JP2006526009A5 - - Google Patents

Info

Publication number

JP2006526009A5

JP2006526009A5 JP2006509370A JP2006509370A JP2006526009A5 JP 2006526009 A5 JP2006526009 A5 JP 2006526009A5 JP 2006509370 A JP2006509370 A JP 2006509370A JP 2006509370 A JP2006509370 A JP 2006509370A JP 2006526009 A5 JP2006526009 A5 JP 2006526009A5

Authority

JP

Japan

Prior art keywords

cyclodextrin

cladribine

complex

use according

hydroxypropyl

Prior art date

2004-03-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 229920000858 Cyclodextrin Polymers 0.000 claims description 42
• PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims description 32
• 229960002436 cladribine Drugs 0.000 claims description 32
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 19
• 239000008194 pharmaceutical composition Substances 0.000 claims description 11
• 239000006186 oral dosage form Substances 0.000 claims description 6
• 229920006395 saturated elastomer Polymers 0.000 claims description 5
• 239000007787 solid Substances 0.000 claims description 5
• 239000000203 mixture Substances 0.000 claims description 4
• 229940097362 cyclodextrins Drugs 0.000 claims description 2
• 229940080345 gamma-cyclodextrin Drugs 0.000 claims 15
• GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims 12
• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 5
• 238000004519 manufacturing process Methods 0.000 claims 2
• 201000006417 multiple sclerosis Diseases 0.000 claims 2
• 238000010591 solubility diagram Methods 0.000 claims 2
• 229920001353 Dextrin Polymers 0.000 claims 1
• 239000004375 Dextrin Substances 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 235000019425 dextrin Nutrition 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 239000002552 dosage form Substances 0.000 description 5
• 210000004877 mucosa Anatomy 0.000 description 2
• 210000005178 buccal mucosa Anatomy 0.000 description 1
• 210000001156 gastric mucosa Anatomy 0.000 description 1
• 210000002850 nasal mucosa Anatomy 0.000 description 1