JP2007510889A5 - - Google Patents
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- Publication number
- JP2007510889A5 JP2007510889A5 JP2006534165A JP2006534165A JP2007510889A5 JP 2007510889 A5 JP2007510889 A5 JP 2007510889A5 JP 2006534165 A JP2006534165 A JP 2006534165A JP 2006534165 A JP2006534165 A JP 2006534165A JP 2007510889 A5 JP2007510889 A5 JP 2007510889A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- acrylamide
- substrate
- methacrylamide
- biomolecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 N-substituted acrylamide Chemical class 0.000 claims 77
- 239000000203 mixture Substances 0.000 claims 60
- 229920000642 polymer Polymers 0.000 claims 59
- 239000000758 substrate Substances 0.000 claims 33
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 12
- 239000000178 monomer Substances 0.000 claims 12
- 150000003140 primary amides Chemical class 0.000 claims 12
- 125000000524 functional group Chemical group 0.000 claims 11
- 239000011248 coating agent Substances 0.000 claims 10
- 238000000576 coating method Methods 0.000 claims 10
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 238000002493 microarray Methods 0.000 claims 8
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical class CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 4
- WUIJTQZXUURFQU-UHFFFAOYSA-N 1-methylsulfonylethene Chemical compound CS(=O)(=O)C=C WUIJTQZXUURFQU-UHFFFAOYSA-N 0.000 claims 4
- FTALTLPZDVFJSS-UHFFFAOYSA-N 2-(2-ethoxyethoxy)ethyl prop-2-enoate Chemical compound CCOCCOCCOC(=O)C=C FTALTLPZDVFJSS-UHFFFAOYSA-N 0.000 claims 4
- XWRBMHSLXKNRJX-UHFFFAOYSA-N 2-ethenyl-1-oxidopyridin-1-ium Chemical compound [O-][N+]1=CC=CC=C1C=C XWRBMHSLXKNRJX-UHFFFAOYSA-N 0.000 claims 4
- MXRGSJAOLKBZLU-UHFFFAOYSA-N 3-ethenylazepan-2-one Chemical compound C=CC1CCCCNC1=O MXRGSJAOLKBZLU-UHFFFAOYSA-N 0.000 claims 4
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 claims 4
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 4
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 4
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims 4
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims 4
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical group CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims 4
- PNLUGRYDUHRLOF-UHFFFAOYSA-N n-ethenyl-n-methylacetamide Chemical compound C=CN(C)C(C)=O PNLUGRYDUHRLOF-UHFFFAOYSA-N 0.000 claims 4
- 229920001451 polypropylene glycol Polymers 0.000 claims 4
- 150000003961 organosilicon compounds Chemical class 0.000 claims 3
- XLPJNCYCZORXHG-UHFFFAOYSA-N 1-morpholin-4-ylprop-2-en-1-one Chemical compound C=CC(=O)N1CCOCC1 XLPJNCYCZORXHG-UHFFFAOYSA-N 0.000 claims 2
- AKVUWTYSNLGBJY-UHFFFAOYSA-N 2-methyl-1-morpholin-4-ylprop-2-en-1-one Chemical compound CC(=C)C(=O)N1CCOCC1 AKVUWTYSNLGBJY-UHFFFAOYSA-N 0.000 claims 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- 150000001299 aldehydes Chemical class 0.000 claims 2
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 claims 2
- 150000004056 anthraquinones Chemical class 0.000 claims 2
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 claims 2
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 claims 2
- 239000012965 benzophenone Substances 0.000 claims 2
- 150000002118 epoxides Chemical class 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- 230000003100 immobilizing effect Effects 0.000 claims 2
- 150000002540 isothiocyanates Chemical class 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- WFKDPJRCBCBQNT-UHFFFAOYSA-N n,2-dimethylprop-2-enamide Chemical compound CNC(=O)C(C)=C WFKDPJRCBCBQNT-UHFFFAOYSA-N 0.000 claims 2
- QRWZCJXEAOZAAW-UHFFFAOYSA-N n,n,2-trimethylprop-2-enamide Chemical compound CN(C)C(=O)C(C)=C QRWZCJXEAOZAAW-UHFFFAOYSA-N 0.000 claims 2
- JMCVCHBBHPFWBF-UHFFFAOYSA-N n,n-diethyl-2-methylprop-2-enamide Chemical compound CCN(CC)C(=O)C(C)=C JMCVCHBBHPFWBF-UHFFFAOYSA-N 0.000 claims 2
- OVHHHVAVHBHXAK-UHFFFAOYSA-N n,n-diethylprop-2-enamide Chemical compound CCN(CC)C(=O)C=C OVHHHVAVHBHXAK-UHFFFAOYSA-N 0.000 claims 2
- OHLHOLGYGRKZMU-UHFFFAOYSA-N n-benzylprop-2-enamide Chemical compound C=CC(=O)NCC1=CC=CC=C1 OHLHOLGYGRKZMU-UHFFFAOYSA-N 0.000 claims 2
- PMJFVKWBSWWAKT-UHFFFAOYSA-N n-cyclohexylprop-2-enamide Chemical compound C=CC(=O)NC1CCCCC1 PMJFVKWBSWWAKT-UHFFFAOYSA-N 0.000 claims 2
- ZIWDVJPPVMGJGR-UHFFFAOYSA-N n-ethyl-2-methylprop-2-enamide Chemical compound CCNC(=O)C(C)=C ZIWDVJPPVMGJGR-UHFFFAOYSA-N 0.000 claims 2
- AWGZKFQMWZYCHF-UHFFFAOYSA-N n-octylprop-2-enamide Chemical compound CCCCCCCCNC(=O)C=C AWGZKFQMWZYCHF-UHFFFAOYSA-N 0.000 claims 2
- BPCNEKWROYSOLT-UHFFFAOYSA-N n-phenylprop-2-enamide Chemical compound C=CC(=O)NC1=CC=CC=C1 BPCNEKWROYSOLT-UHFFFAOYSA-N 0.000 claims 2
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 claims 2
- 239000004033 plastic Substances 0.000 claims 2
- 229920003023 plastic Polymers 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 229910052990 silicon hydride Inorganic materials 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 239000002023 wood Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/677,022 | 2003-10-01 | ||
| US10/677,022 US7309593B2 (en) | 2003-10-01 | 2003-10-01 | Attachment of molecules to surfaces |
| PCT/US2004/032443 WO2005033158A2 (en) | 2003-10-01 | 2004-09-30 | Attachment of molecules to surfaces |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007510889A JP2007510889A (ja) | 2007-04-26 |
| JP2007510889A5 true JP2007510889A5 (https=) | 2007-11-01 |
| JP4741499B2 JP4741499B2 (ja) | 2011-08-03 |
Family
ID=34393654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006534165A Expired - Lifetime JP4741499B2 (ja) | 2003-10-01 | 2004-09-30 | 表面への分子の結合 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7309593B2 (https=) |
| EP (1) | EP1668050B1 (https=) |
| JP (1) | JP4741499B2 (https=) |
| AT (1) | ATE448258T1 (https=) |
| AU (1) | AU2004278408B2 (https=) |
| CA (1) | CA2536303C (https=) |
| DE (1) | DE602004024095D1 (https=) |
| WO (1) | WO2005033158A2 (https=) |
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| JP4630817B2 (ja) * | 2003-03-31 | 2011-02-09 | 独立行政法人理化学研究所 | 物質固定化剤、それを用いた物質固定化方法及びそれを用いた物質固定化基体 |
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| AU2002368411A1 (en) | 2002-11-29 | 2004-06-23 | Marcella Chiari | Method for immobilizing biologic molecules on solid surfaces |
| US7820158B2 (en) | 2003-04-10 | 2010-10-26 | Surmodics, Inc. | Ligand-coupled initiator polymers and methods of use |
| US7309593B2 (en) * | 2003-10-01 | 2007-12-18 | Surmodics, Inc. | Attachment of molecules to surfaces |
-
2003
- 2003-10-01 US US10/677,022 patent/US7309593B2/en not_active Expired - Lifetime
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2004
- 2004-09-30 WO PCT/US2004/032443 patent/WO2005033158A2/en not_active Ceased
- 2004-09-30 AU AU2004278408A patent/AU2004278408B2/en not_active Expired
- 2004-09-30 EP EP04789464A patent/EP1668050B1/en not_active Expired - Lifetime
- 2004-09-30 CA CA 2536303 patent/CA2536303C/en not_active Expired - Lifetime
- 2004-09-30 DE DE200460024095 patent/DE602004024095D1/de not_active Expired - Lifetime
- 2004-09-30 JP JP2006534165A patent/JP4741499B2/ja not_active Expired - Lifetime
- 2004-09-30 AT AT04789464T patent/ATE448258T1/de not_active IP Right Cessation
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2007
- 2007-09-14 US US11/901,033 patent/US7829317B2/en not_active Expired - Lifetime
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2010
- 2010-09-09 US US12/878,236 patent/US8129159B2/en not_active Expired - Lifetime
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