CA2571302C - Drug-eluting articles with improved drug release profiles - Google Patents

Drug-eluting articles with improved drug release profiles Download PDF

Info

Publication number
CA2571302C
CA2571302C CA2571302A CA2571302A CA2571302C CA 2571302 C CA2571302 C CA 2571302C CA 2571302 A CA2571302 A CA 2571302A CA 2571302 A CA2571302 A CA 2571302A CA 2571302 C CA2571302 C CA 2571302C
Authority
CA
Canada
Prior art keywords
drug
pharmacologically active
active compound
polymeric layer
polymeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2571302A
Other languages
English (en)
French (fr)
Other versions
CA2571302A1 (en
Inventor
Robert Falotico
Jonathon Z. Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Cardinal Health Switzerland 515 GmbH
Cordis Corp
Cardinal Health 529 LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardinal Health Switzerland 515 GmbH, Cordis Corp, Cardinal Health 529 LLC filed Critical Cardinal Health Switzerland 515 GmbH
Publication of CA2571302A1 publication Critical patent/CA2571302A1/en
Application granted granted Critical
Publication of CA2571302C publication Critical patent/CA2571302C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A61L2300/61—Coatings having two or more layers containing two or more active agents in different layers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
CA2571302A 2005-12-15 2006-12-14 Drug-eluting articles with improved drug release profiles Active CA2571302C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/300,821 US10029034B2 (en) 2005-12-15 2005-12-15 Drug-eluting articles with improved drug release profiles
US11/300,821 2005-12-15

Publications (2)

Publication Number Publication Date
CA2571302A1 CA2571302A1 (en) 2007-06-15
CA2571302C true CA2571302C (en) 2014-11-18

Family

ID=37964483

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2571302A Active CA2571302C (en) 2005-12-15 2006-12-14 Drug-eluting articles with improved drug release profiles

Country Status (5)

Country Link
US (1) US10029034B2 (enExample)
EP (1) EP1808167B1 (enExample)
JP (1) JP2007190369A (enExample)
CA (1) CA2571302C (enExample)
ES (1) ES2686778T3 (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006036982A2 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Drug delivery coating for use with a stent
US9801913B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Barrier layer
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US9592324B2 (en) 2006-11-06 2017-03-14 Atrium Medical Corporation Tissue separating device with reinforced support for anchoring mechanisms
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
EP1933991A4 (en) 2005-10-15 2012-05-02 Atrium Medical Corp HYDROPHOBIC NETWORKED GEL FOR BIOABSORBIBLE MEDICINAL CARRIER COVERS
US7671095B2 (en) * 2006-05-31 2010-03-02 The Trustees Of The Boston University Films and particles
US20070298067A1 (en) * 2006-06-22 2007-12-27 Boston Scientific Scimed, Inc. Control release drug coating for medical devices
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
CA2670944A1 (en) * 2006-12-18 2008-06-26 Alcon Research, Ltd. Devices and methods for ophthalmic drug delivery
US20080255658A1 (en) * 2007-04-12 2008-10-16 Medtronic Vascular, Inc. Degradation Associated Drug Delivery for Drug Eluting Stent and Medical Device Coatings
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
CN101940802B (zh) * 2007-09-04 2015-02-04 株式会社日本斯滕特技术 药物缓释性支架
US8661630B2 (en) * 2008-05-21 2014-03-04 Abbott Cardiovascular Systems Inc. Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer
US8642062B2 (en) * 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
US8057876B2 (en) * 2008-02-25 2011-11-15 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with layers having different degradation rates
CA2716896C (en) * 2008-02-29 2016-08-09 Smith & Nephew, Inc. Gradient antimicrobial coating for medical implants
US8557273B2 (en) * 2008-04-18 2013-10-15 Medtronic, Inc. Medical devices and methods including polymers having biologically active agents therein
US8916188B2 (en) * 2008-04-18 2014-12-23 Abbott Cardiovascular Systems Inc. Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block
US20090285873A1 (en) * 2008-04-18 2009-11-19 Abbott Cardiovascular Systems Inc. Implantable medical devices and coatings therefor comprising block copolymers of poly(ethylene glycol) and a poly(lactide-glycolide)
WO2009140131A2 (en) * 2008-05-13 2009-11-19 The Trustees Of Boston University Compliant composites for application of drug-eluting coatings to tissue surfaces
US8697113B2 (en) 2008-05-21 2014-04-15 Abbott Cardiovascular Systems Inc. Coating comprising a terpolymer comprising caprolactone and glycolide
KR101087088B1 (ko) * 2008-12-29 2011-11-25 한국과학기술연구원 나노 구조 패턴을 갖는 약물 방출용 스텐트의 제조방법 및 이로부터 제조된 약물 방출용 스텐트
CN102316823B (zh) * 2009-02-11 2016-06-08 新加坡南洋理工大学 多层外科用假体
JP5597625B2 (ja) 2009-03-02 2014-10-01 株式会社日本ステントテクノロジー 薬剤溶出性ステント
US8697110B2 (en) 2009-05-14 2014-04-15 Abbott Cardiovascular Systems Inc. Polymers comprising amorphous terpolymers and semicrystalline blocks
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
US8685433B2 (en) * 2010-03-31 2014-04-01 Abbott Cardiovascular Systems Inc. Absorbable coating for implantable device
US9211175B2 (en) * 2010-07-08 2015-12-15 Covidien Lp Self-detachable medical devices
US10322213B2 (en) 2010-07-16 2019-06-18 Atrium Medical Corporation Compositions and methods for altering the rate of hydrolysis of cured oil-based materials
WO2012091680A1 (en) * 2010-12-30 2012-07-05 Nanyang Technological University A device for controlled release of a bioactive agent
JP5727292B2 (ja) * 2011-05-11 2015-06-03 富士フイルム株式会社 複合フィルム
KR20120135689A (ko) * 2011-06-07 2012-12-17 (주) 태웅메디칼 약물 방출 스텐트 코팅제의 제조방법 및 이에 의해 제조된 약물 방출 스텐트 코팅제
US9867880B2 (en) * 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
US9901663B2 (en) 2013-05-06 2018-02-27 Abbott Cardiovascular Systems Inc. Hollow stent filled with a therapeutic agent formulation
CN113679931A (zh) * 2015-01-22 2021-11-23 因特尔赛克特耳鼻喉公司 药物涂覆的气囊
WO2016137327A1 (en) * 2015-02-27 2016-09-01 Polyganics Ip B.V. Drug eluting foams and the production thereof
CA2989171A1 (en) 2015-06-18 2016-12-22 Acuitybio Corporation Implantable drug delivery compositions and methods of use thereof
JP2017144110A (ja) 2016-02-18 2017-08-24 テルモ株式会社 処置方法、および医療装置
JP7198218B2 (ja) * 2017-11-22 2022-12-28 テルモ株式会社 薬剤付与器具および薬剤層の形成方法
CN111542364B (zh) * 2017-12-27 2022-07-15 株式会社钟化 导管及其制造方法
CN111989068B (zh) 2018-05-24 2024-10-25 塞拉尼斯伊娃高性能聚合物公司 用于持续释放大分子药物化合物的可植入器件
EP3803866A4 (en) 2018-05-24 2022-03-16 Nureva Inc. METHOD, APPARATUS, AND COMPUTER READABLE MATERIALS FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE CATCH/HOME AREAS
CA3087238A1 (en) 2018-05-24 2019-11-28 Celanese EVA Performance Polymers Corporation Implantable device for sustained release of a macromolecular drug compound
KR102402859B1 (ko) * 2020-06-17 2022-05-30 한국과학기술연구원 3차원으로 연결된 유연한 나노 구조 필름을 포함하는 약물 방출용 스텐트의 제조 방법 및 이에 의해 제조된 약물 방출용 스텐트
KR102290367B1 (ko) * 2020-08-28 2021-08-19 (주)솔시온바이오메디칼 기공 내에 생리활성화 물질을 함유한 기공성 다층의 관형 구조체
EP4329734A4 (en) 2021-04-26 2025-04-02 Celanese EVA Performance Polymers LLC Implantable device for the delayed release of a macromolecular drug compound

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824048A (en) * 1993-04-26 1998-10-20 Medtronic, Inc. Method for delivering a therapeutic substance to a body lumen
CA2133815A1 (en) * 1993-10-12 1995-04-13 Jeffrey Alan Dodge Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
AU716005B2 (en) * 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US8029561B1 (en) 2000-05-12 2011-10-04 Cordis Corporation Drug combination useful for prevention of restenosis
US7682647B2 (en) * 1999-09-03 2010-03-23 Advanced Cardiovascular Systems, Inc. Thermal treatment of a drug eluting implantable medical device
US7807211B2 (en) * 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
SE0000363A0 (sv) * 2000-02-04 2001-08-05 Zoucas Kirurgkonsult Ab Belagd medicinsk anordning
WO2002026139A1 (en) * 2000-09-29 2002-04-04 Cordis Corporation Coated medical devices
US20020113183A1 (en) * 2001-01-12 2002-08-22 Magla Products, L.L.C. Merchandise display system
JP4062622B2 (ja) * 2001-06-08 2008-03-19 ネイチャーワークス・エル・エル・シー 単環式エステル及びカーボネートの共重合体並びにその製造方法
US6927898B2 (en) * 2001-08-15 2005-08-09 Photon-X, Llc Ultra-wide bandwidth optical amplifier
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US20050163821A1 (en) * 2002-08-02 2005-07-28 Hsing-Wen Sung Drug-eluting Biodegradable Stent and Delivery Means
EP1545505A4 (en) 2002-08-02 2008-01-02 Gp Medical BIOLOGICAL MATERIAL CHARGED WITH CHEMICALLY TREATED MEDICINE BY GENIPINE
WO2004026361A1 (en) 2002-09-18 2004-04-01 Medtronic Vascular, Inc. Controllable drug releasing gradient coatings for medical devices
US20050070989A1 (en) * 2002-11-13 2005-03-31 Whye-Kei Lye Medical devices having porous layers and methods for making the same
AU2003242054A1 (en) 2003-06-09 2005-01-04 Cardiovascular Institute, Ltd. Stem cell invasion inhibitor
CN100558321C (zh) * 2003-06-16 2009-11-11 南洋理工大学 聚合物支架和其制造方法
DK1638624T3 (da) 2003-06-19 2014-02-03 Vascular Therapies Llc Vaskulær lukkeindretning
US7875282B2 (en) 2004-03-22 2011-01-25 Cordis Corporation Coated medical device for local vascular delivery of Panzem® in combination with rapamycin to prevent restenosis following vascular injury
US20050232965A1 (en) 2004-04-15 2005-10-20 Robert Falotico Local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque
KR20080008364A (ko) 2005-05-05 2008-01-23 헤모텍 아게 관 스텐트의 전면 코팅
US20060275341A1 (en) * 2005-06-02 2006-12-07 Miv Therapeutics Inc. Thin foam coating comprising discrete, closed-cell capsules

Also Published As

Publication number Publication date
EP1808167B1 (en) 2018-07-04
US20070141112A1 (en) 2007-06-21
ES2686778T3 (es) 2018-10-19
CA2571302A1 (en) 2007-06-15
EP1808167A1 (en) 2007-07-18
US10029034B2 (en) 2018-07-24
JP2007190369A (ja) 2007-08-02

Similar Documents

Publication Publication Date Title
US10029034B2 (en) Drug-eluting articles with improved drug release profiles
EP2291431B1 (en) Bio-degradable block co-polymers for controlled release
EP1986711B1 (en) Implantable medical device with surface-eroding polyester drug delivery coating
US9056156B2 (en) Medical devices comprising polymeric drug delivery systems with drug solubility gradients
US20060198868A1 (en) Biodegradable coating compositions comprising blends
US20060147491A1 (en) Biodegradable coating compositions including multiple layers
EP1440698A1 (en) Drug-polymer coated stent with pegylated styrenic block polymers
US20070128289A1 (en) Nano-and/or micro-particulate formulations for local injection-based treatment of vascular diseases
US7442721B2 (en) Durable biocompatible controlled drug release polymeric coatings for medical devices
JP2011514231A (ja) 生分解性炭素ジアゼニウムジオレート系酸化窒素供与重合体
WO2009020797A2 (en) Polymers for implantable devices exhibiting shape-memory effects
EP1470830A1 (en) Drug-polymer coated stent with polysulfone and styrenic block copolymer
EP2442841A1 (en) Implantable medical devices and coatings therefor comprising block copolymers of poly (ethylene glycol) and a poly (lactide-glycolide)
US7041308B2 (en) Drug-polymer coated stents with segmented homochain copolyesters
JP2007190369A5 (enExample)
CN101346156A (zh) 具有附加在电移植底涂层上的可生物降解释放层的药物洗脱支架

Legal Events

Date Code Title Description
EEER Examination request
H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20240726