018083704A1 (en) | 2016-11-07 | 2018-05-11 | Vidac Pharma Ltd. | Use of hexokinase 2/mitochondria-detaching compounds for activating immune responses |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0441414A (ja) * | 1990-06-04 | 1992-02-12 | Fujisawa Pharmaceut Co Ltd | 育毛料 |
| WO2002080890A2 (en) * | 2001-04-04 | 2002-10-17 | Ramot University Authority For Applied Research And Industrial Development Ltd. | A jasmonate pharmaceutical composition for treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118711A (en) * | 1990-09-27 | 1992-06-02 | International Flavors & Fragrances Inc. | Ketone, ketoesters and alcohol in repelling insects; use of aliphatic ester in attracting insects and process and apparatus for determination of insect repellency and attractancy |
| US5436226A (en) * | 1993-11-03 | 1995-07-25 | The United States Of America, As Represented By The Secretary Of Agriculture | Natural suppression of sprouting in stored potatoes using jasmonates |
| ES2176686T3 (es) * | 1996-02-28 | 2002-12-01 | Nippon Zeon Co | Regulador del crecimiento para plantas de cultivo y procedimiento para la regulacion del crecimiento de plantas de cultivo. |
| JP3568325B2 (ja) | 1996-07-12 | 2004-09-22 | 株式会社ノエビア | 抗アンドロゲン剤及び養毛剤並びに毛髪用化粧料 |
| WO2005054172A2 (en) * | 2003-12-02 | 2005-06-16 | Ramot At Tel-Aviv University Ltd. | Jasmonate derivative compounds, pharmaceuticals compositions and methods of use thereof |
-
2004
- 2004-12-01 WO PCT/IL2004/001098 patent/WO2005054172A2/en not_active Ceased
- 2004-12-01 US US10/581,546 patent/US7425651B2/en not_active Expired - Lifetime
- 2004-12-01 JP JP2006542113A patent/JP2007514663A/ja active Pending
- 2004-12-01 EP EP04801585A patent/EP1689696A2/en not_active Withdrawn
- 2004-12-01 CN CNA2004800358482A patent/CN1902156A/zh active Pending
- 2004-12-01 CA CA002548173A patent/CA2548173A1/en not_active Abandoned
- 2004-12-01 AU AU2004295206A patent/AU2004295206A1/en not_active Abandoned
-
2008
- 2008-08-26 US US12/198,559 patent/US7683211B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0441414A (ja) * | 1990-06-04 | 1992-02-12 | Fujisawa Pharmaceut Co Ltd | 育毛料 |
| WO2002080890A2 (en) * | 2001-04-04 | 2002-10-17 | Ramot University Authority For Applied Research And Industrial Development Ltd. | A jasmonate pharmaceutical composition for treatment of cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005054172A3 (en) | 2005-07-07 |
| EP1689696A2 (en) | 2006-08-16 |
| CA2548173A1 (en) | 2005-06-16 |
| WO2005054172A2 (en) | 2005-06-16 |
| US20070142474A1 (en) | 2007-06-21 |
| AU2004295206A1 (en) | 2005-06-16 |
| CN1902156A (zh) | 2007-01-24 |
| US20080319066A1 (en) | 2008-12-25 |
| US7425651B2 (en) | 2008-09-16 |
| US7683211B2 (en) | 2010-03-23 |
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