JP2006526590A5 - - Google Patents
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- Publication number
- JP2006526590A5 JP2006526590A5 JP2006508257A JP2006508257A JP2006526590A5 JP 2006526590 A5 JP2006526590 A5 JP 2006526590A5 JP 2006508257 A JP2006508257 A JP 2006508257A JP 2006508257 A JP2006508257 A JP 2006508257A JP 2006526590 A5 JP2006526590 A5 JP 2006526590A5
- Authority
- JP
- Japan
- Prior art keywords
- cor
- alkyl
- optionally
- conr
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Claims (4)
- 式(Ia):
Tは存在しないか、あるいはO、S、NR17またはCR17R18を表し;
---は場合により結合を表し;
R15およびR16は、互いに独立して、ハロゲン、シアノ、ニトロ、OR17、SR17、COR17、NR18COR17、CONR17R18、場合により置換されていてもよいフェノキシ、またはOR17によって場合により置換されていてもよいC1-6アルキルを表し;
R17は、H、C1-6アルキルまたはC1-4アルキルアリールを表し;
R18は、HまたはC1-6アルキルを表し;
mおよびnは、互いに独立して、0または1、2もしくは3の整数を表わし;
但し、以下を条件とする:Tが存在しない場合、R15はオルト位のNR18COR17またはCONR17R18ではない)
で表される化合物、またはその生理学上機能的な誘導体。 - 薬剤において使用するための請求項1に記載の化合物。
- 炎症性症状または自己免疫疾患治療用薬剤の製造における請求項1に記載の化合物の使用。
- 請求項1に記載の化合物および製薬上許容可能な担体、ならびに場合により1種または複数の他の治療薬を含む医薬組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0312654.7A GB0312654D0 (en) | 2003-06-03 | 2003-06-03 | Therapeutically useful compounds |
PCT/EP2004/005966 WO2004110974A1 (en) | 2003-06-03 | 2004-06-01 | Matrix metalloproteinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006526590A JP2006526590A (ja) | 2006-11-24 |
JP2006526590A5 true JP2006526590A5 (ja) | 2007-06-28 |
Family
ID=9959187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006508257A Withdrawn JP2006526590A (ja) | 2003-06-03 | 2004-06-01 | マトリックスメタロプロテイナーゼ阻害剤 |
Country Status (8)
Country | Link |
---|---|
US (1) | US7250439B2 (ja) |
EP (1) | EP1654213B1 (ja) |
JP (1) | JP2006526590A (ja) |
AT (1) | ATE362910T1 (ja) |
DE (1) | DE602004006631T2 (ja) |
ES (1) | ES2287739T3 (ja) |
GB (1) | GB0312654D0 (ja) |
WO (1) | WO2004110974A1 (ja) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0321538D0 (en) * | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
PL1856063T3 (pl) * | 2005-02-22 | 2012-07-31 | Sun Pharmaceutical Ind Ltd | Pochodne kwasu 5-fenylopentantowego jako inhibitory metaloproteinazy macierzy do leczenia astmy i innych chorób |
EP2474531A3 (en) | 2006-08-22 | 2013-12-04 | Ranbaxy Laboratories Limited | Matrix metalloproteinase inhibitors |
CN103450077B (zh) | 2007-06-08 | 2016-07-06 | 满康德股份有限公司 | IRE-1α抑制剂 |
WO2012014114A1 (en) | 2010-07-30 | 2012-02-02 | Ranbaxy Laboratories Limited | Matrix metalloproteinase inhibitors |
KR20130140688A (ko) | 2010-09-24 | 2013-12-24 | 랜박시 래보러터리스 리미티드 | 기질 메탈로프로테나제 저해제 |
ES2775125T3 (es) | 2010-11-03 | 2020-07-23 | Dow Agrosciences Llc | Composiciones plaguicidas y procedimientos relacionados |
WO2012112945A1 (en) * | 2011-02-18 | 2012-08-23 | The Trustees Of Columbia University In The City Of New York | Use of matrix metalloproteinase inhibitors to treat tuberculosis |
US8937083B2 (en) | 2011-10-26 | 2015-01-20 | DowAgroSciences, LLC | Pesticidal compositions and processes related thereto |
EP2601941A1 (en) * | 2011-12-06 | 2013-06-12 | Ludwig-Maximilians-Universität München | Beta-O/S/N fatty acid based compounds as antibacterial and antiprotozoal agents |
US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
US9708288B2 (en) | 2012-04-27 | 2017-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
MA37572B1 (fr) | 2012-04-27 | 2017-10-31 | Dow Agrosciences Llc | Compositions pesticides et procédés correspondants |
EP2926808A1 (en) | 2012-11-28 | 2015-10-07 | Administración General De La Communidad Autónoma De Euskadi | Use of metalloprotease inhibitors for the treatment of polycystic liver diseases |
US9102655B2 (en) | 2013-10-17 | 2015-08-11 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
WO2015058020A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
MX2016004941A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Proceso para la preparacion de compuestos plaguicidas. |
MX2016004940A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Proceso para la preparacion de compuestos plaguicidas. |
CN105636440A (zh) | 2013-10-17 | 2016-06-01 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
WO2015058023A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
CN105636441B (zh) | 2013-10-17 | 2018-06-15 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
EP3060042A4 (en) | 2013-10-22 | 2017-04-26 | Dow AgroSciences LLC | Synergistic pesticidal compositions and related methods |
EP3060043A4 (en) | 2013-10-22 | 2017-04-12 | Dow AgroSciences, LLC | Pesticidal compositions and related methods |
JP2016538266A (ja) | 2013-10-22 | 2016-12-08 | ダウ アグロサイエンシィズ エルエルシー | 相乗的有害生物防除組成物および関連する方法 |
US9295258B2 (en) | 2013-10-22 | 2016-03-29 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
AU2014340424B2 (en) | 2013-10-22 | 2017-06-29 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
AU2014340430B2 (en) | 2013-10-22 | 2017-05-25 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
EP3094183A4 (en) | 2013-10-22 | 2017-08-09 | Dow AgroSciences LLC | Synergistic pesticidal compositions and related methods |
KR20160077113A (ko) | 2013-10-22 | 2016-07-01 | 다우 아그로사이언시즈 엘엘씨 | 살충 조성물 및 관련 방법 |
TW201519775A (zh) | 2013-10-22 | 2015-06-01 | Dow Agrosciences Llc | 協同性殺蟲組成物及相關方法(七) |
JP2016534068A (ja) | 2013-10-22 | 2016-11-04 | ダウ アグロサイエンシィズ エルエルシー | 相乗的有害生物防除組成物および関連する方法 |
NZ719634A (en) | 2013-10-22 | 2017-09-29 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
RU2656894C2 (ru) | 2013-10-22 | 2018-06-07 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Пестицидные композиции и соответствующие способы |
TW201519778A (zh) | 2013-10-22 | 2015-06-01 | Dow Agrosciences Llc | 協同性殺蟲組成物及相關方法(十) |
WO2015061142A1 (en) | 2013-10-22 | 2015-04-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
RU2016119530A (ru) | 2013-10-22 | 2017-11-28 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Синергетические пестицидные композиции и относящиеся к ним способы |
RU2016119553A (ru) | 2013-10-22 | 2017-12-04 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Синергетические пестицидные композиции и связанные с ними способы |
NZ719754A (en) | 2013-10-22 | 2017-06-30 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
CA2954631A1 (en) | 2014-07-31 | 2016-02-04 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
US9029555B1 (en) | 2014-07-31 | 2015-05-12 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine |
US9029556B1 (en) | 2014-07-31 | 2015-05-12 | Dow Argosciences Llc | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine |
CA2958058A1 (en) | 2014-08-19 | 2016-02-25 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
KR20170058388A (ko) | 2014-09-12 | 2017-05-26 | 다우 아그로사이언시즈 엘엘씨 | 3-(3-클로로-1h-피라졸-1-일)피리딘의 제조 방법 |
MX2017007874A (es) | 2014-12-24 | 2018-01-24 | Lg Chemical Ltd | Derivado de biarilo como agonista de gpr120. |
WO2018125815A1 (en) | 2016-12-29 | 2018-07-05 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
WO2018125817A1 (en) | 2016-12-29 | 2018-07-05 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4159197A (en) | 1996-09-04 | 1998-03-26 | Warner-Lambert Company | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
AU4229499A (en) * | 1998-07-30 | 2000-02-21 | Warner-Lambert Company | Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases |
-
2003
- 2003-06-03 GB GBGB0312654.7A patent/GB0312654D0/en not_active Ceased
-
2004
- 2004-06-01 JP JP2006508257A patent/JP2006526590A/ja not_active Withdrawn
- 2004-06-01 ES ES04739544T patent/ES2287739T3/es not_active Expired - Lifetime
- 2004-06-01 WO PCT/EP2004/005966 patent/WO2004110974A1/en active IP Right Grant
- 2004-06-01 DE DE602004006631T patent/DE602004006631T2/de not_active Expired - Lifetime
- 2004-06-01 EP EP04739544A patent/EP1654213B1/en not_active Expired - Lifetime
- 2004-06-01 AT AT04739544T patent/ATE362910T1/de not_active IP Right Cessation
- 2004-06-01 US US10/559,600 patent/US7250439B2/en not_active Expired - Fee Related
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