JP2007063288A5 - - Google Patents

Info

Publication number

JP2007063288A5

JP2007063288A5 JP2006302712A JP2006302712A JP2007063288A5 JP 2007063288 A5 JP2007063288 A5 JP 2007063288A5 JP 2006302712 A JP2006302712 A JP 2006302712A JP 2006302712 A JP2006302712 A JP 2006302712A JP 2007063288 A5 JP2007063288 A5 JP 2007063288A5

Authority

JP

Japan

Prior art keywords

alkylene

pharmaceutical composition

lower alkyl

aryl

composition according

Prior art date

2006-11-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000002947 alkylene group Chemical group 0.000 claims 14
• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 125000000217 alkyl group Chemical group 0.000 claims 13
• 125000003118 aryl group Chemical group 0.000 claims 10
• 229910052739 hydrogen Inorganic materials 0.000 claims 10
• 239000001257 hydrogen Substances 0.000 claims 10
• 125000004450 alkenylene group Chemical group 0.000 claims 9
• 125000003710 aryl alkyl group Chemical group 0.000 claims 9
• 125000001188 haloalkyl group Chemical group 0.000 claims 9
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims 8
• 206010065687 Bone loss Diseases 0.000 claims 6
• 206010028980 Neoplasm Diseases 0.000 claims 6
• 125000003342 alkenyl group Chemical group 0.000 claims 6
• 201000011510 cancer Diseases 0.000 claims 6
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 6
• 125000000753 cycloalkyl group Chemical group 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 6
• 229940124597 therapeutic agent Drugs 0.000 claims 6
• 125000000304 alkynyl group Chemical group 0.000 claims 5
• 125000004994 halo alkoxy alkyl group Chemical group 0.000 claims 5
• 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 5
• 125000000623 heterocyclic group Chemical group 0.000 claims 5
• 150000002431 hydrogen Chemical class 0.000 claims 5
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
• 230000002401 inhibitory effect Effects 0.000 claims 4
• 229940122361 Bisphosphonate Drugs 0.000 claims 3
• 206010060862 Prostate cancer Diseases 0.000 claims 3
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
• 125000003545 alkoxy group Chemical group 0.000 claims 3
• 150000004663 bisphosphonates Chemical group 0.000 claims 3
• 125000004663 dialkyl amino group Chemical group 0.000 claims 3
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
• 102000017914 EDNRA Human genes 0.000 claims 2
• 101150062404 EDNRA gene Proteins 0.000 claims 2
• 102000002045 Endothelin Human genes 0.000 claims 2
• 108050009340 Endothelin Proteins 0.000 claims 2
• 125000005081 alkoxyalkoxyalkyl group Chemical group 0.000 claims 2
• -1 alkoxyhaloalkyl Chemical group 0.000 claims 2
• 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 2
• 125000003282 alkyl amino group Chemical group 0.000 claims 2
• 125000004103 aminoalkyl group Chemical group 0.000 claims 2
• 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 2
• ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 239000002464 receptor antagonist Substances 0.000 claims 2
• 229940044551 receptor antagonist Drugs 0.000 claims 2
• 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
• 125000004689 alkyl amino carbonyl alkyl group Chemical group 0.000 claims 1
• 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
• 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 1
• 125000005127 aryl alkoxy alkyl group Chemical group 0.000 claims 1
• 230000004097 bone metabolism Effects 0.000 claims 1
• 125000001589 carboacyl group Chemical group 0.000 claims 1
• 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
• 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 1
• 125000000262 haloalkenyl group Chemical group 0.000 claims 1
• 125000004438 haloalkoxy group Chemical group 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 125000005020 hydroxyalkenyl group Chemical group 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 1
• 125000003831 tetrazolyl group Chemical group 0.000 claims 1
• 0 C*C(*)C(*)C(*)*N(C)* Chemical compound C*C(*)C(*)C(*)*N(C)* 0.000 description 6