JP2007510800A5 - - Google Patents
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- Publication number
- JP2007510800A5 JP2007510800A5 JP2006539659A JP2006539659A JP2007510800A5 JP 2007510800 A5 JP2007510800 A5 JP 2007510800A5 JP 2006539659 A JP2006539659 A JP 2006539659A JP 2006539659 A JP2006539659 A JP 2006539659A JP 2007510800 A5 JP2007510800 A5 JP 2007510800A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxylic acid
- peg
- salt
- convert
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- -1 carboxylate salt Chemical class 0.000 claims 1
- 150000001734 carboxylic acid salts Chemical class 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51779403P | 2003-11-06 | 2003-11-06 | |
| US60/517,794 | 2003-11-06 | ||
| PCT/US2004/036850 WO2005047366A1 (en) | 2003-11-06 | 2004-11-05 | Method of preparing carboxylic acid functionalized polymers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007510800A JP2007510800A (ja) | 2007-04-26 |
| JP2007510800A5 true JP2007510800A5 (https=) | 2007-11-22 |
| JP5101884B2 JP5101884B2 (ja) | 2012-12-19 |
Family
ID=34590189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539659A Expired - Lifetime JP5101884B2 (ja) | 2003-11-06 | 2004-11-05 | カルボン酸官能化重合体の調製方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20050214250A1 (https=) |
| EP (1) | EP1692206B1 (https=) |
| JP (1) | JP5101884B2 (https=) |
| KR (1) | KR101157007B1 (https=) |
| CN (1) | CN100580005C (https=) |
| AT (1) | ATE465204T1 (https=) |
| AU (1) | AU2004289992B2 (https=) |
| CA (1) | CA2544697C (https=) |
| CY (1) | CY1110303T1 (https=) |
| DE (1) | DE602004026770D1 (https=) |
| DK (1) | DK1692206T3 (https=) |
| ES (1) | ES2342294T3 (https=) |
| IL (1) | IL175406A (https=) |
| PL (1) | PL1692206T3 (https=) |
| PT (1) | PT1692206E (https=) |
| SI (1) | SI1692206T1 (https=) |
| WO (1) | WO2005047366A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050214250A1 (en) * | 2003-11-06 | 2005-09-29 | Harris J M | Method of preparing carboxylic acid functionalized polymers |
| ES2720078T3 (es) * | 2004-01-21 | 2019-07-17 | Nektar Therapeutics | Método para preparar polímeros terminados en ácido propiónico |
| CA2584510C (en) * | 2004-10-25 | 2013-05-28 | Intezyne Technologies, Incorporated | Heterobifunctional poly(ethylene glycol) and uses thereof |
| US7989554B2 (en) * | 2006-01-10 | 2011-08-02 | Enzon Pharmaceuticals, Inc. | Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid |
| US8133707B2 (en) | 2006-01-17 | 2012-03-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing activated polymers having alpha nitrogen groups |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7560588B2 (en) * | 2006-04-27 | 2009-07-14 | Intezyne Technologies, Inc. | Poly(ethylene glycol) containing chemically disparate endgroups |
| PL2054074T3 (pl) | 2006-08-04 | 2015-03-31 | Prolong Pharmaceuticals Llc | Zmodyfikowana erytropoetyna |
| WO2008098178A2 (en) * | 2007-02-09 | 2008-08-14 | Enzon Pharmaceuticals, Inc. | Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| JP2008308690A (ja) * | 2007-06-13 | 2008-12-25 | Bio-Cancer Treatment Internatl Ltd | ポリ(エチレングリコール)機能性誘導体およびその製造方法 |
| TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
| WO2010037045A1 (en) | 2008-09-28 | 2010-04-01 | Nerites Corporation | Multi-armed catechol compound blends |
| CA2738807A1 (en) * | 2008-10-21 | 2010-04-29 | Enzon Pharmaceuticals, Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| CA2751573C (en) * | 2009-02-06 | 2014-05-13 | Knc Ner Acquisition Sub, Inc. | Multi-linked star-shaped polymers and synthetic methods therfor |
| WO2011140409A2 (en) * | 2010-05-06 | 2011-11-10 | Cornell University | Tunable lcst polymers and methods of preparation |
| EP2606884A1 (en) | 2011-12-21 | 2013-06-26 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Inhibitors of notch signaling pathway and use thereof in treatment of cancers |
| ES2774330T3 (es) | 2013-04-09 | 2020-07-20 | Massachusetts Inst Technology | Polímero de suministro de fármaco y usos del mismo |
| US9447129B2 (en) | 2014-02-07 | 2016-09-20 | Massachusetts Institute Of Technology | Suprametallogels and uses thereof |
| WO2016167759A1 (en) * | 2015-04-15 | 2016-10-20 | Multisorb Technologies, Inc. | Surface modification of a resin |
| JP6777390B2 (ja) * | 2015-10-30 | 2020-10-28 | 株式会社日本触媒 | 生体適合性医療用材料 |
| EP3187254B1 (en) * | 2015-12-30 | 2020-09-02 | Italmatch SC, LLC | Polymeric emulsifier and lubricity additives for aqueous metal removal, forming, rolling or other applications |
| WO2017214337A1 (en) | 2016-06-07 | 2017-12-14 | Massachusetts Institute Of Technology | Drug delivery polymers and uses thereof |
| WO2018039577A1 (en) | 2016-08-26 | 2018-03-01 | Massachusetts Institute Of Technology | Bottlebrush polymers and uses thereof |
| WO2018067702A1 (en) | 2016-10-04 | 2018-04-12 | Massachusetts Institute Of Technology | Bottlebrush copolymers and uses thereof |
| JP6935059B2 (ja) * | 2017-03-30 | 2021-09-15 | 日油株式会社 | カルボキシル基を一つ有するポリエチレングリコールの精製方法 |
| JP7158143B2 (ja) * | 2017-04-13 | 2022-10-21 | 株式会社日本触媒 | 生体適合性医療用材料 |
| WO2019006425A1 (en) | 2017-06-30 | 2019-01-03 | Massachusetts Institute Of Technology | IMAGING AGENTS OF BRUSH ARRAY STAR POLYMERS AND USES THEREOF |
| US10973847B2 (en) | 2017-06-30 | 2021-04-13 | Massachusetts Institute Of Technology | Core-to-surface polymerization for the synthesis of star polymers and uses thereof |
| JP7187048B2 (ja) | 2017-06-30 | 2022-12-12 | マサチューセッツ インスティテュート オブ テクノロジー | 分枝多官能性マクロモノマーおよび関連ポリマーならびにそれらの使用 |
| EP3774986A1 (en) | 2018-04-13 | 2021-02-17 | Massachusetts Institute of Technology | Brush prodrugs and uses thereof |
| MA52954A (fr) | 2018-06-21 | 2021-04-28 | Cellestia Biotech Ag | Procédé pour la fabrication d'aminoéthers de diaryle et sels de chlorhydrate d'aminoéthers de diaryle |
| EP3837266A1 (en) | 2018-08-17 | 2021-06-23 | Massachusetts Institute of Technology | Degradable polymers of a cyclic silyl ether and uses thereof |
| US12018120B2 (en) * | 2019-03-29 | 2024-06-25 | Nof Corporation | Method for producing terminal carboxyl group-containing polyethylene glycol and method for producing activated polyethylene glycol |
| CA3134791A1 (en) | 2019-04-10 | 2020-10-15 | Cellestia Biotech Ag | Inhibitors of notch signalling pathway and use thereof in treatment of cancers |
| KR20220085791A (ko) | 2019-10-16 | 2022-06-22 | 메사추세츠 인스티튜트 오브 테크놀로지 | 브러시 전구약물 및 그의 용도 |
| WO2021141662A1 (en) | 2020-01-10 | 2021-07-15 | Massachusetts Institute Of Technology | Proteolysis targeting chimeric molecules (protacs) with functional handles and uses thereof |
| EP4169113A2 (en) | 2020-06-19 | 2023-04-26 | Debreceni Egyetem | Zn-air rechargeable battery |
| EP4008324A1 (en) | 2020-12-07 | 2022-06-08 | Cellestia Biotech AG | Combinations comprising an inhibitor of an anti-apoptotic protein, such as bcl-2, bcl-xl, bclw or mcl-1, and a notch signaling pathway inhibitor for treating cancer |
| EP4255409A1 (en) | 2020-12-07 | 2023-10-11 | Cellestia Biotech AG | Pharmaceutical combinations for treating cancer |
| US20240269120A1 (en) | 2021-06-02 | 2024-08-15 | Cellestia Biotech Ag | Method for Treating an Autoimmune and Inflammatory Disease |
| WO2023079132A1 (en) | 2021-11-08 | 2023-05-11 | Cellestia Biotech Ag | Pharmaceutical combinations for treating cancer |
| US12084415B2 (en) | 2021-12-20 | 2024-09-10 | Massachusetts Institute Of Technology | Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent |
| EP4223292A1 (en) | 2022-02-07 | 2023-08-09 | Cellestia Biotech AG | Pharmaceutical combinations for treating cancer |
| CN115193363B (zh) * | 2022-09-16 | 2023-02-24 | 世名(苏州)新材料研究院有限公司 | 高酸值低酯值氧化蜡、其制备工艺及由其制得的酯化蜡 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721579A (en) * | 1980-08-15 | 1988-01-26 | Basf Corporation | Sodium carboxymethyl derivatives of polyoxyalkylene glycols, their production, and use in functional fluids |
| DE3032061C1 (de) * | 1980-08-26 | 1982-06-09 | Chem-y, Fabriek van Chemische Produkten B.V., Bodegraven | Verfahren zur Herstellung eines verpumpbaren oberflaechenaktiven Produktes auf Basis von Polyaetheressigsaeuren |
| DE3120195C2 (de) * | 1981-05-21 | 1986-09-04 | Degussa Ag, 6000 Frankfurt | Polymere Ammoniumverbindungen mit kieselsäureartigem Grundgerüst, Verfahren zu ihrer Herstellung und Verwendung |
| JPH04199152A (ja) * | 1990-11-29 | 1992-07-20 | Toshiba Corp | 感光性組成物 |
| US5483008A (en) * | 1992-02-07 | 1996-01-09 | Research Development Corporation Of Japan | Polyether having heterofunctional groups at both ends, process for the preparation thereof and polymerization initiator therefor |
| US5278303A (en) | 1992-06-12 | 1994-01-11 | University Of Toronto Innovations Foundation | Polymer-supported solution synthesis of oligosaccharides |
| JP3236087B2 (ja) * | 1992-10-26 | 2001-12-04 | 株式会社トクヤマ | 重合性磁性流体製造用界面活性剤 |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5605976A (en) * | 1995-05-15 | 1997-02-25 | Enzon, Inc. | Method of preparing polyalkylene oxide carboxylic acids |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| JPH1087815A (ja) | 1996-08-22 | 1998-04-07 | Enzon Inc | ポリアルキレンオキシドカルボン酸の改良製造方法 |
| JP3855344B2 (ja) * | 1997-02-19 | 2006-12-06 | 日本油脂株式会社 | ポリオキシアルキレンカルボン酸の製造方法 |
| US6448369B1 (en) * | 1997-11-06 | 2002-09-10 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
| DK1411075T3 (da) | 1998-03-12 | 2008-10-27 | Nektar Therapeutics Al Corp | Fremgangsmåde til fremstilling af polymerkonjugater |
| DE19928128C1 (de) * | 1999-06-19 | 2000-11-30 | Clariant Gmbh | Verfahren zur Herstellung von Ethercarbonsäuren mit niedrigem Restalkohol |
| CN1284603C (zh) * | 1999-10-08 | 2006-11-15 | 内科塔治疗亚拉巴马公司 | 杂双官能聚乙二醇衍生物和它们的制备方法 |
| TWI246524B (en) | 2001-01-19 | 2006-01-01 | Shearwater Corp | Multi-arm block copolymers as drug delivery vehicles |
| DK1539857T3 (da) * | 2002-07-24 | 2007-03-12 | Hoffmann La Roche | Polyethylenglycol-aldehydderivater |
| US20050214250A1 (en) | 2003-11-06 | 2005-09-29 | Harris J M | Method of preparing carboxylic acid functionalized polymers |
-
2004
- 2004-11-04 US US10/982,303 patent/US20050214250A1/en not_active Abandoned
- 2004-11-05 DE DE602004026770T patent/DE602004026770D1/de not_active Expired - Lifetime
- 2004-11-05 ES ES04810369T patent/ES2342294T3/es not_active Expired - Lifetime
- 2004-11-05 EP EP04810369A patent/EP1692206B1/en not_active Expired - Lifetime
- 2004-11-05 CA CA2544697A patent/CA2544697C/en not_active Expired - Lifetime
- 2004-11-05 DK DK04810369.1T patent/DK1692206T3/da active
- 2004-11-05 PL PL04810369T patent/PL1692206T3/pl unknown
- 2004-11-05 AU AU2004289992A patent/AU2004289992B2/en not_active Expired
- 2004-11-05 KR KR1020067008804A patent/KR101157007B1/ko not_active Expired - Lifetime
- 2004-11-05 SI SI200431461T patent/SI1692206T1/sl unknown
- 2004-11-05 AT AT04810369T patent/ATE465204T1/de active
- 2004-11-05 CN CN200480039882A patent/CN100580005C/zh not_active Expired - Lifetime
- 2004-11-05 PT PT04810369T patent/PT1692206E/pt unknown
- 2004-11-05 JP JP2006539659A patent/JP5101884B2/ja not_active Expired - Lifetime
- 2004-11-05 WO PCT/US2004/036850 patent/WO2005047366A1/en not_active Ceased
-
2006
- 2006-05-04 IL IL175406A patent/IL175406A/en active IP Right Grant
-
2010
- 2010-07-09 CY CY20101100646T patent/CY1110303T1/el unknown
-
2011
- 2011-02-09 US US13/023,960 patent/US8067505B2/en not_active Expired - Lifetime
- 2011-10-21 US US13/279,134 patent/US20120041155A1/en not_active Abandoned
-
2013
- 2013-06-19 US US13/922,020 patent/US10011682B2/en not_active Expired - Lifetime
-
2018
- 2018-06-05 US US16/000,561 patent/US11111335B2/en not_active Expired - Fee Related
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