JP2007512302A - カスパーゼ−３阻害剤を含む新規な造影剤 - Google Patents

カスパーゼ−３阻害剤を含む新規な造影剤 Download PDF

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Publication number
JP2007512302A
JP2007512302A JP2006540617A JP2006540617A JP2007512302A JP 2007512302 A JP2007512302 A JP 2007512302A JP 2006540617 A JP2006540617 A JP 2006540617A JP 2006540617 A JP2006540617 A JP 2006540617A JP 2007512302 A JP2007512302 A JP 2007512302A
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JP
Japan
Prior art keywords
caspase
group
contrast agent
radioactive
inhibitor
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Pending
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JP2006540617A
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Japanese (ja)
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JP2007512302A5 (https=
Inventor
ヒスコック，ダンカン
ニュートン，ベン
ギルベルト，ベネディクテ
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of JP2007512302A publication Critical patent/JP2007512302A/ja
Publication of JP2007512302A5 publication Critical patent/JP2007512302A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/0429—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K51/0431—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • AIDS & HIV (AREA)
JP2006540617A 2003-11-26 2004-11-26 カスパーゼ−３阻害剤を含む新規な造影剤 Pending JP2007512302A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0327494.1A GB0327494D0 (en) 2003-11-26 2003-11-26 Novel imaging agents
PCT/GB2004/005003 WO2005053752A2 (en) 2003-11-26 2004-11-26 Novel imaging agents comprising caspase-3 inhibitors

Publications (2)

Publication Number Publication Date
JP2007512302A true JP2007512302A (ja) 2007-05-17
JP2007512302A5 JP2007512302A5 (https=) 2008-01-31

Family

ID=29797853

Family Applications (1)

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JP2006540617A Pending JP2007512302A (ja) 2003-11-26 2004-11-26 カスパーゼ−３阻害剤を含む新規な造影剤

Country Status (15)

Country Link
US (1) US20060275215A1 (https=)
EP (1) EP1763371A2 (https=)
JP (1) JP2007512302A (https=)
KR (1) KR101236124B1 (https=)
CN (1) CN1905904B (https=)
AU (1) AU2004294784B2 (https=)
BR (1) BRPI0416938A (https=)
CA (1) CA2547236A1 (https=)
GB (1) GB0327494D0 (https=)
IL (1) IL175667A (https=)
MX (1) MXPA06006045A (https=)
NO (1) NO20062387L (https=)
RU (1) RU2006117819A (https=)
WO (1) WO2005053752A2 (https=)
ZA (1) ZA200603887B (https=)

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JP2008505884A (ja) 2004-07-08 2008-02-28 エヌエスティー・ニューロサバイバル・テクノロジーズ・リミテッド 疾患を検出する方法および化合物
WO2006074799A2 (en) * 2005-01-17 2006-07-20 Universitätsklinikum Münster 5-pyrrolidinylsulfonyl isatin derivatives
GB0502277D0 (en) * 2005-02-04 2005-03-09 Amersham Plc Novel imaging agents
WO2007050319A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis
GB0610395D0 (en) * 2006-05-25 2006-07-05 Ge Healthcare Ltd Novel imaging agents
GB0612333D0 (en) * 2006-06-21 2006-08-02 Ge Healthcare Ltd Radiopharmaceutical products
PL2029178T3 (pl) * 2006-06-21 2012-08-31 Ge Healthcare Ltd Produkty radiofarmaceutyczne
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
KR100845010B1 (ko) * 2007-08-29 2008-07-08 한국생명공학연구원 Ｎｉｒ／ｍｒ 이중모드 분자영상용 고분자 입자 및 그제조방법
CA2722858C (en) * 2008-04-30 2017-08-29 Siemens Medical Solutions Usa, Inc. Substrate based pet imaging agents
WO2010028156A2 (en) * 2008-09-04 2010-03-11 Board Of Regents, The University Of Texas System Dual modality detection of apoptosis
EP2367816B1 (en) 2008-09-05 2016-11-09 Imperial Innovations Limited Isatin derivatives for use as in vivo imaging agents
GB0818738D0 (en) * 2008-10-13 2008-11-19 Ge Healthcare Ltd Imaging neuroflammation
WO2014186737A1 (en) * 2013-05-16 2014-11-20 The Johns Hopkins University Compositions and methods for chemical exchange saturation transfer (cest) based magnetic resonance imaging (mri)
WO2017053864A1 (en) * 2015-09-23 2017-03-30 Intracellular Technologies, Llc Cysteine protease inhibitors
CN107655871A (zh) * 2017-09-12 2018-02-02 重庆医科大学 一种阿仑膦酸钠的高灵敏宽检测范围荧光检测新方法
KR20240132016A (ko) * 2021-12-08 2024-09-02 사이토사이트 바이오파마 인코포레이티드 그랜자임 b에 특이적인 화합물 및 그의 용도
TW202508601A (zh) * 2023-06-07 2025-03-01 美商塞托賽特生物製藥股份有限公司 對顆粒酶ｂ具有特異性之化合物之前驅藥及其用途

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JP2003531871A (ja) * 2000-04-25 2003-10-28 ワシントン・ユニバーシティ 医用画像解析、診断、および薬物療法のための膜透過性ペプチド複合体
JP2003534297A (ja) * 2000-05-23 2003-11-18 アメルシャム ヘルス アクスイェ セルスカプ 造影剤
JP2006519777A (ja) * 2003-02-07 2006-08-31 メルク フロスト カナダ リミテツド 活性部位プローブとしての不可逆的カスパーゼ３インヒビター

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AR016384A1 (es) * 1997-07-30 2001-07-04 Smithkline Beecham Corp Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta.
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JP2003534297A (ja) * 2000-05-23 2003-11-18 アメルシャム ヘルス アクスイェ セルスカプ 造影剤
JP2006519777A (ja) * 2003-02-07 2006-08-31 メルク フロスト カナダ リミテツド 活性部位プローブとしての不可逆的カスパーゼ３インヒビター

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ZA200603887B (en) 2008-02-27
EP1763371A2 (en) 2007-03-21
WO2005053752A2 (en) 2005-06-16
MXPA06006045A (es) 2006-08-23
CA2547236A1 (en) 2005-06-16
CN1905904B (zh) 2011-12-21
AU2004294784A1 (en) 2005-06-16
BRPI0416938A (pt) 2007-02-13
AU2004294784B2 (en) 2008-04-24
IL175667A0 (en) 2006-09-05
NO20062387L (no) 2006-05-31
US20060275215A1 (en) 2006-12-07
CN1905904A (zh) 2007-01-31
GB0327494D0 (en) 2003-12-31
KR20060123196A (ko) 2006-12-01
RU2006117819A (ru) 2008-01-10
KR101236124B1 (ko) 2013-02-21
IL175667A (en) 2013-09-30
WO2005053752A3 (en) 2005-10-06

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