JP2007513093A5 - - Google Patents
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- Publication number
- JP2007513093A5 JP2007513093A5 JP2006541750A JP2006541750A JP2007513093A5 JP 2007513093 A5 JP2007513093 A5 JP 2007513093A5 JP 2006541750 A JP2006541750 A JP 2006541750A JP 2006541750 A JP2006541750 A JP 2006541750A JP 2007513093 A5 JP2007513093 A5 JP 2007513093A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hetaryl
- independently
- aryl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 169
- 229910052799 carbon Inorganic materials 0.000 claims 42
- 229910052739 hydrogen Inorganic materials 0.000 claims 41
- 125000001072 heteroaryl group Chemical group 0.000 claims 37
- 125000003118 aryl group Chemical group 0.000 claims 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 28
- 125000004429 atom Chemical group 0.000 claims 21
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 19
- 201000010099 disease Diseases 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 13
- 208000035475 disorder Diseases 0.000 claims 12
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 229910052717 sulfur Inorganic materials 0.000 claims 12
- 125000002877 alkyl aryl group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 10
- -1 hydrate Substances 0.000 claims 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 230000003463 hyperproliferative effect Effects 0.000 claims 8
- 230000029115 microtubule polymerization Effects 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 5
- 102000001253 Protein Kinase Human genes 0.000 claims 4
- 108060006633 protein kinase Proteins 0.000 claims 4
- 208000035473 Communicable disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 208000037803 restenosis Diseases 0.000 claims 3
- 230000002792 vascular Effects 0.000 claims 3
- 206010003645 Atopy Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000025747 Rheumatic disease Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000009610 hypersensitivity Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 0 CCCC(c1ccccc1)Nc1cccc(-c2cc(OC)c(*C)c(OC)c2)c1 Chemical compound CCCC(c1ccccc1)Nc1cccc(-c2cc(OC)c(*C)c(OC)c2)c1 0.000 description 5
- IGKDGMIOXKIFEQ-UHFFFAOYSA-N CCCC(CC(C1)C1c1ncnc(-c(cc2CC)ccc2O)c1)c1cnccc1 Chemical compound CCCC(CC(C1)C1c1ncnc(-c(cc2CC)ccc2O)c1)c1cnccc1 IGKDGMIOXKIFEQ-UHFFFAOYSA-N 0.000 description 1
- FZHRPCVAGYIQMR-GOSISDBHSA-N C[C@H](CCCc1ccnc(-c2ccc(C)c(OC)c2)c1)c1ccccc1 Chemical compound C[C@H](CCCc1ccnc(-c2ccc(C)c(OC)c2)c1)c1ccccc1 FZHRPCVAGYIQMR-GOSISDBHSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003906680A AU2003906680A0 (en) | 2003-12-03 | Tubulin Inhibitors | |
| AU2003906680 | 2003-12-03 | ||
| PCT/AU2004/001689 WO2005054199A1 (en) | 2003-12-03 | 2004-12-03 | Tubulin inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011002891A Division JP5318126B2 (ja) | 2003-12-03 | 2011-01-11 | チューブリン阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007513093A JP2007513093A (ja) | 2007-05-24 |
| JP2007513093A5 true JP2007513093A5 (https=) | 2007-08-09 |
| JP4772690B2 JP4772690B2 (ja) | 2011-09-14 |
Family
ID=34637692
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541750A Expired - Fee Related JP4772690B2 (ja) | 2003-12-03 | 2004-12-03 | チューブリン阻害剤 |
| JP2011002891A Expired - Fee Related JP5318126B2 (ja) | 2003-12-03 | 2011-01-11 | チューブリン阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011002891A Expired - Fee Related JP5318126B2 (ja) | 2003-12-03 | 2011-01-11 | チューブリン阻害剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US7981900B2 (https=) |
| EP (2) | EP1689715B1 (https=) |
| JP (2) | JP4772690B2 (https=) |
| KR (2) | KR101206843B1 (https=) |
| CN (2) | CN1890218B (https=) |
| AT (1) | ATE497949T1 (https=) |
| AU (1) | AU2004294354B2 (https=) |
| BR (1) | BRPI0417354A (https=) |
| CA (2) | CA2545422C (https=) |
| CY (1) | CY1111410T1 (https=) |
| DE (1) | DE602004031357D1 (https=) |
| DK (1) | DK1689715T3 (https=) |
| ES (2) | ES2528302T3 (https=) |
| IL (1) | IL175576A (https=) |
| NZ (1) | NZ546057A (https=) |
| PL (1) | PL1689715T3 (https=) |
| PT (2) | PT1689715E (https=) |
| SI (1) | SI1689715T1 (https=) |
| WO (1) | WO2005054199A1 (https=) |
| ZA (1) | ZA200602664B (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002953255A0 (en) * | 2002-12-11 | 2003-01-02 | Cytopia Research Pty Ltd | Protein kinase inhibitors |
| CA2546002C (en) | 2003-11-20 | 2012-09-18 | Janssen Pharmaceutica N.V. | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
| BRPI0416206A (pt) | 2003-11-20 | 2006-12-26 | Janssen Pharmaceutica Nv | 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose) |
| CA2545422C (en) | 2003-12-03 | 2015-06-02 | Cytopia Research Pty Ltd | Tubulin inhibitors |
| ATE540936T1 (de) | 2004-06-30 | 2012-01-15 | Janssen Pharmaceutica Nv | Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer |
| SG154433A1 (en) | 2004-06-30 | 2009-08-28 | Janssen Pharmaceutica Nv | Phthalazine derivatives as parp inhibitors |
| EA011552B1 (ru) | 2004-06-30 | 2009-04-28 | Янссен Фармацевтика Н.В. | Производные хиназолиндиона в качестве ингибиторов parp |
| WO2006010637A2 (en) * | 2004-07-30 | 2006-02-02 | Gpc Biotech Ag | Pyridinylamines |
| WO2006133498A1 (en) * | 2005-06-15 | 2006-12-21 | Cytopia Research Pty Ltd | Acid addition salts of n-ethyi-n'-[2-methoxy-4-(5-methyi-4-{[(1s)-1-pyridin-3-ylbutyi]amino}pyrimidin- 2-yl)phenyl]urea and uses thereof |
| CA2660560A1 (en) * | 2006-08-16 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Pyrazine compounds, their use and methods of preparation |
| DE102006049618A1 (de) * | 2006-10-20 | 2008-05-08 | Tschesche, Harald, Prof. Dr. | Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren |
| US8461161B2 (en) * | 2006-11-15 | 2013-06-11 | Ym Biosciences Australia Pty Ltd | Substituted pyrazines as inhibitors of kinase activity |
| AU2013273769B2 (en) * | 2006-11-15 | 2016-05-12 | Ym Biosciences Australia Pty Ltd | Inhibitors of Kinase Activity |
| US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
| WO2009096198A1 (ja) * | 2008-02-01 | 2009-08-06 | Pharma Ip Limited Liability Intermediary Corporations | 新規ビアリール誘導体 |
| ES2367760T3 (es) | 2008-03-27 | 2011-11-08 | Janssen Pharmaceutica, N.V. | Derivados de quinazolinona como inhibidores de la polimerización de la tubulina. |
| CN101981013B (zh) | 2008-03-27 | 2013-05-29 | 詹森药业有限公司 | 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮 |
| US20090275529A1 (en) * | 2008-05-05 | 2009-11-05 | Reiss Allison B | Method for improving cardiovascular risk profile of cox inhibitors |
| MX353308B (es) | 2008-05-21 | 2018-01-08 | Ariad Pharma Inc | Derivados fosforosos como inhibidores de cinasa. |
| JP5555236B2 (ja) | 2008-08-25 | 2014-07-23 | アイアールエム・リミテッド・ライアビリティ・カンパニー | ヘッジホッグ経路モジュレーター |
| WO2010046780A2 (en) * | 2008-10-22 | 2010-04-29 | Institut Pasteur Korea | Anti viral compounds |
| US8546405B2 (en) | 2008-12-23 | 2013-10-01 | Abbott Laboratories | Anti-viral compounds |
| SG172352A1 (en) | 2008-12-23 | 2011-07-28 | Abbott Lab | Anti-viral compounds |
| US9278922B2 (en) | 2009-04-15 | 2016-03-08 | Abbvie Inc. | Anti-viral compounds |
| CN102648208B (zh) * | 2009-11-12 | 2016-04-27 | R&D生技药品有限责任公司 | 微管蛋白抑制剂 |
| EP2322537A1 (en) * | 2009-11-12 | 2011-05-18 | R & D Biopharmaceuticals Gmbh | Tubulin inhibitors |
| BR112013032108B1 (pt) * | 2011-06-13 | 2021-10-26 | The Board Of Trustees Of The University Of Illinois | Peptídeos conjugados, usos dos mesmos e de um peptídeo isolado, bem como formulação farmacêutica |
| LT2814820T (lt) * | 2012-02-17 | 2016-10-25 | University Of Cape Town | Antimaliariniai agentai |
| CN102826985B (zh) * | 2012-09-18 | 2015-08-19 | 厦门大学 | 一种1-(3,4,5-三羟基)苯基-1-烷基酮的制备方法 |
| ES2675720T3 (es) | 2013-01-10 | 2018-07-12 | Pulmokine, Inc. | Inhibidores de quinasa no selectivos |
| EP2988738A4 (en) * | 2013-01-10 | 2016-11-09 | Pulmokine Inc | THERAPEUTIC INDICATIONS OF KINASE INHIBITORS |
| US9925184B2 (en) | 2013-10-11 | 2018-03-27 | Pulmokine, Inc. | Spray-dry formulations |
| WO2016167795A1 (en) * | 2015-04-17 | 2016-10-20 | Southern Research Institute | Treatment of hepatitis b viral |
| CN106167482A (zh) * | 2015-05-19 | 2016-11-30 | 重庆大学 | 一种抑制前列腺癌生长的化合物及其应用 |
| WO2017181974A1 (zh) * | 2016-04-20 | 2017-10-26 | 苏州苏领生物医药有限公司 | 五元杂环类化合物及其制备方法、药物组合物和用途 |
| CN107304203A (zh) * | 2016-04-20 | 2017-10-31 | 苏州苏领生物医药有限公司 | 五元杂环类化合物及其制备方法、药物组合物和用途 |
| CN106565685B (zh) * | 2016-10-11 | 2019-03-01 | 深圳海王医药科技研究院有限公司 | 微管蛋白抑制剂 |
| CA3041679A1 (en) | 2016-10-27 | 2018-05-03 | Lawrence S. ZISMAN | Combination therapy for treating pulmonary hypertension |
| EP3720436A4 (en) * | 2017-12-06 | 2021-06-02 | Lin Bioscience, Pty Ltd. | TUBULIN INHIBITORS |
| AU2019215799B2 (en) * | 2018-02-01 | 2022-04-14 | The University Of Sydney | Anti-cancer compounds |
| CN108658963A (zh) * | 2018-06-20 | 2018-10-16 | 桑文军 | 一种作用于微管蛋白的抗肿瘤药物 |
| WO2021219513A1 (en) | 2020-04-28 | 2021-11-04 | Basf Se | Pesticidal compounds |
| KR20250107752A (ko) * | 2024-01-05 | 2025-07-14 | 주식회사 큐피크바이오 | 튜불린 저해제를 포함하는 피부 질환 예방 또는 치료용 조성물 |
| WO2026064520A1 (en) | 2024-09-19 | 2026-03-26 | Tesseract Medicines Us, Llc | Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload |
| WO2026064527A1 (en) | 2024-09-19 | 2026-03-26 | Tesseract Medicines Us, Llc | Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE82928C (https=) | 1893-06-18 | 1895-10-01 | ||
| FR352807A (fr) | 1905-03-28 | 1905-08-22 | Julius Schroeder | Perfectionnements apportés aux boites à fumée des chaudières à tubes bouilleurs et aux brosses de nettoyage |
| GB253816A (en) | 1925-12-29 | 1926-06-24 | Spencer Bonecourt Ltd | Improvements relating to the cleaning of the fire-tubes of a boiler |
| US3354490A (en) | 1964-06-15 | 1967-11-28 | Power Tube Inc | Boiler tube cleaning apparatus |
| CH593266A5 (https=) * | 1973-09-20 | 1977-11-30 | Delalande Sa | |
| US4367790A (en) | 1980-12-16 | 1983-01-11 | Draeger Walter A | Multiple tube cleaning apparatus |
| JPS61228296A (ja) | 1985-03-30 | 1986-10-11 | Takao Sakamoto | 熱交換器における伝熱管の内面洗浄方法 |
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| US6147080A (en) | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| AT405973B (de) | 1998-06-26 | 2000-01-25 | Hackl Hubert | Reinigungsvorrichtung für wärmetauscherzüge |
| DE19853278A1 (de) | 1998-11-19 | 2000-05-25 | Aventis Pharma Gmbh | Substituierte 4-Amino-2-aryl-cyclopenta[d]pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| JP2000180093A (ja) | 1998-12-15 | 2000-06-30 | Toshiba Plant Kensetsu Co Ltd | 熱交換器の管内清掃・探傷検査装置、及び管内清掃・探傷検査方法 |
| AU779908B2 (en) | 1999-09-10 | 2005-02-17 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| EP1317266A2 (en) * | 2000-08-08 | 2003-06-11 | Ortho-McNeil Pharmaceutical, Inc. | Neuroprotective 2-pyridinamine compositions and related methods |
| AU9502601A (en) * | 2000-09-06 | 2002-03-22 | Chiron Corp | Inhibitors of glycogen synthase kinase 3 |
| WO2002022605A1 (en) * | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US7129242B2 (en) * | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| EP1351691A4 (en) * | 2000-12-12 | 2005-06-22 | Cytovia Inc | SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGUES AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCERS, AND USE THEREOF |
| US20040102455A1 (en) * | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
| CA2441733A1 (en) * | 2001-03-29 | 2002-10-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| WO2003026661A1 (fr) * | 2001-09-14 | 2003-04-03 | Yamanouchi Pharmaceutical Co., Ltd. | Accelerateur de secretion de l'insuline et nouveau derive de pyrimidine |
| EP1578722A4 (en) * | 2001-10-12 | 2006-09-06 | Irm Llc | KINASEINHIBITOR SCAFFOLD AND METHOD FOR THE PRODUCTION THEREOF |
| CA2486183C (en) | 2002-05-23 | 2012-01-10 | Cytopia Pty Ltd. | Protein kinase inhibitors |
| AUPS251502A0 (en) * | 2002-05-23 | 2002-06-13 | Cytopia Pty Ltd | Protein kinase inhibitors |
| AU2003232919B2 (en) * | 2002-05-23 | 2009-03-05 | Ym Biosciences Australia Pty Ltd | Protein kinase inhibitors |
| AU2003249369A1 (en) * | 2002-06-21 | 2004-01-06 | Cellular Genomics, Inc. | Certain amino-substituted monocycles as kinase modulators |
| AU2003286876A1 (en) * | 2002-11-01 | 2004-06-07 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of jak and other protein kinases |
| EP1560824A1 (en) * | 2002-11-05 | 2005-08-10 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of jak and other protein kinases |
| WO2004043926A1 (en) * | 2002-11-11 | 2004-05-27 | Bayer Healthcare Ag | Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist |
| AU2002953255A0 (en) * | 2002-12-11 | 2003-01-02 | Cytopia Research Pty Ltd | Protein kinase inhibitors |
| GB2400101A (en) | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
| US20050014753A1 (en) * | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
| WO2005003101A2 (en) * | 2003-07-02 | 2005-01-13 | Biofocus Discovery Limited | Pyrazine and pyridine derivatives as rho kinase inhibitors |
| EP1648875A1 (en) * | 2003-07-30 | 2006-04-26 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
| CA2545422C (en) * | 2003-12-03 | 2015-06-02 | Cytopia Research Pty Ltd | Tubulin inhibitors |
| WO2006133498A1 (en) | 2005-06-15 | 2006-12-21 | Cytopia Research Pty Ltd | Acid addition salts of n-ethyi-n'-[2-methoxy-4-(5-methyi-4-{[(1s)-1-pyridin-3-ylbutyi]amino}pyrimidin- 2-yl)phenyl]urea and uses thereof |
| PT2114900T (pt) | 2007-01-31 | 2019-01-17 | Ym Biosciences Australia Pty | Compostos à base de tiopirimidina e as suas utilizações |
-
2004
- 2004-12-03 CA CA2545422A patent/CA2545422C/en not_active Expired - Fee Related
- 2004-12-03 AU AU2004294354A patent/AU2004294354B2/en not_active Ceased
- 2004-12-03 ZA ZA200602664A patent/ZA200602664B/en unknown
- 2004-12-03 PT PT04801111T patent/PT1689715E/pt unknown
- 2004-12-03 NZ NZ546057A patent/NZ546057A/en not_active IP Right Cessation
- 2004-12-03 KR KR20067010930A patent/KR101206843B1/ko not_active Expired - Fee Related
- 2004-12-03 JP JP2006541750A patent/JP4772690B2/ja not_active Expired - Fee Related
- 2004-12-03 EP EP04801111A patent/EP1689715B1/en not_active Expired - Lifetime
- 2004-12-03 DE DE200460031357 patent/DE602004031357D1/de not_active Expired - Lifetime
- 2004-12-03 AT AT04801111T patent/ATE497949T1/de active
- 2004-12-03 DK DK04801111T patent/DK1689715T3/da active
- 2004-12-03 EP EP20100010746 patent/EP2277865B1/en not_active Expired - Lifetime
- 2004-12-03 US US10/581,534 patent/US7981900B2/en active Active
- 2004-12-03 CA CA2857067A patent/CA2857067C/en not_active Expired - Fee Related
- 2004-12-03 CN CN2004800361061A patent/CN1890218B/zh not_active Expired - Fee Related
- 2004-12-03 ES ES10010746.5T patent/ES2528302T3/es not_active Expired - Lifetime
- 2004-12-03 PT PT100107465T patent/PT2277865E/pt unknown
- 2004-12-03 CN CN2010106215795A patent/CN102127056B/zh not_active Expired - Fee Related
- 2004-12-03 ES ES04801111T patent/ES2360703T3/es not_active Expired - Lifetime
- 2004-12-03 KR KR1020117031131A patent/KR101260717B1/ko not_active Expired - Fee Related
- 2004-12-03 SI SI200431653T patent/SI1689715T1/sl unknown
- 2004-12-03 PL PL04801111T patent/PL1689715T3/pl unknown
- 2004-12-03 BR BRPI0417354-6A patent/BRPI0417354A/pt not_active Application Discontinuation
- 2004-12-03 WO PCT/AU2004/001689 patent/WO2005054199A1/en not_active Ceased
-
2006
- 2006-05-11 IL IL175576A patent/IL175576A/en not_active IP Right Cessation
-
2011
- 2011-01-11 JP JP2011002891A patent/JP5318126B2/ja not_active Expired - Fee Related
- 2011-05-05 CY CY20111100435T patent/CY1111410T1/el unknown
- 2011-07-14 US US13/183,348 patent/US8394806B2/en not_active Expired - Lifetime
-
2013
- 2013-03-12 US US13/797,568 patent/US20130274263A1/en not_active Abandoned
-
2014
- 2014-02-28 US US14/194,543 patent/US9139560B2/en not_active Expired - Lifetime
-
2015
- 2015-07-28 US US14/811,503 patent/US9732046B2/en not_active Expired - Lifetime
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