JP2007511519A5 - - Google Patents
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- Publication number
- JP2007511519A5 JP2007511519A5 JP2006539847A JP2006539847A JP2007511519A5 JP 2007511519 A5 JP2007511519 A5 JP 2007511519A5 JP 2006539847 A JP2006539847 A JP 2006539847A JP 2006539847 A JP2006539847 A JP 2006539847A JP 2007511519 A5 JP2007511519 A5 JP 2007511519A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- topiramate
- layer
- form according
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002552 dosage form Substances 0.000 claims 57
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims 27
- 229960004394 topiramate Drugs 0.000 claims 27
- 239000007788 liquid Substances 0.000 claims 16
- 239000002904 solvent Substances 0.000 claims 14
- 230000004888 barrier function Effects 0.000 claims 8
- 239000004094 surface-active agent Substances 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000012669 liquid formulation Substances 0.000 claims 5
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000003204 osmotic effect Effects 0.000 claims 3
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical group C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 claims 3
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 239000007902 hard capsule Substances 0.000 claims 2
- 208000030814 Eating disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000013583 drug formulation Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical group OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51995803P | 2003-11-14 | 2003-11-14 | |
| PCT/US2004/037616 WO2005048981A1 (en) | 2003-11-14 | 2004-11-12 | Controlled release of topirimate in liquid dosage forms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007511519A JP2007511519A (ja) | 2007-05-10 |
| JP2007511519A5 true JP2007511519A5 (cg-RX-API-DMAC7.html) | 2007-12-27 |
Family
ID=34619401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539847A Pending JP2007511519A (ja) | 2003-11-14 | 2004-11-12 | 液状投薬形態物におけるトピラメートの制御放出 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050129765A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1684713A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2007511519A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20060120193A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1905857A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004291081A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2545834A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL175605A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA06005462A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20062739L (cg-RX-API-DMAC7.html) |
| TW (1) | TW200528144A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005048981A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200604882B (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| MXPA06002067A (es) * | 2003-08-22 | 2006-08-11 | Johnson & Johnson | Suministro gradual de topiramato durante periodo prolongado. |
| WO2005065648A2 (en) * | 2003-12-29 | 2005-07-21 | Alza Corporation, Inc., | Novel drug compositions and dosage forms of topiramate |
| AU2004312082A1 (en) * | 2003-12-29 | 2005-07-21 | Alza Corporation, Inc. | Novel drug compositions and dosage forms |
| MX2007014713A (es) * | 2005-05-25 | 2008-02-14 | Janssen Pharmaceutica Nv | Formulacion pediatrica de topiramato. |
| WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| EP2394643B1 (en) | 2006-11-17 | 2015-09-02 | Supernus Pharmaceuticals, Inc. | Sustained-release formulations of topiramate |
| EP2363113B1 (en) * | 2006-12-04 | 2017-08-02 | Supernus Pharmaceuticals, Inc. | Enhanced immediate release formulations of topiramate |
| EP2219624A2 (en) * | 2007-11-08 | 2010-08-25 | Glaxo Group Limited | Pharmaceutical formulations |
| US20120145572A1 (en) * | 2009-04-20 | 2012-06-14 | Ecole Polytechnique Federale De Lausanne (Epfl) | Containers assembled in fluid and corresponding production |
| CN102579367B (zh) * | 2012-03-23 | 2014-03-12 | 中国人民解放军军事医学科学院毒物药物研究所 | 托吡酯缓释药物组合物、其制备方法及用途 |
| CN103316026B (zh) | 2012-03-23 | 2016-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 含芬特明和托吡酯的联合产品及其制备方法 |
| EP2829270B1 (en) | 2012-03-23 | 2020-11-11 | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China | Joint product containing synephrine and topiramate |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN108379588B (zh) * | 2018-03-05 | 2024-07-02 | 合肥合源药业有限公司 | 托吡酯组合物 |
| US20210169844A1 (en) | 2019-12-10 | 2021-06-10 | Tulex Pharmaceuticals Inc. | Compositions and methods for treating epilepsy, seizures and other conditions |
| US12290504B2 (en) | 2023-04-11 | 2025-05-06 | Tap Pharmaceuticals Ag | Aqueous formulations of topiramate |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2707154A (en) * | 1952-06-09 | 1955-04-26 | Monsanto Chemicals | Antioxidants and compositions containing same |
| US3173876A (en) * | 1960-05-27 | 1965-03-16 | John C Zobrist | Cleaning methods and compositions |
| NL271831A (cg-RX-API-DMAC7.html) * | 1960-11-29 | |||
| US3276586A (en) * | 1963-08-30 | 1966-10-04 | Rosaen Filter Co | Indicating means for fluid filters |
| US3546142A (en) * | 1967-01-19 | 1970-12-08 | Amicon Corp | Polyelectrolyte structures |
| CH508415A (de) * | 1967-10-27 | 1971-06-15 | Hoffmann La Roche | Antioxydative Mischung und deren Verwendung |
| US3573936A (en) * | 1967-12-15 | 1971-04-06 | Rayonier Inc | Plicatic acid and thiodipropionic acid as antioxidants for use in animal fats and vegetable oils |
| US3541006A (en) * | 1968-07-03 | 1970-11-17 | Amicon Corp | Ultrafiltration process |
| US3541005A (en) * | 1969-02-05 | 1970-11-17 | Amicon Corp | Continuous ultrafiltration of macromolecular solutions |
| US3865108A (en) * | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4002173A (en) * | 1974-07-23 | 1977-01-11 | International Paper Company | Diester crosslinked polyglucan hydrogels and reticulated sponges thereof |
| US4077407A (en) * | 1975-11-24 | 1978-03-07 | Alza Corporation | Osmotic devices having composite walls |
| US4038434A (en) * | 1976-03-12 | 1977-07-26 | Howard Hall & Company | Antioxidant stabilized edible compositions |
| US4111201A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for delivering selected beneficial agents having varying degrees of solubility |
| US4207893A (en) * | 1977-08-29 | 1980-06-17 | Alza Corporation | Device using hydrophilic polymer for delivering drug to biological environment |
| US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4259323A (en) * | 1980-03-24 | 1981-03-31 | Hoffmann-La Roche Inc. | Potassium chloride emulsion |
| IN159370B (cg-RX-API-DMAC7.html) * | 1982-01-15 | 1987-05-09 | Ciba Geigy Ag | |
| US4513600A (en) * | 1983-01-03 | 1985-04-30 | The Minster Machine Company | Cam actuated ejector for a shell press |
| US4783337A (en) * | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US4627850A (en) * | 1983-11-02 | 1986-12-09 | Alza Corporation | Osmotic capsule |
| US4663148A (en) * | 1984-03-21 | 1987-05-05 | Alza Corporation | Dispenser comprising telescopically engaging members |
| US4915949A (en) * | 1987-07-13 | 1990-04-10 | Alza Corporation | Dispenser with movable matrix comprising a plurality of tiny pills |
| US5024842A (en) * | 1988-04-28 | 1991-06-18 | Alza Corporation | Annealed coats |
| US4931285A (en) * | 1988-04-28 | 1990-06-05 | Alza Corporation | Aqueous based pharmaceutical coating composition for dosage forms |
| US5006346A (en) * | 1988-04-28 | 1991-04-09 | Alza Corporation | Delivery system |
| CA1340821C (en) * | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| US5126142A (en) * | 1989-07-18 | 1992-06-30 | Alza Corporation | Dispenser comprising ionophore |
| US5324280A (en) * | 1990-04-02 | 1994-06-28 | Alza Corporation | Osmotic dosage system for delivering a formulation comprising liquid carrier and drug |
| US5190765A (en) * | 1991-06-27 | 1993-03-02 | Alza Corporation | Therapy delayed |
| US5252338A (en) * | 1991-06-27 | 1993-10-12 | Alza Corporation | Therapy delayed |
| AU651244B2 (en) * | 1991-09-19 | 1994-07-14 | Mcneilab, Inc. | Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-0-(1-methylethylidene)-beta-D- fructopyranose and (1-methylcyclohexyl)methanol |
| US5643909A (en) * | 1993-04-19 | 1997-07-01 | Syntex (U.S.A.) Inc. | 10,11-Methanodibenzosuberane derivatives |
| ZA953078B (en) * | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| US5633011A (en) * | 1994-08-04 | 1997-05-27 | Alza Corporation | Progesterone replacement therapy |
| US5614578A (en) * | 1994-10-28 | 1997-03-25 | Alza Corporation | Injection-molded dosage form |
| US5824638A (en) * | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
| US6551613B1 (en) * | 1998-09-08 | 2003-04-22 | Alza Corporation | Dosage form comprising therapeutic formulation |
| US6174547B1 (en) * | 1999-07-14 | 2001-01-16 | Alza Corporation | Dosage form comprising liquid formulation |
| DE69915346T2 (de) * | 1998-12-17 | 2004-07-22 | Alza Corp., Mountain View | Umwandlung von flüssigkeitsgefüllten gelatinkapseln in systeme mit gesteuerter wirkstoffabgabe durch mehrfache beschichtungen |
| US6342249B1 (en) * | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
| US6559293B1 (en) * | 2002-02-15 | 2003-05-06 | Transform Pharmaceuticals, Inc. | Topiramate sodium trihydrate |
| DE60322371D1 (de) * | 2002-03-29 | 2008-09-04 | Alza Corp | Volumensparende arzneiform zur kontrollierten freisetzung |
| US20070243254A1 (en) * | 2002-06-26 | 2007-10-18 | David Edgren | Novel drug compositions and dosage forms of topiramate |
| EP1534238A1 (en) * | 2002-07-29 | 2005-06-01 | ALZA Corporation | Formulations and dosage forms for controlled delivery of topiramate |
-
2004
- 2004-11-12 EP EP04819096A patent/EP1684713A1/en not_active Withdrawn
- 2004-11-12 TW TW093134553A patent/TW200528144A/zh unknown
- 2004-11-12 WO PCT/US2004/037616 patent/WO2005048981A1/en not_active Ceased
- 2004-11-12 CA CA002545834A patent/CA2545834A1/en not_active Abandoned
- 2004-11-12 MX MXPA06005462A patent/MXPA06005462A/es unknown
- 2004-11-12 JP JP2006539847A patent/JP2007511519A/ja active Pending
- 2004-11-12 CN CNA200480039213XA patent/CN1905857A/zh active Pending
- 2004-11-12 KR KR1020067011334A patent/KR20060120193A/ko not_active Withdrawn
- 2004-11-12 US US10/986,962 patent/US20050129765A1/en not_active Abandoned
- 2004-11-12 AU AU2004291081A patent/AU2004291081A1/en not_active Abandoned
-
2006
- 2006-05-11 IL IL175605A patent/IL175605A0/en unknown
- 2006-06-13 ZA ZA200604882A patent/ZA200604882B/en unknown
- 2006-06-13 NO NO20062739A patent/NO20062739L/no not_active Application Discontinuation
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