JP2007512371A - ビタミン化合物を用いる体脂肪の減少方法 - Google Patents

ビタミン化合物を用いる体脂肪の減少方法 Download PDF

Info

Publication number
JP2007512371A
JP2007512371A JP2006541701A JP2006541701A JP2007512371A JP 2007512371 A JP2007512371 A JP 2007512371A JP 2006541701 A JP2006541701 A JP 2006541701A JP 2006541701 A JP2006541701 A JP 2006541701A JP 2007512371 A JP2007512371 A JP 2007512371A
Authority
JP
Japan
Prior art keywords
vitamin
day
body fat
animal
specific embodiments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2006541701A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007512371A5 (https=
Inventor
エフ． デルカ，ヘクター
エー． プラム，ロリ
ツェ ケ，ハウ
エー． ブラウン，トーマス
Original Assignee
デルタノイド ファーマシューティカルズ，インコーポレイティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デルタノイド ファーマシューティカルズ，インコーポレイティド filed Critical デルタノイド ファーマシューティカルズ，インコーポレイティド
Publication of JP2007512371A publication Critical patent/JP2007512371A/ja
Publication of JP2007512371A5 publication Critical patent/JP2007512371A5/ja
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006541701A 2003-11-25 2004-11-24 ビタミン化合物を用いる体脂肪の減少方法 Ceased JP2007512371A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52481303P 2003-11-25 2003-11-25
US52479803P 2003-11-25 2003-11-25
PCT/US2004/039524 WO2005051396A2 (en) 2003-11-25 2004-11-24 Methods for reducing body fat using vitamin d compounds

Publications (2)

Publication Number Publication Date
JP2007512371A true JP2007512371A (ja) 2007-05-17
JP2007512371A5 JP2007512371A5 (https=) 2008-01-24

Family

ID=41057500

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006541701A Ceased JP2007512371A (ja) 2003-11-25 2004-11-24 ビタミン化合物を用いる体脂肪の減少方法

Country Status (4)

Country Link
US (1) US7053075B2 (https=)
EP (1) EP1694333A2 (https=)
JP (1) JP2007512371A (https=)
WO (1) WO2005051396A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532540A (ja) * 2004-04-09 2007-11-15 ウィスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキリデン１８，１９−ジノル−ビタミンｄ化合物
JP2012016293A (ja) * 2010-07-06 2012-01-26 Nippon Formula Feed Mfg Co Ltd 家禽用飼料

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122533B2 (en) * 1999-11-29 2006-10-17 The United States Of America As Represented By The Department Of Health And Human Services Cosalane compounds and methods for their use
ZA200506204B (en) * 2003-04-10 2006-10-25 Wisconsin Alumni Res Found 2-propylidene-19-nor-vitamin D compounds
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
MX2007006261A (es) * 2004-11-22 2007-07-10 Wisconsin Alumni Res Found Analogos de 17,20(z)-deshidro vitamina d y sus usos.
DE602005021245D1 (de) * 2004-11-22 2010-06-24 Wisconsin Alumni Res Found 2-methylen-19,26,27-trinor-(20s)-1-alpha-hydroxyvitamin d3 and dessen verwendungen
WO2006086613A2 (en) * 2005-02-11 2006-08-17 Wisconsin Alumni Research Foundation 2-METHYLENE-19-NOR- (20S-24S) - 1α, 25-D IHYDROXYVITAMIN-D2
DK1848442T3 (da) * 2005-02-11 2012-05-29 Wisconsin Alumni Res Found 2-methylene-19-nor-(20s-24epi)-1alfa,25-dihydroxyvitamine-d2
US8945652B2 (en) 2005-11-23 2015-02-03 The Coca-Cola Company High-potency sweetener for weight management and compositions sweetened therewith
US7803789B2 (en) 2006-02-02 2010-09-28 Wisconsin Alumni Research Foundation Vitamin D analog—RAK, methods and uses thereof
US7528122B2 (en) * 2006-02-02 2009-05-05 Wisconsin Alumni Research Foundation Vitamin D analog—NEL, methods and uses thereof
SI3095447T1 (sl) 2006-02-03 2022-02-28 Opko Renal, Llc Zdravljenje pomanjkanja vitamina D s 25-hidroksivitaminom D2 in 25-hidroksivitaminom D3
US20070232014A1 (en) * 2006-04-03 2007-10-04 Honeywell International Inc. Method of fabricating a planar MIM capacitor
NZ570712A (en) * 2006-04-06 2011-11-25 Wisconsin Alumni Res Found 2-methylene-1alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof
EP2001860A2 (en) * 2006-04-06 2008-12-17 Wisconsin Alumni Research Foundation 19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring
WO2008035207A2 (en) * 2006-04-06 2008-03-27 Wisconsin Alumni Research Foundation 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof
NZ570711A (en) 2006-04-06 2012-10-26 Wisconsin Alumni Res Found 2-Substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
MX2008012912A (es) * 2006-04-06 2008-11-26 Wisconsin Alumni Res Found Analogos de 2-metilen-1a,25-dihidroxi-19,21-dinorvitamina d3 y sus usos.
EP2021321B1 (en) * 2006-04-06 2012-06-20 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof
EP2004597B1 (en) * 2006-04-10 2011-01-26 Wisconsin Alumni Research Foundation 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds with a 1,1-dimethylpropyl side chain
HUE037309T2 (hu) 2006-06-21 2018-08-28 Opko Ireland Global Holdings Ltd Terápia D-vitamin telítési szer alkalmazásával és D-vitamin hormon helyettesítõ szer
US20080153775A1 (en) * 2006-12-21 2008-06-26 Dillard Floyd S Weight reduction program and method
PT3335712T (pt) * 2007-04-25 2025-10-23 Opko Renal Llc Método de tratamento e prevenção seguro e eficaz do hiperparatiroidismo secundário na doença renal crónica
PL2148661T3 (pl) 2007-04-25 2013-07-31 Cytochroma Inc Doustne kompozycje o kontrolowanym uwalnianiu zawierające związek będący witaminą D i woskowy nośnik
DK2148684T3 (da) 2007-04-25 2013-04-22 Cytochroma Inc Fremgangsmåde til behandling af vitamin D-insufficiens og -deficiens
CN101951917A (zh) * 2008-02-13 2011-01-19 帝斯曼知识产权资产管理有限公司 用25-羟基维生素d3治疗高血压
CN102046812A (zh) 2008-04-02 2011-05-04 赛特克罗公司 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒
US7648974B1 (en) * 2008-07-10 2010-01-19 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 3,2-dihydrofuran ring
US8604009B2 (en) * 2010-03-23 2013-12-10 Wisconsin Alumni Research Foundation (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3
US8664206B2 (en) 2010-03-23 2014-03-04 Wisconsin Alumni Research Foundation Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
CA2793727C (en) * 2010-03-23 2017-01-03 Wisconsin Alumni Research Foundation Diastereomers of 2-methylene-19-nor-22-methyl-1.alpha.,25-dihydroxyvitamin d3
PT2552484T (pt) 2010-03-29 2020-04-03 Opko Ireland Global Holdings Ltd Métodos e composições para redução dos níveis de parafróides
US8420839B1 (en) * 2011-10-05 2013-04-16 Wisconsin Alumni Research Foundation Crystallization of 1α-hydroxy-2-methylene-18,19-dinor-homopregnacalciferol
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
MY198547A (en) 2016-03-28 2023-09-04 Opko Ireland Global Holdings Ltd Methods of vitamin d treatment

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03210156A (ja) * 1990-01-12 1991-09-13 Itochu Shiryo Kk 体脂肪の蓄積量を減少させるブロイラー用飼料
JP2000513010A (ja) * 1997-03-17 2000-10-03 ウイスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキル−１９−ノル−ビタミンｄ化合物
JP2001504135A (ja) * 1997-03-17 2001-03-27 ウイスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキリデン−１９−ノル−ビタミンｄ化合物
JP2003529581A (ja) * 2000-03-31 2003-10-07 ウィスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキリデン−１９−ノル−ビタミンｄ化合物及びその治療的使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5086191A (en) 1991-05-28 1992-02-04 Wisconsin Alumni Research Foundation Intermediates for the synthesis of 19-nor vitamin D compounds
EP0619306B1 (en) 1993-04-05 1996-09-11 Wisconsin Alumni Research Foundation 19-Nor-vitamin D3 compounds with substituent at 2-position
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US6132765A (en) * 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
US6310105B1 (en) * 2000-02-15 2001-10-30 Wisconsin Alumni Research Foundation Carboxyl-modified superabsorbent protein hydrogel
NZ524657A (en) * 2000-09-08 2004-12-24 Wisconsin Alumni Res Found 1 alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications
US6566352B1 (en) * 2002-02-18 2003-05-20 Wisconsin Alumni Research Foudation 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
WO2005027929A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an estrogen
WO2005027931A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an ep2 or ep4 selective agonist
WO2005027913A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue
KR20060058133A (ko) * 2003-09-19 2006-05-29 화이자 프로덕츠 인코포레이티드 2-알킬리덴-19-노르-비타민 ｄ 유도체 및 부갑상선호르몬의 조합을 포함하는 약학 조성물 및 방법
BRPI0414448A (pt) * 2003-09-19 2006-11-14 Pfizer Prod Inc composições farmacêuticas e métodos compreendendo combinações de derivados de 2-alquilideno-19-nor-vitamina d e um agonista/antagonista de estrogênio

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03210156A (ja) * 1990-01-12 1991-09-13 Itochu Shiryo Kk 体脂肪の蓄積量を減少させるブロイラー用飼料
JP2000513010A (ja) * 1997-03-17 2000-10-03 ウイスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキル−１９−ノル−ビタミンｄ化合物
JP2001504135A (ja) * 1997-03-17 2001-03-27 ウイスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキリデン−１９−ノル−ビタミンｄ化合物
JP2003529581A (ja) * 2000-03-31 2003-10-07 ウィスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキリデン−１９−ノル−ビタミンｄ化合物及びその治療的使用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532540A (ja) * 2004-04-09 2007-11-15 ウィスコンシン・アルムニ・リサーチ・ファウンデーション ２−アルキリデン１８，１９−ジノル−ビタミンｄ化合物
JP2012016293A (ja) * 2010-07-06 2012-01-26 Nippon Formula Feed Mfg Co Ltd 家禽用飼料

Also Published As

Publication number Publication date
US20050143358A1 (en) 2005-06-30
WO2005051396A3 (en) 2005-11-17
US7053075B2 (en) 2006-05-30
EP1694333A2 (en) 2006-08-30
WO2005051396A2 (en) 2005-06-09

Similar Documents

Publication Publication Date Title
US7053075B2 (en) Methods for reducing body fat using vitamin D compounds
JP4493340B2 (ja) １α−ヒドロキシ−２−メチレン−１９−ノル−プレグナカルシフェロール及びその使用
KR100345820B1 (ko) 2-알킬-19-노르-비타민 ｄ 화합물
JP4022071B2 (ja) ２−アルキリデン−１９−ノル−ビタミンｄ化合物及びその治療的使用
JP4022144B2 (ja) １アルファ−ヒドロキシ−２−メチレン−１９−ノル−ホモプレグナカルシフェロール及びその療法的適用
US7064115B2 (en) (20S)-1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses
JP4035144B2 (ja) ２−アルキリデン−１９−ノル−ビタミンｄ化合物
CN1250225C (zh) 2α－甲基－19－去甲－20(S)－1α,25－二羟维生素D3生产用于增加骨强度的药物的用途
JP5113766B2 (ja) ビタミンｄ類似体：ｒａｋ、その方法および使用
JP2009525980A (ja) ビタミンｄ類似体：ｎｅｌ、その方法および使用
KR20050057180A (ko) 비타민 ｄ 화합물의 투여량 범위를 확장시키는 방법
JP2004505022A (ja) 骨強度を増加するための２−メチレン−１９−ノル−２０（Ｓ）−１α，２５−ジヒドロキシビタミンＤ３の使用
WO2005027915A1 (en) Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone
JP4282234B2 (ja) カルセミック活性を持つ１９−ノル−ビタミンｄ３化合物
AU2004280176B2 (en) Use of 2-methylene-19-nor-20(S)-1a,25-dihydroxyvitamin D3 to increase the life expectancy of human beings
US20050063992A1 (en) Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and an estrogen
RU2326674C2 (ru) Производные 2-алкилиден-19-нор-витамина d для лечения слабости, поражения мышц или саркопении
JP4619360B2 (ja) ２−メチレン−１９−ノル−２０（Ｓ）−２５−メチル−１α−ヒドロキシカルシフェロール及びその使用
US20050065126A1 (en) Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin D derivatives and aromatase inhibitors
AU2002360534B2 (en) 1-alpha-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses
WO2005027918A1 (en) Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a cyclooxgenase-2 inhibitor
HK1066487B (en) USE OF 2α-METHYL-19-NOR-20(S)-1α, 25-DIHYDROXYVITAMIN D3 FOR THE MANUFACTURE OF MEDICAMENTS FOR INCREASING BONE STRENGTH
HK1060304B (en) USE OF 2-METHYLENE-19-NOR-20(S)-1α, 25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071126

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071126

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20080131

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110315

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110614

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110614

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110621

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110621

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110913

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120207

A045 Written measure of dismissal of application [lapsed due to lack of payment]

Free format text: JAPANESE INTERMEDIATE CODE: A045

Effective date: 20120626