JP2007508381A - 勃起障害治療のための方法および組成物 - Google Patents

勃起障害治療のための方法および組成物 Download PDF

Info

Publication number
JP2007508381A
JP2007508381A JP2006535493A JP2006535493A JP2007508381A JP 2007508381 A JP2007508381 A JP 2007508381A JP 2006535493 A JP2006535493 A JP 2006535493A JP 2006535493 A JP2006535493 A JP 2006535493A JP 2007508381 A JP2007508381 A JP 2007508381A
Authority
JP
Japan
Prior art keywords
testosterone
formulation
aerosolized
sildenafil
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006535493A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007508381A5 (https=
Inventor
リード エム. ラブスアーメン
ロバート コール
ジェイムズ ブランチャード
ジェフリー シュースター
ローレンス リン
ジョン ティップファウォン
Original Assignee
アラダイム コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アラダイム コーポレーション filed Critical アラダイム コーポレーション
Publication of JP2007508381A publication Critical patent/JP2007508381A/ja
Publication of JP2007508381A5 publication Critical patent/JP2007508381A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/095Oxytocins; Vasopressins; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2278Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51Lyases (4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2006535493A 2003-10-14 2004-09-09 勃起障害治療のための方法および組成物 Pending JP2007508381A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/685,746 US7258850B2 (en) 1999-05-04 2003-10-14 Methods and compositions for treating erectile dysfunction
PCT/US2004/029374 WO2005039530A1 (en) 2003-10-14 2004-09-09 Methods and compositions for treating erectile dysfunction

Publications (2)

Publication Number Publication Date
JP2007508381A true JP2007508381A (ja) 2007-04-05
JP2007508381A5 JP2007508381A5 (https=) 2007-09-20

Family

ID=34520662

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006535493A Pending JP2007508381A (ja) 2003-10-14 2004-09-09 勃起障害治療のための方法および組成物

Country Status (5)

Country Link
US (3) US7258850B2 (https=)
EP (1) EP1677754A4 (https=)
JP (1) JP2007508381A (https=)
CA (1) CA2539845A1 (https=)
WO (1) WO2005039530A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7258850B2 (en) * 1999-05-04 2007-08-21 Aradigm Corporation Methods and compositions for treating erectile dysfunction
US7235625B2 (en) 1999-06-29 2007-06-26 Palatin Technologies, Inc. Multiple agent therapy for sexual dysfunction
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
AU2003903597A0 (en) * 2003-07-11 2003-07-24 Jakov Vaisman Treatment of premature ejaculation
EP1750766B1 (en) * 2004-05-11 2013-07-03 Emotional Brain B.V. Pharmaceutical formulations and uses thereof in the treatment of female sexual dysfunction
BRPI0514410A (pt) * 2004-08-23 2008-06-10 Mannkind Corp fornecimento pulmonar de inibidores de fosfodiesterase do tipo 5
EP1790343A1 (en) 2005-11-11 2007-05-30 Emotional Brain B.V. Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction
EP1925307A1 (en) 2006-11-03 2008-05-28 Emotional Brain B.V. Use of 3-alpha-androstanediol in the treatment of sexual dysfunction
WO2009091777A1 (en) * 2008-01-15 2009-07-23 Forest Laboratories Holdings Limited Nebivolol in the treatment of sexual dysfunction
EP2285362B1 (en) * 2008-06-19 2017-08-09 LTS LOHMANN Therapie-Systeme AG Composition for transdermal delivery of cationic active agents
WO2011156405A2 (en) * 2010-06-07 2011-12-15 Novadel Pharma Inc. Oral spray formulations and methods for administration of sildenafil
US20160151275A1 (en) * 2014-06-16 2016-06-02 James Kevin Shurtleff Method and devices for manufacturing and delivering of aerosolized formulations
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066084A1 (en) * 1999-05-04 2000-11-09 Aradigm Corporation Aerosol formulations and devices for increasing libido in women via acute testosterone administration
EP1097711A2 (en) * 1999-11-02 2001-05-09 Pfizer Limited Treatment of pulmonary hypertension
WO2002017963A2 (en) * 2000-09-01 2002-03-07 Pfizer Limited Modulators of intermediate conductance calcium-activated potassium (ikca) channel activity for treating sexual dysfunction
US20030017120A1 (en) * 2001-05-24 2003-01-23 Rabinowitz Joshua D. Delivery of erectile dysfunction drugs through an inhalation route
US20030144296A1 (en) * 1999-04-30 2003-07-31 Lilly Icos Llc Daily treatment for erectile dysfunction using a PDE5 inhibitor

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63500175A (ja) * 1985-05-22 1988-01-21 リポソ−ム テクノロジ−,インコ−ポレイテツド リポソ−ム吸入法および吸入システム
GB9114760D0 (en) 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
DK0567271T3 (da) 1992-04-20 1998-02-16 Sankyo Co Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
US5756071A (en) 1992-06-03 1998-05-26 Arrowdean Limited Method for nasally administering aerosols of therapeutic agents to enhance penetration of the blood brain barrier
JPH06211675A (ja) 1993-01-11 1994-08-02 Shiro Tezuka 山椒入り局部塗付液
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
US6395744B1 (en) * 1994-04-22 2002-05-28 Queen's University At Kingston Method and compositions for the treatment or amelioration of female sexual dysfunction
WO1995028930A1 (en) * 1994-04-22 1995-11-02 Pentech Pharmaceuticals, Inc. Dosage forms and method for ameliorating male erectile dysfunction
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
AU5719798A (en) 1996-12-31 1998-07-31 Inhale Therapeutic Systems, Inc. Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
CA2277801C (en) 1997-01-16 2002-10-15 Massachusetts Institute Of Technology Preparation of particles for inhalation
JP2001511160A (ja) 1997-02-05 2001-08-07 ヤゴ リサーチ アクチェンゲゼルシャフト 医学用エアゾール配合物
US6037346A (en) * 1997-10-28 2000-03-14 Vivus, Inc. Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US5877216A (en) * 1997-10-28 1999-03-02 Vivus, Incorporated Treatment of female sexual dysfunction
DE69831421T2 (de) * 1997-12-02 2006-06-22 Archimedes Development Ltd. Zusammensetzungen zur nasalen verabreichung
ES2234266T3 (es) * 1998-07-24 2005-06-16 Jago Research Ag Formulaciones medicas para aerosoles.
PL200941B1 (pl) * 1998-11-13 2009-02-27 Jagotec Ag Suchy proszkowy preparat inhalacyjny
US6455564B1 (en) 1999-01-06 2002-09-24 Pharmacia & Upjohn Company Method of treating sexual disturbances
US7258850B2 (en) * 1999-05-04 2007-08-21 Aradigm Corporation Methods and compositions for treating erectile dysfunction
US6632419B2 (en) * 1999-05-04 2003-10-14 Aradigm Corporation Increasing libido in humans via acute testosterone administration
US6579968B1 (en) * 1999-06-29 2003-06-17 Palatin Technologies, Inc. Compositions and methods for treatment of sexual dysfunction
US20030119714A1 (en) 2000-12-15 2003-06-26 Naylor Alasdair Mark Treatment of male sexual dysfunction
WO2004022128A2 (en) * 2002-09-06 2004-03-18 Chrysalis Technologies Incorporated Liquid aerosol formulations and aerosol generating devices and methods for generating aerosols
US20040204439A1 (en) * 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144296A1 (en) * 1999-04-30 2003-07-31 Lilly Icos Llc Daily treatment for erectile dysfunction using a PDE5 inhibitor
WO2000066084A1 (en) * 1999-05-04 2000-11-09 Aradigm Corporation Aerosol formulations and devices for increasing libido in women via acute testosterone administration
EP1097711A2 (en) * 1999-11-02 2001-05-09 Pfizer Limited Treatment of pulmonary hypertension
WO2002017963A2 (en) * 2000-09-01 2002-03-07 Pfizer Limited Modulators of intermediate conductance calcium-activated potassium (ikca) channel activity for treating sexual dysfunction
US20030017120A1 (en) * 2001-05-24 2003-01-23 Rabinowitz Joshua D. Delivery of erectile dysfunction drugs through an inhalation route

Also Published As

Publication number Publication date
EP1677754A4 (en) 2010-01-20
US20040208829A1 (en) 2004-10-21
US20080095718A1 (en) 2008-04-24
WO2005039530A1 (en) 2005-05-06
US7258850B2 (en) 2007-08-21
EP1677754A1 (en) 2006-07-12
CA2539845A1 (en) 2005-05-06
US20080008661A1 (en) 2008-01-10

Similar Documents

Publication Publication Date Title
US20080008661A1 (en) Methods and compositions for treating erectile dysfunction
US6428769B1 (en) Acute testosterone administration
JP2022088592A (ja) アルコール使用障害の処置のための組成物、装置、及び、方法
HU227519B1 (en) Synergic pharmaceutical composition containing combination of formoterol and budesonide
WO2000047203A1 (en) Formulation and system for intra-oral delivery of pharmaceutical agents
JP2002500192A (ja) AspB28−ヒトインシュリンの投与方法
JP2002532537A (ja) 肺への薬物送達
US20020013320A1 (en) Use of growth hormone secretagogues to treat systemic lupus erythematosus and inflammatory bowel disease
US6632419B2 (en) Increasing libido in humans via acute testosterone administration
WO2021211858A1 (en) Inhalable formulation of a solution containing tiotropium bromide and olodaterol
KR20060011783A (ko) 데하이드로에피안드로스테론 스테로이드 및항-무스카린제와 더불어 호흡기 및 폐 질환을 치료하기위한 조성물, 제제 및 키트
RS63866B1 (sr) Intranazalne formulacije epinefrina i postupci za lečenje bolesti
US20160354444A1 (en) Compositions and methods for the treatment of sexual dysfunction
CY1490A (en) Improvements in or relating to nasal pharmaceutical compositions
WO2021003277A1 (en) Exenatide compositions for pulmonary administration and use thereof
EP1175204A1 (en) Aerosol formulations and devices for increasing libido in women via acute testosterone administration
JPH01501708A (ja) アミノ酸の経鼻投与
Dugger III et al. Immediate-Immediate Release (I2R) Lingual or Buccal Spray Formulations for Transmucosal Delivery of Drug Substances
JP2025160345A (ja) 薬学的組成物
US20240408003A1 (en) Compositions, devices and methods for the treatment of alcohol use disorder
HU191512B (en) Process for production of dosed through the nose medical preparatives containing ergot-alcaloids
US7893044B2 (en) Composition and method for altering levels of or sensitivity to adenosine with analogs of dehydroepiandrosterone
WO2021211854A1 (en) Inhalable formulation of a solution containing tiotropium bromide
WO2021211850A1 (en) Inhalable formulation of a solution containing olodaterol
Ranade Inhalation therapy: new delivery systems

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070801

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070801

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100830

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110221