JP2007171182A - チャネル又はその構成部分への光の供給 - Google Patents
チャネル又はその構成部分への光の供給 Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
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- B01L2300/0627—Sensor or part of a sensor is integrated
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- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/168—Specific optical properties, e.g. reflective coatings
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
Abstract
【解決手段】チャネル内流体がより高屈折率の物質により囲まれて界面を形成するよう構造物内にチャネルを形成する。更に、光透過性の仕切部材184を配置してチャネル内を第1領域180と第2領域182とに区画する。プレート94に入射された光190は、チャネル長手方向に対し角度βだけ傾斜した光192となって第2領域182に入り、仕切部材184を通り抜けた後、チャネル長手方向に対し角度β’だけ傾斜した光194となって第1領域180内を伝搬する。伝搬する光のうちの有意な部分、少なくとも断面内強度比で約10%超の部分が流体内に閉じこめられるため、実効的且つ効率的に流体内の物体を照明できる。光194に反応してチャネル内物体から放出される光子を、チャネル沿いの集積回路上にあるフォトセンサアレイの構成セル群にて検知する。
【選択図】図9
Description
(数1)
β’=arcsin{(nA/nL)sinβ}
となる。この式中、nAは領域182内に存する空気、気体若しくは真空の屈折率、nLは領域180内に存する流体の屈折率である。
(数2)
β’=arcsin[(nB/nL)sin{arcsin{(nA/nB)sin(α+β)}−α}]
により計算できる値を有している。この式中、βは光210の面164への入射角、nBは仕切部材200を形成する素材の屈折率である。面202が傾斜している分、角β’が小さくなるため、効率を損なわずに結合角βを増すことができ、それによって面164における反射損失を低減することができる。
Claims (3)
- チャネル内部の流体がそれより概ね高屈折率になるであろう物質と所与の長手方向沿い区間を通じ何れの断面でも接触するよう、且つ当該区間内の何れの断面でも当該物質によって当該流体が概ね囲まれることとなるよう、構造物内に流路として形成されているチャネルを、その対象として実行され、
上記区間のうち少なくとも一部にて、伝搬する光のうち断面内強度比で約10%超の部分が流体内を伝搬することとなるよう、当該区間内で主として当該流体によりチャネル長手方向沿いに、光を伝搬させるステップと、
伝搬する光に反応してチャネルから放出される光子を、チャネル沿いに配置され且つ集積回路上に設けられたフォトセンサアレイを構成するセル群を検知手段として用いて、検知するステップと、
を有するチャネル外放出光子検知方法。 - 流路付構造物と、
その内部の流体がそれより概ね高屈折率になるであろう物質と所与の長手方向沿い区間を通じ何れの断面でも接触するよう、且つ当該区間内の何れの断面でも当該物質によって当該流体が概ね囲まれることとなるようその流体を収容すべく、流路付構造物内に形成されたチャネルと、
上記区間のうち少なくとも一部にて、伝搬光のうち断面内強度比で約10%超の部分が流体内を伝搬することとなるよう、チャネルに対し光を供給しチャネル内を長手方向に沿って伝搬させる照明部材と、
伝搬する光に反応してチャネルから放出される光子を検知できるよう、チャネル沿いに配置されセル群から構成されたフォトセンサアレイを有する集積回路と、
を備える装置。 - 流路付構造物と、流路付構造物内に所定方向に沿って長く形成されたチャネルと、流路付構造物内に形成されチャネルを第1領域と第2領域とに区画する光透過性の仕切部材と、流路付構造物に形成され第1領域への流体の入口及び第1領域からの流体の出口となる少なくとも2個のポートと、を備え、
更に、チャネル長手方向に対し傾斜している第1の方向から第2領域内に光を入射することができ、その後仕切部材を通り抜けた光がチャネル長手方向に対し傾斜している第2の方向から第1領域内に入射されるよう、仕切部材が配置された装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US11/316,660 | 2005-12-22 | ||
US11/316,660 US7386199B2 (en) | 2005-12-22 | 2005-12-22 | Providing light to channels or portions |
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JP2007171182A true JP2007171182A (ja) | 2007-07-05 |
JP2007171182A5 JP2007171182A5 (ja) | 2010-03-11 |
JP5160776B2 JP5160776B2 (ja) | 2013-03-13 |
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JP2006339568A Expired - Fee Related JP5160776B2 (ja) | 2005-12-22 | 2006-12-18 | チャネルから放出される光子を検知する光子検知方法及びチャネルに光を供給する装置 |
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US (1) | US7386199B2 (ja) |
EP (1) | EP1801564B1 (ja) |
JP (1) | JP5160776B2 (ja) |
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JP5160776B2 (ja) | 2013-03-13 |
US7386199B2 (en) | 2008-06-10 |
US20070147728A1 (en) | 2007-06-28 |
EP1801564A1 (en) | 2007-06-27 |
EP1801564B1 (en) | 2018-06-20 |
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