JP2006520803A - エステル化脂肪酸組成物 - Google Patents
エステル化脂肪酸組成物 Download PDFInfo
- Publication number
- JP2006520803A JP2006520803A JP2006507432A JP2006507432A JP2006520803A JP 2006520803 A JP2006520803 A JP 2006520803A JP 2006507432 A JP2006507432 A JP 2006507432A JP 2006507432 A JP2006507432 A JP 2006507432A JP 2006520803 A JP2006520803 A JP 2006520803A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- acid
- fatty acid
- administered
- arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 134
- 235000014113 dietary fatty acids Nutrition 0.000 title claims abstract description 111
- 239000000194 fatty acid Substances 0.000 title claims abstract description 111
- 229930195729 fatty acid Natural products 0.000 title claims abstract description 111
- 150000004665 fatty acids Chemical class 0.000 title claims abstract description 95
- 238000011282 treatment Methods 0.000 claims abstract description 43
- 206010003246 arthritis Diseases 0.000 claims abstract description 36
- 238000000034 method Methods 0.000 claims abstract description 33
- 208000028169 periodontal disease Diseases 0.000 claims abstract description 23
- 239000000787 lecithin Substances 0.000 claims abstract description 18
- 235000010445 lecithin Nutrition 0.000 claims abstract description 18
- 229940067606 lecithin Drugs 0.000 claims abstract description 18
- 235000008390 olive oil Nutrition 0.000 claims abstract description 18
- 239000004006 olive oil Substances 0.000 claims abstract description 18
- 201000004681 Psoriasis Diseases 0.000 claims abstract description 17
- 230000002757 inflammatory effect Effects 0.000 claims abstract description 16
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 18
- -1 lecithin fatty acids Chemical class 0.000 claims description 18
- 230000000699 topical effect Effects 0.000 claims description 14
- 201000008482 osteoarthritis Diseases 0.000 claims description 12
- 235000021314 Palmitic acid Nutrition 0.000 claims description 9
- 206010025135 lupus erythematosus Diseases 0.000 claims description 9
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 9
- 235000021355 Stearic acid Nutrition 0.000 claims description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 8
- 239000008117 stearic acid Substances 0.000 claims description 8
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 7
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 7
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 7
- 239000005642 Oleic acid Substances 0.000 claims description 7
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 7
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 7
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 7
- 235000021313 oleic acid Nutrition 0.000 claims description 7
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- YWWVWXASSLXJHU-AATRIKPKSA-N (9E)-tetradecenoic acid Chemical compound CCCC\C=C\CCCCCCCC(O)=O YWWVWXASSLXJHU-AATRIKPKSA-N 0.000 claims description 6
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 6
- 201000005569 Gout Diseases 0.000 claims description 5
- 241000124008 Mammalia Species 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 210000002216 heart Anatomy 0.000 claims description 5
- 208000010191 Osteitis Deformans Diseases 0.000 claims description 4
- 208000027868 Paget disease Diseases 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 4
- VKOBVWXKNCXXDE-UHFFFAOYSA-N icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCC(O)=O VKOBVWXKNCXXDE-UHFFFAOYSA-N 0.000 claims description 4
- 208000027202 mammary Paget disease Diseases 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims description 3
- YWWVWXASSLXJHU-UHFFFAOYSA-N 9E-tetradecenoic acid Natural products CCCCC=CCCCCCCCC(O)=O YWWVWXASSLXJHU-UHFFFAOYSA-N 0.000 claims description 3
- 206010006811 Bursitis Diseases 0.000 claims description 3
- 208000001640 Fibromyalgia Diseases 0.000 claims description 3
- 208000003456 Juvenile Arthritis Diseases 0.000 claims description 3
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 3
- 206010031264 Osteonecrosis Diseases 0.000 claims description 3
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 3
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 3
- 229920000249 biocompatible polymer Polymers 0.000 claims description 3
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims description 3
- 208000019069 chronic childhood arthritis Diseases 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 230000001681 protective effect Effects 0.000 claims description 3
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 claims description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 2
- 239000005639 Lauric acid Substances 0.000 claims description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 229960004488 linolenic acid Drugs 0.000 claims description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 2
- 230000008961 swelling Effects 0.000 claims description 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 12
- 229940114079 arachidonic acid Drugs 0.000 abstract description 10
- 235000021342 arachidonic acid Nutrition 0.000 abstract description 10
- 150000002066 eicosanoids Chemical class 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 8
- 230000002265 prevention Effects 0.000 abstract description 8
- 230000008901 benefit Effects 0.000 abstract description 7
- 230000005540 biological transmission Effects 0.000 abstract description 6
- 230000001413 cellular effect Effects 0.000 abstract description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract description 4
- 230000009134 cell regulation Effects 0.000 abstract description 4
- 230000003247 decreasing effect Effects 0.000 abstract description 4
- 150000002989 phenols Chemical class 0.000 abstract description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 28
- 241001465754 Metazoa Species 0.000 description 24
- 210000001519 tissue Anatomy 0.000 description 20
- 238000012360 testing method Methods 0.000 description 18
- 150000002632 lipids Chemical class 0.000 description 17
- 230000004054 inflammatory process Effects 0.000 description 16
- 241000282472 Canis lupus familiaris Species 0.000 description 15
- 206010061218 Inflammation Diseases 0.000 description 14
- 229960000541 cetyl alcohol Drugs 0.000 description 14
- 241000700159 Rattus Species 0.000 description 13
- 239000003814 drug Substances 0.000 description 13
- 210000004185 liver Anatomy 0.000 description 12
- 229940079593 drug Drugs 0.000 description 11
- 150000003904 phospholipids Chemical class 0.000 description 11
- 238000009472 formulation Methods 0.000 description 10
- 210000003127 knee Anatomy 0.000 description 10
- 241000283973 Oryctolagus cuniculus Species 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 9
- 235000005911 diet Nutrition 0.000 description 9
- 239000000499 gel Substances 0.000 description 8
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 8
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 230000037213 diet Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 230000006872 improvement Effects 0.000 description 7
- 239000000902 placebo Substances 0.000 description 7
- 229940068196 placebo Drugs 0.000 description 7
- 150000003626 triacylglycerols Chemical class 0.000 description 7
- 208000024172 Cardiovascular disease Diseases 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 150000001840 cholesterol esters Chemical class 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 208000019622 heart disease Diseases 0.000 description 6
- 210000001503 joint Anatomy 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 6
- 230000036407 pain Effects 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 150000003408 sphingolipids Chemical class 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 5
- 239000006071 cream Substances 0.000 description 5
- 230000004968 inflammatory condition Effects 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 210000003205 muscle Anatomy 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 238000001647 drug administration Methods 0.000 description 4
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 210000002435 tendon Anatomy 0.000 description 4
- 238000011200 topical administration Methods 0.000 description 4
- 230000008733 trauma Effects 0.000 description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 102000003820 Lipoxygenases Human genes 0.000 description 3
- 108090000128 Lipoxygenases Proteins 0.000 description 3
- 208000001132 Osteoporosis Diseases 0.000 description 3
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 3
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 229940124599 anti-inflammatory drug Drugs 0.000 description 3
- 239000006227 byproduct Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 230000000747 cardiac effect Effects 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 208000037976 chronic inflammation Diseases 0.000 description 3
- 239000003246 corticosteroid Substances 0.000 description 3
- 210000004513 dentition Anatomy 0.000 description 3
- 230000031891 intestinal absorption Effects 0.000 description 3
- 210000002414 leg Anatomy 0.000 description 3
- 150000002617 leukotrienes Chemical class 0.000 description 3
- 210000004373 mandible Anatomy 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- 230000003239 periodontal effect Effects 0.000 description 3
- 238000000554 physical therapy Methods 0.000 description 3
- 229960004889 salicylic acid Drugs 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000036346 tooth eruption Effects 0.000 description 3
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 208000000094 Chronic Pain Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 2
- 238000012404 In vitro experiment Methods 0.000 description 2
- 208000004575 Infectious Arthritis Diseases 0.000 description 2
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 2
- 208000012659 Joint disease Diseases 0.000 description 2
- 206010072574 Periodontal inflammation Diseases 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 241000605862 Porphyromonas gingivalis Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000001054 cortical effect Effects 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 210000001513 elbow Anatomy 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000003511 endothelial effect Effects 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 201000005884 exanthem Diseases 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 210000003736 gastrointestinal content Anatomy 0.000 description 2
- 150000002313 glycerolipids Chemical class 0.000 description 2
- 210000002288 golgi apparatus Anatomy 0.000 description 2
- 210000002758 humerus Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000003960 inflammatory cascade Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 229960002725 isoflurane Drugs 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
- 210000002379 periodontal ligament Anatomy 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 230000000770 proinflammatory effect Effects 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 201000001223 septic arthritis Diseases 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 231100000046 skin rash Toxicity 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 210000000707 wrist Anatomy 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 102000014777 Adipokines Human genes 0.000 description 1
- 108010078606 Adipokines Proteins 0.000 description 1
- 208000002679 Alveolar Bone Loss Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000036490 Arterial inflammations Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000025978 Athletic injury Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 241000723418 Carya Species 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 108010004103 Chylomicrons Proteins 0.000 description 1
- 208000001708 Dupuytren contracture Diseases 0.000 description 1
- 208000014094 Dystonic disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015548 Euthanasia Diseases 0.000 description 1
- 208000009386 Experimental Arthritis Diseases 0.000 description 1
- 241000285018 Formosa algae Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000034619 Gingival inflammation Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 102000016267 Leptin Human genes 0.000 description 1
- 108010092277 Leptin Proteins 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- 208000023178 Musculoskeletal disease Diseases 0.000 description 1
- 235000021360 Myristic acid Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 206010029155 Nephropathy toxic Diseases 0.000 description 1
- 206010074074 Oesophageal compression Diseases 0.000 description 1
- 208000026616 Ollier disease Diseases 0.000 description 1
- 206010058667 Oral toxicity Diseases 0.000 description 1
- 208000006024 Osteochondromatosis Diseases 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 102000019280 Pancreatic lipases Human genes 0.000 description 1
- 108050006759 Pancreatic lipases Proteins 0.000 description 1
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 1
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 description 1
- 241000669298 Pseudaulacaspis pentagona Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 206010058571 Spinal cord infarction Diseases 0.000 description 1
- 208000020307 Spinal disease Diseases 0.000 description 1
- 201000002661 Spondylitis Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 208000002240 Tennis Elbow Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 208000026062 Tissue disease Diseases 0.000 description 1
- 206010044074 Torticollis Diseases 0.000 description 1
- 208000030019 Traumatic avascular necrosis Diseases 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- 241000469816 Varus Species 0.000 description 1
- 208000035868 Vascular inflammations Diseases 0.000 description 1
- 206010053648 Vascular occlusion Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 208000028752 abnormal posture Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000002917 arthritic effect Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000012754 cardiac puncture Methods 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 229960001338 colchicine Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 229940111134 coxibs Drugs 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000013367 dietary fats Nutrition 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 229960003722 doxycycline Drugs 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 208000010118 dystonia Diseases 0.000 description 1
- 230000000773 effect on pain Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 206010016629 fibroma Diseases 0.000 description 1
- 206010049444 fibromatosis Diseases 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000005021 gait Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002344 gold compounds Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036732 histological change Effects 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940124589 immunosuppressive drug Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 210000004283 incisor Anatomy 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 208000018197 inherited torticollis Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000001847 jaw Anatomy 0.000 description 1
- 208000018937 joint inflammation Diseases 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000002684 laminectomy Methods 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical group O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 1
- 229940039781 leptin Drugs 0.000 description 1
- VNYSSYRCGWBHLG-AMOLWHMGSA-M leukotriene B4(1-) Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC([O-])=O VNYSSYRCGWBHLG-AMOLWHMGSA-M 0.000 description 1
- 229940040461 lipase Drugs 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 210000004446 longitudinal ligament Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000008558 metabolic pathway by substance Effects 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 229960004023 minocycline Drugs 0.000 description 1
- 230000037230 mobility Effects 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 description 1
- 238000013425 morphometry Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 208000017445 musculoskeletal system disease Diseases 0.000 description 1
- 210000003739 neck Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000007694 nephrotoxicity Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 210000002475 olfactory pathway Anatomy 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 231100000418 oral toxicity Toxicity 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000003349 osteoarthritic effect Effects 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 229940116369 pancreatic lipase Drugs 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 201000006651 patellofemoral pain syndrome Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 238000013102 re-test Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008085 renal dysfunction Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 201000005671 spondyloarthropathy Diseases 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 229940125379 topical corticosteroid Drugs 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000002385 vertebral artery Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229940087652 vioxx Drugs 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45586003P | 2003-03-20 | 2003-03-20 | |
| PCT/US2004/008650 WO2004084829A2 (en) | 2003-03-20 | 2004-03-22 | Esterified fatty acid composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006520803A true JP2006520803A (ja) | 2006-09-14 |
| JP2006520803A5 JP2006520803A5 (https=) | 2007-05-17 |
Family
ID=33098072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006507432A Pending JP2006520803A (ja) | 2003-03-20 | 2004-03-22 | エステル化脂肪酸組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7612111B2 (https=) |
| EP (1) | EP1617830A4 (https=) |
| JP (1) | JP2006520803A (https=) |
| AU (2) | AU2004224332A1 (https=) |
| CA (1) | CA2519278C (https=) |
| WO (1) | WO2004084829A2 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010005004A1 (ja) * | 2008-07-07 | 2010-01-14 | 花王株式会社 | キサンチンオキシダーゼ阻害剤及び尿酸生成阻害剤 |
| JP2010531298A (ja) * | 2007-06-12 | 2010-09-24 | エックスバシブ， インコーポレイテッド | 疼痛を治療するための局所用組成物 |
| JP2011510059A (ja) * | 2008-01-25 | 2011-03-31 | ビー アンド ティー エッセ．エッレ．エッレ． | 化粧品分野におけるエステル交換オリーブ油の使用 |
| JP2022177123A (ja) * | 2019-05-09 | 2022-11-30 | 株式会社島津製作所 | 試料の評価方法、分析方法、劣化試料の検出方法、劣化血漿試料検出用マーカーおよび劣化血清試料検出用マーカー |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776914B2 (en) * | 2004-03-22 | 2010-08-17 | Imagenetix, Inc. | Esterified fatty acid composition |
| DK2234994T3 (da) * | 2007-12-27 | 2017-11-13 | Cibus Europe Bv | Fedtsyre-butylester-blandinger |
| US20120142776A1 (en) * | 2009-04-09 | 2012-06-07 | Leinwand Leslie A | Methods and compositions for inducing physiological hypertrophy |
| CA2795907A1 (en) * | 2009-04-09 | 2010-10-14 | The Regents Of The University Of Colorado, A Body Corporate | Methods and compositions for inducing physiological hypertrophy |
| WO2011109472A1 (en) * | 2010-03-02 | 2011-09-09 | Imagenetix, Inc. | Compositions comprising myristic acid and uses thereof |
| ES2395539B1 (es) * | 2011-06-16 | 2014-01-20 | Agencia Pública Empresarial Sanitaria Hospital Alto Guadalquivir | Uso del aceite de oliva en la prevención y el tratamiento de las enfermedades que cursan con un proceso isquémico |
| ITMI20130354A1 (it) * | 2013-03-08 | 2014-09-09 | Again Life Italia Srl | Miscela di acidi grassi (f.a.g. fatty acids group) per uso nel trattamento di patologie infiammatorie. |
| DK3097910T3 (da) * | 2014-01-24 | 2020-07-27 | Univ Kyoto | Antiinflamatorisk middel indeholdende sjælden fedtsyre |
| CA2977237A1 (en) * | 2015-02-18 | 2016-08-25 | Tersus Life Sciences, LLC | Methods for improving joint function |
| ITUB20153130A1 (it) * | 2015-08-14 | 2017-02-14 | Pharmanutra S P A | Acidi grassi cetilati, impianto per la loro preparazione e relativo uso |
| WO2018081694A1 (en) * | 2016-10-31 | 2018-05-03 | The Cleveland Clinic Foundation | Capric acid and myristic acid compositions for treating conditions |
| IT201700089258A1 (it) | 2017-08-02 | 2019-02-02 | Pharmanutra S P A | Composizione per uso nella prevenzione e nel trattamento di carenza di ferro |
| IT201900007326A1 (it) | 2019-05-27 | 2020-11-27 | Alesco Srl | Composizioni comprendenti acidi grassi cetilati e loro uso nel trattamento di artriti e stati infiammatori articolari |
| IT201900007311A1 (it) * | 2019-05-27 | 2020-11-27 | Alesco Srl | Procedimento per la preparazione di una composizione comprendente acidi grassi cetilati |
| IT201900007329A1 (it) | 2019-05-27 | 2020-11-27 | Alesco Srl | Composizioni comprendenti acidi grassi cetilati per uso nel trattamento della mucosa gastrica, diabete e alti livelli di glicemia |
| IT202300004227A1 (it) | 2023-03-07 | 2024-09-07 | Pharmanutra S P A | Composizioni comprendenti acidi grassi cetilati e vitamina d, e loro usi relativi |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60215624A (ja) * | 1984-04-11 | 1985-10-29 | Akira Kitano | 消炎鎮痛剤 |
| JPS6172715A (ja) * | 1984-09-18 | 1986-04-14 | Kao Corp | 外用抗炎症剤 |
| JPH06247852A (ja) * | 1993-02-22 | 1994-09-06 | Sekisui Chem Co Ltd | 炎症性皮膚疾患治療用外用剤 |
| JP2002511401A (ja) * | 1998-04-16 | 2002-04-16 | ドスム−ジョンソン，トーマス | 喘息治療法 |
| WO2002083122A1 (en) * | 2001-04-11 | 2002-10-24 | Yeda Research And Development Co. Ltd. | Fatty alcohols and fatty acid esters useful for treatment of inflammation |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4049824A (en) * | 1976-05-03 | 1977-09-20 | Harry Weldon Diehl | Cetyl myristoleate |
| US4330557A (en) | 1979-05-21 | 1982-05-18 | Claudio Cavazza | Acyl-carnitine and use thereof in parenteral administration of triglycerides |
| US4454159A (en) * | 1981-12-28 | 1984-06-12 | Albert Musher | Dermatological treatment preparations |
| JP2530661B2 (ja) * | 1987-07-31 | 1996-09-04 | ピジョン株式会社 | 乳液状皮膚清拭剤 |
| JPH0423298Y2 (https=) | 1987-08-19 | 1992-05-29 | ||
| US5569676A (en) * | 1995-05-24 | 1996-10-29 | Diehl; Harry W. | Method for the treatment of osteoarthritis |
| US6022551A (en) | 1998-01-20 | 2000-02-08 | Ethicon, Inc. | Antimicrobial composition |
| US6417227B1 (en) * | 1999-04-28 | 2002-07-09 | Cg And Associates | Methods of delivery of cetyl myristoleate |
| GB9927629D0 (en) * | 1999-11-24 | 2000-01-19 | Croda Int Plc | Compounds |
| EP1282412B1 (en) * | 2000-05-12 | 2008-01-16 | Meracol Corporation Limited | Treating irritable bowel syndrome or disease |
-
2004
- 2004-03-22 AU AU2004224332A patent/AU2004224332A1/en not_active Abandoned
- 2004-03-22 CA CA2519278A patent/CA2519278C/en not_active Expired - Fee Related
- 2004-03-22 JP JP2006507432A patent/JP2006520803A/ja active Pending
- 2004-03-22 EP EP04757977A patent/EP1617830A4/en not_active Withdrawn
- 2004-03-22 US US10/805,386 patent/US7612111B2/en not_active Expired - Lifetime
- 2004-03-22 WO PCT/US2004/008650 patent/WO2004084829A2/en not_active Ceased
-
2010
- 2010-05-28 AU AU2010202187A patent/AU2010202187A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60215624A (ja) * | 1984-04-11 | 1985-10-29 | Akira Kitano | 消炎鎮痛剤 |
| JPS6172715A (ja) * | 1984-09-18 | 1986-04-14 | Kao Corp | 外用抗炎症剤 |
| JPH06247852A (ja) * | 1993-02-22 | 1994-09-06 | Sekisui Chem Co Ltd | 炎症性皮膚疾患治療用外用剤 |
| JP2002511401A (ja) * | 1998-04-16 | 2002-04-16 | ドスム−ジョンソン，トーマス | 喘息治療法 |
| WO2002083122A1 (en) * | 2001-04-11 | 2002-10-24 | Yeda Research And Development Co. Ltd. | Fatty alcohols and fatty acid esters useful for treatment of inflammation |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010531298A (ja) * | 2007-06-12 | 2010-09-24 | エックスバシブ， インコーポレイテッド | 疼痛を治療するための局所用組成物 |
| JP2011510059A (ja) * | 2008-01-25 | 2011-03-31 | ビー アンド ティー エッセ．エッレ．エッレ． | 化粧品分野におけるエステル交換オリーブ油の使用 |
| WO2010005004A1 (ja) * | 2008-07-07 | 2010-01-14 | 花王株式会社 | キサンチンオキシダーゼ阻害剤及び尿酸生成阻害剤 |
| US9827279B2 (en) | 2008-07-07 | 2017-11-28 | Kao Corporation | Xanthine oxidase inhibitor and uric acid production inhibitor |
| JP2022177123A (ja) * | 2019-05-09 | 2022-11-30 | 株式会社島津製作所 | 試料の評価方法、分析方法、劣化試料の検出方法、劣化血漿試料検出用マーカーおよび劣化血清試料検出用マーカー |
| JP7578125B2 (ja) | 2019-05-09 | 2024-11-06 | 株式会社島津製作所 | 試料の評価方法、分析方法、劣化試料の検出方法、劣化血漿試料検出用マーカーおよび劣化血清試料検出用マーカー |
Also Published As
| Publication number | Publication date |
|---|---|
| US7612111B2 (en) | 2009-11-03 |
| WO2004084829A2 (en) | 2004-10-07 |
| EP1617830A2 (en) | 2006-01-25 |
| AU2004224332A1 (en) | 2004-10-07 |
| CA2519278C (en) | 2012-06-05 |
| WO2004084829A3 (en) | 2005-01-27 |
| CA2519278A1 (en) | 2004-10-07 |
| US20050208162A1 (en) | 2005-09-22 |
| EP1617830A4 (en) | 2008-09-24 |
| AU2010202187A1 (en) | 2010-06-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2010202187A1 (en) | Esterified fatty acid composition | |
| JP5662492B2 (ja) | 抗炎症製剤 | |
| McCarthy et al. | Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis | |
| Park et al. | Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model | |
| JP7761371B2 (ja) | 対象におけるマイトファジーを改善するための方法 | |
| JP7761372B2 (ja) | 対象におけるマイトファジーを改善するための方法 | |
| JP2021521277A (ja) | 動物における疼痛の処置のためのアサ抽出物 | |
| CA2923422C (en) | Use of a ppar-delta agonist for treating muscle atrophy | |
| JP2005501043A (ja) | 関節の炎症、疼痛、および可動性の減少を治療するための方法 | |
| JP2015091817A (ja) | イヌにおける軟骨損傷を軽減するための方法 | |
| Merolla et al. | Co-analgesic therapy for arthroscopic supraspinatus tendon repair pain using a dietary supplement containing Boswellia serrata and Curcuma longa: a prospective randomized placebo-controlled study | |
| RU2714312C1 (ru) | Способ оценки лекарственных средств для суставных хрящей | |
| Karmakar et al. | Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis | |
| JP2007508371A (ja) | 軟骨再生剤としてアピゲニンを含有する骨関節炎治療組成物 | |
| US7776914B2 (en) | Esterified fatty acid composition | |
| Wang et al. | The Evaluation of 68Ga-Citrate PET/CT Imaging for Dihydroartemisinin in the Treatment of Rheumatoid Arthritis | |
| KR101039818B1 (ko) | 남성 갱년기에 의해 유발되는 질환의 예방 및/또는 치료를위한 카르니틴의 용도 | |
| CN101653436B (zh) | 用于治疗犬骨关节炎的ω‑3脂肪酸 | |
| JP7114458B2 (ja) | 軟組織外傷からの回復を増強するためのβ－ヒドロキシ－β－メチルブチレート（ＨＭＢ）の組成物および使用方法 | |
| JPH0276813A (ja) | 神経変性疾患の治療薬 | |
| JP2018531228A6 (ja) | 軟組織外傷からの回復を増強するためのβ−ヒドロキシ−β−メチルブチレート（ＨＭＢ）の組成物および使用方法 | |
| CN118806879A (zh) | 一种具有骨关节保健作用的组合物及其应用 | |
| Maatuf et al. | EXAMINING THE ROLE OF SIRT1 CLEAVAGE ON AGE-DEPENDENT OA PROGRESSION FOR MALE MICE | |
| Su | Effects of multi-modal exercise and nutritional intervention nursing on microcirculation function and functional recovery in elderly patients with fracture. | |
| Guertin | No-Laminectomy Spinal Cord-Transected Murine Model |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070320 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070320 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100830 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20101129 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20101206 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20101227 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110107 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110128 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110204 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110228 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111101 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120402 |