JP2006526011A - セリンプロテアーゼ(特に、hcvns3−ns4aプロテアーゼ)のインヒビター - Google Patents
セリンプロテアーゼ(特に、hcvns3−ns4aプロテアーゼ)のインヒビター Download PDFInfo
- Publication number
- JP2006526011A JP2006526011A JP2006509873A JP2006509873A JP2006526011A JP 2006526011 A JP2006526011 A JP 2006526011A JP 2006509873 A JP2006509873 A JP 2006509873A JP 2006509873 A JP2006509873 A JP 2006509873A JP 2006526011 A JP2006526011 A JP 2006526011A
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- optionally
- compound
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC*N(CCC**)C(*)C(N(*)C(*)C(N(CC(*)(C1(*)[Rn])I)C1C(N(*)C(*)(*)C=C)=O)=O)=O Chemical compound CC*N(CCC**)C(*)C(N(*)C(*)C(N(CC(*)(C1(*)[Rn])I)C1C(N(*)C(*)(*)C=C)=O)=O)=O 0.000 description 8
- HJNDAJNKJBWREZ-ASLNEKEESA-N CC(C)(C)OC([C@H]1NCC[C@@H]1C(O)=O)O Chemical compound CC(C)(C)OC([C@H]1NCC[C@@H]1C(O)=O)O HJNDAJNKJBWREZ-ASLNEKEESA-N 0.000 description 1
- XZISOEPNTDOUEA-UHFFFAOYSA-N CC(C)c(cc1)ccc1F Chemical compound CC(C)c(cc1)ccc1F XZISOEPNTDOUEA-UHFFFAOYSA-N 0.000 description 1
- WKNOTDFRQWDMPQ-UHFFFAOYSA-N CC(c(ccc(Cl)c1)c1Cl)NC Chemical compound CC(c(ccc(Cl)c1)c1Cl)NC WKNOTDFRQWDMPQ-UHFFFAOYSA-N 0.000 description 1
- WZTWPNDSZMOORY-UHFFFAOYSA-N CC(c(ccc(F)c1)c1F)NC Chemical compound CC(c(ccc(F)c1)c1F)NC WZTWPNDSZMOORY-UHFFFAOYSA-N 0.000 description 1
- RCSSHZGQHHEHPZ-UHFFFAOYSA-N CC(c1ccccc1)NC Chemical compound CC(c1ccccc1)NC RCSSHZGQHHEHPZ-UHFFFAOYSA-N 0.000 description 1
- MUIKHERDKLRMFH-UHFFFAOYSA-N CC(c1ccncc1)NC Chemical compound CC(c1ccncc1)NC MUIKHERDKLRMFH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/412,600 US7273885B2 (en) | 2002-04-11 | 2003-04-11 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
US51376503P | 2003-10-23 | 2003-10-23 | |
PCT/US2004/011012 WO2004092162A1 (en) | 2003-04-11 | 2004-04-09 | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010243570A Division JP2011068655A (ja) | 2003-04-11 | 2010-10-29 | セリンプロテアーゼ(特に、hcvns3−ns4aプロテアーゼ)のインヒビター |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006526011A true JP2006526011A (ja) | 2006-11-16 |
JP2006526011A5 JP2006526011A5 (US08039623-20111018-C00020.png) | 2007-05-31 |
Family
ID=33302781
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006509873A Pending JP2006526011A (ja) | 2003-04-11 | 2004-04-09 | セリンプロテアーゼ(特に、hcvns3−ns4aプロテアーゼ)のインヒビター |
JP2010243570A Pending JP2011068655A (ja) | 2003-04-11 | 2010-10-29 | セリンプロテアーゼ(特に、hcvns3−ns4aプロテアーゼ)のインヒビター |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010243570A Pending JP2011068655A (ja) | 2003-04-11 | 2010-10-29 | セリンプロテアーゼ(特に、hcvns3−ns4aプロテアーゼ)のインヒビター |
Country Status (11)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007532474A (ja) * | 2003-10-10 | 2007-11-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ、特にhcvのns3−ns4aプロテアーゼの阻害剤 |
Families Citing this family (78)
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HU227742B1 (en) | 1996-10-18 | 2012-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
DE60111509T2 (de) * | 2000-04-03 | 2006-05-11 | Vertex Pharmaceuticals Inc., Cambridge | Inhibitoren von Serin-Proteasen, insbesondere der Hepatitis-C-Virus NS23-Protease |
SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
TW200403236A (en) * | 2002-04-11 | 2004-03-01 | Vertex Pharma | Inhibitors or serine proteases, particularly HCV NS3-NS4A protease |
EP1613620A1 (en) * | 2003-04-11 | 2006-01-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
PE20050251A1 (es) * | 2003-07-18 | 2005-04-13 | Vertex Pharma | Inhibidores de proteasas serinas, en especial proteasa ns3-ns4a del vhc |
AR045596A1 (es) * | 2003-09-05 | 2005-11-02 | Vertex Pharma | Inhibidores de proteasas de serina en particular proteasa ns3-ns4a del vhc |
CA2538791A1 (en) | 2003-09-18 | 2005-03-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
EP2311851A3 (en) * | 2004-02-04 | 2011-05-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
NZ563909A (en) | 2005-05-13 | 2011-10-28 | Virochem Pharma Inc | Thiophene derivatives and their use for the treatment or prevention of flavivirus infections |
AU2006275413B2 (en) * | 2005-08-02 | 2012-07-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
KR20140098867A (ko) | 2005-11-11 | 2014-08-08 | 버텍스 파마슈티칼스 인코포레이티드 | C형 간염 바이러스 변이체 |
US7456165B2 (en) * | 2006-02-08 | 2008-11-25 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
WO2007098270A2 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising vx-950 and pharmaceutical compositions comprising the same |
BRPI0709567A2 (pt) * | 2006-03-16 | 2011-07-12 | Vertex Pharma | inibidores deuterados de protease de hepatite c |
MX2008012225A (es) * | 2006-03-23 | 2008-12-03 | Schering Corp | Combinaciones de inhibidores de proteasa de virus de hepatitis c e inhibidores de isoenzima 3a4 del citocromo p450, y metodos de tratamiento relacionados con las mismas. |
MX2009005185A (es) | 2006-11-15 | 2009-07-07 | Virochem Pharma Inc | Analogos de tiofeno para el tratamiento o prevencion de infecciones de flavivirus. |
AP2009004960A0 (en) * | 2007-02-27 | 2009-08-31 | Vertex Pharma | Co-crystals and pharmaceutical compositions comprising the same |
NZ579295A (en) * | 2007-02-27 | 2012-03-30 | Vertex Pharma | Inhibitors of serine proteases |
WO2009003009A1 (en) * | 2007-06-26 | 2008-12-31 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolidine as anti-infectives |
US20090022689A1 (en) * | 2007-07-18 | 2009-01-22 | Yat Sun Or | C4-spiro-pyrrolidine antivirals |
US8492546B2 (en) | 2007-08-30 | 2013-07-23 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
US20090060874A1 (en) * | 2007-09-05 | 2009-03-05 | Yao-Ling Qiu | Bicyclic pyrrolidine derivatives |
NZ587133A (en) * | 2008-02-04 | 2012-10-26 | Idenix Pharmaceuticals Inc | Macrocyclic serine protease inhibitor compounds for treating an HCV infection |
US20090233972A1 (en) * | 2008-03-12 | 2009-09-17 | Yat Sun Or | Substituted heterocycles as anti-infectives |
US20090324544A1 (en) * | 2008-06-11 | 2009-12-31 | Yao-Ling Qiu | Substituted cyclic pyrrolidine derivatives |
US20090326019A1 (en) * | 2008-06-11 | 2009-12-31 | Yat Sun Or | 3,4-bicyclic pyrrolidine antivirals |
US20100074863A1 (en) * | 2008-09-17 | 2010-03-25 | Yat Sun Or | Anti-infective pyrrolidine derivatives and analogs |
US8102720B2 (en) * | 2009-02-02 | 2012-01-24 | Qualcomm Incorporated | System and method of pulse generation |
JP5690286B2 (ja) | 2009-03-04 | 2015-03-25 | イデニク プハルマセウティカルス,インコーポレイテッド | ホスホチオフェン及びホスホチアゾールhcvポリメラーゼ阻害剤 |
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US8980920B2 (en) | 2009-05-29 | 2015-03-17 | Merck Sharp & Dohme Corp. | Antiviral compounds of three linked aryl moieties to treat diseases such as hepatitis C |
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HUE030402T2 (en) | 2009-09-15 | 2017-05-29 | Taigen Biotechnology Co Ltd | HCV protease inhibitors |
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JP2013514982A (ja) | 2009-12-18 | 2013-05-02 | イデニク プハルマセウティカルス,インコーポレイテッド | 5,5−縮合アリーレン又はヘテロアリーレンc型肝炎ウイルス阻害剤 |
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US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
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KR102161077B1 (ko) * | 2012-06-29 | 2020-09-29 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치 |
WO2014053533A1 (en) | 2012-10-05 | 2014-04-10 | Sanofi | Use of substituted 3-heteroaroylamino-propionic acid derivatives as pharmaceuticals for prevention/treatment of atrial fibrillation |
US20150065439A1 (en) | 2013-02-28 | 2015-03-05 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
US20160229866A1 (en) | 2013-09-20 | 2016-08-11 | Idenix Pharmaceuticals Inc. | Hepatitis c virus inhibitors |
EP3063140A4 (en) | 2013-10-30 | 2017-11-08 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof |
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BR112018076614A2 (pt) | 2016-06-21 | 2019-04-02 | Orion Ophthalmology LLC | derivados heterocíclicos de prolinamida |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998017679A1 (en) * | 1996-10-18 | 1998-04-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
WO1998046630A1 (en) * | 1997-04-16 | 1998-10-22 | Peptide Therapeutics Limited | Hepatitis c ns3 protease inhibitors |
WO1999050230A1 (en) * | 1998-03-31 | 1999-10-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
WO2001040262A1 (en) * | 1999-12-03 | 2001-06-07 | Bristol-Myers Squibb Pharma Company | Alpha-ketoamide inhibitors of hepatitis c virus ns3 protease |
WO2001074768A2 (en) * | 2000-04-03 | 2001-10-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
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- 2004-04-09 CN CNB2004800140478A patent/CN100453553C/zh not_active Expired - Fee Related
- 2004-04-09 WO PCT/US2004/011012 patent/WO2004092162A1/en active Application Filing
- 2004-04-09 ES ES04759362T patent/ES2381548T3/es not_active Expired - Lifetime
- 2004-04-09 EP EP10178023A patent/EP2332935A1/en not_active Withdrawn
- 2004-04-09 CA CA002521678A patent/CA2521678A1/en not_active Abandoned
- 2004-04-09 AU AU2004230946A patent/AU2004230946A1/en not_active Abandoned
- 2004-04-09 AT AT04759362T patent/ATE547412T1/de active
- 2004-04-09 EP EP04759362A patent/EP1636208B1/en not_active Expired - Lifetime
- 2004-04-09 JP JP2006509873A patent/JP2006526011A/ja active Pending
- 2004-04-09 US US10/821,793 patent/US20050090450A1/en not_active Abandoned
- 2004-04-12 AR ARP040101227A patent/AR044513A1/es unknown
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2006
- 2006-10-18 HK HK06111435.4A patent/HK1090644A1/xx not_active IP Right Cessation
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2008
- 2008-07-08 US US12/169,209 patent/US20090022688A1/en not_active Abandoned
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2010
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2011
- 2011-09-21 US US13/238,386 patent/US8618152B2/en not_active Expired - Fee Related
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JP2007532474A (ja) * | 2003-10-10 | 2007-11-15 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ、特にhcvのns3−ns4aプロテアーゼの阻害剤 |
JP2011246487A (ja) * | 2003-10-10 | 2011-12-08 | Vertex Pharmaceuticals Inc | セリンプロテアーゼ、特にhcvのns3−ns4aプロテアーゼの阻害剤 |
Also Published As
Publication number | Publication date |
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US20120014914A1 (en) | 2012-01-19 |
US8618152B2 (en) | 2013-12-31 |
EP1636208B1 (en) | 2012-02-29 |
EP2332935A1 (en) | 2011-06-15 |
JP2011068655A (ja) | 2011-04-07 |
WO2004092162A1 (en) | 2004-10-28 |
ES2381548T3 (es) | 2012-05-29 |
CN1795188A (zh) | 2006-06-28 |
AU2004230946A1 (en) | 2004-10-28 |
AR044513A1 (es) | 2005-09-14 |
CN100453553C (zh) | 2009-01-21 |
HK1090644A1 (en) | 2006-12-29 |
CA2521678A1 (en) | 2004-10-28 |
EP1636208A1 (en) | 2006-03-22 |
ATE547412T1 (de) | 2012-03-15 |
US20090022688A1 (en) | 2009-01-22 |
US20050090450A1 (en) | 2005-04-28 |
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