JP2007512297A - 生物活性メチレンブルー誘導体（２）における開発 - Google Patents
生物活性メチレンブルー誘導体（２）における開発 Download PDFInfo
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- JP2007512297A JP2007512297A JP2006540597A JP2006540597A JP2007512297A JP 2007512297 A JP2007512297 A JP 2007512297A JP 2006540597 A JP2006540597 A JP 2006540597A JP 2006540597 A JP2006540597 A JP 2006540597A JP 2007512297 A JP2007512297 A JP 2007512297A
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- Prior art keywords
- ium
- phenothiazine
- compound
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- alkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0327672.2A GB0327672D0 (en) | 2003-11-28 | 2003-11-28 | Developments in biologically active methylene blue derivatives (phenothiazines) |
| GB0329809A GB0329809D0 (en) | 2003-12-23 | 2003-12-23 | Developments in biologically active methylene blue derivatives (2) (phenothiazines) |
| PCT/GB2004/004918 WO2005054217A1 (en) | 2003-11-28 | 2004-11-22 | Developments in biologically active methylene blue derivatives (2) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007512297A true JP2007512297A (ja) | 2007-05-17 |
| JP2007512297A5 JP2007512297A5 (https=) | 2008-01-17 |
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| JP2006540597A Abandoned JP2007512297A (ja) | 2003-11-28 | 2004-11-22 | 生物活性メチレンブルー誘導体（２）における開発 |
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| Country | Link |
|---|---|
| EP (1) | EP1687286A1 (https=) |
| JP (1) | JP2007512297A (https=) |
| KR (1) | KR20060111536A (https=) |
| AU (1) | AU2004295148A1 (https=) |
| BR (1) | BRPI0416928A (https=) |
| CA (1) | CA2547556A1 (https=) |
| WO (1) | WO2005054217A1 (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008513535A (ja) * | 2004-09-23 | 2008-05-01 | ヴィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| JP2010538051A (ja) * | 2007-09-07 | 2010-12-09 | ファルマ イドロ デヴロプマン ペ．アッシュ．デ． | 新規なジアミノフェノチアジン化合物、その製造方法、およびその使用 |
| JP2016528237A (ja) * | 2013-08-15 | 2016-09-15 | ユーファーマ ピーティーワイ リミテッド | ジアミノフェノチアジニウム化合物の精製方法 |
| KR20170029636A (ko) | 2014-08-27 | 2017-03-15 | 후지필름 가부시키가이샤 | 광선역학 요법용 조성물, 살균 방법, 살균 시스템 및 살균 시스템의 작동 방법 |
| JP2020509019A (ja) * | 2017-03-02 | 2020-03-26 | プロヴファーム ライフ ソリューションズ | ３，７−ビス（ジメチルアミノ）フェノチアジン−５−イリウムヨウ化物の製造方法 |
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| US7176308B2 (en) * | 2002-06-17 | 2007-02-13 | Verification Technologies, Inc. | Processes for preparing novel methylene blue derivative |
| SI2322517T1 (sl) | 2004-09-23 | 2019-06-28 | Wista Laboratories Ltd. | Postopki za kemijsko sintezo in čiščenje diaminofenotiazinijevih spojin, vključno metiltioninijevega klorida (MTC) |
| WO2007110630A1 (en) * | 2006-03-29 | 2007-10-04 | Wista Laboratories Ltd. | Thioninium compounds and their use |
| SI2004155T1 (en) | 2006-03-29 | 2018-05-31 | Wista Laboratories Ltd. | Inhibitors of protein aggregation |
| ES2349322T7 (es) | 2006-03-29 | 2019-10-17 | Wista Lab Ltd | Sales de 3,7-diamino-10H-fenotiazina y su utilización |
| MY148145A (en) | 2006-07-11 | 2013-03-15 | Wista Lab Ltd | Methods of synthesis and/or purification of diaminophenothiazinium compounds |
| FR2903696B1 (fr) | 2006-07-12 | 2011-02-11 | Provence Technologies | Procede de purification de composes diaminophenothiazium |
| US8227459B2 (en) * | 2007-04-03 | 2012-07-24 | Prosetta Antiviral Inc. | Diamino-phenothiazinyl derivatives as antiviral treatments |
| GB2453564A (en) * | 2007-10-11 | 2009-04-15 | Liverpool John Moores University | Ring-fused derivatives of 3,7-diamino- phenothiazinium & phenoselenazinium salts for use as antimicrobial agents |
| JP5868955B2 (ja) * | 2010-04-30 | 2016-02-24 | プロセッタ アンチバイラル インコーポレイテッド | 抗ウイルス化合物 |
| WO2012085250A1 (en) * | 2010-12-22 | 2012-06-28 | Ortner Cleanroom Engineering Gmbh | Clean room device with movable electromagnetic radiation source |
| EP2654806B1 (en) * | 2010-12-22 | 2019-05-22 | Ortner Cleanroom Engineering GmbH | Photodynamic control of microbial growth on surfaces |
| JP5898701B2 (ja) | 2011-02-11 | 2016-04-13 | ウィスタ ラボラトリーズ リミテッド | フェノチアジンジアミニウム塩およびそれらの使用 |
| WO2012125983A1 (en) | 2011-03-17 | 2012-09-20 | Prosetta Antiviral Inc. | Antiviral treatments |
| EP2694478B1 (en) * | 2011-04-04 | 2018-08-22 | Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University | Methylene violet analogs as multifunctional radical quenchers for the treatment of mitochondrial dysfunction |
| EP2699241B1 (en) * | 2011-04-20 | 2016-07-27 | Prosetta Antiviral Inc. | Antiviral compounds |
| US20120301904A1 (en) | 2011-04-26 | 2012-11-29 | Prosetta Antiviral, Inc | Multiprotein assemblies |
| AU2013341383B2 (en) | 2012-11-12 | 2017-08-24 | The Roger B. And Ann K. Mcnamee Trust U/T/A/D | Systems and methods for communicating a live event to users using the internet |
| EP3397623A1 (en) | 2015-12-28 | 2018-11-07 | John V. Frangioni | Method of preparing diaminophenothiazinium |
| CA3072418A1 (en) * | 2017-08-08 | 2019-02-14 | Board Of Trustees Of Michigan State University | Tunable luminescent organic salts for enhanced imaging and photodynamic therapy |
| US12215234B2 (en) | 2019-09-21 | 2025-02-04 | RK Pharma Solutions LLC | Process for the purification of methylene blue |
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| AUPP751298A0 (en) * | 1998-12-04 | 1999-01-07 | Csl Limited | Inactivation of non-enveloped viruses |
| JP2002534483A (ja) * | 1999-01-15 | 2002-10-15 | ライト サイエンシーズ コーポレイション | 代謝性骨障害または骨転移のための治療的組成物 |
| RU2184737C2 (ru) * | 1999-02-23 | 2002-07-10 | Институт нефтехимии и катализа АН РБ и УНЦ РАН | Органические комплексы цефалоспориновых антибиотиков, обладающие антимикробными свойствами |
| WO2001049328A1 (en) * | 2000-01-05 | 2001-07-12 | The American National Red Cross | Photodynamic inactivation of pathogens in blood by phenothiazines and oxygen |
| GB0002719D0 (en) * | 2000-02-08 | 2000-03-29 | Tissuemed Ltd | Thermal ablation of tissue |
| RU2176505C2 (ru) * | 2000-02-15 | 2001-12-10 | Третьяков Василий Васильевич | Средство, обладающее противовирусной активностью, на основе соединений серебра и золота с тиазином и способ его получения |
| CA2401624C (en) * | 2000-02-26 | 2011-08-16 | Merrill A. Biel | Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant |
| JP2004502704A (ja) * | 2000-06-30 | 2004-01-29 | ジラ・インク | 上皮癌の検出のためのメチレンブルー診断剤および診断方法 |
| US6881731B1 (en) * | 2000-10-23 | 2005-04-19 | Shanbrom Technologies, Llc | Enhancers for microbiological disinfection |
| US6623513B2 (en) * | 2001-01-19 | 2003-09-23 | Advanced Photodynamic Technologies, Inc. | Apparatus and method of photodynamic eradication of organisms utilizing pyrrolnitrin |
| GB0113121D0 (en) * | 2001-05-30 | 2001-07-18 | Univ Leeds | Biologically active photosensitisers |
| RU2209072C2 (ru) * | 2001-09-25 | 2003-07-27 | Орловский Евгений Владимирович | Антивирусная композиция для лечения вич-инфицированных больных с высокой вирусной нагрузкой |
-
2004
- 2004-11-22 EP EP04798628A patent/EP1687286A1/en not_active Withdrawn
- 2004-11-22 AU AU2004295148A patent/AU2004295148A1/en not_active Abandoned
- 2004-11-22 WO PCT/GB2004/004918 patent/WO2005054217A1/en not_active Ceased
- 2004-11-22 KR KR1020067010376A patent/KR20060111536A/ko not_active Withdrawn
- 2004-11-22 CA CA002547556A patent/CA2547556A1/en not_active Abandoned
- 2004-11-22 JP JP2006540597A patent/JP2007512297A/ja not_active Abandoned
- 2004-11-22 BR BRPI0416928-0A patent/BRPI0416928A/pt not_active IP Right Cessation
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008513535A (ja) * | 2004-09-23 | 2008-05-01 | ヴィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| JP2010538051A (ja) * | 2007-09-07 | 2010-12-09 | ファルマ イドロ デヴロプマン ペ．アッシュ．デ． | 新規なジアミノフェノチアジン化合物、その製造方法、およびその使用 |
| JP2016528237A (ja) * | 2013-08-15 | 2016-09-15 | ユーファーマ ピーティーワイ リミテッド | ジアミノフェノチアジニウム化合物の精製方法 |
| KR20170029636A (ko) | 2014-08-27 | 2017-03-15 | 후지필름 가부시키가이샤 | 광선역학 요법용 조성물, 살균 방법, 살균 시스템 및 살균 시스템의 작동 방법 |
| JP2020509019A (ja) * | 2017-03-02 | 2020-03-26 | プロヴファーム ライフ ソリューションズ | ３，７−ビス（ジメチルアミノ）フェノチアジン−５−イリウムヨウ化物の製造方法 |
| JP2022068343A (ja) * | 2017-03-02 | 2022-05-09 | プロヴファーム ライフ ソリューションズ | ３，７－ビス（ジメチルアミノ）フェノチアジン－５－イリウムヨウ化物の製造方法 |
| JP2023011886A (ja) * | 2017-03-02 | 2023-01-24 | プロヴファーム ライフ ソリューションズ | ３，７－ビス（ジメチルアミノ）フェノチアジン－５－イリウムヨウ化物の製造方法 |
| JP7482161B2 (ja) | 2017-03-02 | 2024-05-13 | プロヴファーム ライフ ソリューションズ | ３，７－ビス（ジメチルアミノ）フェノチアジン－５－イリウムヨウ化物の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1687286A1 (en) | 2006-08-09 |
| BRPI0416928A (pt) | 2007-01-16 |
| CA2547556A1 (en) | 2005-06-16 |
| AU2004295148A1 (en) | 2005-06-16 |
| WO2005054217A1 (en) | 2005-06-16 |
| KR20060111536A (ko) | 2006-10-27 |
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