JP2007500158A5 - - Google Patents
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- Publication number
- JP2007500158A5 JP2007500158A5 JP2006521514A JP2006521514A JP2007500158A5 JP 2007500158 A5 JP2007500158 A5 JP 2007500158A5 JP 2006521514 A JP2006521514 A JP 2006521514A JP 2006521514 A JP2006521514 A JP 2006521514A JP 2007500158 A5 JP2007500158 A5 JP 2007500158A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- aryl
- formula
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000004404 heteroalkyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 125000003302 alkenyloxy group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000004001 thioalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49061403P | 2003-07-28 | 2003-07-28 | |
| PCT/EP2004/008426 WO2005013946A2 (en) | 2003-07-28 | 2004-07-27 | Methods of treatment inflammatory bowel with lxr agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007500158A JP2007500158A (ja) | 2007-01-11 |
| JP2007500158A5 true JP2007500158A5 (https=) | 2007-08-02 |
Family
ID=34135107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521514A Pending JP2007500158A (ja) | 2003-07-28 | 2004-07-27 | Ｌｘｒアゴニストを用いる炎症性腸疾患の治療方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20060205819A1 (https=) |
| EP (1) | EP1653938A2 (https=) |
| JP (1) | JP2007500158A (https=) |
| WO (1) | WO2005013946A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7247748B2 (en) | 2002-03-27 | 2007-07-24 | Smithkline Corporation | Amide compounds and methods of using the same |
| AU2003226094A1 (en) | 2002-03-27 | 2003-10-13 | Smithkline Beecham Corporation | Compounds and methods |
| EP1487776A4 (en) | 2002-03-27 | 2005-05-25 | Smithkline Beecham Corp | ACID COMPOUNDS AND ESTERS AND METHODS OF USE THEREOF |
| ATE453389T1 (de) | 2002-03-27 | 2010-01-15 | Smithkline Beecham Corp | Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen |
| CN109071516B (zh) | 2015-12-15 | 2021-08-31 | 阿斯利康(瑞典)有限公司 | 新颖的化合物 |
| WO2017182981A1 (en) | 2016-04-20 | 2017-10-26 | Washington University | Ppar agonist or lxr agonist for use in the treatment of systemic lupus erythematosus by modulation of lap activity |
| JP2020524660A (ja) | 2017-06-14 | 2020-08-20 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | Ｒｏｒ−ガンマモジュレーターとして有用な２，３−ジヒドロイソインドール−１−カルボキサミド |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| JP2004509161A (ja) * | 2000-09-18 | 2004-03-25 | グラクソ グループ リミテッド | Ｌｘｒのアゴニストとして有用な置換アミノプロポキシアリール誘導体 |
| WO2004009091A1 (en) * | 2002-06-17 | 2004-01-29 | Glaxo Group Limited | Purine derivatives as liver x receptor agonists |
-
2004
- 2004-07-27 EP EP04763551A patent/EP1653938A2/en not_active Withdrawn
- 2004-07-27 JP JP2006521514A patent/JP2007500158A/ja active Pending
- 2004-07-27 US US10/566,637 patent/US20060205819A1/en not_active Abandoned
- 2004-07-27 WO PCT/EP2004/008426 patent/WO2005013946A2/en not_active Ceased
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