JP2007500158A - Lxrアゴニストを用いる炎症性腸疾患の治療方法 - Google Patents

Lxrアゴニストを用いる炎症性腸疾患の治療方法 Download PDF

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Publication number
JP2007500158A
JP2007500158A JP2006521514A JP2006521514A JP2007500158A JP 2007500158 A JP2007500158 A JP 2007500158A JP 2006521514 A JP2006521514 A JP 2006521514A JP 2006521514 A JP2006521514 A JP 2006521514A JP 2007500158 A JP2007500158 A JP 2007500158A
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Japan
Prior art keywords
alkyl
group
formula
compound
aryl
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Pending
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JP2006521514A
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English (en)
Japanese (ja)
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JP2007500158A5 (https=
Inventor
幸夫 後藤
日出雄 吉川
美弥 木下
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Glaxo Group Ltd
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Glaxo Group Ltd
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Publication of JP2007500158A publication Critical patent/JP2007500158A/ja
Publication of JP2007500158A5 publication Critical patent/JP2007500158A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2006521514A 2003-07-28 2004-07-27 Lxrアゴニストを用いる炎症性腸疾患の治療方法 Pending JP2007500158A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49061403P 2003-07-28 2003-07-28
PCT/EP2004/008426 WO2005013946A2 (en) 2003-07-28 2004-07-27 Methods of treatment inflammatory bowel with lxr agonists

Publications (2)

Publication Number Publication Date
JP2007500158A true JP2007500158A (ja) 2007-01-11
JP2007500158A5 JP2007500158A5 (https=) 2007-08-02

Family

ID=34135107

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006521514A Pending JP2007500158A (ja) 2003-07-28 2004-07-27 Lxrアゴニストを用いる炎症性腸疾患の治療方法

Country Status (4)

Country Link
US (1) US20060205819A1 (https=)
EP (1) EP1653938A2 (https=)
JP (1) JP2007500158A (https=)
WO (1) WO2005013946A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7247748B2 (en) 2002-03-27 2007-07-24 Smithkline Corporation Amide compounds and methods of using the same
AU2003226094A1 (en) 2002-03-27 2003-10-13 Smithkline Beecham Corporation Compounds and methods
EP1487776A4 (en) 2002-03-27 2005-05-25 Smithkline Beecham Corp ACID COMPOUNDS AND ESTERS AND METHODS OF USE THEREOF
ATE453389T1 (de) 2002-03-27 2010-01-15 Smithkline Beecham Corp Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen
CN109071516B (zh) 2015-12-15 2021-08-31 阿斯利康(瑞典)有限公司 新颖的化合物
WO2017182981A1 (en) 2016-04-20 2017-10-26 Washington University Ppar agonist or lxr agonist for use in the treatment of systemic lupus erythematosus by modulation of lap activity
JP2020524660A (ja) 2017-06-14 2020-08-20 アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag Ror−ガンマモジュレーターとして有用な2,3−ジヒドロイソインドール−1−カルボキサミド

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000054759A2 (en) * 1999-03-15 2000-09-21 Tularik Inc. Lxr modulators
WO2002024632A2 (en) * 2000-09-18 2002-03-28 Glaxo Group Limited Substituted aminopropoxyaryl derivatives useful as agonists for lxr

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009091A1 (en) * 2002-06-17 2004-01-29 Glaxo Group Limited Purine derivatives as liver x receptor agonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000054759A2 (en) * 1999-03-15 2000-09-21 Tularik Inc. Lxr modulators
WO2002024632A2 (en) * 2000-09-18 2002-03-28 Glaxo Group Limited Substituted aminopropoxyaryl derivatives useful as agonists for lxr

Also Published As

Publication number Publication date
EP1653938A2 (en) 2006-05-10
WO2005013946A3 (en) 2005-04-07
US20060205819A1 (en) 2006-09-14
WO2005013946A2 (en) 2005-02-17

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