JP2012526612A - カプロラクトン及びグリコリドを含むターポリマーを含むコーティング - Google Patents
カプロラクトン及びグリコリドを含むターポリマーを含むコーティング Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
Abstract
【選択図】図2
Description
これは、2008年5月21日に出願された米国特許出願第12/124,991号の一部継続出願であり、前記出願の教示は参照により全体が本明細書に組み込まれる。
[定義]
[ターポリマー組成]
[非晶質ポリマー]
非晶質ポリ(D,L−ラクチド)(PDLA)、
約30モル%以上のD,L−ラクチド含量を有する非晶質ポリ(L−ラクチド−co−D,L−ラクチド)(PLLLA)、
約10〜約50モル%のグリコリド含量を有する非晶質ポリ(D,L−ラクチド−co−グリコリド)(PDLGA)
約70モル%以下のL−ラクチド含量を有する非晶質ポリ(L−ラクチド−co−グリコリド)(PLLGA)
約70モル%以下のグリコリド含量を有する非晶質ポリ(グリコリド−co−カプロラクトン)(PGACL)
約70モル%以下のカプロラクトン含量を有する非晶質ポリ(D,L−ラクチド−co−カプロラクトン)(PDLACL)
70モル%を下回るが30モル%を上回るL−ラクチド含量を有する非晶質ポリ(L−ラクチド−co−カプロラクトン)(PLLACL)
グリコリド、D,L−ラクチド、及び/又はL−ラクチドを有する炭酸トリメチレンの非晶質コポリマー、並びに
約65モル%以下のL−ラクチド含量を有する非晶質PDLGA−CL及びPLLA−GA−CLターポリマーが含まれるが、これらに限定されない。
[生物学的活性剤]
[コーティング構築物]
(1)プライマー層;
(2)少なくとも1つのポリマーを含む薬剤−ポリマー層(薬剤−ポリマー層)又は、或いは、ポリマーを含まない薬剤層であってもよい貯留層(「マトリックス層」又は「薬剤マトリックス」とも呼ばれる);
(3)放出制御層(「律速層」とも呼ばれる);
(4)トップコート層;及び/又は
(5)仕上げコート層。
[埋め込み型装置の製作方法]
[障害の治療又は予防方法]
Claims (31)
- カプロラクトン、グリコリド及び第3のモノマーを含むターポリマーを含む層を含むコーティングを備える埋め込み型装置であって、
ターポリマーが、カプロラクトンが約20%以上、及びグリコリドが約10%以上であるモル組成を有し、
コーティングが、約5ミクロン以下の厚さを有し、そして、埋め込み型装置の配置後6カ月の期間内に、コーティングが約80%以上の質量損失を有する分解又は吸収速度を有する、埋め込み型装置。 - 第3のモノマーがラクチドである、請求項1に記載の埋め込み型装置。
- ラクチドがD,L−ラクチド又はL−ラクチドである、請求項2に記載の埋め込み型装置。
- ターポリマーが37℃未満のガラス転移温度(Tg)を有する、請求項1に記載の埋め込み型装置。
- ターポリマーが37℃未満のTgを有する、請求項3に記載の埋め込み型装置。
- コーティングが生分解性非晶質ポリマーを含むプライマーをさらに含む、請求項1に記載の埋め込み型装置。
- コーティングが生分解性非晶質ポリマーを含むプライマーをさらに含む、請求項3に記載の埋め込み型装置。
- コーティングが生物活性剤をさらに含み、埋め込み型装置が配置されたときに生物活性剤の制御放出を提供する、請求項1に記載の埋め込み型装置。
- コーティングが生物活性剤をさらに含み、埋め込み型装置が配置されたときに生物活性剤の制御放出を提供する、請求項3に記載の埋め込み型装置。
- コーティングがターポリマーを含む層に生物活性剤をさらに含み、埋め込み型装置が配置されたときに生物活性剤の制御放出を提供する、請求項8に記載の埋め込み型装置。
- コーティングが、埋め込み型装置の配置後約100日の期間内に、コーティングが約80%以上の質量損失を有する分解又は吸収速度を有する、請求項1に記載の埋め込み型装置。
- ステントである、請求項1に記載の埋め込み型装置。
- 生体吸収性ステントである、請求項1に記載の埋め込み型装置。
- コーティングがエチレンオキサイド(ETO)滅菌又はeビーム処理後に完全性を維持する、請求項1に記載の埋め込み型装置。
- コーティングが埋め込み型装置の配置後100日又は180日以内に約100%の質量損失を有する、請求項1に記載の埋め込み型装置。
- 生物活性剤が、パクリタキセル、ドセタキセル、エストラジオール、17−ベータ−エストラジオール、一酸化窒素供与体、スーパーオキシドジスムターゼ、スーパーオキシドジスムターゼ模倣体、4−アミノ−2,2,6,6−テトラメチルピペリジン−1−オキシル(4−アミノ−TEMPO)、バイオリムス、タクロリムス、デキサメタゾン、デキサメタゾン誘導体、グルココルチコイド、ラパマイシン、ラパマイシン誘導体、40−O−(2−ヒドロキシ)エチル−ラパマイシン(エベロリムス)、40−O−(3−ヒドロキシ)プロピル−ラパマイシン、40−O−[2−(2−ヒドロキシ)エトキシ]エチル−ラパマイシン、及び40−O−テトラゾール−ラパマイシン、40−エピ−(N1−テトラゾリル)−ラパマイシン(ABT−578)、テムシロリムス、デフォロリムス、γ−ヒリダン、クロベタゾール、ピメクロリムス、メシル酸イマチニブ、ミドスタウリン、フェノフィブラート、これらのプロドラッグ、これらのコドラッグ、並びにこれらの組合せから選択される、請求項8に記載の埋め込み型装置。
- 生物活性剤が、パクリタキセル、ドセタキセル、エストラジオール、17−ベータ−エストラジオール、一酸化窒素供与体、スーパーオキシドジスムターゼ、スーパーオキシドジスムターゼ模倣体、4−アミノ−2,2,6,6−テトラメチルピペリジン−1−オキシル(4−アミノ−TEMPO)、バイオリムス、タクロリムス、デキサメタゾン、デキサメタゾン誘導体、グルココルチコイドラパマイシン、ラパマイシン誘導体、40−O−(2−ヒドロキシ)エチル−ラパマイシン(エベロリムス)、40−O−(3−ヒドロキシ)プロピル−ラパマイシン、40−O−[2−(2−ヒドロキシ)エトキシ]エチル−ラパマイシン、及び40−O−テトラゾール−ラパマイシン、40−エピ−(N1−テトラゾリル)−ラパマイシン(ABT−578)、テムシロリムス、デフォロリムス、γ−ヒリダン、クロベタゾール、ピメクロリムス、メシル酸イマチニブ、ミドスタウリン、フェノフィブラート、これらのプロドラッグ、これらのコドラッグ、並びにこれらの組合せから選択される、請求項8に記載の埋め込み型装置。
- カプロラクトン、グリコリド及び第3のモノマーを含むターポリマーを含む層を含むコーティングを形成するステップ
を含む埋め込み型装置の製作方法であって、
ターポリマーが、カプロラクトンが約20%以上、及びグリコリドが約10%以上であるモル組成を有し、
コーティングが、約5ミクロン以下の厚さを有し、そして、埋め込み型装置の配置後6カ月の期間内に、コーティングが約80%以上の質量損失を有する分解又は吸収速度を有する方法。 - 第3のモノマーがラクチドである、請求項18に記載の方法。
- ラクチドがD,L−ラクチド又はL−ラクチドである、請求項19に記載の方法。
- ターポリマーが37℃未満のガラス転移温度(Tg)を有する、請求項20に記載の方法。
- コーティングが生分解性非晶質ポリマーを含むプライマーをさらに含む、請求項18に記載の方法。
- コーティングが生分解性非晶質ポリマーを含むプライマーをさらに含む、請求項20に記載の方法。
- コーティングが生物活性剤をさらに含み、埋め込み型装置が配置されたときに生物活性剤の制御放出を提供する、請求項18に記載の方法。
- コーティングが生物活性剤をさらに含み、埋め込み型装置が配置されたときに生物活性剤の制御放出を提供する、請求項20に記載の方法。
- コーティングが、埋め込み型装置の配置後約100日又は180日の期間内に、コーティングが約80%以上の質量損失を有する分解又は吸収速度を有する、請求項18に記載の方法。
- ステントである、請求項18に記載の方法。
- 生体吸収性ステントである、請求項18に記載の方法。
- コーティングがエチレンオキサイド(ETO)滅菌又はeビーム処理後に完全性を維持する、請求項18に記載の方法。
- コーティングが埋め込み型装置の配置後100日又は180日以内に約100%の質量損失を有する、請求項18に記載の方法。
- 患者に請求項1に記載の埋め込み型装置を埋め込むステップを含む、血管の病状を治療、予防、又は改善する方法であって、血管の病状が、再狭窄、アテローム性動脈硬化、血栓症、出血、血管の解離若しくは穿孔、血管動脈瘤、不安定プラーク、慢性完全閉塞、跛行、吻合部増殖(静脈及び人工グラフトの)、胆管閉塞、尿管閉塞、腫瘍閉塞、又はこれらの組合せから選択される方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/466,317 US8697113B2 (en) | 2008-05-21 | 2009-05-14 | Coating comprising a terpolymer comprising caprolactone and glycolide |
US12/466,317 | 2009-05-14 | ||
PCT/US2010/033787 WO2010132258A2 (en) | 2009-05-14 | 2010-05-05 | Coating comprising a terpolymer comprising caprolactone and glycolide |
Related Child Applications (1)
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JP2015113423A Division JP6103606B2 (ja) | 2009-05-14 | 2015-06-03 | カプロラクトン及びグリコリドを含むターポリマーを含むコーティング |
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JP2012526612A true JP2012526612A (ja) | 2012-11-01 |
JP2012526612A5 JP2012526612A5 (ja) | 2013-06-20 |
JP5804604B2 JP5804604B2 (ja) | 2015-11-04 |
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JP2012510857A Expired - Fee Related JP5804604B2 (ja) | 2009-05-14 | 2010-05-05 | カプロラクトン及びグリコリドを含むターポリマーを含むコーティング |
JP2015113423A Expired - Fee Related JP6103606B2 (ja) | 2009-05-14 | 2015-06-03 | カプロラクトン及びグリコリドを含むターポリマーを含むコーティング |
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Country Status (6)
Country | Link |
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US (2) | US8697113B2 (ja) |
EP (2) | EP2429602B1 (ja) |
JP (2) | JP5804604B2 (ja) |
ES (1) | ES2566907T3 (ja) |
HK (1) | HK1215798A1 (ja) |
WO (1) | WO2010132258A2 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8661630B2 (en) | 2008-05-21 | 2014-03-04 | Abbott Cardiovascular Systems Inc. | Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer |
US8697113B2 (en) * | 2008-05-21 | 2014-04-15 | Abbott Cardiovascular Systems Inc. | Coating comprising a terpolymer comprising caprolactone and glycolide |
US8697110B2 (en) * | 2009-05-14 | 2014-04-15 | Abbott Cardiovascular Systems Inc. | Polymers comprising amorphous terpolymers and semicrystalline blocks |
US9993441B2 (en) * | 2009-12-30 | 2018-06-12 | Surmodics, Inc. | Controlled release matrix barrier structure for subcutaneous medical devices |
US20150305899A1 (en) * | 2014-04-24 | 2015-10-29 | Abbott Cardiovascular Systems Inc. | Branched polyhydroxyalkanoate systems for bioresorbable vascular scaffold applications |
SG11201809800TA (en) | 2016-05-06 | 2018-12-28 | Saudi Arabian Oil Co | Succinimide-based copolymers and use as hydrate inhibitors |
JP6824562B2 (ja) | 2016-05-06 | 2021-02-03 | サウジ アラビアン オイル カンパニーSaudi Arabian Oil Company | アクリルアミドベースのコポリマー、ターポリマー、および水化物阻害剤としての使用 |
US20170320985A1 (en) | 2016-05-06 | 2017-11-09 | Saudi Arabian Oil Company | Methods for synthesizing acryloyl-based copolymers, terpolymers |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03205059A (ja) * | 1989-09-27 | 1991-09-06 | Bristol Myers Squibb Co | 生分解ステント |
WO2009055426A2 (en) * | 2007-10-23 | 2009-04-30 | Abbott Cardiovascular Systems Inc. | Random amorphous terpolymer containing lactide and glycolide |
WO2009058666A1 (en) * | 2007-10-31 | 2009-05-07 | Abbott Cardiovascular Systems Inc. | Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices |
Family Cites Families (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5502158A (en) | 1988-08-08 | 1996-03-26 | Ecopol, Llc | Degradable polymer composition |
US5272012A (en) | 1989-06-23 | 1993-12-21 | C. R. Bard, Inc. | Medical apparatus having protective, lubricious coating |
US5702754A (en) | 1995-02-22 | 1997-12-30 | Meadox Medicals, Inc. | Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings |
US6143037A (en) | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
DE19641335A1 (de) * | 1996-10-08 | 1998-04-09 | Inst Textil & Faserforschung | Triblockterpolymer, seine Verwendung für chirurgisches Nahtmaterial und Verfahren zur Herstellung |
US5997517A (en) | 1997-01-27 | 1999-12-07 | Sts Biopolymers, Inc. | Bonding layers for medical device surface coatings |
US6110483A (en) * | 1997-06-23 | 2000-08-29 | Sts Biopolymers, Inc. | Adherent, flexible hydrogel and medicated coatings |
US6210703B1 (en) * | 1997-12-19 | 2001-04-03 | Ppg Industries Ohio, Inc. | Glass fiber chemical delivery system |
US6001117A (en) | 1998-03-19 | 1999-12-14 | Indigo Medical, Inc. | Bellows medical construct and apparatus and method for using same |
US6165202A (en) * | 1998-07-06 | 2000-12-26 | United States Surgical Corporation | Absorbable polymers and surgical articles fabricated therefrom |
US6494862B1 (en) | 1999-07-13 | 2002-12-17 | Advanced Cardiovascular Systems, Inc. | Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway |
US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
US20070032853A1 (en) * | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6790228B2 (en) * | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US7850643B1 (en) | 1999-09-27 | 2010-12-14 | Advanced Cardiovascular Systems, Inc. | Drug diffusion barriers for a catheter assembly |
US6908624B2 (en) * | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US20010007083A1 (en) * | 1999-12-29 | 2001-07-05 | Roorda Wouter E. | Device and active component for inhibiting formation of thrombus-inflammatory cell matrix |
US6703040B2 (en) * | 2000-01-11 | 2004-03-09 | Intralytix, Inc. | Polymer blends as biodegradable matrices for preparing biocomposites |
DE10001222A1 (de) * | 2000-01-14 | 2001-08-09 | Basf Coatings Ag | Beschichtung, enthaltend kolloidal verteiltes metallisches Bismut |
US6527801B1 (en) * | 2000-04-13 | 2003-03-04 | Advanced Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
US6585765B1 (en) | 2000-06-29 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Implantable device having substances impregnated therein and a method of impregnating the same |
US6503538B1 (en) * | 2000-08-30 | 2003-01-07 | Cornell Research Foundation, Inc. | Elastomeric functional biodegradable copolyester amides and copolyester urethanes |
US6758859B1 (en) * | 2000-10-30 | 2004-07-06 | Kenny L. Dang | Increased drug-loading and reduced stress drug delivery device |
US6824559B2 (en) | 2000-12-22 | 2004-11-30 | Advanced Cardiovascular Systems, Inc. | Ethylene-carboxyl copolymers as drug delivery matrices |
US6544543B1 (en) * | 2000-12-27 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Periodic constriction of vessels to treat ischemic tissue |
US6663662B2 (en) * | 2000-12-28 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Diffusion barrier layer for implantable devices |
US7504125B1 (en) * | 2001-04-27 | 2009-03-17 | Advanced Cardiovascular Systems, Inc. | System and method for coating implantable devices |
US6544223B1 (en) * | 2001-01-05 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Balloon catheter for delivering therapeutic agents |
US6712845B2 (en) * | 2001-04-24 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | Coating for a stent and a method of forming the same |
US6660034B1 (en) * | 2001-04-30 | 2003-12-09 | Advanced Cardiovascular Systems, Inc. | Stent for increasing blood flow to ischemic tissues and a method of using the same |
US6656506B1 (en) | 2001-05-09 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Microparticle coated medical device |
US6743462B1 (en) * | 2001-05-31 | 2004-06-01 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating implantable devices |
US7247313B2 (en) * | 2001-06-27 | 2007-07-24 | Advanced Cardiovascular Systems, Inc. | Polyacrylates coatings for implantable medical devices |
US6695920B1 (en) * | 2001-06-27 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Mandrel for supporting a stent and a method of using the mandrel to coat a stent |
US6673154B1 (en) * | 2001-06-28 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Stent mounting device to coat a stent |
US6656216B1 (en) | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
US6753071B1 (en) * | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
US20030073961A1 (en) * | 2001-09-28 | 2003-04-17 | Happ Dorrie M. | Medical device containing light-protected therapeutic agent and a method for fabricating thereof |
US20030104028A1 (en) * | 2001-11-29 | 2003-06-05 | Hossainy Syed F.A. | Rate limiting barriers for implantable devices and methods for fabrication thereof |
US7175874B1 (en) * | 2001-11-30 | 2007-02-13 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating implantable devices |
US6663880B1 (en) | 2001-11-30 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Permeabilizing reagents to increase drug delivery and a method of local delivery |
US6709514B1 (en) | 2001-12-28 | 2004-03-23 | Advanced Cardiovascular Systems, Inc. | Rotary coating apparatus for coating implantable medical devices |
CN1279984C (zh) * | 2002-02-15 | 2006-10-18 | Cv医药有限公司 | 用于医用装置的聚合物涂层 |
US7232490B1 (en) * | 2002-03-15 | 2007-06-19 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating stents |
US7022334B1 (en) * | 2002-03-20 | 2006-04-04 | Advanced Cardiovascular Systems, Inc. | Therapeutic composition and a method of coating implantable medical devices |
US7217426B1 (en) * | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
US7005137B1 (en) * | 2002-06-21 | 2006-02-28 | Advanceed Cardiovascular Systems, Inc. | Coating for implantable medical devices |
US7396539B1 (en) * | 2002-06-21 | 2008-07-08 | Advanced Cardiovascular Systems, Inc. | Stent coatings with engineered drug release rate |
US7794743B2 (en) * | 2002-06-21 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of making the same |
US7294329B1 (en) | 2002-07-18 | 2007-11-13 | Advanced Cardiovascular Systems, Inc. | Poly(vinyl acetal) coatings for implantable medical devices |
US20040054104A1 (en) * | 2002-09-05 | 2004-03-18 | Pacetti Stephen D. | Coatings for drug delivery devices comprising modified poly(ethylene-co-vinyl alcohol) |
US7201935B1 (en) * | 2002-09-17 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Plasma-generated coatings for medical devices and methods for fabricating thereof |
US20040063805A1 (en) * | 2002-09-19 | 2004-04-01 | Pacetti Stephen D. | Coatings for implantable medical devices and methods for fabrication thereof |
US6818063B1 (en) | 2002-09-24 | 2004-11-16 | Advanced Cardiovascular Systems, Inc. | Stent mandrel fixture and method for minimizing coating defects |
US7232573B1 (en) * | 2002-09-26 | 2007-06-19 | Advanced Cardiovascular Systems, Inc. | Stent coatings containing self-assembled monolayers |
US7135038B1 (en) | 2002-09-30 | 2006-11-14 | Advanced Cardiovascular Systems, Inc. | Drug eluting stent |
US7335265B1 (en) * | 2002-10-08 | 2008-02-26 | Advanced Cardiovascular Systems Inc. | Apparatus and method for coating stents |
US7087263B2 (en) * | 2002-10-09 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Rare limiting barriers for implantable medical devices |
US7169178B1 (en) * | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
US7758880B2 (en) * | 2002-12-11 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Biocompatible polyacrylate compositions for medical applications |
US7074276B1 (en) * | 2002-12-12 | 2006-07-11 | Advanced Cardiovascular Systems, Inc. | Clamp mandrel fixture and a method of using the same to minimize coating defects |
US20060002968A1 (en) * | 2004-06-30 | 2006-01-05 | Gordon Stewart | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders |
US7628859B1 (en) | 2002-12-27 | 2009-12-08 | Advanced Cardiovascular Systems, Inc. | Mounting assembly for a stent and a method of using the same to coat a stent |
US6926919B1 (en) * | 2003-02-26 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Method for fabricating a coating for a medical device |
US7354480B1 (en) * | 2003-02-26 | 2008-04-08 | Advanced Cardiovascular Systems, Inc. | Stent mandrel fixture and system for reducing coating defects |
US7255891B1 (en) * | 2003-02-26 | 2007-08-14 | Advanced Cardiovascular Systems, Inc. | Method for coating implantable medical devices |
US7288609B1 (en) | 2003-03-04 | 2007-10-30 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices based on poly (orthoesters) |
US7563454B1 (en) * | 2003-05-01 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
US7323209B1 (en) * | 2003-05-15 | 2008-01-29 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating stents |
BRPI0410953A (pt) * | 2003-05-30 | 2006-06-27 | Alza Corp | composições de depósito elastoméricas que podem ser implantadas, usos das mesmas e processo de produção |
US7186789B2 (en) | 2003-06-11 | 2007-03-06 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings |
US20050118344A1 (en) * | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US7645504B1 (en) * | 2003-06-26 | 2010-01-12 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices comprising hydrophobic and hydrophilic polymers |
US7341630B1 (en) * | 2003-06-26 | 2008-03-11 | Advanced Cardiovascular Systems, Inc. | Stent coating system |
US20050021127A1 (en) * | 2003-07-21 | 2005-01-27 | Kawula Paul John | Porous glass fused onto stent for drug retention |
US7056591B1 (en) * | 2003-07-30 | 2006-06-06 | Advanced Cardiovascular Systems, Inc. | Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same |
US7169404B2 (en) * | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
US7785512B1 (en) * | 2003-07-31 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices |
US7431959B1 (en) | 2003-07-31 | 2008-10-07 | Advanced Cardiovascular Systems Inc. | Method and system for irradiation of a drug eluting implantable medical device |
US7704544B2 (en) * | 2003-10-07 | 2010-04-27 | Advanced Cardiovascular Systems, Inc. | System and method for coating a tubular implantable medical device |
US7329413B1 (en) * | 2003-11-06 | 2008-02-12 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof |
US7261946B2 (en) * | 2003-11-14 | 2007-08-28 | Advanced Cardiovascular Systems, Inc. | Block copolymers of acrylates and methacrylates with fluoroalkenes |
US20050112170A1 (en) * | 2003-11-20 | 2005-05-26 | Hossainy Syed F. | Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same |
US8192752B2 (en) * | 2003-11-21 | 2012-06-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same |
US7435788B2 (en) * | 2003-12-19 | 2008-10-14 | Advanced Cardiovascular Systems, Inc. | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents |
US8309112B2 (en) * | 2003-12-24 | 2012-11-13 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same |
JP2007517550A (ja) * | 2004-01-02 | 2007-07-05 | アドヴァンスド カーディオヴァスキュラー システムズ, インコーポレイテッド | 高比重リポ蛋白をコーティングした医療デバイス |
US8685431B2 (en) * | 2004-03-16 | 2014-04-01 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same |
US20050214339A1 (en) * | 2004-03-29 | 2005-09-29 | Yiwen Tang | Biologically degradable compositions for medical applications |
US20050226991A1 (en) | 2004-04-07 | 2005-10-13 | Hossainy Syed F | Methods for modifying balloon of a catheter assembly |
US20060246109A1 (en) * | 2005-04-29 | 2006-11-02 | Hossainy Syed F | Concentration gradient profiles for control of agent release rates from polymer matrices |
US20050265960A1 (en) | 2004-05-26 | 2005-12-01 | Pacetti Stephen D | Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
US7390524B1 (en) * | 2004-05-20 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Method for electrostatic spraying of an abluminal stent surface |
US20050271700A1 (en) | 2004-06-03 | 2005-12-08 | Desnoyer Jessica R | Poly(ester amide) coating composition for implantable devices |
US20050287184A1 (en) | 2004-06-29 | 2005-12-29 | Hossainy Syed F A | Drug-delivery stent formulations for restenosis and vulnerable plaque |
US7494665B1 (en) * | 2004-07-30 | 2009-02-24 | Advanced Cardiovascular Systems, Inc. | Polymers containing siloxane monomers |
US8357391B2 (en) * | 2004-07-30 | 2013-01-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages |
US7311980B1 (en) | 2004-08-02 | 2007-12-25 | Advanced Cardiovascular Systems, Inc. | Polyactive/polylactic acid coatings for an implantable device |
US7648727B2 (en) * | 2004-08-26 | 2010-01-19 | Advanced Cardiovascular Systems, Inc. | Methods for manufacturing a coated stent-balloon assembly |
US7244443B2 (en) * | 2004-08-31 | 2007-07-17 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrophilic monomers |
US8110211B2 (en) * | 2004-09-22 | 2012-02-07 | Advanced Cardiovascular Systems, Inc. | Medicated coatings for implantable medical devices including polyacrylates |
US7166680B2 (en) * | 2004-10-06 | 2007-01-23 | Advanced Cardiovascular Systems, Inc. | Blends of poly(ester amide) polymers |
US20060088571A1 (en) * | 2004-10-21 | 2006-04-27 | Medtronic Vascular, Inc. | Biocompatible and hemocompatible polymer compositions |
US20060089485A1 (en) * | 2004-10-27 | 2006-04-27 | Desnoyer Jessica R | End-capped poly(ester amide) copolymers |
US20060095122A1 (en) * | 2004-10-29 | 2006-05-04 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable star polymers and methods for fabricating the same |
US7481835B1 (en) * | 2004-10-29 | 2009-01-27 | Advanced Cardiovascular Systems, Inc. | Encapsulated covered stent |
US20060115449A1 (en) * | 2004-11-30 | 2006-06-01 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial, tyrosine-based polymers for use in drug eluting stent coatings |
US7632307B2 (en) * | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
US7604818B2 (en) * | 2004-12-22 | 2009-10-20 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrocarbon monomers |
US7202325B2 (en) * | 2005-01-14 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles |
US20070026039A1 (en) * | 2005-07-29 | 2007-02-01 | Drumheller Paul D | Composite self-cohered web materials |
JP5283509B2 (ja) * | 2005-12-07 | 2013-09-04 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド | 薬物送達複合構造体 |
US10029034B2 (en) | 2005-12-15 | 2018-07-24 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Drug-eluting articles with improved drug release profiles |
US20070149640A1 (en) * | 2005-12-28 | 2007-06-28 | Sasa Andjelic | Bioabsorbable polymer compositions exhibiting enhanced crystallization and hydrolysis rates |
US9040069B2 (en) * | 2006-07-07 | 2015-05-26 | Biotronik Vi Patent Ag | Process for manufacturing a stationary state of crystalline polymer of a biodegradable polymer matrix carrying an active substance and a polymer matrix produced thereby |
US20090004243A1 (en) * | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
WO2009036083A2 (en) * | 2007-09-12 | 2009-03-19 | Curexo Usa, Inc. | Polymer compositions for controllable drug delivery |
US8661630B2 (en) | 2008-05-21 | 2014-03-04 | Abbott Cardiovascular Systems Inc. | Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer |
US20090111787A1 (en) * | 2007-10-31 | 2009-04-30 | Florencia Lim | Polymer blends for drug delivery stent matrix with improved thermal stability |
US8697113B2 (en) * | 2008-05-21 | 2014-04-15 | Abbott Cardiovascular Systems Inc. | Coating comprising a terpolymer comprising caprolactone and glycolide |
US8697110B2 (en) | 2009-05-14 | 2014-04-15 | Abbott Cardiovascular Systems Inc. | Polymers comprising amorphous terpolymers and semicrystalline blocks |
-
2009
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-
2010
- 2010-05-05 JP JP2012510857A patent/JP5804604B2/ja not_active Expired - Fee Related
- 2010-05-05 ES ES10718390.7T patent/ES2566907T3/es active Active
- 2010-05-05 WO PCT/US2010/033787 patent/WO2010132258A2/en active Application Filing
- 2010-05-05 EP EP10718390.7A patent/EP2429602B1/en not_active Not-in-force
- 2010-05-05 EP EP15159649.1A patent/EP2932988A1/en not_active Withdrawn
-
2013
- 2013-12-13 US US14/106,029 patent/US20140107592A1/en not_active Abandoned
-
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-
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- 2016-03-31 HK HK16103724.9A patent/HK1215798A1/zh unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03205059A (ja) * | 1989-09-27 | 1991-09-06 | Bristol Myers Squibb Co | 生分解ステント |
WO2009055426A2 (en) * | 2007-10-23 | 2009-04-30 | Abbott Cardiovascular Systems Inc. | Random amorphous terpolymer containing lactide and glycolide |
WO2009058666A1 (en) * | 2007-10-31 | 2009-05-07 | Abbott Cardiovascular Systems Inc. | Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices |
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JP6103606B2 (ja) | 2017-03-29 |
JP2015186586A (ja) | 2015-10-29 |
US8697113B2 (en) | 2014-04-15 |
WO2010132258A3 (en) | 2011-04-07 |
EP2429602B1 (en) | 2016-01-06 |
EP2429602A2 (en) | 2012-03-21 |
HK1215798A1 (zh) | 2016-09-15 |
US20100209476A1 (en) | 2010-08-19 |
US20140107592A1 (en) | 2014-04-17 |
WO2010132258A2 (en) | 2010-11-18 |
ES2566907T3 (es) | 2016-04-18 |
EP2932988A1 (en) | 2015-10-21 |
JP5804604B2 (ja) | 2015-11-04 |
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