JP2007509981A5 - - Google Patents
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- JP2007509981A5 JP2007509981A5 JP2006538369A JP2006538369A JP2007509981A5 JP 2007509981 A5 JP2007509981 A5 JP 2007509981A5 JP 2006538369 A JP2006538369 A JP 2006538369A JP 2006538369 A JP2006538369 A JP 2006538369A JP 2007509981 A5 JP2007509981 A5 JP 2007509981A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- peptide
- composition according
- polysaccharide
- nanoparticles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 29
- 239000002105 nanoparticle Substances 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 150000004676 glycans Chemical class 0.000 claims 19
- 229920001282 polysaccharide Polymers 0.000 claims 19
- 239000005017 polysaccharide Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 16
- 102000003886 Glycoproteins Human genes 0.000 claims 15
- 108090000288 Glycoproteins Proteins 0.000 claims 15
- 108010072051 Glatiramer Acetate Proteins 0.000 claims 11
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims 11
- 229960003776 glatiramer acetate Drugs 0.000 claims 11
- 239000002202 Polyethylene glycol Substances 0.000 claims 7
- 239000000194 fatty acid Substances 0.000 claims 7
- 229920001223 polyethylene glycol Polymers 0.000 claims 7
- 239000001993 wax Substances 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 5
- 238000002844 melting Methods 0.000 claims 5
- 230000008018 melting Effects 0.000 claims 5
- 150000003626 triacylglycerols Chemical class 0.000 claims 5
- 230000007515 enzymatic degradation Effects 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000004530 micro-emulsion Substances 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- -1 polyoxy Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
- 229930182566 Gentamicin Natural products 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 229960004821 amikacin Drugs 0.000 claims 1
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 229960000541 cetyl alcohol Drugs 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims 1
- 229960000878 docusate sodium Drugs 0.000 claims 1
- 229960002518 gentamicin Drugs 0.000 claims 1
- 125000005456 glyceride group Chemical group 0.000 claims 1
- 229940049654 glyceryl behenate Drugs 0.000 claims 1
- FETSQPAGYOVAQU-UHFFFAOYSA-N glyceryl palmitostearate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O FETSQPAGYOVAQU-UHFFFAOYSA-N 0.000 claims 1
- 229940046813 glyceryl palmitostearate Drugs 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 210000002429 large intestine Anatomy 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims 1
- 229940113124 polysorbate 60 Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 229960000707 tobramycin Drugs 0.000 claims 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 238000005809 transesterification reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51632403P | 2003-10-31 | 2003-10-31 | |
| PCT/US2004/036172 WO2005041933A1 (en) | 2003-10-31 | 2004-10-28 | Nanoparticles for drug delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007509981A JP2007509981A (ja) | 2007-04-19 |
| JP2007509981A5 true JP2007509981A5 (cg-RX-API-DMAC7.html) | 2007-12-13 |
Family
ID=34549527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538369A Withdrawn JP2007509981A (ja) | 2003-10-31 | 2004-10-28 | 薬物デリバリー用ナノ粒子 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050170004A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1680087A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2007509981A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20060097020A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2004285553B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2541445A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA200600877A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL174748A0 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ546379A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2005041933A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (46)
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| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
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| EP2699317B1 (en) | 2011-04-21 | 2016-08-10 | Mapi Pharma Limited | Random pentapolymer for treatment of autoimmune diseases |
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-
2004
- 2004-10-28 NZ NZ546379A patent/NZ546379A/en unknown
- 2004-10-28 EP EP04796839A patent/EP1680087A1/en not_active Withdrawn
- 2004-10-28 KR KR1020067007794A patent/KR20060097020A/ko not_active Ceased
- 2004-10-28 EA EA200600877A patent/EA200600877A1/ru unknown
- 2004-10-28 US US10/977,926 patent/US20050170004A1/en not_active Abandoned
- 2004-10-28 JP JP2006538369A patent/JP2007509981A/ja not_active Withdrawn
- 2004-10-28 WO PCT/US2004/036172 patent/WO2005041933A1/en not_active Ceased
- 2004-10-28 CA CA002541445A patent/CA2541445A1/en not_active Abandoned
- 2004-10-28 AU AU2004285553A patent/AU2004285553B2/en not_active Ceased
-
2006
- 2006-04-03 IL IL174748A patent/IL174748A0/en unknown
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