JP2006520359A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006520359A5 JP2006520359A5 JP2006504723A JP2006504723A JP2006520359A5 JP 2006520359 A5 JP2006520359 A5 JP 2006520359A5 JP 2006504723 A JP2006504723 A JP 2006504723A JP 2006504723 A JP2006504723 A JP 2006504723A JP 2006520359 A5 JP2006520359 A5 JP 2006520359A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- pharmaceutical composition
- nucleotide derivative
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 3
- -1 and not substituted Chemical class 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 3
- 125000004423 acyloxy group Chemical group 0.000 description 3
- 150000003835 adenosine derivatives Chemical class 0.000 description 3
- 239000001177 diphosphate Substances 0.000 description 3
- 229930024421 Adenine Natural products 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 229960000643 adenine Drugs 0.000 description 2
- WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45600303P | 2003-03-19 | 2003-03-19 | |
| EP03006059A EP1460082A1 (en) | 2003-03-19 | 2003-03-19 | Phospholipid esters of clofarabine derivatives |
| PCT/EP2004/002810 WO2004083155A2 (en) | 2003-03-19 | 2004-03-18 | Nucleotide lipid ester derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006520359A JP2006520359A (ja) | 2006-09-07 |
| JP2006520359A5 true JP2006520359A5 (enExample) | 2007-04-19 |
Family
ID=33031244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006504723A Pending JP2006520359A (ja) | 2003-03-19 | 2004-03-18 | ヌクレオチド脂質エステル誘導体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7419965B2 (enExample) |
| EP (2) | EP1460082A1 (enExample) |
| JP (1) | JP2006520359A (enExample) |
| KR (1) | KR20050109939A (enExample) |
| CN (1) | CN100369926C (enExample) |
| AT (1) | ATE328000T1 (enExample) |
| AU (1) | AU2004222163A1 (enExample) |
| CA (1) | CA2519434A1 (enExample) |
| CY (1) | CY1105572T1 (enExample) |
| DE (1) | DE602004001047T2 (enExample) |
| DK (1) | DK1606233T3 (enExample) |
| ES (1) | ES2265636T3 (enExample) |
| MX (1) | MXPA05008817A (enExample) |
| NO (1) | NO20053903L (enExample) |
| NZ (1) | NZ542011A (enExample) |
| PL (1) | PL1606233T3 (enExample) |
| PT (1) | PT1606233E (enExample) |
| RU (1) | RU2347786C2 (enExample) |
| SI (1) | SI1606233T1 (enExample) |
| WO (1) | WO2004083155A2 (enExample) |
| ZA (1) | ZA200507541B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2070938A1 (en) | 2007-12-13 | 2009-06-17 | Heidelberg Pharma AG | Clofarabine dietherphospholipid derivatives |
| CN102079766A (zh) * | 2009-11-29 | 2011-06-01 | 海南中化联合制药工业股份有限公司 | 一种单磷酸阿糖腺苷的制备方法 |
| CN101709073B (zh) * | 2009-12-01 | 2013-01-23 | 北京大学 | 核苷酸磷脂分子及脂质体及其制备方法和应用 |
| CN103232510B (zh) * | 2012-11-23 | 2015-12-23 | 北京大学 | 5’-氨基-2’,5’-双脱氧核苷酸磷脂分子及其制备方法和应用 |
| US9771385B2 (en) * | 2014-11-26 | 2017-09-26 | Vascular Biogenics Ltd. | Oxidized lipids |
| KR102371969B1 (ko) | 2016-12-23 | 2022-03-08 | 주식회사 엘지에너지솔루션 | 배터리 모듈 |
| US12397058B2 (en) | 2018-06-26 | 2025-08-26 | Tsrl, Inc. | Metabolically stable prodrugs |
| WO2024059754A1 (en) * | 2022-09-14 | 2024-03-21 | Quantapore, Inc. | Polythiolated linkers for stable nanoparticle suspensions and uses thereof |
| WO2025096481A1 (en) * | 2023-10-29 | 2025-05-08 | Maia Biotechnology, Inc. | Telomere-targeting phosphatidyl-thio conjugates |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| US4751221A (en) * | 1985-10-18 | 1988-06-14 | Sloan-Kettering Institute For Cancer Research | 2-fluoro-arabinofuranosyl purine nucleosides |
| JPS6383094A (ja) * | 1986-09-27 | 1988-04-13 | Toyo Jozo Co Ltd | エ−テル型ヌクレオシド−リン脂質複合体 |
| DE4026265A1 (de) | 1990-08-20 | 1992-02-27 | Boehringer Mannheim Gmbh | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
| US5512671A (en) * | 1993-02-16 | 1996-04-30 | Wake Forest University | Ether lipid-nucleoside covalent conjugates |
| DE4321978A1 (de) * | 1993-07-01 | 1995-01-12 | Boehringer Mannheim Gmbh | Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel |
| DK0791056T3 (da) * | 1994-11-12 | 2005-07-04 | Heidelberg Pharma Gmbh | Lipidopspaltende enzymkompleks |
| US7517858B1 (en) * | 1995-06-07 | 2009-04-14 | The Regents Of The University Of California | Prodrugs of pharmaceuticals with improved bioavailability |
| US6670341B1 (en) * | 1999-10-28 | 2003-12-30 | Wake Forest University Health Sciences | Compositions and methods for double-targeting virus infections and targeting cancer cells |
| US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
-
2003
- 2003-03-19 EP EP03006059A patent/EP1460082A1/en not_active Withdrawn
-
2004
- 2004-03-18 AT AT04721537T patent/ATE328000T1/de not_active IP Right Cessation
- 2004-03-18 ES ES04721537T patent/ES2265636T3/es not_active Expired - Lifetime
- 2004-03-18 NZ NZ542011A patent/NZ542011A/en unknown
- 2004-03-18 US US10/549,799 patent/US7419965B2/en not_active Expired - Fee Related
- 2004-03-18 SI SI200430052T patent/SI1606233T1/sl unknown
- 2004-03-18 DE DE602004001047T patent/DE602004001047T2/de not_active Expired - Lifetime
- 2004-03-18 JP JP2006504723A patent/JP2006520359A/ja active Pending
- 2004-03-18 CN CNB2004800073933A patent/CN100369926C/zh not_active Expired - Fee Related
- 2004-03-18 AU AU2004222163A patent/AU2004222163A1/en not_active Abandoned
- 2004-03-18 PL PL04721537T patent/PL1606233T3/pl unknown
- 2004-03-18 RU RU2005130992/04A patent/RU2347786C2/ru not_active IP Right Cessation
- 2004-03-18 CA CA002519434A patent/CA2519434A1/en not_active Abandoned
- 2004-03-18 DK DK04721537T patent/DK1606233T3/da active
- 2004-03-18 KR KR1020057014672A patent/KR20050109939A/ko not_active Abandoned
- 2004-03-18 MX MXPA05008817A patent/MXPA05008817A/es active IP Right Grant
- 2004-03-18 PT PT04721537T patent/PT1606233E/pt unknown
- 2004-03-18 WO PCT/EP2004/002810 patent/WO2004083155A2/en not_active Ceased
- 2004-03-18 EP EP04721537A patent/EP1606233B1/en not_active Expired - Lifetime
-
2005
- 2005-08-22 NO NO20053903A patent/NO20053903L/no not_active Application Discontinuation
- 2005-09-16 ZA ZA200507541A patent/ZA200507541B/en unknown
-
2006
- 2006-08-07 CY CY20061101101T patent/CY1105572T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6893501B2 (ja) | スルフィニルフェニル又はスルホンイミドイルフェニルベンザゼピン | |
| JP5271913B2 (ja) | 化合物 | |
| JP4923216B2 (ja) | 化合物 | |
| CN104640444B (zh) | 双肝脏靶向氨基磷酸酯和氨基膦酸酯前药 | |
| ES2707534T3 (es) | Compuestos útiles como inmunomoduladores | |
| AU2015277312B2 (en) | Synthesis of polycyclic-carbamoylpyridone compounds | |
| WO2001060834A1 (en) | Novel pyrazine derivatives or salts thereof, pharmaceutical compositions containing the derivatives or the salts and intermediates for the preparation of both | |
| CN102574837B (zh) | 新的5-氟尿嘧啶衍生物 | |
| CN107108676A (zh) | 用于制备非对映异构纯的磷酰胺酯前药的方法 | |
| RS60430B1 (sr) | Jedinjenja 4-amino-imidazohinolina | |
| JPS6259715B2 (enExample) | ||
| TNSN07154A1 (en) | Purine derivatives for use as adenosin a-2a receptor agonists | |
| JP2006520359A5 (enExample) | ||
| US9481678B2 (en) | Substituted pyrrolo[2,3-D]dipyrimidines for selectively targeting tumor cells with FR-alpha and FR-beta type receptors | |
| CN108602842B (zh) | 杂环化合物及其制备方法和用途 | |
| US6372725B1 (en) | Specific lipid conjugates to nucleoside diphosphates and their use as drugs | |
| JP2019506382A (ja) | 癌及びウイルスを阻害するための化合物 | |
| EP4143182B1 (en) | Novel compounds useful as poly(adp-ribose) polymerase (parp) inhibitors | |
| WO2013016321A1 (en) | Minor groove binder phosphoramidites and methods of use | |
| JP2008514581A (ja) | 生体還元により活性化されるプロドラッグ | |
| JP2006521295A (ja) | 水溶性のサリドマイド誘導体 | |
| JPH10251285A (ja) | 白金（ｉｖ）錯体及びこれを含有する医薬 | |
| RU2005130992A (ru) | Производные сложноэфирных липидов нуклеотидов | |
| JP2010500971A5 (enExample) | ||
| JP3025557B2 (ja) | ２‐アルキニルアデノシン誘導体 |