JP2006524331A5 - - Google Patents
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- JP2006524331A5 JP2006524331A5 JP2006507518A JP2006507518A JP2006524331A5 JP 2006524331 A5 JP2006524331 A5 JP 2006524331A5 JP 2006507518 A JP2006507518 A JP 2006507518A JP 2006507518 A JP2006507518 A JP 2006507518A JP 2006524331 A5 JP2006524331 A5 JP 2006524331A5
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- protein
- calgranulin
- infection
- amniotic
- maternal
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Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1578205A4 (en) * | 2002-11-14 | 2008-01-02 | Ciphergen Biosystems Inc | BIOMARKERS FOR INTRA-AMNIOTIC INFLAMMATION |
| US8068990B2 (en) * | 2003-03-25 | 2011-11-29 | Hologic, Inc. | Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids |
| US7191068B2 (en) * | 2003-03-25 | 2007-03-13 | Proteogenix, Inc. | Proteomic analysis of biological fluids |
| GB0313828D0 (en) * | 2003-06-16 | 2003-07-23 | Owen Smith Brian D O | Salivary urate for diagnosis of pre-eclampsia |
| BRPI0418980A (pt) * | 2003-08-21 | 2007-12-11 | Univ Mcgill | método e aparelho para analisar fluido amniótico |
| US20050233400A1 (en) * | 2004-03-03 | 2005-10-20 | Weiner Carl P | Proteomic method for predicting success of rescue cerclage |
| WO2005093413A2 (en) * | 2004-03-22 | 2005-10-06 | Yale University | Diagnosis and treatment of preeclampsia |
| WO2006076025A2 (en) * | 2004-05-14 | 2006-07-20 | Amaox, Inc. | Immune cell biosensors and methods of using same |
| WO2012047930A2 (en) | 2010-10-04 | 2012-04-12 | The Regents Of The University Of California | Compositions and methods for treatment of gynecologic cancers |
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| EP2199801B1 (en) * | 2004-07-14 | 2013-05-29 | The Regents of The University of California | Biomarkers for early detection of ovarian cancer |
| US9488655B2 (en) * | 2004-07-14 | 2016-11-08 | The Regents Of The University Of California | Biomarkers for detection of early- and late-stage endometrial cancer |
| EP1799861A2 (en) * | 2004-09-20 | 2007-06-27 | Proteogenix, Inc. | Diagnosis of fetal aneuploidy |
| DE602005023216D1 (de) * | 2004-12-15 | 2010-10-07 | Beth Israel Hospital | Nukleinsäuren und polypeptide zur diagnose und behandlung von schwangerschaftskomplikationen |
| ATE490465T1 (de) | 2005-01-28 | 2010-12-15 | Childrens Medical Center | Diagnose- und prognoseverfahren von blasenkrebs. |
| US7645576B2 (en) * | 2005-03-18 | 2010-01-12 | The Chinese University Of Hong Kong | Method for the detection of chromosomal aneuploidies |
| JP2008538007A (ja) | 2005-04-15 | 2008-10-02 | ベクトン，ディッキンソン アンド カンパニー | 敗血症の診断 |
| US20070087387A1 (en) * | 2005-04-21 | 2007-04-19 | Prasad Devarajan | Method for the Early Detection of Renal Disease Using Proteomics |
| EP1937706A4 (en) * | 2005-09-09 | 2008-10-22 | Univ Iowa Res Found | ORGANIC MARKERS RELATED TO AGE DEPENDENT MAKULAR GENERATION |
| US7312079B1 (en) | 2005-10-06 | 2007-12-25 | Lexicon Pharmaceuticals, Inc. | Variants of FAM3C |
| US20070190580A1 (en) * | 2005-10-31 | 2007-08-16 | Beckman Coulter, Inc. | Immunoassay of Fragments of Insulin-Like Growth Factor Binding Proteins |
| US20070162992A1 (en) * | 2006-01-09 | 2007-07-12 | Mcgill University | Metabolomic determination in assisted reproductive technology |
| US20090215085A1 (en) * | 2006-01-27 | 2009-08-27 | Eastern Virginia Medical School | Proteomic Fingerprinting of Human IVF-Derived Embryos: Identification of Biomarkers of Developmental Potential |
| US7790463B2 (en) | 2006-02-02 | 2010-09-07 | Yale University | Methods of determining whether a pregnant woman is at risk of developing preeclampsia |
| US20090305259A1 (en) * | 2006-03-21 | 2009-12-10 | Yale University | Early Diagnosis of Congenital Abnormalities in the Offspring of Diabetic Mothers |
| EP2462945B1 (en) * | 2006-08-16 | 2014-06-04 | National Research Council of Canada | Method of inhibiting angiogenesis, tumorigenesis and cathepsin activity |
| WO2008046160A1 (en) * | 2006-10-20 | 2008-04-24 | Newcastle Innovation Limited | Assay for the detection of biomarkers associated with pregnancy related conditions |
| JP5194212B2 (ja) * | 2006-12-26 | 2013-05-08 | ブリガム・ヤング・ユニバーシティ | 血清プロテオミクスシステムと関連する方法 |
| WO2008112424A1 (en) * | 2007-03-08 | 2008-09-18 | Mayo Foundation For Medical Education And Research | Assessing heart failure |
| CN101680884A (zh) * | 2007-05-05 | 2010-03-24 | 西安大略大学 | 检测先兆子痫的方法 |
| GB0711327D0 (en) | 2007-06-12 | 2007-07-25 | Hansa Medical Ab | Diagnostic method |
| FR2919060B1 (fr) | 2007-07-19 | 2012-11-30 | Biomerieux Sa | Procede de dosage de l'ezrine pour le diagnostic in vitro du cancer colorectal. |
| FR2919065B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'apolipoproteine ai pour le diagnostic in vitro du cancer colorectal |
| FR2919063B1 (fr) * | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage du leucocyte elastase inhibitor pour le diagnostic in vitro du cancer colorectal. |
| JP5715817B2 (ja) | 2007-07-19 | 2015-05-13 | ビオメリューＢｉｏｍｅｒｉｅｕｘ | 結腸直腸癌のインビトロ診断のための肝臓脂肪酸結合タンパク質、ｃｅａおよびｃａ１９−９のアッセイのための方法 |
| CA2694112A1 (en) * | 2007-07-20 | 2009-01-29 | The University Of Utah Research Foundation | Identification and quantification of biomarkers for evaluating the risk of preterm birth |
| WO2009046447A1 (en) * | 2007-10-06 | 2009-04-09 | Katalin Polgar | Fetal open lesion detection system |
| WO2009076425A2 (en) * | 2007-12-13 | 2009-06-18 | 3M Innovative Properties Company | Methods of analyzing wound samples |
| WO2009097579A1 (en) * | 2008-01-30 | 2009-08-06 | Proteogenix, Inc. | Gestational age dependent proteomic changes of human maternal serum for monitoring maternal and fetal health |
| WO2009097584A1 (en) * | 2008-01-30 | 2009-08-06 | Proteogenix, Inc. | Maternal serum biomarkers for detection of pre-eclampsia |
| US8669113B2 (en) | 2008-04-03 | 2014-03-11 | Becton, Dickinson And Company | Advanced detection of sepsis |
| US8481273B2 (en) * | 2008-06-20 | 2013-07-09 | University Of Delaware | Perlecan fragments as biomarkers of bone stromal lysis |
| US20110247404A1 (en) * | 2008-06-25 | 2011-10-13 | University Of Utah Research Foundation | Identifying and quantifying biomarkers associated with preeclampsia |
| FR2933773B1 (fr) | 2008-07-10 | 2013-02-15 | Biomerieux Sa | Procede de dosage de la proteine disulfide isomerase pour le diagnostic in vitro du cancer colorectal |
| US8476008B2 (en) | 2008-07-23 | 2013-07-02 | Diabetomics, Llc | Methods for detecting pre-diabetes and diabetes |
| WO2011053832A1 (en) * | 2009-10-29 | 2011-05-05 | The Trustees Of Columbia University In The City Of New York | Use of urinary ngal to diagnose sepsis in very low birth weight infants |
| CA2780976C (en) * | 2009-11-25 | 2020-03-31 | Hologic, Inc. | Detection of intraamniotic infection |
| WO2011112993A2 (en) | 2010-03-11 | 2011-09-15 | University Of Louisville Research Foundation, Inc. | Methods of predicting and decreasing the risk of pregnancy loss |
| WO2011149962A1 (en) | 2010-05-24 | 2011-12-01 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
| US20130072437A1 (en) * | 2010-05-28 | 2013-03-21 | Mind-Nrg Sa | Neuregulin isoforms,neuregulin polypeptides and uses thereof |
| GB201016161D0 (en) | 2010-09-24 | 2010-11-10 | Hansa Medical Ab | Diagnostic method |
| US20120142559A1 (en) * | 2010-12-06 | 2012-06-07 | Pronota N.V. | Biomarkers and parameters for hypertensive disorders of pregnancy |
| GB201102108D0 (en) * | 2011-02-07 | 2011-03-23 | Hansa Medical Ab | Diagnostic method |
| US20140162941A1 (en) * | 2011-07-27 | 2014-06-12 | Baylor College Of Medicine | Process for preparing biological samples |
| US9241976B2 (en) | 2011-08-29 | 2016-01-26 | The Regents Of The University Of California | Use of HDL-related molecules to treat and prevent proinflammatory conditions |
| KR101142434B1 (ko) * | 2011-09-08 | 2012-05-08 | (주)오비메드 | 조기양막파수 산모에서 비침습적인 양수 내 염증 및 감염의 예측 또는 진단 방법 |
| CN102426243B (zh) * | 2011-11-17 | 2014-03-19 | 成都创宜生物科技有限公司 | 以补体因子d为检测指标的子痫前期检测试剂盒的制备方法 |
| EP2879697A4 (en) | 2012-08-03 | 2016-01-20 | Lfb Usa Inc | USE OF ANTITHROMBIN IN OXYGENATION OF EXTRACORPOREAL MEMBRANE |
| ES2690782T3 (es) | 2012-10-24 | 2018-11-22 | Nyu Winthrop Hospital | Biomarcador no invasivo para identificar sujetos en riesgo de parto prematuro |
| EP2925337B1 (en) | 2012-11-21 | 2019-07-03 | The Trustees of Columbia University in the City of New York | Mutant ngal proteins and uses thereof |
| US20140178911A1 (en) * | 2012-12-20 | 2014-06-26 | Roche Molecular Systems, Inc. | Characterization of thermostable dna polymerase |
| GB201305317D0 (en) * | 2013-03-22 | 2013-05-08 | Iles Raymond K | Prenatal screening for fetal abnormalities and disorders of pregnancy |
| US10126305B2 (en) * | 2013-06-25 | 2018-11-13 | University of Pittsburg—Of the Commonwealth System of Higher Education | Proteomic biomarkers of sepsis in elderly patients |
| FR3036188B1 (fr) * | 2015-05-12 | 2019-06-07 | Biomerieux | Prediction du risque de developper, pour des patients admis en service de reanimation, une infection disseminee |
| KR20180029046A (ko) | 2015-06-19 | 2018-03-19 | 세라 프로그노스틱스 인코포레이티드 | 조산 예측용 바이오마커 쌍 |
| WO2017003954A1 (en) | 2015-06-27 | 2017-01-05 | Stimlabs Llc | Products derived from amniotic fluid and methods of use |
| CN105372414B (zh) * | 2015-10-09 | 2017-12-22 | 成都大熊猫繁育研究基地 | 大熊猫乳汁中关键因子的分析方法 |
| CN110366597B (zh) * | 2016-12-20 | 2024-03-29 | 善威生物私人有限公司 | 用蛋白酶抑制剂进行血液图谱分析 |
| EP4530633A3 (en) | 2017-08-18 | 2026-03-25 | Sera Prognostics, Inc. | Pregnancy clock proteins for predicting due date and time to birth |
| CA3075688A1 (en) | 2017-09-13 | 2019-03-21 | Progenity, Inc. | Preeclampsia biomarkers and related systems and methods |
| WO2019144140A1 (en) * | 2018-01-22 | 2019-07-25 | CyPhi LLC | Bio-mimetic formulation |
| EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECLAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR TESTS |
| CN113092773A (zh) * | 2019-12-23 | 2021-07-09 | 首都医科大学附属北京世纪坛医院 | 尿液α-胰蛋白酶抑制剂重链H4及其多肽片段在过敏性疾病中的应用 |
| CN113092771A (zh) * | 2019-12-23 | 2021-07-09 | 首都医科大学附属北京世纪坛医院 | 尿液α-1B-糖蛋白及其多肽片段在过敏性疾病中的应用 |
| CN111951969A (zh) * | 2020-08-05 | 2020-11-17 | 中翰盛泰生物技术股份有限公司 | Hbp在高危妊娠预测中的应用 |
| WO2025243332A1 (en) * | 2024-05-24 | 2025-11-27 | Intignus Biotech Private Limited | Lfa device for detecting biomarkers for intrapartum and neonatal complications and method thereof |
| CN120233090B (zh) * | 2025-03-28 | 2025-09-09 | 中日友好医院(中日友好临床医学研究所) | 一组尿蛋白标志物及其在制备非小细胞肺癌预后预测产品中的应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5871937A (en) * | 1985-04-30 | 1999-02-16 | The Scripps Research Institute | Acute phase protein modulating endotoxic activity of lipopolysaccharides, assay methods and polypeptides |
| US5516702A (en) * | 1991-11-06 | 1996-05-14 | Adeza Biomedical Corporation | Screening method for identifying women at increased risk for imminent delivery |
| US6036955A (en) * | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
| US5484705A (en) * | 1994-01-24 | 1996-01-16 | Xoma Corporation | Method for quantifying lipopolysaccharide binding protein |
| US5891618A (en) * | 1994-01-24 | 1999-04-06 | Xoma Corporation | Method for quantifying LBP in body fluids |
| US5932536A (en) * | 1994-06-14 | 1999-08-03 | The Rockefeller University | Compositions for neutralization of lipopolysaccharides |
| WO1996037777A1 (en) * | 1995-05-23 | 1996-11-28 | Nelson Randall W | Mass spectrometric immunoassay |
| US20020164818A1 (en) * | 1995-05-23 | 2002-11-07 | Gruber Karl F. | Mass spectrometric immunoassay analysis of specific proteins and variants present in various biological fluids |
| WO1999043851A1 (en) * | 1998-02-25 | 1999-09-02 | National University Of Ireland, Cork | Hla linked pre-eclampsia and miscarriage susceptibility gene |
| US6324479B1 (en) * | 1998-05-08 | 2001-11-27 | Rosetta Impharmatics, Inc. | Methods of determining protein activity levels using gene expression profiles |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| EP1143246A4 (en) * | 1998-12-28 | 2004-11-24 | Advance Kk | IDENTIFICATION SYSTEM OF MICROORGANISMS |
| AU3712200A (en) * | 1999-03-01 | 2000-09-21 | Board Of Trustees Of The Leland Stanford Junior University | Rapid assay for chorioamnionitis |
| CA2368975A1 (en) * | 1999-04-07 | 2000-10-12 | Unilever Plc | Lipopolysaccharide immunoassay and test device |
| AU6615500A (en) * | 1999-07-28 | 2001-02-19 | Genetics Institute Inc. | Preventing immune-mediated abortion by inhibiting costimulation |
| US6653151B2 (en) * | 1999-07-30 | 2003-11-25 | Large Scale Proteomics Corporation | Dry deposition of materials for microarrays using matrix displacement |
| WO2001040517A2 (en) * | 1999-11-30 | 2001-06-07 | Oxo Chemie Ag | Evaluating and predicting clinical outcomes by gene expression analysis |
| EP1481249A1 (en) * | 2002-03-07 | 2004-12-01 | Cambridge University Technical Services Limited | Scd fingerprints |
| CN1395103A (zh) * | 2002-07-31 | 2003-02-05 | 中华人民共和国北京出入境检验检疫局 | 疯牛病病原检测压电生物芯片及其制备方法 |
| EP1578205A4 (en) * | 2002-11-14 | 2008-01-02 | Ciphergen Biosystems Inc | BIOMARKERS FOR INTRA-AMNIOTIC INFLAMMATION |
| WO2004072638A1 (en) * | 2003-02-05 | 2004-08-26 | Ciphergen Biosystems, Inc. | Non-invasive assessment of intra-amniotic environment |
| US7191068B2 (en) * | 2003-03-25 | 2007-03-13 | Proteogenix, Inc. | Proteomic analysis of biological fluids |
| US7323346B2 (en) * | 2003-08-14 | 2008-01-29 | The General Hospital Corporation | Screening for gestational disorders |
| ES2556164T3 (es) * | 2003-09-23 | 2016-01-13 | The General Hospital Corporation | Cribado de la preeclampsia |
| US20060063162A1 (en) * | 2004-09-23 | 2006-03-23 | Deng David X | Biological marker for inflammation |
| JP2008514955A (ja) * | 2004-09-28 | 2008-05-08 | シンギュレックス・インコーポレイテッド | サンプル分析システムおよび方法 |
| GB0426982D0 (en) * | 2004-12-09 | 2005-01-12 | Secr Defence | Early detection of sepsis |
| JP2008538007A (ja) * | 2005-04-15 | 2008-10-02 | ベクトン，ディッキンソン アンド カンパニー | 敗血症の診断 |
| DE602006019262D1 (de) * | 2005-08-11 | 2011-02-10 | Siemens Healthcare Diagnostics | QUANTITATIVE ASSAYS FÜR PDGFR-beta- IN KÖRPERFLÜSSIGKEITEN |
| AU2006299417A1 (en) * | 2005-10-03 | 2007-04-12 | Biosite Incorporated | Methods and compositions for diagnosis and/or prognosis in Systemic Inflammatory Response Syndromes |
| WO2007047041A2 (en) * | 2005-10-14 | 2007-04-26 | Hyperion Biotechnology, Inc. | Methods and compositions for biomarkers associated with change in physical performance |
| US7790463B2 (en) * | 2006-02-02 | 2010-09-07 | Yale University | Methods of determining whether a pregnant woman is at risk of developing preeclampsia |
| US20080031874A1 (en) * | 2006-02-06 | 2008-02-07 | Sanders Martin E | Treatment of endotoxemia using endotoxin neutralizing agents |
| WO2007139359A1 (en) * | 2006-05-31 | 2007-12-06 | Hanwha Chemical Corporation | Vcam-1 specific monoclonal antibody |
| US20080199426A1 (en) * | 2007-01-11 | 2008-08-21 | Sukhatme Vikas P | Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders |
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