CN1905904B - 包含半胱氨酸天冬氨酸蛋白酶3抑制剂的新型显像剂 - Google Patents

包含半胱氨酸天冬氨酸蛋白酶3抑制剂的新型显像剂 Download PDF

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Publication number
CN1905904B
CN1905904B CN2004800406077A CN200480040607A CN1905904B CN 1905904 B CN1905904 B CN 1905904B CN 2004800406077 A CN2004800406077 A CN 2004800406077A CN 200480040607 A CN200480040607 A CN 200480040607A CN 1905904 B CN1905904 B CN 1905904B
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caspase
radioactive
imaging
inhibitor
alkyl
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Expired - Fee Related
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Chinese (zh)
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CN1905904A (zh
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D·希斯科克
B·牛顿
B·吉伯特
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GE Healthcare Ltd
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GE Healthcare Ltd
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    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
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CN2004800406077A 2003-11-26 2004-11-26 包含半胱氨酸天冬氨酸蛋白酶3抑制剂的新型显像剂 Expired - Fee Related CN1905904B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0327494.1 2003-11-26
GBGB0327494.1A GB0327494D0 (en) 2003-11-26 2003-11-26 Novel imaging agents
PCT/GB2004/005003 WO2005053752A2 (en) 2003-11-26 2004-11-26 Novel imaging agents comprising caspase-3 inhibitors

Publications (2)

Publication Number Publication Date
CN1905904A CN1905904A (zh) 2007-01-31
CN1905904B true CN1905904B (zh) 2011-12-21

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CN2004800406077A Expired - Fee Related CN1905904B (zh) 2003-11-26 2004-11-26 包含半胱氨酸天冬氨酸蛋白酶3抑制剂的新型显像剂

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US (1) US20060275215A1 (https=)
EP (1) EP1763371A2 (https=)
JP (1) JP2007512302A (https=)
KR (1) KR101236124B1 (https=)
CN (1) CN1905904B (https=)
AU (1) AU2004294784B2 (https=)
BR (1) BRPI0416938A (https=)
CA (1) CA2547236A1 (https=)
GB (1) GB0327494D0 (https=)
IL (1) IL175667A (https=)
MX (1) MXPA06006045A (https=)
NO (1) NO20062387L (https=)
RU (1) RU2006117819A (https=)
WO (1) WO2005053752A2 (https=)
ZA (1) ZA200603887B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505884A (ja) 2004-07-08 2008-02-28 エヌエスティー・ニューロサバイバル・テクノロジーズ・リミテッド 疾患を検出する方法および化合物
WO2006074799A2 (en) * 2005-01-17 2006-07-20 Universitätsklinikum Münster 5-pyrrolidinylsulfonyl isatin derivatives
GB0502277D0 (en) * 2005-02-04 2005-03-09 Amersham Plc Novel imaging agents
WO2007050319A1 (en) * 2005-10-21 2007-05-03 Immunochemistry Technologies, Llc In vivo detection of apoptosis
GB0610395D0 (en) * 2006-05-25 2006-07-05 Ge Healthcare Ltd Novel imaging agents
GB0612333D0 (en) * 2006-06-21 2006-08-02 Ge Healthcare Ltd Radiopharmaceutical products
PL2029178T3 (pl) * 2006-06-21 2012-08-31 Ge Healthcare Ltd Produkty radiofarmaceutyczne
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
KR100845010B1 (ko) * 2007-08-29 2008-07-08 한국생명공학연구원 Ｎｉｒ／ｍｒ 이중모드 분자영상용 고분자 입자 및 그제조방법
CA2722858C (en) * 2008-04-30 2017-08-29 Siemens Medical Solutions Usa, Inc. Substrate based pet imaging agents
WO2010028156A2 (en) * 2008-09-04 2010-03-11 Board Of Regents, The University Of Texas System Dual modality detection of apoptosis
EP2367816B1 (en) 2008-09-05 2016-11-09 Imperial Innovations Limited Isatin derivatives for use as in vivo imaging agents
GB0818738D0 (en) * 2008-10-13 2008-11-19 Ge Healthcare Ltd Imaging neuroflammation
WO2014186737A1 (en) * 2013-05-16 2014-11-20 The Johns Hopkins University Compositions and methods for chemical exchange saturation transfer (cest) based magnetic resonance imaging (mri)
WO2017053864A1 (en) * 2015-09-23 2017-03-30 Intracellular Technologies, Llc Cysteine protease inhibitors
CN107655871A (zh) * 2017-09-12 2018-02-02 重庆医科大学 一种阿仑膦酸钠的高灵敏宽检测范围荧光检测新方法
KR20240132016A (ko) * 2021-12-08 2024-09-02 사이토사이트 바이오파마 인코포레이티드 그랜자임 b에 특이적인 화합물 및 그의 용도
TW202508601A (zh) * 2023-06-07 2025-03-01 美商塞托賽特生物製藥股份有限公司 對顆粒酶ｂ具有特異性之化合物之前驅藥及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589503B1 (en) * 1998-06-20 2003-07-08 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5601801A (en) * 1994-08-02 1997-02-11 Merck Frosst Canada, Inc. Radiolabelled angiotensin converting enzyme inhibitors
AR016384A1 (es) * 1997-07-30 2001-07-04 Smithkline Beecham Corp Inhibidores de caspasas, composiciones farmaceuticas que comprenden dichos inhibidores de caspasas y uso de los inhibidores de caspasas para prepararun medicamento util para el tratamiento de apoptosis y desordenes asociados con excesiva actividad de la convertosa il-1 beta.
NO20002644D0 (no) * 2000-05-23 2000-05-23 Nycomed Imaging As Kontrastmiddel
EP1283728A2 (en) * 2000-05-23 2003-02-19 Amersham Health AS Contrast agents
WO2002070020A2 (en) * 2001-03-02 2002-09-12 University Of Western Ontario Polymer precursors of radiolabeled compounds, and methods of making and using the same
WO2004028449A2 (en) * 2002-09-24 2004-04-08 The General Hospital Corporation Azulene dimer-quenched, near-infrared fluorescent probes
CA2514441A1 (en) * 2003-02-07 2004-10-19 Merck Frosst Canada & Co. Irreversible caspase-3 inhibitors as active site probes
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589503B1 (en) * 1998-06-20 2003-07-08 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BHARATHI 等.Noninvasive real-time imaging of apoptosis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITIDE STATE OF AMERICA99 26.2002,99(26),16551-16555.
BHARATHI 等.Noninvasive real-time imaging of apoptosis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITIDE STATE OF AMERICA99 26.2002,99(26),16551-16555. *
HABERKORN UWE 等.Investigation of a potential scintigraphic marker of apoptosis:Radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethylketone.NUCLEAR MEDICINE AND BIOLOGY28 7.2001,28(7),793-798.
HABERKORN UWE 等.Investigation of a potential scintigraphic marker of apoptosis:Radioiodinated Z-Val-Ala-DL-Asp(O-methyl)-fluoromethylketone.NUCLEAR MEDICINE AND BIOLOGY28 7.2001,28(7),793-798. *

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ZA200603887B (en) 2008-02-27
EP1763371A2 (en) 2007-03-21
JP2007512302A (ja) 2007-05-17
WO2005053752A2 (en) 2005-06-16
MXPA06006045A (es) 2006-08-23
CA2547236A1 (en) 2005-06-16
AU2004294784A1 (en) 2005-06-16
BRPI0416938A (pt) 2007-02-13
AU2004294784B2 (en) 2008-04-24
IL175667A0 (en) 2006-09-05
NO20062387L (no) 2006-05-31
US20060275215A1 (en) 2006-12-07
CN1905904A (zh) 2007-01-31
GB0327494D0 (en) 2003-12-31
KR20060123196A (ko) 2006-12-01
RU2006117819A (ru) 2008-01-10
KR101236124B1 (ko) 2013-02-21
IL175667A (en) 2013-09-30
WO2005053752A3 (en) 2005-10-06

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