JP2006528664A5 - - Google Patents
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- Publication number
- JP2006528664A5 JP2006528664A5 JP2006529485A JP2006529485A JP2006528664A5 JP 2006528664 A5 JP2006528664 A5 JP 2006528664A5 JP 2006529485 A JP2006529485 A JP 2006529485A JP 2006529485 A JP2006529485 A JP 2006529485A JP 2006528664 A5 JP2006528664 A5 JP 2006528664A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- spp
- candida
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 206010017533 Fungal infection Diseases 0.000 claims 6
- 208000031888 Mycoses Diseases 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims 2
- 241000222122 Candida albicans Species 0.000 claims 2
- 241001527609 Cryptococcus Species 0.000 claims 2
- 241000223218 Fusarium Species 0.000 claims 2
- 241000187747 Streptomyces Species 0.000 claims 2
- 241000222126 [Candida] glabrata Species 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 241000228257 Aspergillus sp. Species 0.000 claims 1
- 241000335423 Blastomyces Species 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 241000222173 Candida parapsilosis Species 0.000 claims 1
- 241000222178 Candida tropicalis Species 0.000 claims 1
- 241001508813 Clavispora lusitaniae Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000228402 Histoplasma Species 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000003351 Melanosis Diseases 0.000 claims 1
- 241000235395 Mucor Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 241000235645 Pichia kudriavzevii Species 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 241000223230 Trichosporon Species 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 208000032343 candida glabrata infection Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000000287 crude extract Substances 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46981003P | 2003-05-13 | 2003-05-13 | |
| US49151603P | 2003-08-01 | 2003-08-01 | |
| PCT/CA2004/000711 WO2004101502A1 (en) | 2003-05-13 | 2004-05-13 | Polyene polyketides, processes for their production and their use as pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006528664A JP2006528664A (ja) | 2006-12-21 |
| JP2006528664A5 true JP2006528664A5 (enExample) | 2007-06-21 |
Family
ID=32872274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006529485A Pending JP2006528664A (ja) | 2003-05-13 | 2004-05-13 | ポリエンポリケチド、その調製方法及び医薬品としてのその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20040266008A1 (enExample) |
| EP (1) | EP1567484A1 (enExample) |
| JP (1) | JP2006528664A (enExample) |
| CA (1) | CA2467249C (enExample) |
| WO (1) | WO2004101502A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7375088B2 (en) * | 2003-01-21 | 2008-05-20 | Thallion Pharmaceuticals Inc. | Polyene polyketides, processes for their production and their use as a pharmaceutical |
| KR20060110865A (ko) * | 2003-11-27 | 2006-10-25 | 에자이 가부시키가이샤 | 매크로라이드계 화합물의 수산화에 관여하는 ｄｎａ |
| JP4599357B2 (ja) * | 2004-07-20 | 2010-12-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プラジエノライドの生合成に関与するポリペプチドをコードするｄｎａ |
| FR2951720B1 (fr) * | 2009-10-28 | 2011-12-16 | Pf Medicament | Molecules polyketides comme agents anticancereux |
| KR101379978B1 (ko) * | 2011-12-30 | 2014-04-02 | 인하대학교 산학협력단 | 신규 폴리엔 화합물, 이의 제조방법 및 이를 유효성분으로 포함하는 항진균제 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US4452775A (en) * | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US5039660A (en) * | 1988-03-02 | 1991-08-13 | Endocon, Inc. | Partially fused peptide pellet |
| US7375088B2 (en) * | 2003-01-21 | 2008-05-20 | Thallion Pharmaceuticals Inc. | Polyene polyketides, processes for their production and their use as a pharmaceutical |
-
2004
- 2004-05-13 US US10/844,547 patent/US20040266008A1/en not_active Abandoned
- 2004-05-13 CA CA002467249A patent/CA2467249C/en not_active Expired - Fee Related
- 2004-05-13 EP EP04732559A patent/EP1567484A1/en not_active Withdrawn
- 2004-05-13 WO PCT/CA2004/000711 patent/WO2004101502A1/en not_active Ceased
- 2004-05-13 US US10/844,701 patent/US20050004185A1/en not_active Abandoned
- 2004-05-13 JP JP2006529485A patent/JP2006528664A/ja active Pending
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