JP2007502283A

JP2007502283A - メラニン凝集ホルモン受容体アンタゴニスト

メラニン凝集ホルモン受容体アンタゴニスト Download PDF

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Publication number: JP2007502283A
Authority: JP; Japan
Prior art keywords: group; hydrogen; alkyl; aryl; ethyl
Prior art date: 2003-08-13
Legal status : Withdrawn

Application number

JP2006523322A

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English (en)

Japanese (ja)

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JP2007502283A5 (enExample

Inventor

ポール・テンペスト

クリストファー・ハルム

ヴ・マ

Original Assignee

アムジェンインコーポレイテッド

Priority date

2003-08-13

Filing date

2004-08-11

Publication date

2007-02-08

2004-08-11 Application filed by アムジェンインコーポレイテッド filed Critical アムジェンインコーポレイテッド

2007-02-08 Publication of JP2007502283A publication Critical patent/JP2007502283A/ja

2007-06-28 Publication of JP2007502283A5 publication Critical patent/JP2007502283A5/ja

Status Withdrawn legal-status Critical Current

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229940122023 Melanin concentrating hormone receptor antagonist Drugs 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 64
150000003839 salts Chemical class 0.000 claims abstract description 47
238000000034 method Methods 0.000 claims abstract description 37
101800002739 Melanin-concentrating hormone Proteins 0.000 claims abstract description 21
ORRDHOMWDPJSNL-UHFFFAOYSA-N melanin concentrating hormone Chemical compound N1C(=O)C(C(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CCSC)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(NC(=O)C(N)CC(O)=O)C(C)O)CCSC)CSSCC(C(=O)NC(CC=2C3=CC=CC=C3NC=2)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)C)C(O)=O)NC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C1CC1=CC=C(O)C=C1 ORRDHOMWDPJSNL-UHFFFAOYSA-N 0.000 claims abstract description 21
239000000651 prodrug Substances 0.000 claims abstract description 19
229940002612 prodrug Drugs 0.000 claims abstract description 19
238000011282 treatment Methods 0.000 claims abstract description 12
230000001404 mediated effect Effects 0.000 claims abstract description 5
230000002265 prevention Effects 0.000 claims abstract description 4
102000047659 melanin-concentrating hormone Human genes 0.000 claims abstract 2
-1 aralkenyl Chemical group 0.000 claims description 1773
125000000217 alkyl group Chemical group 0.000 claims description 262
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 195
229910052739 hydrogen Inorganic materials 0.000 claims description 194
239000001257 hydrogen Substances 0.000 claims description 194
125000003118 aryl group Chemical group 0.000 claims description 181
150000002431 hydrogen Chemical class 0.000 claims description 179
125000000753 cycloalkyl group Chemical group 0.000 claims description 161
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 160
229910052757 nitrogen Inorganic materials 0.000 claims description 153
125000003710 aryl alkyl group Chemical group 0.000 claims description 136
125000005843 halogen group Chemical group 0.000 claims description 118
125000000623 heterocyclic group Chemical group 0.000 claims description 114
125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 111
125000004183 alkoxy alkyl group Chemical group 0.000 claims description 110
125000003545 alkoxy group Chemical group 0.000 claims description 109
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 105
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 105
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 102
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 101
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 99
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 96
125000004181 carboxyalkyl group Chemical group 0.000 claims description 90
125000004104 aryloxy group Chemical group 0.000 claims description 89
125000002768 hydroxyalkyl group Chemical group 0.000 claims description 89
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 83
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 83
125000001624 naphthyl group Chemical group 0.000 claims description 81
239000004305 biphenyl Chemical group 0.000 claims description 80
235000010290 biphenyl Nutrition 0.000 claims description 80
125000001424 substituent group Chemical group 0.000 claims description 79
125000004093 cyano group Chemical group *C#N 0.000 claims description 77
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims description 77
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 73
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 73
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 73
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 71
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 71
125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 66
229920006395 saturated elastomer Polymers 0.000 claims description 66
125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 64
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 63
125000006232 ethoxy propyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 50
125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 50
125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims description 50
125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 50
125000005815 pentoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims description 49
125000004043 oxo group Chemical group O=* 0.000 claims description 47
125000001072 heteroaryl group Chemical group 0.000 claims description 44
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 40
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 40
125000006233 propoxy propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 39
125000006225 propoxyethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 39
125000001041 indolyl group Chemical group 0.000 claims description 36
125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 claims description 33
125000000719 pyrrolidinyl group Chemical group 0.000 claims description 33
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 30
125000003386 piperidinyl group Chemical group 0.000 claims description 30
125000001309 chloro group Chemical group Cl* 0.000 claims description 28
125000001153 fluoro group Chemical group F* 0.000 claims description 28
125000001246 bromo group Chemical group Br* 0.000 claims description 27
UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims description 24
125000003342 alkenyl group Chemical group 0.000 claims description 23
125000006226 butoxyethyl group Chemical group 0.000 claims description 23
125000002541 furyl group Chemical group 0.000 claims description 22
125000002883 imidazolyl group Chemical group 0.000 claims description 22
125000000842 isoxazolyl group Chemical group 0.000 claims description 22
125000001715 oxadiazolyl group Chemical group 0.000 claims description 22
125000002971 oxazolyl group Chemical group 0.000 claims description 22
125000003226 pyrazolyl group Chemical group 0.000 claims description 22
125000000168 pyrrolyl group Chemical group 0.000 claims description 22
125000003831 tetrazolyl group Chemical group 0.000 claims description 22
125000000335 thiazolyl group Chemical group 0.000 claims description 22
125000001544 thienyl group Chemical group 0.000 claims description 22
125000001425 triazolyl group Chemical group 0.000 claims description 22
BWCDLEQTELFBAW-UHFFFAOYSA-N 3h-dioxazole Chemical compound N1OOC=C1 BWCDLEQTELFBAW-UHFFFAOYSA-N 0.000 claims description 21
125000002047 benzodioxolyl group Chemical group O1OC(C2=C1C=CC=C2)* 0.000 claims description 21
125000001786 isothiazolyl group Chemical group 0.000 claims description 21
208000008589 Obesity Diseases 0.000 claims description 18
125000004350 aryl cycloalkyl group Chemical group 0.000 claims description 18
125000004446 heteroarylalkyl group Chemical group 0.000 claims description 18
235000020824 obesity Nutrition 0.000 claims description 18
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 17
125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims description 17
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 17
125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims description 16
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 16
125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims description 14
125000005186 naphthyloxy group Chemical group C1(=CC=CC2=CC=CC=C12)O* 0.000 claims description 12
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 12
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 11
125000004611 dihydroisoindolyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims description 11
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
125000000304 alkynyl group Chemical group 0.000 claims description 10
125000004369 butenyl group Chemical group C(=CCC)* 0.000 claims description 9
125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims description 9
239000008194 pharmaceutical composition Substances 0.000 claims description 9
125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims description 9
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 8
239000002671 adjuvant Substances 0.000 claims description 8
125000004744 butyloxycarbonyl group Chemical group 0.000 claims description 8
125000000480 butynyl group Chemical group [*]C#CC([H])([H])C([H])([H])[H] 0.000 claims description 8
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 8
125000005935 hexyloxycarbonyl group Chemical group 0.000 claims description 8
125000004368 propenyl group Chemical group C(=CC)* 0.000 claims description 8
125000004742 propyloxycarbonyl group Chemical group 0.000 claims description 8
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 8
125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 7
125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 7
208000030814 Eating disease Diseases 0.000 claims description 7
208000019454 Feeding and Eating disease Diseases 0.000 claims description 7
125000005044 dihydroquinolinyl group Chemical group N1(CC=CC2=CC=CC=C12)* 0.000 claims description 7
125000005980 hexynyl group Chemical group 0.000 claims description 7
125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims description 7
125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 claims description 7
125000001148 pentyloxycarbonyl group Chemical group 0.000 claims description 7
125000005981 pentynyl group Chemical group 0.000 claims description 7
125000004351 phenylcyclohexyl group Chemical group C1(=CC=CC=C1)C1(CCCCC1)* 0.000 claims description 7
125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims description 7
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 7
UWYZHKAOTLEWKK-UHFFFAOYSA-N tetrahydro-isoquinoline Natural products C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims description 7
206010006550 Bulimia nervosa Diseases 0.000 claims description 6
239000003085 diluting agent Substances 0.000 claims description 6
235000014632 disordered eating Nutrition 0.000 claims description 6
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims description 6
125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 6
206010020772 Hypertension Diseases 0.000 claims description 5
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
239000003937 drug carrier Substances 0.000 claims description 4
208000032841 Bulimia Diseases 0.000 claims description 3
206010019280 Heart failures Diseases 0.000 claims description 3
238000011321 prophylaxis Methods 0.000 claims description 3
125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims description 2
208000019901 Anxiety disease Diseases 0.000 claims description 2
206010007559 Cardiac failure congestive Diseases 0.000 claims description 2
206010008111 Cerebral haemorrhage Diseases 0.000 claims description 2
206010010904 Convulsion Diseases 0.000 claims description 2
230000036506 anxiety Effects 0.000 claims description 2
230000001850 reproductive effect Effects 0.000 claims description 2
208000012201 sexual and gender identity disease Diseases 0.000 claims description 2
208000015891 sexual disease Diseases 0.000 claims description 2
208000019116 sleep disease Diseases 0.000 claims description 2
125000004356 hydroxy functional group Chemical group O* 0.000 claims 62
125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 20
125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 10
125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
SIIVUJQTZGMQAY-UHFFFAOYSA-N 1-[6-phenoxy-3-phenyl-2-(1,2,3,4-tetrahydronaphthalen-1-yloxy)phenoxy]naphthalene Chemical group O(C1=CC=CC=C1)C1=C(C(=C(C=C1)C1=CC=CC=C1)OC1CCCC2=CC=CC=C12)OC1=CC=CC2=CC=CC=C12 SIIVUJQTZGMQAY-UHFFFAOYSA-N 0.000 claims 5
NOJVDSZMTUASRT-UHFFFAOYSA-N 1-[2-(3,4-dimethylphenoxy)-5-(2-methyl-2-pyrrolidin-1-ylpyrrolidine-1-carbonyl)phenyl]-3-phenylurea Chemical compound C1=C(C)C(C)=CC=C1OC1=CC=C(C(=O)N2C(CCC2)(C)N2CCCC2)C=C1NC(=O)NC1=CC=CC=C1 NOJVDSZMTUASRT-UHFFFAOYSA-N 0.000 claims 2
125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 2
IGYFZBXKJNFUNF-UHFFFAOYSA-N 1-[2-(3,4-dimethylphenoxy)-5-[(2-pyrrolidin-1-ylethylamino)methyl]phenyl]-3-(3-fluorophenyl)urea Chemical compound C1=C(C)C(C)=CC=C1OC(C(=C1)NC(=O)NC=2C=C(F)C=CC=2)=CC=C1CNCCN1CCCC1 IGYFZBXKJNFUNF-UHFFFAOYSA-N 0.000 claims 1
QDKWLJJOYIFEBS-UHFFFAOYSA-N 1-fluoro-4-$l^{1}-oxidanylbenzene Chemical group [O]C1=CC=C(F)C=C1 QDKWLJJOYIFEBS-UHFFFAOYSA-N 0.000 claims 1
125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 1
125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 1
125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 1
DLYZTARPCXSNNB-UHFFFAOYSA-N 3-[(3-fluorophenyl)carbamoylamino]-4-(3-methylphenoxy)-n-(2-pyrrolidin-1-ylethyl)benzamide Chemical compound CC1=CC=CC(OC=2C(=CC(=CC=2)C(=O)NCCN2CCCC2)NC(=O)NC=2C=C(F)C=CC=2)=C1 DLYZTARPCXSNNB-UHFFFAOYSA-N 0.000 claims 1
125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
NOHYKQAGOKRKCR-UHFFFAOYSA-N 4-(3,4-dimethylphenoxy)-3-[(4-phenylphenyl)carbamoylamino]-n-(2-pyrrolidin-1-ylethyl)benzamide Chemical compound C1=C(C)C(C)=CC=C1OC1=CC=C(C(=O)NCCN2CCCC2)C=C1NC(=O)NC1=CC=C(C=2C=CC=CC=2)C=C1 NOHYKQAGOKRKCR-UHFFFAOYSA-N 0.000 claims 1
125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
125000004861 4-isopropyl phenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 1
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
YUFJEALKMHLNLU-UHFFFAOYSA-N n-[2-(3,4-dimethylphenoxy)-5-(2-pyrrolidin-1-ylethylcarbamoyl)phenyl]-1,3-dihydroisoindole-2-carboxamide Chemical compound C1=C(C)C(C)=CC=C1OC1=CC=C(C(=O)NCCN2CCCC2)C=C1NC(=O)N1CC2=CC=CC=C2C1 YUFJEALKMHLNLU-UHFFFAOYSA-N 0.000 claims 1
NYRXUFQAPFKBTJ-UHFFFAOYSA-N n-[2-(3,4-dimethylphenoxy)-5-(2-pyrrolidin-1-ylethylcarbamoyl)phenyl]naphthalene-2-carboxamide Chemical compound C1=C(C)C(C)=CC=C1OC1=CC=C(C(=O)NCCN2CCCC2)C=C1NC(=O)C1=CC=C(C=CC=C2)C2=C1 NYRXUFQAPFKBTJ-UHFFFAOYSA-N 0.000 claims 1
125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 52
125000004432 carbon atom Chemical group C* 0.000 description 34
102000029828 Melanin-concentrating hormone receptor Human genes 0.000 description 32
108010047068 Melanin-concentrating hormone receptor Proteins 0.000 description 32
235000002639 sodium chloride Nutrition 0.000 description 20
102400001132 Melanin-concentrating hormone Human genes 0.000 description 19
206010033307 Overweight Diseases 0.000 description 15
102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 13
108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 13
239000002464 receptor antagonist Substances 0.000 description 13
229940044551 receptor antagonist Drugs 0.000 description 13
239000000203 mixture Substances 0.000 description 10
230000027455 binding Effects 0.000 description 9
125000004433 nitrogen atom Chemical group N* 0.000 description 9
125000004434 sulfur atom Chemical group 0.000 description 9
101150104680 MCH1 gene Proteins 0.000 description 8
101100382379 Rattus norvegicus Cap1 gene Proteins 0.000 description 8
239000002253 acid Substances 0.000 description 8
125000004430 oxygen atom Chemical group O* 0.000 description 8
102000005962 receptors Human genes 0.000 description 8
108020003175 receptors Proteins 0.000 description 8
125000004390 alkyl sulfonyl group Chemical group 0.000 description 7
125000002911 monocyclic heterocycle group Chemical group 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
241000699670 Mus sp. Species 0.000 description 6
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
125000002252 acyl group Chemical group 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
208000035475 disorder Diseases 0.000 description 6
238000000338 in vitro Methods 0.000 description 6
229910052717 sulfur Inorganic materials 0.000 description 6
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 5
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 5
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 5
125000004414 alkyl thio group Chemical group 0.000 description 5
125000003277 amino group Chemical group 0.000 description 5
230000002950 deficient Effects 0.000 description 5
230000000694 effects Effects 0.000 description 5
125000004438 haloalkoxy group Chemical group 0.000 description 5
125000001188 haloalkyl group Chemical group 0.000 description 5
230000002401 inhibitory effect Effects 0.000 description 5
239000000725 suspension Substances 0.000 description 5
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