JP2006521399A - 疼痛管理用ムスカリンｍ１受容体アゴニスト - Google Patents

疼痛管理用ムスカリンｍ１受容体アゴニスト Download PDF

Info

Publication number
JP2006521399A
JP2006521399A JP2006509357A JP2006509357A JP2006521399A JP 2006521399 A JP2006521399 A JP 2006521399A JP 2006509357 A JP2006509357 A JP 2006509357A JP 2006509357 A JP2006509357 A JP 2006509357A JP 2006521399 A JP2006521399 A JP 2006521399A
Authority
JP
Japan
Prior art keywords
compound
receptor
optionally substituted
muscarinic
neuropathic pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2006509357A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006521399A5 (enExample
Inventor
デイビス、ロバート、アール．
ヴァノヴァー、キンバリー
ロドリゲス、マリオ
Original Assignee
アカディア ファーマシューティカルズ，インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アカディア ファーマシューティカルズ，インコーポレーテッド filed Critical アカディア ファーマシューティカルズ，インコーポレーテッド
Publication of JP2006521399A publication Critical patent/JP2006521399A/ja
Publication of JP2006521399A5 publication Critical patent/JP2006521399A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2006509357A 2003-03-28 2004-03-26 疼痛管理用ムスカリンｍ１受容体アゴニスト Withdrawn JP2006521399A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45904503P 2003-03-28 2003-03-28
PCT/US2004/009339 WO2004087158A2 (en) 2003-03-28 2004-03-26 Muscarinic m1 receptor agonists for pain management

Publications (2)

Publication Number Publication Date
JP2006521399A true JP2006521399A (ja) 2006-09-21
JP2006521399A5 JP2006521399A5 (enExample) 2007-05-10

Family

ID=33131858

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006509357A Withdrawn JP2006521399A (ja) 2003-03-28 2004-03-26 疼痛管理用ムスカリンｍ１受容体アゴニスト

Country Status (13)

Country Link
US (1) US20050130961A1 (enExample)
EP (1) EP1613321A2 (enExample)
JP (1) JP2006521399A (enExample)
KR (1) KR20050112116A (enExample)
CN (1) CN1777425A (enExample)
AU (1) AU2004226430A1 (enExample)
BR (1) BRPI0409523A (enExample)
CA (1) CA2520125A1 (enExample)
MX (1) MXPA05010171A (enExample)
NZ (1) NZ542690A (enExample)
RU (1) RU2358735C2 (enExample)
WO (1) WO2004087158A2 (enExample)
ZA (1) ZA200508733B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016513677A (ja) * 2013-03-15 2016-05-16 アカディア ファーマシューティカルズ インコーポレイテッド ムスカリンアゴニスト

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7307075B2 (en) * 2001-12-28 2007-12-11 Acadia Pharmaceuticals Inc. Tetrahydroquinoline analogues as muscarinic agonists
US7550459B2 (en) * 2001-12-28 2009-06-23 Acadia Pharmaceuticals, Inc. Tetrahydroquinoline analogues as muscarinic agonists
KR20070036149A (ko) * 2004-07-16 2007-04-02 얀센 파마슈티카 엔.브이. 이량체 피페리딘 유도체
AU2006282896A1 (en) * 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
ES2573253T3 (es) 2006-09-20 2016-06-06 The Board Of Regents Of The University Of Texas System Métodos para el suministro de anestésicos volátiles para anestesia regional y/o alivio del dolor
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
CN107661293A (zh) 2008-01-22 2018-02-06 得克萨斯大学体系董事会 用于局部麻醉和/或疼痛缓解的含有萃取溶剂的挥发性麻醉剂组合物
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
NZ602312A (en) 2010-03-10 2014-02-28 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
KR102349237B1 (ko) 2014-04-23 2022-01-07 다케다 야쿠힌 고교 가부시키가이샤 알츠하이머 병의 치료를 위한 콜린작동성 무스카린 ｍ１ 수용체 양성 알로스테릭 조절인자 활성을 갖는 이소인돌린-1-온 유도체
TN2017000508A1 (en) 2015-06-26 2019-04-12 Takeda Pharmaceuticals Co 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
JP6787913B2 (ja) 2015-10-20 2020-11-18 武田薬品工業株式会社 複素環化合物
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
CA3131128A1 (en) * 2019-02-22 2020-08-27 Karuna Therapeutics, Inc. Compounds and methods of deuterated xanomeline for treating neurological disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
US5155166A (en) * 1990-06-18 1992-10-13 Eastman Kodak Company Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach compounds to carboxylated particles and a kit containing same
FR2663929A1 (fr) * 1990-06-29 1992-01-03 Adir Nouveaux derives d'oxazolo pyridines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IL110298A (en) * 1993-07-13 1999-04-11 Brann Mark Robert Identification of ligands by selective amplification of cells transfected with receptors
GB2292685A (en) * 1994-07-27 1996-03-06 Sankyo Co Allosteric effectors at muscarinic receptors
US6271196B1 (en) * 1996-03-05 2001-08-07 Regents Of The University Of Ca Methods of alleviating neuropathic pain using prosaposin-derived peptides
FR2747041B1 (fr) * 1996-04-05 1998-05-22 Cird Galderma Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies
US6528529B1 (en) * 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
AU1596099A (en) * 1998-11-23 2000-06-13 Eisai Co. Ltd. Aryl and heteroaryl compounds useful as fibroblast growth factor antagonists
BR0110420A (pt) * 2000-04-28 2003-07-01 Acadia Pharm Inc Agonistas muscarìnicos
ATE516030T1 (de) * 2001-10-02 2011-07-15 Acadia Pharm Inc Benzimidazolidinon-derivate als muscarinische mittel
US7307075B2 (en) * 2001-12-28 2007-12-11 Acadia Pharmaceuticals Inc. Tetrahydroquinoline analogues as muscarinic agonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016513677A (ja) * 2013-03-15 2016-05-16 アカディア ファーマシューティカルズ インコーポレイテッド ムスカリンアゴニスト

Also Published As

Publication number Publication date
AU2004226430A1 (en) 2004-10-14
WO2004087158A2 (en) 2004-10-14
RU2358735C2 (ru) 2009-06-20
RU2005133197A (ru) 2006-04-27
WO2004087158A3 (en) 2005-03-31
ZA200508733B (en) 2006-09-27
CN1777425A (zh) 2006-05-24
BRPI0409523A (pt) 2006-04-18
US20050130961A1 (en) 2005-06-16
CA2520125A1 (en) 2004-10-14
MXPA05010171A (es) 2005-12-12
EP1613321A2 (en) 2006-01-11
NZ542690A (en) 2009-04-30
KR20050112116A (ko) 2005-11-29

Similar Documents

Publication Publication Date Title
JP2006521399A (ja) 疼痛管理用ムスカリンｍ１受容体アゴニスト
JP5921539B2 (ja) 下肢静止不能症候群を治療する方法
JP3553083B2 (ja) 末梢性活性抗痛覚過敏オピエート
US20020173505A1 (en) Medicament
HUP0301822A2 (hu) Gyógyszerkészítmény az akut, a krónikus fájdalom és/vagy a neuropátiás fájdalom és a migrének kezelésére
IL307981A (en) Cancer treatment methods
BRPI0715196A2 (pt) Uso de um composto
JP6528779B2 (ja) びまん性大細胞型ｂ細胞リンパ腫の予防および／または治療剤
WO1995011894A1 (en) Histamine h3-receptor antagonists and therapeutic uses thereof
AU714477B2 (en) Treatment of mood/affective disorders by glutamatergic upmodulators
JP2011522017A (ja) ニコチン受容体の部分アゴニストとアセチルコリンエステラーゼ阻害剤との組み合わせ、これらを含有する医薬組成物、および認知障害の処置におけるこれらの使用
JP2000309545A (ja) 愛玩動物の年齢関連行動障害治療方法および治療用組成物
US20050228019A1 (en) Enhancement of ampakine-Induced facilitation of synaptic responses by cholinesterase inhibitors
ES2307025T3 (es) Combinacion de opioides y un derivado de la piperazina para el tratamiento del dolor.
EP4304717A1 (en) Use of nadolol to treat chronic obstructive pulmonary disease by blockage of the arrestin-2 pathway
US6103712A (en) Therapeutic treatment for asthma
KR20210156400A (ko) Ｃｄｋ 저해제 화합물 및 이의 의약 용도
MX2008015434A (es) Combinanciones de inhibidores de recaptacion de monoamina y activadores de canales de potasio.
JP2019509321A (ja) 疼痛を処置するための組み合わせ
KR20250040692A (ko) Akr1c3 의존성 kars 억제제의 결정질 형태
WO2022197885A1 (en) Compositions and methods for treating neurologic diseases
HK40093291A (en) Autophagy inducing compounds and uses thereof
JPH07503240A (ja) ３‐アリールインドールおよび１‐アリールインダゾール誘導体の精神病の治療のための使用
EA050218B1 (ru) Производные 6-метилурацила, обладающие антихолинэстеразной активностью, и их применение
EP0659409A2 (en) Substance 1 antagonists for the inhibition of angiogenesis

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070315

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070315

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20090602