CN102555282A - Method for manufacturing individual medical packaging bag and individual medical packaging bag - Google Patents
Method for manufacturing individual medical packaging bag and individual medical packaging bag Download PDFInfo
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- CN102555282A CN102555282A CN2011104434190A CN201110443419A CN102555282A CN 102555282 A CN102555282 A CN 102555282A CN 2011104434190 A CN2011104434190 A CN 2011104434190A CN 201110443419 A CN201110443419 A CN 201110443419A CN 102555282 A CN102555282 A CN 102555282A
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Abstract
The invention provides a method for manufacturing an individual medical packaging bag and an individual medical packaging bag, wherein the surfaces of the bags are prevented from being mutually bonded with each other during sterilization. The method for manufacturing an individual medical packaging bag comprises the following steps: the bag body (2) of a medical bag (1) isat least partially provided with liquid wherein the spacing part (5) thereof to be bent is in contact with the bag body (2). The interior of the bag body (2) is divided into a first space (3) and a second space (4) through the spacing part (5). The spacing part (5) is formed by fusing or welding sheets. The medical bag (1) is bent at the spacing part (5) and is accommodated inside the packaging material in a bending state. Then the packaging material is sealed. The medical bag (1) accommodated in the packaging material is subjected to sterilization together with the packaging material.
Description
Technical field
The present invention relates to a kind of manufacturing approach and medical bag individual package of medical bag individual package.
Background technology
In having medical bag of bag main body that inner sealing has transfusion or liquid such as peritoneal dialysis solution; For example when infusing, use and mixed more than 2 kinds under the situation of the medical bag of composition to the patient; If beginning is kept in bag main body after just these compositions being mixed, then rotten, deterioration take place in time dependent ground sometimes.
For this reason, developed multichamber vessel, wherein; The centre of the bag main body that will be made up of resin film-making material is fused into band shape, forms spacer portion, through this spacer portion with being divided into two spaces in the bag main body; Two kinds of liquid separately are contained in each space; Peel off spacer portion in case of necessity, the liquid in two spaces is mixed with each other uses (for example, referring to patent documentation 1).
So medical bag is accommodated in the packaging material with the state in the spacer portion bending, implements high pressure steam sterilization together with this packaging material.
But, during above-mentioned high pressure steam sterilization, have the stick to each other problem of (blocking) of the surface that is in contact with one another of bag main body.
Patent documentation 1: TOHKEMY 2004-208883 communique
Summary of the invention
The object of the present invention is to provide a kind of manufacturing approach and medical bag individual package of the medical bag individual package that the bag body surfaces sticks to each other can prevent to sterilize the time.
Above-mentioned purpose is that the present invention through following (1)～(7) reaches.
(1) a kind of manufacturing approach of medical bag individual package; It is the manufacturing approach that the medical bag with bag main body is accommodated in the medical bag individual package that forms in the packaging material; Said bag main body constitutes by having flexible sheet material, innerly is divided into the 1st space and the 2nd space through spacer portion, and said spacer portion is through with above-mentioned sheet material welding or bonding formation; It is characterized in that said manufacturing approach comprises following operation:
, above-mentioned spacer portion make above-mentioned bag main body be in contact with one another the operation of the surface attachment liquid at least one position in the position when bending in above-mentioned medical bag;
With above-mentioned medical bag of operation that bends in above-mentioned spacer portion;
Above-mentioned medical bag is accommodated in the above-mentioned packaging material with above-mentioned bending state, with the operation of this packaging material sealing; With
The operation that the above-mentioned medical bag that is accommodated in the above-mentioned packaging material is implemented to sterilize together with above-mentioned packaging material.
(2) like the manufacturing approach of above-mentioned (1) described medical bag individual package, wherein, the adhesion amount of aforesaid liquid on the per unit area of above-mentioned bag main body is 0.15～1.5ml/cm
2
(3) like the manufacturing approach of above-mentioned (1) or (2) described medical bag individual package, wherein, in adhering to the operation of aforesaid liquid, this liquid is adhered to through aforesaid liquid is sprayed.
(4) like the manufacturing approach of each described medical bag individual package in above-mentioned (1) to (3), wherein, aforesaid liquid is water or contains water and the mixed liquor of water soluble compound.
(5) like the manufacturing approach of each described medical bag individual package in above-mentioned (1) to (4); Comprising following operation: before with the aforesaid liquid spraying, above-mentioned medical bag is carried out discharge process with the surface that above-mentioned bag of main body is in contact with one another at least one the corresponding above-mentioned sheet material in position in the position when the above-mentioned spacer portion bending pair.
(6) like the manufacturing approach of each described medical bag individual package in above-mentioned (1) to (5), wherein, above-mentioned sheet material is made up of the polyacrylic resin that contains above 50wt%.
(7) a kind of medical bag individual package is characterized in that, is to make through the manufacturing approach of each described medical bag individual package in above-mentioned (1) to (6).
According to the present invention, the bag main body is in contact with one another the surface attachment liquid at least one position in the position when making sterilization, carries out this sterilization, thereby can prevent that the surface of bag main body from sticking to each other.
Description of drawings
Fig. 1 is the stereogram of expression through the formation example of the medical bag individual package of the manufacturing approach manufacturing of medical bag individual package of the present invention.
Fig. 2 is the sectional view of the A-A line among Fig. 1.
Fig. 3 is the front view of the medical bag of expression medical bag individual package shown in Figure 1.
Fig. 4 is the figure that is used to explain the manufacturing process of medical bag individual package shown in Figure 1.
Fig. 5 is the figure that is used to explain the manufacturing process of medical bag individual package shown in Figure 1.
Symbol description
1 medical bag
10 medical bags of individual packages
2 bags of main bodys
21 sheet materials
22,23 sealings
24 holes
3 the 1st spaces
4 the 2nd spaces
30,40 liquid
5 spacer portion
6 outlets
61 outlet main bodys
62 urceolus
7 packaging materials
71 the 1st sheet materials
72 the 2nd sheet materials
73 spaces
75 sealings
76 are prone to tear mark
100 corona discharge assemblies
200 printing equipments
210 rollers
300 sprayer units
310 nozzles
320 pumps
330 reservoir
340 pipes
The specific embodiment
Below, specify the manufacturing approach and the medical bag individual package of medical bag individual package of the present invention based on preferred implementation shown in the drawings.
Fig. 1 is the stereogram of expression through the formation example of the medical bag individual package of the manufacturing approach manufacturing of medical bag individual package of the present invention; Fig. 2 is the sectional view of the A-A line among Fig. 1; Fig. 3 is the front view of the medical bag of expression medical bag individual package shown in Figure 1, and Fig. 3 and Fig. 4 are the figure that is used to explain the manufacturing process of medical bag of individual package shown in Figure 1.
Need to prove, below, with the upside among Fig. 3 as " cardinal extremity ", downside is described as " front end ".In addition, provide side view for medical bag among Fig. 2.
Shown in these figure, medical bag individual package 10 has packaging material 7 and the medical bag 1 that is accommodated in the packaging material 7.Medical bag 1 is incorporated in the packaging material 7 with the state of spacer portion 5 bendings of Yu Houshu.In addition, below, also abbreviate medical bag 1 state as " bending state " in spacer portion 5 bendings.
As shown in Figure 3, medical bag 1 possesses bag main body 2 and outlet 6, in bag main body 2, is filled with liquid.In addition,, both can be divided into the multichamber vessel in a plurality of spaces for the inside of bag main body 2 as medical bag 1, also can be for having the single chamber container in 1 space.In this embodiment, enumerate multichamber vessel, promptly a bag main body 2 has the 1st space 3 of inner receiving fluids and the situation in the 2nd space 4 describes as an example.
The sheet material of stating after bag main body 2 is to use 21 is made, and said sheet material 21 forms tubular through film blowing and constitutes by having flexible soft material.In addition, of the back, sheet material 21 is a plurality of bags of main body shares, use by each bag main body share cutting back, but in following, for arbitrary bag of main body share before and after these sheet material 21 cuttings is also referred to as " sheet material 21 ".
Through welding or bonding both ends sealings such as thermal welding, high frequency weldings with sheet material 21, the bag main body 2 of system pouch.The sealing 22 of the base end side of bag main body 2 and the sealing 23 of front are cut into desired shape respectively.
Be provided with the hole 24 of using in last times such as suspension bracket etc. in that medical bag 1 is being hung in the substantial middle portion of the sealing 22 of the base end side of bag main body 2.
In Fig. 3 of this bag main body 2, formed spacer portion 5 in the way of above-below direction, the inside of bag main body 2 is divided into the 1st space 3 and the 2nd space 4 by this spacer portion 5.
This spacer portion 5 is formed on bag main body 2 with a linearity.And spacer portion 5 forms such form: upwards continue to exist at Fig. 3 of bag main body 2 middle horizontal square, thus this bag main body 2 is cross-section.
In addition, spacer portion 5 is arranged in the inclined to one side base end side of central authorities of Fig. 3 above-below direction of bag main body 2, thus, sets the volume of the volume in the 1st space 3 less than the 2nd space 4.
In the 3, the 2nd space 4, the 1st space, take in respectively by forming different liquid 30,40.At this moment, liquid 30 and liquid 40 are meant that for example glucose infusion liquid preparation and their composition of amino acid transfusion preparation that kind are easy to the liquid that reacts to each other each other.
Before using, liquid 30 and liquid were opened preservation in 40 minutes do not mix, during use, peel off spacer portion 5, make the 1st space 3 and the 2nd space 4 be communicated with mixing material 30 and liquid 40.Thus, rotten, the deterioration of liquid 30,40 etc. can be prevented, the target drug effect can be more positively obtained.
In addition; Liquid through will regulating pH, for example peritoneal dialysis solution and it is adjusted into neutral pH conditioning agent separately takes in, promptly be accommodated in respectively the 1st space 3 and the 2nd space 4 can prevent rotten, the decomposition, deterioration of said liquid, painted, variable color, sedimentary generation etc.
Need to prove, in the present invention, do not limit, for example can enumerate peritoneal dialysis solution, physiological saline, electrolyte solution, ringer's solution, high heat infusion preparation, Glucose Liquid, water for injection, oral feeding agent etc. liquid 30,40 is special.
Need to prove, be not limited to the situation that spacer portion 5 all constitutes with weak seal section, also can constitute the part of spacer portion 5 with weak seal section.And, also can make peel strength possess difference through the method for difference etc. for example is set on the fabric width of the band of spacer portion 5, be provided with and be prone to released part and difficult released part.
In addition, the surface printing at the regulation position of bag main body 2 has the display pattern of the regulations such as literal, composition guide look, useful life of for example scale, capacity, drug concentration, kind, alerting.
In addition, the leading section in bag main body 2 is provided with outlet 6.This outlet 6 is the parts with function of the mixed liquor of discharging liquid at least 30 and liquid 40, possesses the outlet main body 61 and the urceolus 62 that is arranged on outlet main body 61 outsides of band resilient plug.
In addition, this outlet 6 also can be used as the mixed injection inlet performance function of injecting liquid 40.In addition, a plurality of such outlets also can be set.
In addition, be not limited to above-mentioned film blowing, sheet material 21 also can be made through for example the whole bag of tricks such as T modulus method, blow molding method, dry lamination method, hot melt lamination method, coextrusion inflation method, coextrusion T modulus method, pressure sintering.
In addition, in order effectively to prevent the rotten and deterioration of liquid 30,40, the gas-premeable of preferred sheet material 21 is low as far as possible, promptly have barrier properties for gases.
But, the gas-premeable of the packaging material of stating after the gas-premeable of setting sheet material 21 is higher than 7.Thus, after state high pressure steam sterilization the time, can utilize the water vapour of the liquid 30,40 that sees through bag main body 2 that the medical bag 1 in the packaging material 7 is sterilized.
As the constituent material of sheet material 21, preferably use the resin of principal component as polyolefin (particularly polypropylene).This be because, this constituent material has hear resistance, the resistance to water of tolerance high pressure steam sterilization (autoclave sterilization).
When being principal component with the polypropylene, the polypropylene content in the constituent material of sheet material 21 preferably surpasses 50wt%, more preferably about 60～95wt%, further is preferably about 70～80wt%.
In addition, do not limit used polyacrylic average molecular weight Mw is special, but be preferably about 800,000～3,000,000.
Specifically; As the constituent material of sheet material 21, can enumerate polypropylene simple substance for example, polypropylene and copolymer, polypropylene and polymer alloy, polypropylene and other mixture of polymers etc. more than a kind or 2 kinds of other polymer more than a kind or 2 kinds of other polymer more than a kind or 2 kinds.
As above-mentioned other polymer, can enumerate thermoplastic resins such as polyethylene, EVA, polyamide, polyester for example, after the thermoplastic elastomer (TPE) stated etc., can be with being combined into more than a kind or 2 kinds to exercise and using wherein.
In addition, as the constituent material of sheet material 21 special preferable material can enumerate: mix in polypropylene that thermoplastic elastomer (TPE)s such as phenylethylene for example, polyamide-based, polyesters carry out the softnessization processing and the soft resin that obtains.As thermoplastic elastomer (TPE), styrene analog thermoplastic elastomers such as preference such as SB, styrene-ethylene-butylene-styrene block copolymer etc.This be because, the intensity of this material is high and be imbued with flexibility, hear resistance, the hear resistance when particularly sterilizing are high, resistance to water is high, in addition, processability is excellent especially, can realize the reduction of manufacturing cost.
Need to prove that the content of the thermoplastic elastomer (TPE) in the constituent material of sheet material 21 is preferably about 0～49wt%, more preferably about 10～40wt%.
Next, packaging material 7 is described.
As depicted in figs. 1 and 2, packaging material 7 is by a pair of sheet material, promptly the 1st sheet material 71 and the 2nd sheet material 72 constitute.The vertical view shape of these the 1st sheet materials 71 and the 2nd sheet material 72, the shape when promptly from Fig. 2, looking sideways form shape much at one, all form roughly quadrangle.Corresponding therewith, the vertical view shape of packaging material 7 also forms roughly quadrangle.
The 1st sheet material 71 and the 2nd sheet material 72 is overlapping, through welding such as thermal welding, high frequency welding, ultrasonic fusing or utilize cement or that solvent etc. carries out is bonding, with their edge portion sealing, the packaging material 7 of system pouch.Among Fig. 1, the part of representing with double dot dash line to seal is as sealing 75.As shown in the drawing, sealing 75 forms band shape along the peripheral part of packaging material 7.
The 2nd sheet material 72 forms smooth shape.Relative therewith, the 1st sheet material 71 forms the outstanding shape that can hold medical bag 1.That is, the 1st sheet material 71 has the heave place corresponding with medical bag 1 shape, the size of bending state.And the medical bag 1 of bending state is incorporated in this inside of heaving the place, is in the space 73.
These space 73 usefulness the 1st sheet material the 71, the 2nd sheet materials 72 and sealing 75 fence up, and isolate with outside air-tightness.Therefore, be accommodated in medical bag 1 in the space 73 under the situation of the sheet material of the constituent material of stating after the use, when using, all kept moisture resistance and germ-free condition well.
The end of the front side in the end of this packaging material 7, diagram constitute among Fig. 1 be provided with through sheet material is not sealed form be prone to tear mark 76.With this be prone to tear mark 76 for example the 2nd sheet material 72 carrying out tearing in the direction of separating from the 1st sheet material 71, can peel seal portion 75, with packaging material 7 Kaifeng.
In addition, the constituent material of the constituent material of the 1st sheet material 71 and the 2nd sheet material 72 can be identical, in addition also can be different.For example, the 1st sheet material 71 can be used than the 2nd sheet material 72 hard hard materials and constitute.In addition, the 2nd sheet material 72 is preferably and has flexible sheet material.Thus, when separating the 1st sheet material 71 and the 2nd sheet material 72, can easily peel off above-mentioned sealing 75.
In addition, in order to ensure the observability of content, at least one sheet material in the 1st sheet material 71 and the 2nd sheet material 72 is transparent.
In addition, packaging material 7 preferably has barrier properties for gases.
As stated, have barrier properties for gases, can prevent that gas such as water vapour from getting in the space 73 from the outside through packaging material 7.Its result can keep the moisture resistance in the space 73.
As the 1st sheet material the 71, the 2nd sheet material 72 that constitutes packaging material 7, promptly have the sheet material of above-mentioned gas barrier, can use mylar, polyvinylidene chloride, the ethlyene dichloride-vinylidene chloride copolymers etc. such as hybrid resin, PETG of for example vistanex such as polyethylene, polypropylene, these vistanexes monofilm, on these films, steam plated aluminum, silica etc. and metal forming such as the film that obtains, aluminium film, aluminium laminated film or comprise the film of metal forming.And then, also can use lamination these various films and sheet material of obtaining more than 2 layers.
As the manufacturing approach of the 1st sheet material the 71, the 2nd sheet material 72 of above-mentioned formation packaging material 7, can use for example above-mentioned manufacturing approach as sheet material 21 the identical method of illustrative method for making.
In addition; In this embodiment; Formation for packing with blister plastic packaging explains that wherein the 2nd sheet material 72 forms even shape, and the 1st sheet material 71 forms the outstanding shape that can take in medical bag 1; But also can be set at the formation of medical bag 1 being packed, can also be set at the formation of using container molding to pack through lamination packing and film packing etc.
Next, the manufacturing approach of medical bag individual package 10 is described.
[1] prepares the sheet material 21 that forms tubular and the regulation position is sealed through film blowing.This sheet material 21 is a plurality of bags of main body shares, after cut the back by a bag main body share in the operation stated and use.
As stated, this sheet material 21 preferably uses principal component to constitute as the resin of polyolefin (particularly polypropylene).In addition, for the constituent material of sheet material 21, owing to explain, so omit its explanation.
In addition, the Young's modulus under the room temperature of sheet material 21 (20～30 ℃) is preferably about 100～250MPa, more preferably about 170～240MPa.If above-mentioned Young's modulus surpasses above-mentioned higher limit, then according to other conditions, the flexibility of sheet material 21 descends.In addition, if above-mentioned Young's modulus is lower than above-mentioned lower limit, then according to other conditions, the display pattern that is printed on the sheet material 21 is easy to peel off.
In addition, the water contact angle under the room temperature of sheet material 21 (20～30 ℃) is preferably about 70 °～90 °, about more preferably 80 °～90 °.If above-mentioned contact angle surpasses above-mentioned higher limit, then according to other conditions, the display pattern that is printed on the sheet material 21 is easy to peel off.
In addition, sheet material 21 can be handled by drawn, also can unstretchedly handle, but preferred unstretched processing.
As shown in Figure 4; Utilize not shown conveyer that the left side of sheet material 21 from Fig. 4 transmitted to the right; Meanwhile, utilizing of stating after the enforcement Corona discharge Treatment that corona discharge assembly 100 carries out, utilize the printing that printing equipment 200 carries out, the ink solidification due to the ultraviolet ray irradiation etc.In this embodiment, constitute such mode: only sheet material 21 moves, and corona discharge assembly 100, printing equipment 200, not shown ultraviolet lamp are not moved.
Do not limit the translational speed of sheet material 21 is special, set according to all conditions are suitable, but be preferably about 350～450 mm/second, more preferably about 380～420 mm/second.
[2] discharge process is carried out on the surface at the position of the enforcement of sheet material 21 printing.Thus, the soakage on the surface at the position of the enforcement of sheet material 21 printing improves, and can prevent that the display pattern that is printed on the sheet material 21 from peeling off.
In addition, discharge process is implemented on the surface that when spacer portion 5 bends, makes bag main body 2 be in contact with one another the pairing sheet material 21 at least one position in the position in medical bag 1.Thus, the surface of bag main body 2 sticks together each other in the time of can preventing high pressure steam sterilization.In addition; Position as attaching liq; For example can enumerate; The surface at the position corresponding of sheet material 21, sheet material 21 and surface corresponding position, the 2nd space 4 and sheet material 21 and surface corresponding position, the 1st space 3 with the 1st space 3 and with the surface at corresponding position, the 2nd space 4, but wherein the position corresponding of preferred sheet material 21 surperficial with the 1st space 3 and with this two surface, surface at corresponding position, the 2nd space 4.Its reason is through discharge process is carried out on the two sides, can more positively prevent adhesion.
Need to prove; For example carry out discharge process, can the surface at the position of the enforcement printing of above-mentioned sheet material 21, medical bag 1 all surfaces that bag main body 2 is in contact with one another the pairing sheet material 21 in position when spacer portion 5 bendings be covered through whole face to the one side side of sheet material 21.
As this discharge process, so long as utilized the processing of discharge, just not special the qualification can be enumerated for example Corona discharge Treatment, plasma treatment etc., but wherein preferred Corona discharge Treatment.
In this embodiment, describe for the situation of carrying out Corona discharge Treatment.In addition, below Corona discharge Treatment also abbreviated as " discharge process ".
Here, the electrode of corona discharge assembly 100 and sheet material 21 are at a distance of predetermined distance.Face to the enforcement Corona discharge Treatment of sheet material 21 does not limit with the distance between electrodes of the face side of implementing this Corona discharge Treatment is special, can set according to all conditions are suitable, but be preferably about 2～10mm, more preferably about 3～6mm.Thus, can prevent more positively that the display pattern that is printed on the sheet material 21 from peeling off, and the surface of bag main body 2 sticks to each other in the time of can more positively preventing high pressure steam sterilization.
In addition, in discharge process,, can set according to all conditions are suitable, but be preferably about 0.05～1.0kW, more preferably about 0.1～0.5kW not special qualification of electrical power that corona discharge assembly 100 uses.Thus, can prevent more positively that the display pattern that is printed on the sheet material 21 from peeling off, and the surface of bag main body 2 sticks to each other can more positively prevent high pressure steam sterilization the time.
In addition, discharge process is preferably carried out the sheet material 21 enforcement discharge process that transmitting.Do not limit the transfer rate of sheet material 21 is special, can set according to all conditions are suitable, but be preferably about 350～450 mm/second, more preferably about 380～420 mm/second.Thus, can prevent more positively that the display pattern that is printed on the sheet material 21 from peeling off, and the surface of bag main body 2 sticks together each other in the time of can more positively preventing high pressure steam sterilization.
In addition, discharge process can be under reduced pressure, add and depress, carry out under the arbitrary pressure condition under the atmospheric pressure, but preferably under atmospheric pressure carry out.
In addition, as the atmosphere gas in the discharge process, promptly handle gas, not special the qualification can not enumerated for example helium, argon, nitrogen, carbon monoxide, carbon dioxide, oxygen, air etc., can use a kind of gas in these or make up that gas uses more than 2 kinds.In addition, wherein preferred air or oxygen, preferred especially air.
[3] display pattern that uses ultra-violet solidified ink printing to stipulate at the position through discharge process of sheet material 21.
As this printing process, not special the qualification can be enumerated for example letterpress, intaglio printing, hectographic printing etc., but wherein preferred letterpress or hectographic printing.
The printing ink that uses is so long as ultra-violet solidified printing ink gets final product not special the qualification.
In the manufacturing approach of this embodiment,, also can carry out discharge process under these conditions even use above-mentioned hydrophobic printing ink, after make ink solidification under the condition stated, thereby can prevent positively that display pattern from peeling off from sheet material 21.
Need to prove that printing can be single color printing, also can be polychrome printing.Under the polychrome situation, can carry out the printing of polychrome simultaneously, also can print by every kind of color.
[4] utilize not shown ultraviolet lamp, the printing ink irradiation ultraviolet radiation to after the printing on sheet material 21 surfaces makes ink solidification.
In addition, the light that the printing ink after the above-mentioned printing is shone is ultraviolet ray in this embodiment, but is not limited thereto, and except that ultraviolet ray, also can contain the wavelength band light different with ultraviolet ray.That is, so long as contain ultraviolet light and get final product.
Need to prove, before above-mentioned printing, the base treatment that also can stipulate the surface at the position of the enforcement of sheet material 21 printing.This base treatment can be carried out in the arbitrary stage before and after discharge process, but preferably after discharge process, carries out.
In addition, after making ink solidification, the coating that also can form regulation with the enforcement of cover sheets 21 surface at position of printing.
[5] by each bag main body share cutting sheet material 21, with outlet 6 weldings on the bag main body 2 that cutting obtains, filling liquid 30 in the 1st space 3, filling liquid 40 in the 2nd space 4.Liquid 40 carries out through outlet 6 to the filling in the 2nd space 4.In addition, liquid 30 carries out through directly the liquid filling being inserted in the 1st space 3 with nozzle to the filling in the 1st space 3, behind the filling liquid 30, with the hole sealing of inserting this nozzle, seals.Thus, obtain medical bag 1.
[6], spacer portion 5 make bag main body 2 be in contact with one another the surface attachment liquid at least one position in the position when bending in medical bag 1.Thus, the surface of bag main body 2 sticks together each other in the time of can preventing high pressure steam sterilization.
Need to prove; Position as attaching liq; For example can enumerate the position corresponding of bag main body 2 with the 1st space 3 surface, bag main body 2 and surface corresponding position, the 2nd space 4 and bag main body 2 with the surperficial of corresponding position, the 1st space 3 and with the surface at corresponding position, the 2nd space 4, but the surface at the position corresponding of preferred pouches main body 2 wherein with the 1st space 3.Its reason is; The area on the surface at the position corresponding with the 1st space 3 of bag main body 2 is less than area bag main body 2 and surface corresponding position, the 2nd space 4; Thereby can reduce the amount of the liquid that adheres to, can prevent behind the high pressure steam sterilization that this liquid residue is in packaging material 7.
As the liquid that adheres to, preferably contain the liquid of water, for example can enumerate water, contain the mixed liquor of water and water soluble compound etc.As water, preferred distilled water.
In addition, as the water soluble compound of above-mentioned mixed liquor, can enumerate for example alcohol, ester class, ketone, surfactant etc., wherein alcohols.Contain the mixed liquor of water and alcohol through use, not only can obtain Disinfection Effect, and liquid improves the soakages on bag main body 2 surface, can make a spot of this liquid equably on the surface attached to bag main body 2.
In addition, as alcohol, can enumerate for example methyl alcohol, ethanol, propyl alcohol etc., wherein preferred alcohol.In addition, as the ester class, can enumerate for example ethyl acetate etc.In addition, as ketone, can enumerate for example acetone etc.
In addition, the content of the water soluble compound in the above-mentioned mixed liquor is preferably about 10～90wt%, more preferably about 30～70wt%.Thus, the surface of bag main body 2 sticks together each other in the time of can more positively preventing high pressure steam sterilization.
In this embodiment,, use the sprayer unit 300 shown in Fig. 5 (a) as the liquid attachment device that makes liquid attached to bag main body 2 surfaces.
This sprayer unit 300 possesses: with the nozzle 310 of liquid spraying; Store the reservoir 330 of liquid; The pipe 340 that one distolaterally be connected, another is distolateral to be connected with reservoir 330 with nozzle 310; Pump 320 with liquid feeding device in the way that is arranged on pipe 340, conduct conveying liquid.During pump 320 work of sprayer unit 300, the liquid that is stored in reservoir 330 is mobile to nozzle 310 in pipe 340, from this nozzle 310 with vaporific discharge, promptly sparge the surface of bag main body 2.Thus, can make bag main body 2 surface attachment liquid.And,, can make a spot of this liquid equably attached to bag main body 2 surfaces through with the liquid spraying.
In addition, the adhesion amount of liquid on the per unit area of bag main body 2 is preferably 0.15～1.5ml/cm
2, 0.30～0.10ml/cm more preferably
2Thus, the surface of bag main body 2 sticks to each other in the time of can more positively preventing high pressure steam sterilization, and, behind high pressure steam sterilization, can prevent that liquid residue is in packaging material 7.
Need to prove,, be not limited to above-mentioned sprayer unit 300 as long as the liquid adherence method can make the surface of liquid attached to bag main body 2.That is, among the present invention, except that said method, for example also can use method with the brush coating, dip coated method etc. to make the surface of liquid attached to bag main body 2.
[7], medical bag 1 is bent in spacer portion 5 like Fig. 5 (b) and shown in Figure 2.
[8] as shown in Figure 2, medical bag 1 is accommodated in the packaging material 7 sealing with bending state.That is, the medical bag 1 of bending state is accommodated in the 1st sheet material 71, overlapping the 1st sheet material 71 and the 2nd sheet material 72 are through welding of edge portion or bonding sealing the with them.Thus, obtain medical bag individual package 10.In addition, through with medical bag 1 packing in the state of spacer portion 5 bendings, thereby when medical bag 1 is under pressure when the medical bag of transmission individual package 10 etc., can prevent that its spacer portion 5 from peeling off.And, with after bend medical bag 1 after the high pressure steam sterilization stated situation compare, have the advantage that saves trouble.
[9], implement high pressure steam sterilization together with packaging material 7 to medical bag individual package 10, promptly be accommodated in medical bag 1 in the packaging material 7.
At this moment, medical bag 1 is placed under high pressure, the high temperature, but owing under above-mentioned condition, make the surface attachment of bag main body 2 that liquid is arranged, sticks to each other so can prevent the surface of bag main body 2.In addition, owing under above-mentioned condition, implemented the curing of discharge process and printing ink, peel off so can prevent the display pattern that is printed on the sheet material 21.
Do not limit the sterilising conditions in this high pressure steam sterilization is special, but temperature is preferably about 110～121 ℃, more preferably about 115～121 ℃.In addition, sterilization time was preferably about 10～30 minutes.
Need to prove that sterilizing methods is not limited to high pressure steam sterilization, also can sterilize with additive method.
As described above said; Manufacturing approach according to this medical bag individual package 10; Because before high pressure steam sterilization; Bag main body 2 is in contact with one another the surface attachment liquid at least one position in the position when making this high pressure steam sterilization, carries out high pressure steam sterilization, sticks to each other so can prevent the surface of bag main body 2.
More than; Be illustrated based on the manufacturing approach and the medical bag individual package of illustrated embodiment medical bag individual package of the present invention; But the invention is not restricted to this,, can be replaced into component parts arbitrarily with said function for the formation of each one.And, any formation thing, the operation that also can add other to the present invention.
In addition, in the above-mentioned embodiment, be illustrated as the situation of printing ink using ultra-violet solidified printing ink, but be not limited thereto among the present invention, for example also can use the printing ink of other photo-curable, the printing ink of Thermocurable etc.The curing of printing ink is carried out according to the kind of this printing ink.
In addition, also can omit discharge process among the present invention.
Embodiment
Next, specific embodiment of the present invention is described.
(embodiment 1)
Prepare following sheet material: polypropylene and the hydrogenated styrene-butadiene copolymer weight ratio with 6: 4 is cooperated, the resin that mixes is formed thickness 300 μ m cylindric (folding footpath 220mm) through the inflation moulding,, and form spacer portion with the assigned position sealing.
Then; Use the welding, liquid of cutting, outlet of sheet material of Corona discharge Treatment, operation [5] that this sheet material carries out above-mentioned operation [2] to the medical bag of the spraying of the liquid of the filling in the 1st space and the 2nd space, operation [6], operation [7] high pressure steam sterilization, makes 10 (sample No.1～10) shown in Figure 1 medical bag being accommodated in the packaging material and the medical bag of individual package that forms in the medical bag of the bending state of the bending of spacer portion, operation [8] taking in packaging material, sealing, operation [9].
Need to prove that the Corona discharge Treatment of operation [2] is carried out at the whole face of the one side side of sheet material, carry out on the surface at the position corresponding with the 1st space that is sprayed at bag main body of the liquid of operation [6] in addition.In addition, for the size of medical bag, aspect this bag main body, be 25cm * 12.5cm.In addition, each condition, method, rerum natura etc. are as follows.
The soakage of sheet material (not carrying out Corona discharge Treatment): below the 32dyn
The soakage of sheet material (Corona discharge Treatment): more than the 36dyn
The transfer rate of the sheet material during Corona discharge Treatment: 0.3m/ second
The distance between electrodes of the face side of the face of the enforcement Corona discharge Treatment of the sheet material during Corona discharge Treatment and this Corona discharge Treatment of enforcement: 0.4mm
The electrical power of Corona discharge Treatment: 0.20kW
Liquid attached to the bag body surfaces: distilled water
The adhesion amount of liquid on bag main body unit are: 0.48ml/cm
2
That is, to bag main body one side surface (surface area: 312.5cm
2) whole spraying 0.15g distilled water.
High pressure steam sterilization: 115 ℃ * 15 minutes
(embodiment 2)
To change to the mixed liquor (ethanol content in the mixed liquor: 50wt%), likewise make 10 medical bag individual packages with the foregoing description 1 in addition of distilled water and ethanol attached to the liquid of bag body surfaces.
(embodiment 3)
Do not carry out Corona discharge Treatment, likewise make 10 medical bag individual packages with the foregoing description 1 in addition.
(embodiment 4)
Do not carry out Corona discharge Treatment, likewise make 10 medical bag individual packages with the foregoing description 2 in addition.
(comparative example 1)
Do not make a bag body surfaces attaching liq, likewise make 10 medical bag individual packages with the foregoing description 1 in addition.
(comparative example 2)
Do not make a bag body surfaces attaching liq, likewise make 10 medical bag individual packages with the foregoing description 3 in addition.
[evaluation]
For embodiment 1～4, comparative example 1,2, estimate as follows respectively.Its result is shown in below table 1.
(anti-adhesive)
Behind the high pressure steam sterilization, confirm that the bag body surfaces has or not adhesion each other.
Zero: 10 does not all have adhesion
*: stick together in 10
Table 1
| | |
| Embodiment | |
| 1 | ○ |
| |
○ |
| |
○ |
| |
○ |
| Comparative example 1 | × |
| Comparative example 2 | × |
Can know that by above-mentioned table 1 among the embodiment 1～4, the bag body surfaces does not stick together each other.Relative therewith, stick together in the comparative example 1 and 2.
Claims (7)
1. the manufacturing approach of a medical bag individual package; It is the manufacturing approach that the medical bag with bag main body is accommodated in the medical bag individual package that forms in the packaging material; Said bag main body constitutes by having flexible sheet material, innerly is divided into the 1st space and the 2nd space through spacer portion, and said spacer portion is through with above-mentioned sheet material welding or bonding formation; It is characterized in that said manufacturing approach comprises following operation:
, said spacer portion make said bag main body be in contact with one another the operation of the surface attachment liquid at least one position in the position when bending in said medical bag;
With said medical bag of operation that bends in said spacer portion;
Said medical bag is accommodated in the said packaging material with said bending state, with the operation of said packaging material sealing; With
The operation that the said medical bag that is accommodated in the said packaging material is implemented to sterilize together with said packaging material.
2. the manufacturing approach of medical bag individual package as claimed in claim 1, wherein, the adhesion amount of said liquid on the per unit area of said bag main body is 0.15～1.5ml/cm
2
3. according to claim 1 or claim 2 the manufacturing approach of medical bag individual package wherein, in adhering to the operation of said liquid, adheres to said liquid through said liquid is sprayed.
4. like the manufacturing approach of each described medical bag individual package in the claim 1 to 3, wherein, said liquid is water or contains water and the mixed liquor of water soluble compound.
5. like the manufacturing approach of each described medical bag individual package in the claim 1 to 4; Comprising following operation: before with said liquid spraying, said medical bag is carried out discharge process with the surface that said bag of main body is in contact with one another at least one the corresponding said sheet material in position in the position when the said spacer portion bending pair.
6. like the manufacturing approach of each described medical bag individual package in the claim 1 to 5, wherein, said sheet material is made up of the polyacrylic resin that contains above 50wt%.
7. a medical bag individual package is characterized in that, is to make through the manufacturing approach of each described medical bag individual package in the claim 1 to 6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010-283613 | 2010-12-20 | ||
| JP2010283613A JP5628020B2 (en) | 2010-12-20 | 2010-12-20 | Method for producing individual package for medical bag and individual package for medical bag |
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| Publication Number | Publication Date |
|---|---|
| CN102555282A true CN102555282A (en) | 2012-07-11 |
| CN102555282B CN102555282B (en) | 2016-04-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110443419.0A Active CN102555282B (en) | 2010-12-20 | 2011-12-20 | The manufacture method of medical bag individual package and medical bag individual package |
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| CN (1) | CN102555282B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107427409A (en) * | 2015-03-25 | 2017-12-01 | 泰尔茂株式会社 | Medical bag |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5962457B2 (en) | 2012-11-22 | 2016-08-03 | 株式会社ジェイ・エム・エス | Medical extruded double-layer tube and infusion bag products |
| CN111498207B (en) * | 2019-01-30 | 2023-05-02 | 百特国际有限公司 | Medical fluid container preparation system and method |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP5628020B2 (en) | 2014-11-19 |
| JP2012130439A (en) | 2012-07-12 |
| CN102555282B (en) | 2016-04-27 |
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