JP2007190369A - 改善された薬剤放出特性を備えた薬剤溶出物品 - Google Patents
改善された薬剤放出特性を備えた薬剤溶出物品 Download PDFInfo
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- JP2007190369A JP2007190369A JP2006337295A JP2006337295A JP2007190369A JP 2007190369 A JP2007190369 A JP 2007190369A JP 2006337295 A JP2006337295 A JP 2006337295A JP 2006337295 A JP2006337295 A JP 2006337295A JP 2007190369 A JP2007190369 A JP 2007190369A
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| EP4329734A4 (en) | 2021-04-26 | 2025-04-02 | Celanese EVA Performance Polymers LLC | Implantable device for the delayed release of a macromolecular drug compound |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824048A (en) * | 1993-04-26 | 1998-10-20 | Medtronic, Inc. | Method for delivering a therapeutic substance to a body lumen |
| JP2003533493A (ja) * | 2000-05-12 | 2003-11-11 | コーディス・コーポレイション | 再狭窄の予防に有効な薬剤の組み合わせ |
| WO2004012676A2 (en) * | 2002-08-02 | 2004-02-12 | Gp Medical | Drug-loaded biological material chemically treated with genipin |
| WO2005004945A2 (en) * | 2003-06-25 | 2005-01-20 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
| JP2005270658A (ja) * | 2004-03-22 | 2005-10-06 | Cordis Corp | 脈管の傷害後の再狭窄を防ぐためのラパマイシンとの組み合わせにおけるパンゼム（登録商標）の局所的脈管配給 |
| JP2005305154A (ja) * | 2004-04-15 | 2005-11-04 | Cordis Corp | 脆弱性プラークの治療のためのラパマイシンおよび１７ベータ−エストラジオールの組み合わせ物の局所的投与 |
| WO2005115493A2 (en) * | 2004-05-27 | 2005-12-08 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
| US20060122264A1 (en) * | 2003-06-09 | 2006-06-08 | Yasumi Uchida, Etal | Stem cell invasion inhibitor |
| WO2006116989A2 (de) * | 2005-05-05 | 2006-11-09 | Hemoteq Ag | Vollflächige beschichtung von gefässstützen |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2133815A1 (en) * | 1993-10-12 | 1995-04-13 | Jeffrey Alan Dodge | Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof |
| AU716005B2 (en) * | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
| US5747060A (en) * | 1996-03-26 | 1998-05-05 | Euro-Celtique, S.A. | Prolonged local anesthesia with colchicine |
| SE0000363A0 (sv) * | 2000-02-04 | 2001-08-05 | Zoucas Kirurgkonsult Ab | Belagd medicinsk anordning |
| WO2002026139A1 (en) * | 2000-09-29 | 2002-04-04 | Cordis Corporation | Coated medical devices |
| US20020113183A1 (en) * | 2001-01-12 | 2002-08-22 | Magla Products, L.L.C. | Merchandise display system |
| JP4062622B2 (ja) * | 2001-06-08 | 2008-03-19 | ネイチャーワークス・エル・エル・シー | 単環式エステル及びカーボネートの共重合体並びにその製造方法 |
| US6927898B2 (en) * | 2001-08-15 | 2005-08-09 | Photon-X, Llc | Ultra-wide bandwidth optical amplifier |
| US7056338B2 (en) | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
| US20050163821A1 (en) * | 2002-08-02 | 2005-07-28 | Hsing-Wen Sung | Drug-eluting Biodegradable Stent and Delivery Means |
| WO2004026361A1 (en) | 2002-09-18 | 2004-04-01 | Medtronic Vascular, Inc. | Controllable drug releasing gradient coatings for medical devices |
| US20050070989A1 (en) * | 2002-11-13 | 2005-03-31 | Whye-Kei Lye | Medical devices having porous layers and methods for making the same |
| CN100558321C (zh) * | 2003-06-16 | 2009-11-11 | 南洋理工大学 | 聚合物支架和其制造方法 |
| DK1638624T3 (da) | 2003-06-19 | 2014-02-03 | Vascular Therapies Llc | Vaskulær lukkeindretning |
| US20060275341A1 (en) * | 2005-06-02 | 2006-12-07 | Miv Therapeutics Inc. | Thin foam coating comprising discrete, closed-cell capsules |
-
2005
- 2005-12-15 US US11/300,821 patent/US10029034B2/en active Active
-
2006
- 2006-12-12 EP EP06256316.8A patent/EP1808167B1/en not_active Not-in-force
- 2006-12-12 ES ES06256316.8T patent/ES2686778T3/es active Active
- 2006-12-14 CA CA2571302A patent/CA2571302C/en active Active
- 2006-12-14 JP JP2006337295A patent/JP2007190369A/ja active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824048A (en) * | 1993-04-26 | 1998-10-20 | Medtronic, Inc. | Method for delivering a therapeutic substance to a body lumen |
| JP2003533493A (ja) * | 2000-05-12 | 2003-11-11 | コーディス・コーポレイション | 再狭窄の予防に有効な薬剤の組み合わせ |
| WO2004012676A2 (en) * | 2002-08-02 | 2004-02-12 | Gp Medical | Drug-loaded biological material chemically treated with genipin |
| US20060122264A1 (en) * | 2003-06-09 | 2006-06-08 | Yasumi Uchida, Etal | Stem cell invasion inhibitor |
| WO2005004945A2 (en) * | 2003-06-25 | 2005-01-20 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
| JP2005270658A (ja) * | 2004-03-22 | 2005-10-06 | Cordis Corp | 脈管の傷害後の再狭窄を防ぐためのラパマイシンとの組み合わせにおけるパンゼム（登録商標）の局所的脈管配給 |
| JP2005305154A (ja) * | 2004-04-15 | 2005-11-04 | Cordis Corp | 脆弱性プラークの治療のためのラパマイシンおよび１７ベータ−エストラジオールの組み合わせ物の局所的投与 |
| WO2005115493A2 (en) * | 2004-05-27 | 2005-12-08 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
| WO2006116989A2 (de) * | 2005-05-05 | 2006-11-09 | Hemoteq Ag | Vollflächige beschichtung von gefässstützen |
Non-Patent Citations (1)
| Title |
|---|
| JPN6013024959; Ｊ Ｂｉｏｍｅｄ Ｍａｔｅｒ Ｒｅｓ Ｐｔ Ａ．， Ｖｏｌ．７１Ａ Ｎｏ．４ Ｐａｇｅ．６２５-６３４ （２００４） * |
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| US9468707B2 (en) | 2007-06-29 | 2016-10-18 | Abbott Cardiovascular Systems Inc. | Biodegradable triblock copolymers for implantable devices |
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| JP5368991B2 (ja) * | 2007-09-04 | 2013-12-18 | 株式会社日本ステントテクノロジー | 薬剤徐放性ステント |
| JP2013126557A (ja) * | 2007-09-04 | 2013-06-27 | Japan Stent Technology Co Ltd | 薬剤徐放性ステント |
| US9040111B2 (en) | 2007-09-04 | 2015-05-26 | Japan Stent Technology Co., Ltd. | Method of making a stent |
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| US8889170B2 (en) | 2007-10-31 | 2014-11-18 | Abbott Cardiovascular Systems Inc. | Implantable device having a coating with a triblock copolymer |
| US9345668B2 (en) | 2007-10-31 | 2016-05-24 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
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| JP2017060889A (ja) * | 2008-02-29 | 2017-03-30 | スミス アンド ネフュー インコーポレイテッド | 生物医学的応用のための勾配コーティング |
| US9011965B2 (en) | 2008-02-29 | 2015-04-21 | Smith & Nephew, Inc. | Gradient coating for biomedical applications |
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2571302C (en) | 2014-11-18 |
| EP1808167B1 (en) | 2018-07-04 |
| US20070141112A1 (en) | 2007-06-21 |
| ES2686778T3 (es) | 2018-10-19 |
| CA2571302A1 (en) | 2007-06-15 |
| EP1808167A1 (en) | 2007-07-18 |
| US10029034B2 (en) | 2018-07-24 |
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