JP2007020710A - Medical container packing body - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical container packing body in which a weakly sealed part for partitioning is peeled due to dropping in very few cases even when it is dropped from an appropriate height. <P>SOLUTION: The medical container packing body 1 is composed of a wrapping box 2 storing in the inside a plurality of wrapped medical containers 5 composed of a wrapping body 7 for wrapping the medical container 6 having two medicine chambers partitioned by the weakly sealed part 13. The wrapping box 2 comprises a bottom plate member having a plate part 3a and flap parts 3b-3e extended downwards and an inner plate member 4 having an upper plate part 4a covering the upper part of the bottom plate member and flap parts 4b-4e extended downwards. Inside the packing body 1, the plurality of wrapped medical containers are stacked and housed to the upper plate part of the inner plate member so as to form a prescribed space 23 at the upper part, and the plurality of wrapped medical containers are stacked and housed between the inner plate member and the upper lids 22a and 22b of the wrapping box main body so as to form a prescribed space 24 at the upper part. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a medical container package in which a plurality of prepackaged medical containers are stored.

Prior to infusion to the patient, a drug that is difficult to pre-mix in the infusion, such as vitamins or antibiotics, is mixed and dissolved in a vial or soft bag containing the infusion. Has been prepared. In order to prepare such a chemical solution aseptically and with a simple operation, a medical container having a plurality of drug chambers partitioned by a detachable partition weak seal portion is used.
Such a two-chamber medical container is packaged in a package, and then stored in a packaging box (for example, a cardboard box) and transported to a medical institution.
As a packaging form of the packaged medical container, for example, there is one as disclosed in JP 2004-203488 A (Patent Document 1).
JP 2004-203488 A

The thing of patent document 1 is the packing method which accommodates the some infusion bag which has at least 2 chambers divided by the easily peelable partition part in a packaging box, Comprising: The infusion bag of the state folded by the easily peelable partition part The outer bag is enclosed in the outer bag together with the gas, and the outer bag is filled with the infusion bag and the gas so that the total volume of all the packages is 50% or more of the volume of the packaging box. Gas is enclosed, and the packaging bodies are stacked alternately and accommodated in the packaging box, and the uppermost packaging body is in contact with the upper lid of the packaging box.
However, when the packaging body is dropped, a pinhole is generated by the impact of the impact, and the corners of the bag, in particular, the weak sealing parts on both sides that are folded and stored are in contact with the packaging body. Occurrence of this was reduced, compared with the case where the bag was stored vertically, but the load of the stacked package was applied to the lowermost package, and the easily peelable partition ( There is a high possibility that the partition weak seal part) will peel off.
Therefore, the present invention solves the above problems, and even if the package is dropped from an appropriate height, the load applied to the package (packaged medical container) located at the lowest layer of the package is small, It is an object of the present invention to provide a medical container package in which a plurality of prepackaged medical containers that are extremely unlikely to peel off due to the falling of the partition weak seal portion are accommodated.

What achieves the above object is as follows.
(1) From a medical container that is divided by a weak seal part for partitioning and has two medicine chambers containing medicines, and a package that encloses the medical container in a state of being folded in two at the weak seal part A medical container package comprising a packaging box containing a plurality of prepackaged medical containers inside,
The packaging box includes a rectangular parallelepiped packaging box body, a rectangular or square flat plate portion that is slightly smaller than the bottom surface of the packaging box body, and four sides of the flat plate portion. A bottom plate member extending downward and having substantially the same length and having a flap portion with a lower end abutting against the bottom surface, and disposed in the packaging box body so as to enclose the bottom plate member; A rectangular or square upper plate part slightly smaller than the bottom surface, extending downward from the four sides of the upper plate part, penetrating between the flap part of the bottom plate member and the side surface of the packaging box body, and Each having substantially the same length, and having a middle plate member having a flap portion whose lower end is in contact with the bottom surface,
The medical container package includes a plurality of prepackaged medical containers between the bottom plate member and the middle plate member, and a predetermined medical space between the packaged medical container positioned at the top and the upper plate portion of the middle plate member. A plurality of prepackaged medical containers are placed between the middle plate member and the top cover of the packaging box so that a gap is formed, and between the top cover of the prepackaged medical container and the top of the packaging box. A medical container package that is stacked and accommodated so that a predetermined gap is formed in the container.

(2) The packaged medical container according to (1), wherein the packaged medical containers are alternately stacked.
(3) The medical container package according to (1) or (2), wherein the intermediate plate member includes two gripping cutout portions formed to be opposed to each other at a peripheral portion of the upper plate portion. .
(4) The packaging box body includes a gripping cut portion formed on opposite side surfaces and a gripping flap that is bent by the inside of the packaging box body, and is used for gripping the intermediate plate member. The cutout portion is the medical container package according to (3), which is located below the gripping flap.
(5) The said intermediate plate member is a medical container package in any one of (1) thru | or (4) provided with the notch part for internal visual recognition.
(6) The number of stacked medical containers stored between the bottom plate member and the intermediate plate member in the medical container package is stored between the intermediate plate member and the upper cover of the packaging box. The medical container package according to any one of (1) to (5), which is less than the number of stacked medical containers.

  According to the medical container package of the present invention, when the package is dropped from a predetermined height, the load of the plurality of packaged medical containers stacked and accommodated between the middle plate member and the upper cover of the packaging box body is Absorbed by the middle plate member and hardly transmitted to a plurality of prepackaged medical containers stacked and accommodated between the bottom plate member and the middle plate member. Further, since a predetermined gap is formed between the packaged medical container positioned above the plurality of packaged medical containers stacked and accommodated between the bottom plate member and the middle plate member and the upper plate portion of the middle plate member. When the packaging body is dropped from a predetermined height, even if a load is applied to the middle plate member and the upper plate portion is deformed, the deformation is absorbed by the gap, and the upper plate portion is positioned at the upper portion. The container is not strongly pressed. Therefore, in any position of the medical containers in the individual packaged medical containers, the partition weak seal portion is hardly peeled due to dropping.

The medical container package which is an Example of this invention is demonstrated using an accompanying drawing.
1 is a perspective view of a medical container package that is an embodiment of the present invention, FIG. 2 is a cross-sectional view of the medical container package shown in FIG. 1, and FIG. It is explanatory drawing for demonstrating the packing form of the container packaging body. FIG. 4 is a developed view of the middle plate member of the packaging box used for the medical container package of the present invention, and FIG. 5 shows the bottom plate member of the packaging box used for the medical container package of the present invention. FIG. FIG. 6 is a front view of an example of a medical container that is a packing target of the medical container package of the present invention.

The medical container package 1 of the present invention is divided by a partition weak seal 13 and has two medical chambers 11 and 12 in which a medicine is stored, and a packaging that encloses the medical container 6. It is a medical container package body composed of a plurality of packaging boxes 2 in which a packaged medical container 5 composed of a body 7 is folded in two at a weak seal portion.
The packaging box 2 is disposed at a rectangular parallelepiped packaging box body 20, a rectangular or square flat plate portion 3 a slightly smaller than the bottom surface 21, and below the four sides of the flat plate portion 3 a. A bottom plate member 3 that has flap portions 3b, 3c, 3d, and 3e that extend and have substantially the same length and whose bottom ends are in contact with the bottom surface 21, and a packaging box body that encloses the top of the bottom plate member 3 20 is disposed in the upper plate portion 4a, which is slightly smaller than the bottom surface 21 and extends downward from the four sides of the upper plate portion 4a, and the flap portions 3b, 3c, 3d, 3e of the bottom plate member 3; And an intermediate plate member 4 having flap portions 4b, 4c, 4d, and 4e that penetrate between the side surfaces of the packaging box body 20 and have substantially the same length, and whose lower ends are in contact with the bottom surface 21.
The medical container package 1 includes a plurality of prepackaged medical containers 5a and 5b between the bottom plate member 3 and the middle plate member 4, and a top plate of the packaged medical container 5b and the middle plate member 4. A plurality of prepackaged medical containers 5c, 5d, and 5e are placed at the top between the middle plate member 4 and the upper lid of the packaging box 2 so that a predetermined gap 23 is formed between the parts. The stacked medical containers 5e and the upper lid of the packaging box 2 are stacked and stored so that a predetermined gap 24 is formed.

As shown in FIG. 2, the medical container package 1 of the present invention includes a packaging box 2 and a plurality of prepackaged medical containers 5 stacked and accommodated in the packaging box.
The packaging box 2 includes a rectangular parallelepiped packaging box body 20, a bottom plate member 3 housed in the packaging box body 20, and an intermediate plate member 4.
The packaging box body 20 has a rectangular parallelepiped shape as shown in FIGS. 1, 2, and 3, and may have a cubic shape. The shape of the packaging box body can be appropriately set according to the shape of the packaged container to be stored.
The packaging box body 20 includes a rectangular or square bottom surface 21, four side portions, and an upper lid including four flaps 22a, 22b, 22c, and 22d. A so-called cardboard box is suitable as the packaging box body. The size is determined in consideration of the size of the packaged medical container to be stored.
As shown in FIGS. 2, 3, and 5, the bottom plate member 3 extends below the four sides of the flat plate portion 3a and a rectangular or square flat plate portion 3a that is slightly smaller than the bottom surface 21 of the packaging box main body. The flap portions 3b, 3c, 3d, and 3e have substantially the same length and the lower ends abut against the bottom surface 21. For this reason, when the bottom plate member 3 is housed in the packaging box body 20, a gap is formed between the flat plate portion 3 a and the bottom surface 21 as shown in FIG. 2. By having this gap, the flat plate portion 3a can be deformed downward, and when a downward load is applied to the packaged medical container 5 placed on the flat plate portion 3a, the load can be absorbed. It has become.

As a downward length of the flap portions 3b, 3c, 3d, 3e, about 10 to 50 mm is preferable. If it is 10 mm or more, there is a low possibility that the flat plate portion will come into contact with the bottom surface of the packaging box body due to the load of the packaged medical container placed on the bottom plate member 3. It does not grow unnecessarily.
Further, (the total area of the flap portions 3b, 3c, 3d, and 3e) / (the area of the flat plate portion 3a) is preferably 0.1 to 0.6, particularly preferably 0.2 to 0.5. It is. If it is 0.1 or more, there is a low possibility that the flat plate portion will come into contact with the bottom surface of the packaging box body due to the load of the packaged medical container placed on the bottom plate member 3, and 0.6 or less. In this case, the package itself does not become unnecessarily large.

Further, as shown in FIGS. 3 and 5, two gripping cutout portions 31 a and 31 b are provided on the flat plate portion 3 a of the bottom plate member 3. It is preferable that the gripping notches 31a and 31b are formed so as to face each other at the peripheral edge of the flat plate portion 3a. The bottom plate member 3 is preferably formed by bending so-called cardboard paper. In the bottom plate member 3, the width of the facing flap portions 3c and 3e is slightly shorter than the length of the side of the corresponding (in other words, continuous) flat plate portion 3a. Further, the widths of the facing flap portions 3b and 3d, not the facing flap portions 3c and 3e, may be short. By doing in this way, the overlap of the edge part at the time of bending a flap can be prevented.
As shown in FIGS. 2, 3 and 4, the middle plate member 4 is formed in a rectangular or square upper plate portion 4a slightly smaller than the bottom surface 21 of the packaging box body and below the four sides of the upper plate portion 4a. It has flap portions 4b, 4c, 4d, and 4e that extend and have substantially the same length, and whose lower ends abut against the bottom surface 21. Specifically, as shown in FIG. 2, the middle plate member 4 is disposed in the packaging box body 20 so as to enclose the upper portion of the bottom plate member 3, and the upper plate portion 4 a is slightly more than the bottom surface 21. It is a rectangular or square shape that is small and slightly larger than the flat plate portion 3 a of the bottom plate member 3. In particular, the upper plate portion is preferably similar to the flat plate portion and slightly larger.

Then, the four flap portions 4b, 4c, 4d, 4e of the intermediate plate member 4 penetrate between the flap portions 3b, 3c, 3d, 3e of the bottom plate member 3 and the side surface of the packaging box body 20, and the lower end enters the bottom surface 21. It is in contact. The downward length of the flap portions 4b, 4c, 4d, 4e is about 50 to 100 mm longer than the downward length of the flap portions 3b, 3c, 3d, 3e, and the flap portions 4b, 4c, 4d. , 4e is preferably about 65 to 155 mm.
When the middle plate member 4 is housed in the packaging box body 20, a gap is formed between the upper plate portion 4a of the middle plate member 4 and the flat plate portion 3a of the bottom plate member, as shown in FIG. To do. By having this gap, a storage space defined between the upper plate portion 4a of the middle plate member 4 and the flat plate portion 3a of the bottom plate member is formed.

Further, as shown in FIGS. 3 and 5, the upper plate portion 4a of the middle plate member 4 is provided with two gripping cutout portions 41a and 41b. The gripping notches 41a and 41b are preferably formed so as to face the peripheral edge of the upper plate portion 4a and face each other. Moreover, it is preferable that the intermediate | middle board member 4 is equipped with the notch parts 42a and 42b for internal visual recognition. The intermediate plate member 4 is preferably formed by bending so-called cardboard paper. In this intermediate plate member, the widths of the flap portions 4c and 4e facing each other are slightly shorter than the length of the side of the corresponding upper plate portion 4a (in other words, continuous). Moreover, it is good also as a thing with short width | variety of the flap parts 4b and 4d which face each other instead of the flap parts 4c and 4e which face each other. By doing in this way, the overlap of the edge part at the time of bending a flap can be prevented.
Further, as shown in FIGS. 2 and 3, the packaging box body 20 includes gripping cut portions 25 a and 25 b formed on opposite side surfaces and a gripping flap 26 a that bends inside the packaging box body formed by the cut portions. , 26b. The intermediate plate member 4 is accommodated in the packaging box body 20 so that the gripping notches 41a and 41b are positioned below the gripping flaps 26a and 26b.

The medical container package 1 includes a plurality of packaged medical containers 5a and 5b stacked between the bottom plate member 3 and the middle plate member 4 as shown in FIGS. A predetermined gap 23 is formed between the packaged medical container 5 (5b) and the upper plate portion 4a of the middle plate member 4 positioned at (the upper layer of the laminate). The height of the gap 23 is preferably 5 to 30 mm, and particularly preferably 8 to 20 mm.
And it is preferable that the packaged medical container is laminated | stacked alternately. Stacking alternately means stacking so that the first drug chambers of the medical container do not overlap, in other words, the first drug chamber and the second drug chamber overlap. The number of packaged medical containers 5 to be laminated is preferably about 2 to 5. Specifically, when two prepackaged medical containers are stacked, it is preferable to stack as shown in FIG. 8, and when three are stacked, as shown in FIG. Is preferred. When four or more layers are stacked, the odd layers and the even layers are stacked in the same manner.

Furthermore, as shown in FIGS. 2 and 3, the medical container package 1 includes a plurality of prepackaged medical containers 5 c, 5 d, 5 e between the middle plate member 4 and the upper lids 22 a, 22 b of the packaging box body 20. A predetermined space 24 is formed between the packaged medical container 5 (5e) positioned at the top (the upper layer of the laminate) and the upper lid of the packaging box body 20 while being stacked and stored. As height of the space | gap 24, 5-30 mm is preferable, and 8-20 mm is especially preferable.
And it is preferable that the packaged medical container is laminated | stacked alternately like the above. The number of packaged medical containers 5 to be laminated is preferably about 2 to 5. Specifically, when two prepackaged medical containers are stacked, it is preferable to stack as shown in FIG. 8, and when three are stacked, as shown in FIG. Is preferred. When four or more layers are stacked, the odd layers and the even layers are stacked in the same manner.

In addition, the number of packaged medical containers to be laminated is less between the bottom plate member 3 and the middle plate member 4 than between the middle plate member 4 and the upper lids 22a and 22b of the packaging box body 20. preferable. By reducing the number of packaged medical containers 5 stacked and accommodated between the bottom plate member 3 and the middle plate member 4, the load applied to the bottom plate member is also reduced, and the length of the flap of the bottom plate member is short. The size of the package itself can be prevented.
As described above, the base plate member and the middle plate member are provided, and the stacked packaged medical containers are stored in the packaging box body as described above, so that the packaging body is dropped from a predetermined height. The load of a plurality of prepackaged medical containers stacked and accommodated between the middle plate member and the upper lid of the packaging box body is caused by the middle plate member due to the flapping of the four flaps of the middle plate member and the appropriate deflection of the flat plate portion. Absorbed and hardly transmitted to a plurality of prepackaged medical containers that are stacked and accommodated between the bottom plate member and the middle plate member. Further, since a predetermined gap is formed between the packaged medical container positioned above the plurality of packaged medical containers stacked and accommodated between the bottom plate member and the middle plate member and the upper plate portion of the middle plate member. When the packaging body is dropped from a predetermined height, even if a load is applied to the middle plate member and the upper plate portion is deformed, the deformation is absorbed by the gap, and the upper plate portion is positioned at the upper portion. The container is not strongly pressed. Therefore, separation of the partition weak seal portion due to dropping is extremely rare. Furthermore, the pinhole which a corner | angular part of a medical container, especially the weak seal part folded and stored and the corner part of the both sides of a weak seal part produced by contacting a package is also prevented. In particular, when a medical container having notches 8a and 8b on both sides of the weak seal portion forming portion as shown in FIG. 6 is used, the effect of preventing the occurrence of pinholes is particularly high.

Moreover, the medical container package of this invention can be created with the following medical container packaging methods.
This medical container packaging method is a prepackaged medical device comprising a medical container having two drug chambers that are partitioned by a weak seal portion for partitioning and containing a drug, and a package that encloses the medical container. A packaging method for medical containers for storing a plurality of containers inside a packaging box, comprising a rectangular parallelepiped packaging box body, a bottom plate member, and a middle plate member, and the packaging box body having the packaging box body A bottom plate member is disposed so that the flat plate portion is positioned slightly above the bottom surface portion of the main body, and a gap is formed between the flat plate portion and the bottom surface portion, and a plurality of packaged medical containers are placed on the bottom plate portion member. The middle plate member is laminated so that the upper plate portion is positioned slightly above the packaged medical container in the packaging box body, and the gap between the upper plate portion and the packaged medical container is a gap. And place multiple prepackaged medical devices on the middle plate member The vessel was laminated so as not to reach the top of the packaging box main body, and then, in which closing lid of the packing box.
And in the medical container package 1 of the present invention, by opening the upper lid of the packaging box body 20, the packaged medical container stacked and accommodated between the middle plate member and the upper lid of the packaging box body can be taken out, Furthermore, the packaged medical container accommodated between the bottom plate member and the middle plate member can be taken out by removing the middle plate member.
As shown in FIG. 8, the packaged medical container 5 includes a medical container 6 and a package 7 that individually encloses the medical container 6.

As shown in FIG. 6, the medical container 6 includes two drug chambers 11 and 12 that are partitioned by a partition weak seal portion 13 and that store a drug.
Specifically, the medical container 6 is filled in the first drug chamber 11 and the soft bag 8 having the first drug chamber 11 and the second drug chamber 12 partitioned by the partition weak seal portion 13. The first drug solution 15, the second drug solution 16 filled in the second drug chamber 12, and a port 17 that can communicate with the drug chamber 11. The drug chamber 11 and the second drug chamber 12 are filled with a drug.
The soft bag 8 is made of a soft resin sheet. The flexible bag 8 is preferably formed into a cylindrical shape by an inflation molding method. The soft bag 8 is manufactured by various methods such as a T-die method, a blow molding method, a dry laminating method, a hot melt laminating method, a coextrusion inflation method, a coextrusion T die method, and a hot press method. But you can. And the flexible bag 8 is bent in a manufacturing process, and two sides are formed. Moreover, you may form the bent side by lightly pressing as needed.

The soft bag 8 preferably has a water vapor barrier property. As the degree of water vapor barrier property, the water vapor permeability is preferably 50 g / m ² · 24 hrs · 40 ° C. · 90% RH or less, more preferably 10 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. More preferably, it is 1 g / m ² · 24 hrs · 40 ° C. · 90% RH or less. This water vapor permeability is measured by the method described in JISK7129 (Method A).
Thus, since the soft bag 8 has water vapor | steam barrier property, the evaporation of the water | moisture content from the inside of the medical container 6 can be prevented. As a result, it is possible to prevent a decrease in liquid filling and concentration. Moreover, the invasion of water vapor from the outside of the medical container 6 can be prevented.

Examples of the material for forming such a flexible bag 8 include polyethylene (PE), polypropylene (PP), polybutadiene, polyolefin such as ethylene-vinyl acetate copolymer (EVA), olefin elastomer, and styrene elastomer. Various thermoplastic elastomers or those arbitrarily combined (blend resin, polymer alloy, laminate, etc.) can be mentioned. And it is preferable that the resin material to be used has the heat resistance and water resistance which can endure high pressure steam sterilization (autoclave sterilization).
Moreover, although the volume of the medical container 6 changes with kinds etc. of the liquid accommodated in an inside, it is preferable normally that it is about 200-5000 ml, and it is more preferable that it is about 500-5000 ml.

Also, one end of the soft bag 8 according to the embodiment of the present invention is provided with one end side seal portion 81, and the other end of the soft bag 8 is provided with the other end side seal portion 82. The other end side seal portion 82 is provided with a suspension opening 83. The one-end-side seal portion and the other-end-side seal portion of the flexible bag 8 are preferably formed by thermal fusion (heat sealing), high-frequency fusion, ultrasonic fusion, or the like, and particularly by thermal fusion. preferable.
The partition weak seal portion 13 is a peelable weak seal portion formed so as to partition the internal space of the soft bag 8, as shown in FIG. The soft bag 8 is partitioned into a first drug chamber 11 and a second drug chamber 12 by a partition weak seal 13. Further, the both ends of the partition weak seal portion 13 are not substantially peeled off, that is, strongly sealed with such a sealing strength as not to be peeled off by a normal communication operation with respect to the partition weak seal such as pressing and squeezing pressure. A seal portion may be formed. Moreover, in this medical container, the partition weak seal portion 13 is formed at a position where the first drug chamber 11 of the soft bag 8 has a larger internal volume than the second drug chamber 12.

The partition weak seal portion 13 has a seal strength that can be peeled off by pressing (or squeezing and pressing) the first drug chamber 11 or the second drug chamber 12 filled with the chemical solution with a finger or the like. By partitioning the inside of the soft bag 8 with the partition weak seal portion 13 in this way, it can be stored separately until a liquid containing a substance that causes alteration or deterioration due to reaction or the like is used. It can be applied when it is preferable to mix both solutions. Examples of such a liquid include a combination of an amino acid electrolyte solution and a glucose solution, a glucose solution and a sodium bicarbonate solution, and the like.
And in the medical container used in this Example, the notch parts 8a and 8b are provided in the both sides of the part in which the partition weak seal part 13 is formed. By providing such a notch, when the medical container is folded at the weak seal part, the corners on both sides of the weak seal part are less likely to be formed, and a pinhole resulting from contact between the corner part and the package More effectively prevent the occurrence of

Further, the medical container 6 includes a discharge port 17 communicating with the first drug chamber 11 as shown in FIG. A known port is used as the discharge port 17. Further, the medical container 6 includes a mixed injection port 27 communicating with the first medicine chamber 11 as shown in FIG. Known discharge ports and mixed injection ports are used. As the port, for example, a port having a cylindrical port member and a seal member that seals the opening and can be inserted through the needle tube is preferable. Specifically, the port is preferably composed of a cylindrical member having both ends opened and a lid having a sealing member that seals one opening of the cylindrical member.
Moreover, the medical container 6 is provided with the chemical | medical agent container 18, as shown in FIG. The drug container 18 is liquid-tightly fixed to the second drug chamber side of the container body 8. Furthermore, the medicine container 18 includes a medicine container 18 a and an operation part 18 b, and the operation part 18 b projects into the second medicine chamber 12 of the soft bag 8. Further, the medicine container 18 includes a breakable part provided between the medicine storage part 18a and the operation part 4b. Then, by pushing and bending the operation portion 18 b from the outside of the soft bag 8, the medicine container 18 is broken at the breakable portion, and the medicine to be filled flows into the soft bag 8. For example, fat-soluble vitamins are stored in the medicine container 18.

The package 7 encloses the entire medical container 6 and is hermetically sealed.
As the package 7, a sealed one made of a light-shielding and gas-impermeable film is used. Specifically, a packaging material made of a light-shielding and gas-impermeable film having an aluminum vapor deposition layer, an aluminum foil layer, or a silica (SiO ₂ ) vapor deposition layer is suitable. In particular, it is preferable to use a laminated film in which an aluminum vapor-deposited layer or an aluminum foil layer is sandwiched between highly gas-impermeable polymer material films. Examples of the gas-impermeable polymer material forming the gas-impermeable laminated film include biaxially stretched polyamide, an ethylene-vinyl alcohol copolymer, a polyester such as polyethylene terephthalate, and polyvinylidene chloride.

  In the case of a laminated film, the aluminum vapor deposition layer or the aluminum foil layer is preferably an intermediate layer of the laminated film. The laminated film is made of, for example, an adhesive layer (for example, polyethylene or ethylene-vinyl acetate copolymer) made of a low-melting resin, with one layer or two or more layers made of a gas permeable polymer material It can be produced by heat-sealing with an aluminum vapor deposition layer or an aluminum foil layer. Furthermore, it is preferable to provide a low melting point resin layer for sealing on the inner surface of the laminated film. This low melting point resin layer may be provided on the entire inner surface of the film, or may be provided only at or near the heat-sealed portion. A so-called hot melt material is used as a material for forming the low melting point resin layer. Specifically, a low melting point resin such as polyethylene (for example, low molecular weight polyethylene) or ethylene-vinyl acetate copolymer is used.

Specific examples of the package include, for example, a laminated film having a layer structure of biaxially stretched polyamide (OPA) / polyethylene (PE) / aluminum-deposited polyethylene terephthalate (PET) / polyethylene (PE), OPA / PE / aluminum foil / PE / PE laminated film having a layer structure, OPA / PE / aluminum foil / PE / PET / PE laminated film, PET / PE / aluminum-deposited PET / PE / ethylene-vinyl acetate copolymer Laminated film having a layer structure made of a combination (EVA) / PE, Laminated film having a layer structure made of polyvinylidene chloride / PE / aluminum-deposited PET / PE, PET / aluminum-deposited ethylene-vinyl alcohol copolymer (EVOH) / It has a layer structure made of PE And the like can be mentioned layer film.
The gas-impermeable film used for the packaging material used in the present invention has an oxygen transmission rate of 1.0 ml / m ² ··· when measured at 23 ° C., 90% RH, and 101 kPa (1 atm). It is preferably not more than day, and more preferably not more than 0.60 ml / m ² · day. Moreover, it is preferable that the thickness of the aluminum vapor deposition layer or aluminum foil layer in a gas hardly permeable film is 0.05-1.5 micrometers in the case of an aluminum vapor deposition layer, and 5-15 micrometers in the case of an aluminum foil layer.

And after a medical container is accommodated, a package is sealed by heat-sealing an opening part. In the package of this embodiment, the entire peripheral edge of the package is provided with a heat sealed portion.
And in the packaged medical container 5 in the medical container package 1 of this Example, as shown in FIG. 8, it is accommodated in the package in the state folded in half by the partition weak seal part 13. As shown in FIG.

Moreover, as a medical container used for the medical container package 1 of this invention, a thing as shown in FIG. 7 may be sufficient. The medical container 61 in this embodiment is provided with a communication blocking weak seal portion 19 that blocks communication between the drug chamber 11 and the port 17.
The communication-inhibiting weak seal portion 19 is formed so as to surround the upper portion of the discharge port 17. The weak seal portion 19 for inhibiting communication can be formed by heat-sealing the sheet material in a band shape (thermal fusion, high frequency fusion, ultrasonic fusion, etc.). The seal strength of the weak seal portion 19 for inhibiting communication is preferably larger than the seal strength of the weak seal portion 13 for partitioning. With such a configuration, the medicine is prevented from being administered before the medicine in the soft bag 8 and the third medicine in the medicine container 13 are mixed.

The medical container 61 is provided with a mixed injection port 28 that communicates with the second drug chamber 12 instead of the drug container 18. A well-known port is used as the mixed injection port 28. As the co-injection port, for example, a port having a cylindrical port member and a seal member capable of inserting the needle tube while sealing the opening thereof is preferable. Specifically, the port is preferably composed of a cylindrical member having both ends opened and a lid having a sealing member that seals one opening of the cylindrical member.
And in the medical container provided with the weak seal part for communication inhibition as described above, it is bent at the weak seal part 13 for partitioning as in the packaged medical container 52 shown in FIG. Bending further outward at the weak seal portion 19 (tri-folded state), and further bending at the partition weak seal portion 13 as in the packaged medical container 53 shown in FIG. In the case where the portion 19 is provided, the portion 19 may be further bent inward (three-fold state) by the weak seal portion 19 for inhibiting communication. In such a medical container, the three-fold container has less peeling of the partition weak seal when dropped, compared to the two-fold container.

Next, the manufacturing method of the medical container used for the medical container package of this invention is demonstrated easily.
Here, the manufacturing method of the medical container 61 shown in FIG. 7 mentioned above is demonstrated.
In the method for manufacturing the medical container 61 of the present invention, the soft bag 8 partitioned into the first drug chamber 11 and the second drug chamber 12 by the partition weak seal portion 13 and the first drug chamber 11 are filled. In addition, the first drug solution 15, the second drug solution 16 filled in the second drug chamber 12, the discharge port 17 attached to the soft bag 8 so as to communicate with either the drug chamber 11 or 12, and the mixed injection A method of manufacturing a sealed medical container 61 having a port 28, the step of preparing the medical container using the soft bag 8 formed with the weak seal portion 13, and the high-pressure steam sterilization of the medical container. A sterilization step to be performed, and a formation step of the weak seal portion 19 for communication inhibition.

The soft bag 8, the drug chambers 11, 12, the first drug solution 15, the second drug solution 16, the discharge port 17, and the mixed injection port 28 used in the manufacturing method of the present invention are as described above. Refer to
As a manufacturing method of the soft bag 8, a tube body formed of a soft synthetic resin is prepared. And, this tube body has a partially unsealed portion having an upper end side seal portion 82 having one place (drug container attaching portion), a lower end side seal portion 81 having one partially unsealed portion (discharge port attaching portion), A soft bag 8 is formed by forming the partition weak seal portion 13 and the strong seal portion 14.
The weak seal part is formed by forming a strip-like peelable partition weak seal part using a heat seal mold. The mold temperature when forming the partition weak seal portion 13 is preferably 0 to 60 ° C. lower than the melting temperature of the material for forming the soft bag 8, and in particular, the material for forming the soft bag 8. It is preferable that it is 0 to 50 degreeC lower than the melting temperature. Further, the sealing pressure in the weak seal portion forming step varies depending on the forming material of the soft bag 8 and the like, but is preferably 0.2 to 0.5 MPa, more preferably 0.3 to 0.4 MPa. preferable.

Next, the process of preparing the medical container 61 using the soft bag 8 in which the weak seal part 13 is formed will be described.
As described above, the tubular member of the discharge port 17 is inserted into and fixed to the discharge port mounting portion which is a partially unsealed portion of the lower end side seal portion 81 of the soft bag 8 in which the weak seal portion 13 is formed. And after inject | pouring the 1st chemical | medical solution 15 in the 1st chemical | medical agent chamber 11 via a cylindrical member, it fixes to the cylindrical member so that the lower end part of the medical container 61 may become upper, A lid member is attached to a cylindrical member Is fixed and sealed. Next, the cylindrical member of the mixed injection port is inserted into and fixed to the mixed injection port mounting portion which is a partially unsealed portion of the upper end side seal portion 82. And after inject | pouring the 2nd chemical | medical solution 16 into the 2nd chemical | medical agent chamber 12 via this cylindrical member, in the state fixed so that the upper end part of the medical container 6 might become upper, a lid | cover is covered with a cylindrical member. The member is fixed and sealed. In this way, a medical container 61 filled with a medicine as shown in FIG. 7 is produced.

Next, a sterilization process for performing high-pressure steam sterilization of the medical container 61 will be described.
The high-pressure steam sterilization is a method of sterilizing the medical container 61 with high-pressure saturated steam to denature proteins and the like that form microorganisms. The high-pressure steam sterilization method is generally performed by placing a medical container to be sterilized in a pressure container, replacing the air in the container with saturated steam, and holding the container for a certain period of time. In the embodiment of the present invention, the high-pressure steam sterilization is performed by being placed inside the high-pressure steam sterilizer. In the high-pressure steam sterilization method, it is preferable to sterilize an object in a bag or the like, for example, at 121 ° C. for 30 minutes.

  The formation of the weak seal portion 19 for inhibiting communication is easily performed in the process of preparing the medical container 61, but a small amount of water is enclosed in the discharge port or the weak seal portion 19. It is preferable from the viewpoint of sterilization to be separately accommodated in the space. Therefore, after the sterilization step, by forming the weak seal portion 19 for inhibiting communication in the soft bag 8, the space can be sterilized using water vapor generated from the chemical solution filled in the container. The weak seal portion is preferably formed in a shape as shown in FIG. 7, but it may be a belt-like shape like the partition weak seal portion. Formation of the peelable weak seal portion for preventing communication is performed using a heat seal mold. The temperature of the mold when forming the weak seal portion is preferably 0 to 60 ° C. lower than the melting temperature of the forming material of the soft bag 8, and in particular, the melting temperature of the forming material of the soft bag 8 It is preferably 0 to 50 ° C. lower than the temperature. Further, the sealing pressure in the weak seal portion forming step varies depending on the forming material of the soft bag 8 and the like, but is preferably 0.2 to 0.5 MPa, more preferably 0.3 to 0.4 MPa. preferable. The formation of the weak seal portion 19 for inhibiting communication may be performed in a state where there is substantially no drug between the weak seal portion 19 for preventing communication and the discharge port 17. By doing in this way, even if the needle tube is punctured to the discharge port 17 in a state where the weak seal portion is not peeled off, no medicine flows out.

FIG. 1 is a perspective view of a medical container package according to an embodiment of the present invention. 2 is a cross-sectional view of the medical container package shown in FIG. FIG. 3 is an explanatory diagram for explaining a packing form of the medical container package shown in FIG. 1. FIG. 4 is a developed view of the middle plate member of the packaging box used in the medical container package of the present invention. FIG. 5 is a developed view of the bottom plate member of the packaging box used in the medical container package of the present invention. FIG. 6 is a front view of an example of a medical container that is a packing target of the medical container package of the present invention. FIG. 7 is a front view of another example of a medical container that is a packing target of the medical container package of the present invention. FIG. 8 is a cross-sectional view showing an example of the internal form of the packaged medical container housed in the medical container package of the present invention and the stacked state of the packaged medical container. FIG. 9 is a cross-sectional view showing another example of the stacked state of the packaged medical containers housed in the medical container package of the present invention. FIG. 10 is a cross-sectional view of another example of the packaged medical container housed in the medical container package of the present invention. FIG. 11 is a cross-sectional view of another example of the packaged medical container housed in the medical container package of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical container packaging body 2 Packaging box 3 Bottom plate member 4 Middle board member 5 Packaged medical container 6 Medical container 7 Packaging body 20 Packaging box body

Claims (6)

Packaged consisting of a medical container having two drug chambers that are partitioned by a weak seal part for partitioning and containing a drug, and a package that encloses the medical container in a folded state at the weak seal part A medical container package comprising a packaging box containing a plurality of medical containers inside,
The packaging box includes a rectangular parallelepiped packaging box body, a rectangular or square flat plate portion that is slightly smaller than the bottom surface of the packaging box body, and four sides of the flat plate portion. A bottom plate member extending downward and having substantially the same length and having a flap portion with a lower end abutting against the bottom surface, and disposed in the packaging box body so as to enclose the bottom plate member; A rectangular or square upper plate part slightly smaller than the bottom surface, extending downward from the four sides of the upper plate part, penetrating between the flap part of the bottom plate member and the side surface of the packaging box body, and Each having substantially the same length, and having a middle plate member having a flap portion whose lower end is in contact with the bottom surface,
The medical container package includes a plurality of prepackaged medical containers between the bottom plate member and the middle plate member, and a predetermined medical space between the packaged medical container positioned at the top and the upper plate portion of the middle plate member. A plurality of prepackaged medical containers are placed between the middle plate member and the top cover of the packaging box so that a gap is formed, and between the top cover of the prepackaged medical container and the top of the packaging box. A medical container package characterized by being stacked and accommodated so that a predetermined gap is formed in the container. The medical container package according to claim 1, wherein the packaged medical containers are alternately stacked. 3. The medical container package according to claim 1, wherein the middle plate member includes two gripping cutout portions formed so as to face each other at a peripheral portion of the upper plate portion. The packaging box body includes a gripping cut portion formed on opposite side surfaces and a gripping flap that bends to the inside of the packaging box body formed by the cut portion, and the gripping cutout portion of the intermediate plate member is The medical container package according to claim 3, which is located below the gripping flap. The medical container package according to any one of claims 1 to 4, wherein the intermediate plate member includes a notch for visually recognizing the inside. The number of stacked medical containers stacked between the bottom plate member and the middle plate member in the medical container package is the number of stacked medical packages stored between the middle plate member and the upper lid of the packaging box. The medical container package according to any one of claims 1 to 5, wherein the number of the containers is less than the number of stacked containers.

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