JP2006525049A - 鼻吸入器用ノズル - Google Patents
鼻吸入器用ノズル Download PDFInfo
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- JP2006525049A JP2006525049A JP2006505222A JP2006505222A JP2006525049A JP 2006525049 A JP2006525049 A JP 2006525049A JP 2006505222 A JP2006505222 A JP 2006505222A JP 2006505222 A JP2006505222 A JP 2006505222A JP 2006525049 A JP2006525049 A JP 2006525049A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
- B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
- B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
- B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
- B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
- B05B1/3447—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a cylinder having the same axis as the outlet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
- B05B1/3405—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl
- B05B1/341—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet
- B05B1/3421—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber
- B05B1/3431—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves
- B05B1/3442—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to produce swirl before discharging the liquid or other fluent material, e.g. in a swirl chamber upstream the spray outlet with channels emerging substantially tangentially in the swirl chamber the channels being formed at the interface of cooperating elements, e.g. by means of grooves the interface being a cone having the same axis as the outlet
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0027—Means for neutralising the actuation of the sprayer ; Means for preventing access to the sprayer actuation means
- B05B11/0032—Manually actuated means located downstream the discharge nozzle for closing or covering it, e.g. shutters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1042—Components or details
- B05B11/1052—Actuation means
- B05B11/1056—Actuation means comprising rotatable or articulated levers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coating Apparatus (AREA)
- Massaging Devices (AREA)
- Percussion Or Vibration Massage (AREA)
Abstract
Description
流体流路を画定する本体;
前記流路への入口を画定する投入口であって、前記放出口がはめ込まれて前記流路に前記ポンプ送りされる流体医薬を送ることができる形状を有する投入口;および
前記流路からの出口を画定する排出口であって、ユーザーが鼻腔に挿入することで、前記ポンプ送りされる流体医薬を鼻腔に投与できるような形状を有する排出口
を有し;
ネジ山通路が、前記入口と前記出口との間の流路に設けられて、前記ポンプ送りされる流体医薬に角運動量が与えられることを特徴とする鼻投薬ノズルが提供される。
Claims (31)
- ポンプ送りされる流体医薬の放出のための放出口を有する流体医薬放出ポンプ装置で用いられる鼻投薬ノズルにおいて、
流体流路を画定する本体;
前記流路への入口を画定する投入口であって、前記放出口がはめ込まれて前記流路に前記ポンプ送りされる流体医薬を送ることができる形状を有する投入口;および
前記流路からの出口を画定する排出口であって、ユーザーが鼻腔に挿入することで、前記ポンプ送りされる流体医薬を鼻腔に投与できるような形状を有する排出口
を有し;
ネジ山通路が、前記入口と前記出口との間の流路に設けられて、前記ポンプ送りされる流体医薬に角運動量が与えられることを特徴とする鼻投薬ノズル。 - 前記本体がさらに、前記ネジ山通路と前記排出口との間に位置する中空チャンバを画定する請求項1に記載の鼻投薬ノズル。
- 前記ネジ山通路が少なくとも3回の完全ネジ回数を画定する請求項1または2のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山通路がネジ山軸を中心として対称形に延在している請求項1〜3のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山軸が前記流体医薬放出ポンプ装置のポンプ送り軸に対応している請求項4に記載の鼻投薬ノズル。
- 前記流体流路が前記ネジ山軸を中心として対称である請求項4または5に記載の鼻投薬ノズル。
- 前記ノズルの前記本体が前記ネジ山軸を中心として対称である請求項4〜6のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山通路が複数のネジ切りされた経路を有する請求項1〜7のいずれかに記載の鼻投薬ノズル。
- 各ネジ切りされた経路が共通のネジ山軸を中心として配置されている請求項8に記載の鼻投薬ノズル。
- 前記ネジ山通路が2〜8個のネジ切りされた経路を有する請求項8または9のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山通路が前記ノズルの前記本体およびそれに設けられた1以上の挿入物によって包囲された体積部として画定される請求項1〜10のいずれかに記載の鼻投薬ノズル。
- 前記本体が平滑壁を有する円筒形流路を画定し、前記本体がネジ山表面を有する円筒形挿入物をぴったりと収容する請求項11に記載の鼻投薬ノズル。
- 前記本体がほぼ円筒形流路を画定し、該本体において画定されるネジ山表面を有し、前記本体が平滑壁を有する円筒形挿入物をぴったりと収容する請求項11に記載の鼻投薬ノズル。
- 前記本体がほぼ円筒形流路を画定し、該本体おいて画定されるネジ山表面を有し、前記本体が噛み合うネジ山表面を有する円筒形挿入物をぴったりと収容する請求項11に記載の鼻投薬ノズル。
- 前記ネジ山通路の断面積が、進入口からそれへの出口にかけて小さくなる請求項1〜14のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山通路の深さが、前記進入口から前記出口にかけて徐々に小さくなる請求項15に記載の鼻投薬ノズル。
- 前記ネジ山通路の幅が、前記進入口から前記出口にかけて徐々に小さくなる請求項15または16のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山通路のピッチが、前記進入口から前記出口にかけて徐々に小さくなる請求項15〜17のいずれかに記載の鼻投薬ノズル。
- 前記ネジ山通路がテーパ状の輪郭を有する請求項15〜18のいずれかに記載の鼻投薬ノズル。
- 前記排出口に可逆ストッパが設けられている請求項1〜19のいずれかに記載の鼻投薬ノズル。
- 流体医薬を鼻腔内に噴霧する流体医薬放出装置の可逆的収容を行うための筐体アセンブリにおいて、空洞部を画定する本体;ならびに前記本体と係合可能な請求項1〜20のいずれかに記載の投薬ノズルを有する筐体アセンブリ。
- 請求項21に記載の筐体アセンブリおよび該アセンブリによって収容される流体医薬放出ポンプ装置を有する流体医薬投薬装置。
- 前記流体医薬放出ポンプ装置が所定体積の流体医薬を入れるための貯留部を画定する中空ケーシングと該中空ケーシング内に延在する吸引口を持ったポンプを有し;前記ポンプが、前記投薬ノズルと共動して前記貯留部から前記投薬ノズルまでの流体のポンプ送りを可能とするための、前記中空ケーシングの第1の端部から延在する放出口を有する請求項22に記載の流体医薬投薬装置。
- 前記貯留部が所定体積の流体医薬製剤を含む請求項22または23のいずれかに記載の流体医薬投薬装置。
- 前記流体医薬製剤が溶液製剤の形態である請求項24に記載の流体医薬投薬装置。
- 前記流体医薬製剤が懸濁液製剤の形態である請求項25に記載の流体医薬投薬装置。
- 前記流体医薬製剤が抗炎症医薬化合物を含む請求項24〜26のいずれかに記載の流体医薬投薬装置。
- 前記医薬化合物が、糖質コルチコイド化合物である請求項27に記載の流体医薬投薬装置。
- 前記糖質コルチコイド化合物が6α,9α−ジフルオロ−17α−(1−オキソプロポキシ)−11β−ヒドロキシ−16α−メチル−3−オキソ−アンドロスタ−1,4−ジエン−17β−カルボチオ酸S−フルオロメチルエステル;6α,9α−ジフルオロ−17α−[(2−フラニルカルボニル)オキシ]−11β−ヒドロキシ−16α−メチル−3−オキソ−アンドロスタ−1,4−ジエン−17β−カルボチオン酸S−フルオロメチルエステル;および6α,9α−ジフルオロ−11β−ヒドロキシ−16α−メチル−17α−[(4−メチル−1,3−ジアゾール−5−カルボニル)オキシ]−3−オキソ−アンドロスタ−1,4−ジエン−17β−カルボチオ酸S−フルオロメチルエステルからなる群から選択される請求項28に記載の流体医薬投薬装置。
- 前記医薬化合物がPDE4阻害薬、ロイコトリエン拮抗薬、iNOS阻害薬、トリプターゼおよびエラスターゼ阻害薬、β−2インテグリン拮抗薬およびアデノシン2a作働薬からなる群から選択される請求項27に記載の流体医薬投薬装置。
- 請求項20に記載の筐体アセンブリと該アセンブリによって収容可能な流体医薬放出ポンプ装置を有する部品キット。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0309354.9A GB0309354D0 (en) | 2003-04-24 | 2003-04-24 | Nozzle for a nasal inhaler |
PCT/EP2004/004243 WO2004094068A2 (en) | 2003-04-24 | 2004-04-21 | Nozzle for a nasal inhaler |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006525049A true JP2006525049A (ja) | 2006-11-09 |
JP4593558B2 JP4593558B2 (ja) | 2010-12-08 |
Family
ID=9957190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006505222A Expired - Lifetime JP4593558B2 (ja) | 2003-04-24 | 2004-04-21 | 鼻吸入器用ノズル |
Country Status (7)
Country | Link |
---|---|
US (1) | US7484678B2 (ja) |
EP (1) | EP1615724B1 (ja) |
JP (1) | JP4593558B2 (ja) |
AT (1) | ATE413229T1 (ja) |
DE (1) | DE602004017594D1 (ja) |
GB (1) | GB0309354D0 (ja) |
WO (1) | WO2004094068A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009502285A (ja) * | 2005-07-28 | 2009-01-29 | グラクソ グループ リミテッド | 鼻吸入器用ノズル |
Families Citing this family (22)
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US20030180351A1 (en) * | 1998-11-06 | 2003-09-25 | Reinhard Gluck | Pharmaceutically active composition and dispensing device |
GB0312007D0 (en) * | 2003-05-24 | 2003-07-02 | Innovata Biomed Ltd | Container |
FR2887232B1 (fr) * | 2005-06-21 | 2010-11-05 | Rexam Dispensing Sys | Embout poussoir pour distributeur de produit liquide |
SE529956C2 (sv) * | 2005-07-12 | 2008-01-15 | Medux Ab | Sprejanordning, metod för sprejning samt sätt för tillverkning av anordning |
EP1792660A1 (en) * | 2005-12-02 | 2007-06-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device |
SE529863C2 (sv) * | 2006-05-02 | 2007-12-18 | Medux Ab | Sprayanordning med munstycksförslutning |
WO2009100383A2 (en) * | 2008-02-07 | 2009-08-13 | University Of Washington | Circumferential aerosol device |
RU2728583C2 (ru) | 2011-03-03 | 2020-07-30 | Импел Ньюрофарма Инк. | Устройство для назальной доставки лекарственных средств |
RU2618084C2 (ru) | 2011-05-09 | 2017-05-02 | Импел Ньюрофарма Инк. | Наконечники для назальной доставки лекарственных средств |
US9681932B2 (en) * | 2013-04-25 | 2017-06-20 | Hankookin, Inc. | Intraoral biofilm control apparatus |
US10537692B2 (en) | 2013-04-28 | 2020-01-21 | Impel Neuropharma, Inc. | Medical unit dose container |
GB201308679D0 (en) | 2013-05-14 | 2013-06-26 | 3M Innovative Properties Co | Actuator for an inhaler |
CN103623951B (zh) * | 2013-11-13 | 2017-02-22 | 浙江工业大学 | 气雾剂喷头 |
CA2998182A1 (en) | 2015-09-10 | 2017-03-16 | Impel Neuropharma, Inc. | In-line nasal delivery device |
US11571532B2 (en) | 2017-11-21 | 2023-02-07 | Impel Pharmaceuticals Inc. | Intranasal device with dip tube |
CA3081680A1 (en) | 2017-11-21 | 2019-05-31 | Impel Neuropharma, Inc. | Intranasal device with inlet interface |
US10482365B1 (en) * | 2017-11-21 | 2019-11-19 | Wells Fargo Bank, N.A. | Transaction instrument containing metal inclusions |
CA3087698A1 (en) | 2018-01-05 | 2019-07-11 | Impel Neuropharma, Inc. | Intranasal delivery of olanzapine by precision olfactory device |
EP3735244B1 (en) | 2018-01-05 | 2022-11-23 | Impel Pharmaceuticals Inc. | Intranasal delivery of dihydroergotamine by precision olfactory device |
KR20210034047A (ko) | 2018-07-19 | 2021-03-29 | 임펠 뉴로파마 인코포레이티드 | 파킨슨 병 치료를 위한 레보도파 및 도파 데카르복실라아제 저해제의 기도 전달 |
KR20210109007A (ko) | 2019-01-03 | 2021-09-03 | 임펠 뉴로파마 인코포레이티드 | 비강 약물 전달 장치 |
BR112021023049A8 (pt) | 2019-05-17 | 2022-10-18 | Impel Neuropharma Inc | Dispositivo de dispensação nasal de uso único |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1506722A (en) * | 1919-10-16 | 1924-08-26 | Allis Chalmers Mfg Co | Method of producing spray nozzles |
US2435605A (en) * | 1944-03-31 | 1948-02-10 | Herman L Rowell | Spray nozzle |
FR1340235A (fr) * | 1962-08-13 | 1963-10-18 | Anciens Etablissements E Rober | Appareil pulvérisateur à pompe |
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-
2003
- 2003-04-24 GB GBGB0309354.9A patent/GB0309354D0/en not_active Ceased
-
2004
- 2004-04-21 EP EP04728551A patent/EP1615724B1/en not_active Expired - Lifetime
- 2004-04-21 JP JP2006505222A patent/JP4593558B2/ja not_active Expired - Lifetime
- 2004-04-21 US US10/553,688 patent/US7484678B2/en active Active
- 2004-04-21 WO PCT/EP2004/004243 patent/WO2004094068A2/en active Application Filing
- 2004-04-21 DE DE602004017594T patent/DE602004017594D1/de not_active Expired - Lifetime
- 2004-04-21 AT AT04728551T patent/ATE413229T1/de not_active IP Right Cessation
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2009502285A (ja) * | 2005-07-28 | 2009-01-29 | グラクソ グループ リミテッド | 鼻吸入器用ノズル |
Also Published As
Publication number | Publication date |
---|---|
US7484678B2 (en) | 2009-02-03 |
ATE413229T1 (de) | 2008-11-15 |
JP4593558B2 (ja) | 2010-12-08 |
WO2004094068A2 (en) | 2004-11-04 |
WO2004094068A3 (en) | 2004-12-02 |
US20060219813A1 (en) | 2006-10-05 |
EP1615724A2 (en) | 2006-01-18 |
EP1615724B1 (en) | 2008-11-05 |
GB0309354D0 (en) | 2003-06-04 |
DE602004017594D1 (de) | 2008-12-18 |
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