JP2007190369A5 - - Google Patents
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- Publication number
- JP2007190369A5 JP2007190369A5 JP2006337295A JP2006337295A JP2007190369A5 JP 2007190369 A5 JP2007190369 A5 JP 2007190369A5 JP 2006337295 A JP2006337295 A JP 2006337295A JP 2006337295 A JP2006337295 A JP 2006337295A JP 2007190369 A5 JP2007190369 A5 JP 2007190369A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- eluting article
- drug eluting
- pharmacologically active
- active compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940079593 drug Drugs 0.000 claims 54
- 239000003814 drug Substances 0.000 claims 54
- 150000001875 compounds Chemical class 0.000 claims 43
- 229920000249 biocompatible polymer Polymers 0.000 claims 38
- 229920000642 polymer Polymers 0.000 claims 26
- 238000010828 elution Methods 0.000 claims 5
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 4
- 229920000954 Polyglycolide Polymers 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- -1 poly (alkyl methacrylate Chemical compound 0.000 claims 4
- 239000004633 polyglycolic acid Substances 0.000 claims 4
- 230000003110 anti-inflammatory effect Effects 0.000 claims 3
- 230000002965 anti-thrombogenic effect Effects 0.000 claims 3
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 3
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 3
- 208000037803 restenosis Diseases 0.000 claims 3
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 3
- 229960002930 sirolimus Drugs 0.000 claims 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 102000009123 Fibrin Human genes 0.000 claims 2
- 108010073385 Fibrin Proteins 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- 102000008946 Fibrinogen Human genes 0.000 claims 2
- 108010049003 Fibrinogen Proteins 0.000 claims 2
- 229920002732 Polyanhydride Polymers 0.000 claims 2
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 230000000259 anti-tumor effect Effects 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 2
- 229950003499 fibrin Drugs 0.000 claims 2
- 229940012952 fibrinogen Drugs 0.000 claims 2
- 230000001506 immunosuppresive effect Effects 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 2
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 2
- 229920000218 poly(hydroxyvalerate) Polymers 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- 239000002745 poly(ortho ester) Substances 0.000 claims 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- 229920002721 polycyanoacrylate Polymers 0.000 claims 2
- 239000004626 polylactic acid Substances 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- QDLHCMPXEPAAMD-QAIWCSMKSA-N wortmannin Chemical compound C1([C@]2(C)C3=C(C4=O)OC=C3C(=O)O[C@@H]2COC)=C4[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O QDLHCMPXEPAAMD-QAIWCSMKSA-N 0.000 claims 2
- QDLHCMPXEPAAMD-UHFFFAOYSA-N wortmannin Natural products COCC1OC(=O)C2=COC(C3=O)=C2C1(C)C1=C3C2CCC(=O)C2(C)CC1OC(C)=O QDLHCMPXEPAAMD-UHFFFAOYSA-N 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 229940116355 PI3 kinase inhibitor Drugs 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003872 anastomosis Effects 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 150000002605 large molecules Chemical class 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 claims 1
- KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 claims 1
- 229960005330 pimecrolimus Drugs 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229920002477 rna polymer Polymers 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- YYSFXUWWPNHNAZ-PKJQJFMNSA-N umirolimus Chemical compound C1[C@@H](OC)[C@H](OCCOCC)CC[C@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 YYSFXUWWPNHNAZ-PKJQJFMNSA-N 0.000 claims 1
- CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 1
- 229950009819 zotarolimus Drugs 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/300,821 US10029034B2 (en) | 2005-12-15 | 2005-12-15 | Drug-eluting articles with improved drug release profiles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007190369A JP2007190369A (ja) | 2007-08-02 |
| JP2007190369A5 true JP2007190369A5 (https=) | 2009-03-26 |
Family
ID=37964483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006337295A Pending JP2007190369A (ja) | 2005-12-15 | 2006-12-14 | 改善された薬剤放出特性を備えた薬剤溶出物品 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10029034B2 (https=) |
| EP (1) | EP1808167B1 (https=) |
| JP (1) | JP2007190369A (https=) |
| CA (1) | CA2571302C (https=) |
| ES (1) | ES2686778T3 (https=) |
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| US9801982B2 (en) | 2004-09-28 | 2017-10-31 | Atrium Medical Corporation | Implantable barrier device |
| US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| US9012506B2 (en) | 2004-09-28 | 2015-04-21 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| WO2006036984A2 (en) * | 2004-09-28 | 2006-04-06 | Atrium Medical Corporation | Stand-alone film and methods for making the same |
| US8263102B2 (en) | 2004-09-28 | 2012-09-11 | Atrium Medical Corporation | Drug delivery coating for use with a stent |
| US9427423B2 (en) | 2009-03-10 | 2016-08-30 | Atrium Medical Corporation | Fatty-acid based particles |
| US9278161B2 (en) | 2005-09-28 | 2016-03-08 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
| CA2626030A1 (en) | 2005-10-15 | 2007-04-26 | Atrium Medical Corporation | Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings |
| US7671095B2 (en) | 2006-05-31 | 2010-03-02 | The Trustees Of The Boston University | Films and particles |
| US20070298067A1 (en) * | 2006-06-22 | 2007-12-27 | Boston Scientific Scimed, Inc. | Control release drug coating for medical devices |
| US9492596B2 (en) | 2006-11-06 | 2016-11-15 | Atrium Medical Corporation | Barrier layer with underlying medical device and one or more reinforcing support structures |
| WO2008057328A2 (en) | 2006-11-06 | 2008-05-15 | Atrium Medical Corporation | Tissue separating device with reinforced support for anchoring mechanisms |
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| US20080255658A1 (en) * | 2007-04-12 | 2008-10-16 | Medtronic Vascular, Inc. | Degradation Associated Drug Delivery for Drug Eluting Stent and Medical Device Coatings |
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| WO2009140131A2 (en) * | 2008-05-13 | 2009-11-19 | The Trustees Of Boston University | Compliant composites for application of drug-eluting coatings to tissue surfaces |
| US8697113B2 (en) | 2008-05-21 | 2014-04-15 | Abbott Cardiovascular Systems Inc. | Coating comprising a terpolymer comprising caprolactone and glycolide |
| KR101087088B1 (ko) * | 2008-12-29 | 2011-11-25 | 한국과학기술연구원 | 나노 구조 패턴을 갖는 약물 방출용 스텐트의 제조방법 및 이로부터 제조된 약물 방출용 스텐트 |
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| JP5597625B2 (ja) | 2009-03-02 | 2014-10-01 | 株式会社日本ステントテクノロジー | 薬剤溶出性ステント |
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| WO2012009707A2 (en) | 2010-07-16 | 2012-01-19 | Atrium Medical Corporation | Composition and methods for altering the rate of hydrolysis of cured oil-based materials |
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| KR20120135689A (ko) * | 2011-06-07 | 2012-12-17 | (주) 태웅메디칼 | 약물 방출 스텐트 코팅제의 제조방법 및 이에 의해 제조된 약물 방출 스텐트 코팅제 |
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| CN107427668B (zh) * | 2015-01-22 | 2021-09-03 | 因特尔赛克特耳鼻喉公司 | 药物涂覆的气囊 |
| BR112017026746B1 (pt) | 2015-06-18 | 2023-11-28 | Acuitybio Corporation | Composições de liberação de fármacos implantáveis e uso de uma mistura compreendendo copolímero de plga, peg 8000 e paclitaxel |
| JP2017144110A (ja) | 2016-02-18 | 2017-08-24 | テルモ株式会社 | 処置方法、および医療装置 |
| CN111372645A (zh) * | 2017-11-22 | 2020-07-03 | 泰尔茂株式会社 | 药物施用器械及药物层的形成方法 |
| CN111542364B (zh) * | 2017-12-27 | 2022-07-15 | 株式会社钟化 | 导管及其制造方法 |
| KR20260007295A (ko) | 2018-05-24 | 2026-01-13 | 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 | 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치 |
| US11690806B2 (en) | 2018-05-24 | 2023-07-04 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
| US11689849B2 (en) | 2018-05-24 | 2023-06-27 | Nureva, Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| KR102402859B1 (ko) * | 2020-06-17 | 2022-05-30 | 한국과학기술연구원 | 3차원으로 연결된 유연한 나노 구조 필름을 포함하는 약물 방출용 스텐트의 제조 방법 및 이에 의해 제조된 약물 방출용 스텐트 |
| KR102290367B1 (ko) * | 2020-08-28 | 2021-08-19 | (주)솔시온바이오메디칼 | 기공 내에 생리활성화 물질을 함유한 기공성 다층의 관형 구조체 |
| BR112023022439A2 (pt) | 2021-04-26 | 2023-12-26 | Celanese Eva Performance Polymers Llc | Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular |
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| SE0000363A0 (sv) * | 2000-02-04 | 2001-08-05 | Zoucas Kirurgkonsult Ab | Belagd medicinsk anordning |
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| AU2003257179A1 (en) | 2002-08-02 | 2004-02-23 | Gp Medical | Drug-loaded biological material chemically treated with genipin |
| EP1539270A1 (en) | 2002-09-18 | 2005-06-15 | Medtronic Vascular, Inc. | Controllable drug releasing gradient coatings for medical devices |
| US20050070989A1 (en) * | 2002-11-13 | 2005-03-31 | Whye-Kei Lye | Medical devices having porous layers and methods for making the same |
| WO2004108129A1 (ja) | 2003-06-09 | 2004-12-16 | Cardiovascular Institute, Ltd. | 幹細胞侵入防止薬 |
| WO2004110315A1 (en) * | 2003-06-16 | 2004-12-23 | Nanyang Technological University | Polymeric stent and method of manufacture |
| EP1638624B1 (en) | 2003-06-19 | 2013-10-30 | Vascular Therapies, LLC | Vascular closure device |
| US7875282B2 (en) | 2004-03-22 | 2011-01-25 | Cordis Corporation | Coated medical device for local vascular delivery of Panzem® in combination with rapamycin to prevent restenosis following vascular injury |
| US20050232965A1 (en) | 2004-04-15 | 2005-10-20 | Robert Falotico | Local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque |
| KR20080008364A (ko) | 2005-05-05 | 2008-01-23 | 헤모텍 아게 | 관 스텐트의 전면 코팅 |
| US20060275341A1 (en) * | 2005-06-02 | 2006-12-07 | Miv Therapeutics Inc. | Thin foam coating comprising discrete, closed-cell capsules |
-
2005
- 2005-12-15 US US11/300,821 patent/US10029034B2/en active Active
-
2006
- 2006-12-12 EP EP06256316.8A patent/EP1808167B1/en not_active Not-in-force
- 2006-12-12 ES ES06256316.8T patent/ES2686778T3/es active Active
- 2006-12-14 JP JP2006337295A patent/JP2007190369A/ja active Pending
- 2006-12-14 CA CA2571302A patent/CA2571302C/en active Active
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