JP2006527776A5 - - Google Patents
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- JP2006527776A5 JP2006527776A5 JP2006521070A JP2006521070A JP2006527776A5 JP 2006527776 A5 JP2006527776 A5 JP 2006527776A5 JP 2006521070 A JP2006521070 A JP 2006521070A JP 2006521070 A JP2006521070 A JP 2006521070A JP 2006527776 A5 JP2006527776 A5 JP 2006527776A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- substituted
- carbon
- alkyl
- fused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052799 carbon Inorganic materials 0.000 claims 50
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 31
- 125000000217 alkyl group Chemical group 0.000 claims 27
- 125000005843 halogen group Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 20
- 150000001721 carbon Chemical class 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 16
- 125000004429 atom Chemical group 0.000 claims 16
- 125000004093 cyano group Chemical group *C#N 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000005842 heteroatom Chemical group 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 11
- 229910052717 sulfur Inorganic materials 0.000 claims 11
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 239000001301 oxygen Substances 0.000 claims 10
- 239000011593 sulfur Chemical group 0.000 claims 10
- KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 9
- 125000000304 alkynyl group Chemical group 0.000 claims 9
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 9
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 7
- 206010006895 Cachexia Diseases 0.000 claims 6
- 102100023724 Melanocortin receptor 4 Human genes 0.000 claims 6
- 101710085775 Melanocortin receptor 4 Proteins 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000005605 benzo group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 208000016261 weight loss Diseases 0.000 claims 4
- 230000004580 weight loss Effects 0.000 claims 4
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000017667 Chronic Disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000005431 alkyl carboxamide group Chemical group 0.000 claims 1
- 125000005157 alkyl carboxy group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 230000001925 catabolic effect Effects 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000001076 sarcopenia Diseases 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000005389 trialkylsiloxy group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/462,436 US7375125B2 (en) | 1999-08-04 | 2003-06-16 | Melanocortin-4 receptor binding compounds and methods of use thereof |
| PCT/US2004/019124 WO2005121100A1 (en) | 2003-06-16 | 2004-06-15 | Melanocortin-4 receptor binding compounds and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006527776A JP2006527776A (ja) | 2006-12-07 |
| JP2006527776A5 true JP2006527776A5 (https=) | 2007-08-02 |
Family
ID=34958344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521070A Pending JP2006527776A (ja) | 2003-06-16 | 2004-06-15 | メラノコルチン−４レセプター結合化合物およびその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7375125B2 (https=) |
| EP (1) | EP1644337B1 (https=) |
| JP (1) | JP2006527776A (https=) |
| AU (1) | AU2004320025A1 (https=) |
| CA (1) | CA2529445A1 (https=) |
| DE (1) | DE602004022168D1 (https=) |
| WO (1) | WO2005121100A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7375125B2 (en) * | 1999-08-04 | 2008-05-20 | Ore Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| US20070021433A1 (en) * | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| RU2416603C9 (ru) | 2005-10-25 | 2012-06-20 | Сионоги Энд Ко., Лтд. | Производные аминодигидротиазина |
| CA2627489A1 (en) * | 2005-10-27 | 2007-05-03 | Teijin Pharma Limited | Benzo[b]thiophen derivative and process for their production |
| BRPI0709612A2 (pt) * | 2006-03-15 | 2011-07-19 | Wyeth Corp | composto de fórmula i; método para o tratamento de um distúrbio no sistema nervoso central relacionado ou afetado pelo receptor histamina-3 em um paciente que necessita deste tratamento; método para a inibição do receptor h3; composição farmacêutica; e processo para a preparação de um composto de fórmula i |
| EP1974729A1 (en) * | 2007-03-28 | 2008-10-01 | Santhera Pharmaceuticals (Schweiz) AG | Substituted imidazopyridine derivates as melanocortin- 4 receptor antagonists |
| EP2147914B1 (en) | 2007-04-24 | 2014-06-04 | Shionogi&Co., Ltd. | Aminodihydrothiazine derivatives substituted with cyclic groups |
| EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| US10125388B2 (en) | 2007-10-31 | 2018-11-13 | Akonni Biosystems, Inc. | Integrated sample processing system |
| CA2621950A1 (en) * | 2007-12-31 | 2009-06-30 | University Of Basel | Methods for diagnosing and treating obesity by modulating the activity of auto-antibodies against the melanocortin-4 receptor |
| WO2009151098A1 (ja) | 2008-06-13 | 2009-12-17 | 塩野義製薬株式会社 | βセクレターゼ阻害作用を有する含硫黄複素環誘導体 |
| CN102186841A (zh) | 2008-10-22 | 2011-09-14 | 盐野义制药株式会社 | 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物 |
| CA3041540C (en) * | 2009-09-21 | 2021-08-24 | Bio-Rad Laboratories, Inc. | Magnetic lysis method and device |
| TWI488852B (zh) | 2009-12-11 | 2015-06-21 | Shionogi & Co | 衍生物 |
| US8293218B2 (en) | 2010-07-29 | 2012-10-23 | Conopco, Inc. | Skin care compositions comprising substituted monoamines |
| US8476251B2 (en) * | 2010-07-29 | 2013-07-02 | Conopco, Inc. | Skin care compositions comprising substituted diamines |
| JP5816630B2 (ja) | 2010-10-29 | 2015-11-18 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
| JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| TW201247635A (en) | 2011-04-26 | 2012-12-01 | Shionogi & Co | Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them |
| US9562029B2 (en) | 2011-06-25 | 2017-02-07 | Xuanzhu Pharma Co., Ltd. | C-glycoside derivatives |
| CA2859283C (en) * | 2011-12-16 | 2021-03-09 | Transposagen Biopharmaceuticals, Inc. | Trpc4 modulators for use in the treatment or prevention of pain |
| JP2015536914A (ja) | 2012-10-12 | 2015-12-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 置換フェニルカルバメート化合物 |
| EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
| CN104768947A (zh) | 2012-11-08 | 2015-07-08 | 霍夫曼-拉罗奇有限公司 | 作为trpa1拮抗剂用于治疗呼吸系统疾病的[3-杂芳基-2-三氟甲基-丙基]-哌啶-1-基或-吗啉-4-基化合物 |
| AU2014211727B2 (en) | 2013-02-04 | 2018-07-26 | Prexton Therapeutics Sa | Positive allosteric modulators of mGluR3 |
| JP6327841B2 (ja) * | 2013-12-06 | 2018-05-23 | 住友精化株式会社 | 芳香族チアゾール化合物の製造方法 |
| US9315438B2 (en) | 2014-01-03 | 2016-04-19 | Xuanzhu Pharma Co., Ltd | Optically pure benzyl-4-chlorophenyl-C-glucoside derivative |
| WO2016056606A1 (ja) * | 2014-10-07 | 2016-04-14 | 国立大学法人京都大学 | ベンゾイソチアゾロピリミジン誘導体またはその塩、およびウイルス感染阻害剤ならびに医薬品 |
| EA202092441A1 (ru) | 2016-06-07 | 2021-05-21 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| KR20240026521A (ko) | 2017-03-23 | 2024-02-28 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| SG11202102987VA (en) * | 2018-10-01 | 2021-04-29 | Genzyme Corp | Thieno[3,2-b]pyridine derivatives as udp glycosyltransferase inhibitors and methods of use |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3594380A (en) * | 1969-02-18 | 1971-07-20 | American Home Prod | Isoquinolin-1(2h)-ones |
| DE2219841A1 (de) | 1972-04-22 | 1973-10-25 | Basf Ag | Verfahren zur herstellung von 2-(oalkylthiophenyl)-1,3-diazacycloalkenhydrohalogeniden |
| US4122263A (en) * | 1973-04-11 | 1978-10-24 | Basf Aktiengesellschaft | Production of 2-(o-alkylthiophenyl)-1,3-diazocycloalkene hydrohalides |
| DE3046366A1 (de) * | 1980-12-09 | 1982-07-08 | Bayer Ag, 5090 Leverkusen | Tricyclische cytosinderivate zur verwendung in arzneimitteln und verfahren zu ihrer herstellung |
| JPS60130561A (ja) * | 1983-12-16 | 1985-07-12 | Torii Yakuhin Kk | アミジン誘導体およびそれを含む強心剤 |
| ZA923283B (en) * | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
| JPH05156475A (ja) | 1991-12-02 | 1993-06-22 | Hideaki Yamaguchi | 金属の表面処理方法 |
| US5731408A (en) * | 1995-04-10 | 1998-03-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Peptides having potent antagonist and agonist bioactivities at melanocortin receptors |
| US5932779A (en) | 1996-06-10 | 1999-08-03 | Millennium Pharmaceuticals, Inc. | Screening methods for compounds useful in the regulation of body weight |
| AU742425B2 (en) | 1998-06-11 | 2002-01-03 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| US7375125B2 (en) * | 1999-08-04 | 2008-05-20 | Ore Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| US6699873B1 (en) * | 1999-08-04 | 2004-03-02 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| MXPA02001160A (es) * | 1999-08-04 | 2002-07-02 | Millennium Pharm Inc | Compuestos que se unen a los receptores para melanocortina-4, y metodo de uso de estos. |
| WO2002062766A2 (en) * | 2001-02-07 | 2002-08-15 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| JP2004532838A (ja) * | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物 |
| BR0215157A (pt) * | 2001-12-18 | 2004-10-19 | Hoffmann La Roche | Cis-2,4,5-trifenil-imidazolinas e seu uso no tratamento de tumores |
| ATE440827T1 (de) * | 2002-12-04 | 2009-09-15 | Ore Pharmaceuticals Inc | Melanocortin-rezeptormodulatoren |
-
2003
- 2003-06-16 US US10/462,436 patent/US7375125B2/en not_active Expired - Fee Related
-
2004
- 2004-06-15 DE DE602004022168T patent/DE602004022168D1/de not_active Expired - Lifetime
- 2004-06-15 CA CA002529445A patent/CA2529445A1/en not_active Abandoned
- 2004-06-15 JP JP2006521070A patent/JP2006527776A/ja active Pending
- 2004-06-15 EP EP04776621A patent/EP1644337B1/en not_active Expired - Lifetime
- 2004-06-15 WO PCT/US2004/019124 patent/WO2005121100A1/en not_active Ceased
- 2004-06-15 AU AU2004320025A patent/AU2004320025A1/en not_active Abandoned
-
2008
- 2008-05-01 US US12/149,440 patent/US20080269217A1/en not_active Abandoned
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